Class information for:
Level 1: PKM2//PYRUVATE KINASE//PYRUVATE KINASE DEFICIENCY

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
8765 1219 33.7 59%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
408 3       CHIM BIOINORGAN//POLO SCI//CARBONIC ANHYDRASE 29468
2612 2             WARBURG EFFECT//PKM2//PYRUVATE KINASE 3575
8765 1                   PKM2//PYRUVATE KINASE//PYRUVATE KINASE DEFICIENCY 1219

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PKM2 authKW 1626217 7% 73% 89
2 PYRUVATE KINASE authKW 1255125 12% 33% 152
3 PYRUVATE KINASE DEFICIENCY authKW 953962 4% 81% 47
4 PYRUVATE KINASE M2 authKW 612469 3% 68% 36
5 TUMOR M2 PYRUVATE KINASE authKW 475910 2% 100% 19
6 TUM2 PK authKW 350671 1% 100% 14
7 TUMOR M2 PK authKW 302362 1% 93% 13
8 PK LR GENE authKW 200383 1% 100% 8
9 M2 PK authKW 114498 1% 57% 8
10 PKLR GENE MUTATIONS authKW 100192 0% 100% 4

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biochemistry & Molecular Biology 3228 44% 0% 533
2 Hematology 2000 13% 0% 158
3 Oncology 1011 17% 0% 202
4 Cell Biology 699 14% 0% 170
5 Biophysics 641 9% 0% 113
6 Medical Laboratory Technology 95 2% 0% 21
7 Genetics & Heredity 84 5% 0% 60
8 Medicine, Research & Experimental 73 4% 0% 50
9 Gastroenterology & Hepatology 47 3% 0% 33
10 Biochemical Research Methods 32 3% 0% 33

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOCHEM ENDOCRINOL 77230 1% 19% 16
2 PL HUMAN GENET 52892 1% 16% 13
3 PHARMA ETH 50096 0% 100% 2
4 W KENT CANC NETWORK 50096 0% 100% 2
5 TRANSFUS MED CELL PROC 34672 0% 23% 6
6 SE LONDON CANC NETWORK 33396 0% 67% 2
7 ZENTRAL OR ZENTRUM INNERE MED 33396 0% 67% 2
8 BIOCHEM ENDOKRINOL 30725 1% 14% 9
9 ABORAT INNOVAT CANC PERSONALIZED MEDCANC 25048 0% 100% 1
10 ABT MED INFORMAT BIOMET EPIDEMIOL 25048 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 AMERICAN JOURNAL OF HEMATOLOGY 2812 2% 0% 26
2 CANADIAN JOURNAL OF BIOCHEMISTRY 2660 1% 2% 7
3 BLOOD CELLS MOLECULES AND DISEASES 2012 1% 1% 12
4 COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY 1740 2% 0% 26
5 ANTICANCER RESEARCH 1465 3% 0% 34
6 BRITISH JOURNAL OF HAEMATOLOGY 1414 2% 0% 28
7 INTERNATIONAL JOURNAL OF BIOCHEMISTRY 1375 1% 0% 13
8 INTERNATIONAL JOURNAL OF BIO-MEDICAL COMPUTING 1101 0% 1% 6
9 BIOCHEMISTRY 1055 4% 0% 49
10 CLINICS IN HAEMATOLOGY 842 0% 1% 3

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 PKM2 1626217 7% 73% 89 Search PKM2 Search PKM2
2 PYRUVATE KINASE 1255125 12% 33% 152 Search PYRUVATE+KINASE Search PYRUVATE+KINASE
3 PYRUVATE KINASE DEFICIENCY 953962 4% 81% 47 Search PYRUVATE+KINASE+DEFICIENCY Search PYRUVATE+KINASE+DEFICIENCY
4 PYRUVATE KINASE M2 612469 3% 68% 36 Search PYRUVATE+KINASE+M2 Search PYRUVATE+KINASE+M2
5 TUMOR M2 PYRUVATE KINASE 475910 2% 100% 19 Search TUMOR+M2+PYRUVATE+KINASE Search TUMOR+M2+PYRUVATE+KINASE
6 TUM2 PK 350671 1% 100% 14 Search TUM2+PK Search TUM2+PK
7 TUMOR M2 PK 302362 1% 93% 13 Search TUMOR+M2+PK Search TUMOR+M2+PK
8 PK LR GENE 200383 1% 100% 8 Search PK+LR+GENE Search PK+LR+GENE
9 M2 PK 114498 1% 57% 8 Search M2+PK Search M2+PK
10 PKLR GENE MUTATIONS 100192 0% 100% 4 Search PKLR+GENE+MUTATIONS Search PKLR+GENE+MUTATIONS

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 LI, ZW , YANG, P , LI, ZY , (2014) THE MULTIFACETED REGULATION AND FUNCTIONS OF PKM2 IN TUMOR PROGRESSION.BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER. VOL. 1846. ISSUE 2. P. 285 -296 99 73% 17
2 WONG, N , OJO, D , YAN, J , TANG, D , (2015) PKM2 CONTRIBUTES TO CANCER METABOLISM.CANCER LETTERS. VOL. 356. ISSUE 2. P. 184 -191 66 78% 32
3 ISRAELSEN, WJ , VANDER HEIDEN, MG , (2015) PYRUVATE KINASE: FUNCTION, REGULATION AND ROLE IN CANCER.SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY. VOL. 43. ISSUE . P. 43 -51 64 82% 17
4 CANU, G , DE BONIS, M , MINUCCI, A , CAPOLUONGO, E , (2016) RED BLOOD CELL PK DEFICIENCY: AN UPDATE OF PK-LR GENE MUTATION DATABASE.BLOOD CELLS MOLECULES AND DISEASES. VOL. 57. ISSUE . P. 100 -109 62 97% 1
5 GUPTA, V , WELLEN, KE , MAZUREK, S , BAMEZAI, RNK , (2014) PYRUVATE KINASE M2: REGULATORY CIRCUITS AND POTENTIAL FOR THERAPEUTIC INTERVENTION.CURRENT PHARMACEUTICAL DESIGN. VOL. 20. ISSUE 15. P. 2595-2606 75 82% 5
6 CHANETON, B , GOTTLIEB, E , (2012) ROCKING CELL METABOLISM: REVISED FUNCTIONS OF THE KEY GLYCOLYTIC REGULATOR PKM2 IN CANCER.TRENDS IN BIOCHEMICAL SCIENCES. VOL. 37. ISSUE 8. P. 309-316 55 92% 79
7 ZANELLA, A , FERMO, E , BIANCHI, P , VALENTINI, G , (2005) RED CELL PYRUVATE KINASE DEFICIENCY: MOLECULAR AND CLINICAL ASPECTS.BRITISH JOURNAL OF HAEMATOLOGY. VOL. 130. ISSUE 1. P. 11-25 72 94% 73
8 MAZUREK, S , (2011) PYRUVATE KINASE TYPE M2: A KEY REGULATOR OF THE METABOLIC BUDGET SYSTEM IN TUMOR CELLS.INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. VOL. 43. ISSUE 7. P. 969-980 66 56% 225
9 IQBAL, MA , GUPTA, V , GOPINATH, P , MAZUREK, S , BAMEZAI, RNK , (2014) PYRUVATE KINASE M2 AND CANCER: AN UPDATED ASSESSMENT.FEBS LETTERS. VOL. 588. ISSUE 16. P. 2685 -2692 61 73% 36
10 ZANELLA, A , FERMO, E , BIANCHI, P , CHIARELLI, LR , VALENTINI, G , (2007) PYRUVATE KINASE DEFICIENCY: THE GENOTYPE-PHENOTYPE ASSOCIATION.BLOOD REVIEWS. VOL. 21. ISSUE 4. P. 217 -231 61 95% 39

Classes with closest relation at Level 1


Rank Class id link
1 4289 3 BROMOPYRUVATE//WARBURG EFFECT//CANCER METABOLISM
2 6071 6 PHOSPHOFRUCTO 2 KINASE//FRUCTOSE 2 6 BISPHOSPHATE//6 PHOSPHOFRUCTO 2 KINASE FRUCTOSE 2 6 BISPHOSPHATASE
3 15197 HEXOKINASE//HEXOKINASE II//BRAIN HEXOKINASE
4 25683 PHOSPHOGLYCERATE MUTASE//BISPHOSPHOGLYCERATE MUTASE//2 3 BISPHOSPHOGLYCERATE PHOSPHATASE
5 17636 TRIOSEPHOSPHATE ISOMERASE//TRIOSEPHOSPHATE ISOMERASE DEFICIENCY//BIOQUIM BIOL ESTRUCT
6 20583 PHOSPHOGLYCERATE KINASE//PHOSPHOGLYCERATE KINASE DEFICIENCY//PGK1
7 17564 PLANT GLYCOLYSIS//FRUCTOSE 2 6 BISPHOSPHATE//PYROPHOSPHATE DEPENDENT PHOSPHOFRUCTOKINASE
8 12692 CHREBP//CARBOHYDRATE RESPONSE ELEMENT BINDING PROTEIN CHREBP//CARBOHYDRATE RESPONSE ELEMENT BINDING PROTEIN
9 19833 AUTOCRINE MOTILITY FACTOR//AUTOCRINE MOTILITY FACTOR RECEPTOR//PHOSPHOGLUCOSE ISOMERASE
10 14878 FRUCTOSE 1 6 BISPHOSPHATE ALDOLASE//HEREDITARY FRUCTOSE INTOLERANCE//ALDOLASE

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