Class information for:
Level 1: GLYT1//GLYCINE TRANSPORTER//GLYCINE TRANSPORTER INHIBITORS

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
9910 1108 49.8 83%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
11 4 NEUROSCIENCES//CLINICAL NEUROLOGY//NEUROL 1112395
100 3       NEUROSCIENCES//METABOTROPIC GLUTAMATE RECEPTOR//HIPPOCAMPUS 73970
488 2             SIGMA RECEPTOR//NMDA RECEPTOR//PHENCYCLIDINE 15502
9910 1                   GLYT1//GLYCINE TRANSPORTER//GLYCINE TRANSPORTER INHIBITORS 1108

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 GLYT1 authKW 1437382 6% 80% 65
2 GLYCINE TRANSPORTER authKW 1274211 6% 68% 68
3 GLYCINE TRANSPORTER INHIBITORS authKW 360082 1% 93% 14
4 GLYCINE TRANSPORTER 1 authKW 334013 2% 61% 20
5 GLYT1 INHIBITOR authKW 275574 1% 100% 10
6 GLYCINE TRANSPORT authKW 264546 1% 80% 12
7 GLYCINE TRANSPORTER 1 INHIBITOR authKW 256493 1% 85% 11
8 GLYT2 authKW 216243 2% 41% 19
9 GLYCINE RELEASE authKW 211975 1% 77% 10
10 GLYCINE authKW 195030 14% 5% 151

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Neurosciences 9489 54% 0% 593
2 Psychiatry 8448 32% 0% 352
3 Pharmacology & Pharmacy 2367 28% 0% 314
4 Clinical Neurology 532 11% 0% 121
5 Behavioral Sciences 300 4% 0% 46
6 Chemistry, Medicinal 277 5% 0% 60
7 Biochemistry & Molecular Biology 224 16% 0% 178
8 Genetics & Heredity 28 4% 0% 40
9 Chemistry, Organic 22 4% 0% 42
10 Psychology 14 1% 0% 14

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DIS GENESHIGASHI KU 86113 0% 63% 5
2 EZRATH NASHIM HERZOG MEM HOSP 62003 0% 75% 3
3 FULBOURNE HOSP 62003 0% 75% 3
4 MED JOINT PSYCHOL MED 55115 0% 100% 2
5 PHARMACOL TOXICOL SECT 51282 2% 10% 18
6 DISCOVERY IMAGING 36742 0% 67% 2
7 PSYCHIAT EXCELLENCE 36742 0% 67% 2
8 EXCELLENCE BIOMED 28814 2% 4% 24
9 ABORAT HUMAN BRAIN 27557 0% 100% 1
10 ACTUPUNCTURE PHARMACOL 27557 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 NEUROPSYCHOPHARMACOLOGY 3922 2% 1% 27
2 PSYCHIATRIC GENETICS 3691 1% 1% 11
3 BIOLOGICAL PSYCHIATRY 3684 3% 0% 35
4 SYNAPSE 3329 2% 1% 20
5 EUROPEAN NEUROPSYCHOPHARMACOLOGY 2714 1% 1% 15
6 SCHIZOPHRENIA RESEARCH 2681 2% 0% 24
7 MOLECULAR PSYCHIATRY 2351 1% 1% 14
8 WORLD WASTES 2295 0% 8% 1
9 CLINICAL NEUROPHARMACOLOGY 2233 1% 1% 14
10 NEUROCHEMISTRY INTERNATIONAL 1839 2% 0% 19

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 GLYT1 1437382 6% 80% 65 Search GLYT1 Search GLYT1
2 GLYCINE TRANSPORTER 1274211 6% 68% 68 Search GLYCINE+TRANSPORTER Search GLYCINE+TRANSPORTER
3 GLYCINE TRANSPORTER INHIBITORS 360082 1% 93% 14 Search GLYCINE+TRANSPORTER+INHIBITORS Search GLYCINE+TRANSPORTER+INHIBITORS
4 GLYCINE TRANSPORTER 1 334013 2% 61% 20 Search GLYCINE+TRANSPORTER+1 Search GLYCINE+TRANSPORTER+1
5 GLYT1 INHIBITOR 275574 1% 100% 10 Search GLYT1+INHIBITOR Search GLYT1+INHIBITOR
6 GLYCINE TRANSPORT 264546 1% 80% 12 Search GLYCINE+TRANSPORT Search GLYCINE+TRANSPORT
7 GLYCINE TRANSPORTER 1 INHIBITOR 256493 1% 85% 11 Search GLYCINE+TRANSPORTER+1+INHIBITOR Search GLYCINE+TRANSPORTER+1+INHIBITOR
8 GLYT2 216243 2% 41% 19 Search GLYT2 Search GLYT2
9 GLYCINE RELEASE 211975 1% 77% 10 Search GLYCINE+RELEASE Search GLYCINE+RELEASE
10 GLYCINE 195030 14% 5% 151 Search GLYCINE Search GLYCINE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 CIOFFI, CL , GUZZO, PR , (2016) INHIBITORS OF GLYCINE TRANSPORTER-1: POTENTIAL THERAPEUTICS FOR THE TREATMENT OF CNS DISORDERS.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 16. ISSUE 29. P. 3404 -3437 156 70% 0
2 HARSING, LG , (2013) AN OVERVIEW ON GLYT-1 INHIBITORS UNDER EVALUATION FOR THE TREATMENT OF SCHIZOPHRENIA.DRUGS OF THE FUTURE. VOL. 38. ISSUE 8. P. 555-568 79 85% 3
3 HASHIMOTO, K , (2011) GLYCINE TRANSPORTER-1: A NEW POTENTIAL THERAPEUTIC TARGET FOR SCHIZOPHRENIA.CURRENT PHARMACEUTICAL DESIGN. VOL. 17. ISSUE 2. P. 112-120 64 88% 29
4 WOLKENBERG, SE , SUR, C , (2010) RECENT PROGRESS IN THE DISCOVERY OF NON-SARCOSINE BASED GLYT1 INHIBITORS.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 10. ISSUE 2. P. 170-186 63 88% 30
5 HARVEY, RJ , YEE, BK , (2013) GLYCINE TRANSPORTERS AS NOVEL THERAPEUTIC TARGETS IN SCHIZOPHRENIA, ALCOHOL DEPENDENCE AND PAIN.NATURE REVIEWS DRUG DISCOVERY. VOL. 12. ISSUE 11. P. 866-885 88 47% 47
6 CIOFFI, CL , LIU, S , WOLF, MA , GUZZO, PR , SADALAPURE, K , PARTHASARATHY, V , LOONG, DTJ , MAENG, JH , CARULLI, E , FANG, X , ET AL (2016) SYNTHESIS AND BIOLOGICAL EVALUATION OF N-((1-(4-(SULFONYL)PIPERAZIN-1-YL)CYCLOALKYL)METHYL)BENZAMIDE INHIBITORS OF GLYCINE TRANSPORTER-1.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 59. ISSUE 18. P. 8473 -8494 62 74% 0
7 SINGER, P , DUBROQUA, S , YEE, BK , (2015) INHIBITION OF GLYCINE TRANSPORTER 1: THE YELLOW BRICK ROAD TO NEW SCHIZOPHRENIA THERAPY?.CURRENT PHARMACEUTICAL DESIGN. VOL. 21. ISSUE 26. P. 3771 -3787 68 57% 6
8 BRIDGES, TM , WILLIAMS, R , LINDSLEY, CW , (2008) DESIGN OF POTENT GLYT1 INHIBITORS: IN VITRO AND IN VIVO PROFILES.CURRENT OPINION IN MOLECULAR THERAPEUTICS. VOL. 10. ISSUE 6. P. 591-601 54 81% 33
9 HARSING, LG , JURANYI, Z , GACSALYI, I , TAPOLICSANYI, P , CZOMPA, A , MATYUS, P , (2006) GLYCINE TRANSPORTER TYPE-1 AND ITS INHIBITORS.CURRENT MEDICINAL CHEMISTRY. VOL. 13. ISSUE 9. P. 1017 -1044 59 76% 48
10 CIOFFI, CL , LIU, SA , WOLF, MA , (2010) RECENT DEVELOPMENTS IN GLYCINE TRANSPORTER-1 INHIBITORS.ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 45. VOL. 45. ISSUE . P. 19-35 47 84% 3

Classes with closest relation at Level 1


Rank Class id link
1 23200 D CYCLOSERINE//MILACEMIDE//CYCLOSERINE
2 7778 KETAMINE//EXPT THER EUT PATHOPHYSIOL BRANCH//INTEGRAT BIOMED BRAIN DIS
3 13747 MK 801//CGP 43487//JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION
4 5858 D AMINO ACID OXIDASE//D SERINE//SERINE RACEMASE
5 16847 MK 801//NMDA ANTAGONIST//POSTERIOR CINGULATE AND RETROSPLENIAL CORTICES
6 4859 NEUROTRANSMITTER TRANSPORTER//NOREPINEPHRINE TRANSPORTER//DOPAMINE TRANSPORTER
7 6650 GLYCINE RECEPTOR//HYPEREKPLEXIA//GEPHYRIN
8 2042 NMDA RECEPTOR//NR2B//NR2A
9 6946 PHENCYCLIDINE//METAPHIT//BTCP
10 6033 ARCAINE//POLYAMINES//SPERMINE

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