Class information for:
Level 1: X LINKED AGAMMAGLOBULINEMIA//BRUTONS TYROSINE KINASE//BTK

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
8654 1231 46.2 89%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
269 3       CELL BIOLOGY//CAVEOLIN 1//CAVEOLAE 44007
536 2             X LINKED AGAMMAGLOBULINEMIA//BTK//SH2 DOMAIN 14793
8654 1                   X LINKED AGAMMAGLOBULINEMIA//BRUTONS TYROSINE KINASE//BTK 1231

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 X LINKED AGAMMAGLOBULINEMIA authKW 1932464 9% 70% 112
2 BRUTONS TYROSINE KINASE authKW 1499205 7% 66% 91
3 BTK authKW 1409496 9% 54% 105
4 XLA authKW 640662 3% 70% 37
5 ITK authKW 440321 3% 51% 35
6 TEC KINASE authKW 390648 2% 75% 21
7 BRUTONS TYROSINE KINASE BTK authKW 287001 1% 64% 18
8 BTK GENE authKW 274747 1% 92% 12
9 X LINKED AGAMMAGLOBULINEMIA XLA authKW 232872 1% 72% 13
10 X LINKED AGAMMAGLOBULINAEMIA authKW 217204 1% 52% 17

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Immunology 6784 36% 0% 444
2 Biochemistry & Molecular Biology 1123 28% 0% 344
3 Allergy 777 4% 0% 48
4 Cell Biology 651 13% 0% 166
5 Hematology 586 7% 0% 91
6 Genetics & Heredity 562 10% 0% 125
7 Chemistry, Medicinal 269 5% 0% 63
8 Medicine, Research & Experimental 168 6% 0% 68
9 Pediatrics 148 5% 0% 59
10 Oncology 122 7% 0% 90

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MOL IMMUNOL INFECT DIS 76246 2% 13% 23
2 EVANS BIOMED EVANS MEM CLIN 74411 0% 100% 3
3 IMMUNOL INFECT DIS PROGRAM 59078 1% 26% 9
4 IMMUNOBIOL OPT INTEGRATED BIOSCI PROGRAM 49607 0% 100% 2
5 SYST BIOMED BIOPHYS 49607 0% 100% 2
6 CHEM GENOM STRUCT BIOL 33070 0% 67% 2
7 JIANGSU MOL TARGETED ANTITUMOR DRUG 32629 0% 26% 5
8 MOL MED A NOCIVELLI 31152 1% 18% 7
9 ALL CHILDRENS HOSP MED PEDIAT 24804 0% 100% 1
10 AQUAT PROD LIFE 24804 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 INTERNATIONAL REVIEWS OF IMMUNOLOGY 4559 1% 2% 8
2 JOURNAL OF CLINICAL IMMUNOLOGY 3910 2% 1% 20
3 JOURNAL OF IMMUNOLOGY 2726 6% 0% 78
4 CLINICAL IMMUNOLOGY 2655 1% 1% 17
5 EUROPEAN JOURNAL OF IMMUNOLOGY 1886 3% 0% 32
6 IMMUNOLOGICAL REVIEWS 1785 1% 0% 15
7 JOURNAL OF EXPERIMENTAL MEDICINE 1544 2% 0% 28
8 IMMUNITY 1395 1% 0% 14
9 CURRENT OPINION IN IMMUNOLOGY 1071 1% 0% 11
10 INTERNATIONAL IMMUNOLOGY 1022 1% 0% 13

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 X LINKED AGAMMAGLOBULINEMIA 1932464 9% 70% 112 Search X+LINKED+AGAMMAGLOBULINEMIA Search X+LINKED+AGAMMAGLOBULINEMIA
2 BRUTONS TYROSINE KINASE 1499205 7% 66% 91 Search BRUTONS+TYROSINE+KINASE Search BRUTONS+TYROSINE+KINASE
3 BTK 1409496 9% 54% 105 Search BTK Search BTK
4 XLA 640662 3% 70% 37 Search XLA Search XLA
5 ITK 440321 3% 51% 35 Search ITK Search ITK
6 TEC KINASE 390648 2% 75% 21 Search TEC+KINASE Search TEC+KINASE
7 BRUTONS TYROSINE KINASE BTK 287001 1% 64% 18 Search BRUTONS+TYROSINE+KINASE+BTK Search BRUTONS+TYROSINE+KINASE+BTK
8 BTK GENE 274747 1% 92% 12 Search BTK+GENE Search BTK+GENE
9 X LINKED AGAMMAGLOBULINEMIA XLA 232872 1% 72% 13 Search X+LINKED+AGAMMAGLOBULINEMIA+XLA Search X+LINKED+AGAMMAGLOBULINEMIA+XLA
10 X LINKED AGAMMAGLOBULINAEMIA 217204 1% 52% 17 Search X+LINKED+AGAMMAGLOBULINAEMIA Search X+LINKED+AGAMMAGLOBULINAEMIA

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 MOHAMED, AJ , YU, L , BACKESJO, CM , VARGAS, L , FARYAL, R , AINTS, A , CHRISTENSSON, B , BERGLOF, A , VIHINEN, M , NORE, BF , ET AL (2009) BRUTON'S TYROSINE KINASE (BTK): FUNCTION, REGULATION, AND TRANSFORMATION WITH SPECIAL EMPHASIS ON THE PH DOMAIN.IMMUNOLOGICAL REVIEWS. VOL. 228. ISSUE . P. 58 -73 123 78% 132
2 BERG, LJ , FINKELSTEIN, LD , LUCAS, JA , SCHWARTZBERG, PL , (2005) TEC FAMILY KINASES IN T LYMPHOCYTE DEVELOPMENT AND FUNCTION.ANNUAL REVIEW OF IMMUNOLOGY. VOL. 23. ISSUE . P. 549 -600 134 65% 175
3 ORTUTAY, C , NORE, BF , VIHINEN, M , SMITH, CIE , (2008) PHYLOGENY OF TEC FAMILY KINASES: IDENTIFICATION OF A PREMETAZOAN ORIGIN OF BTK, BMX, ITK, TEC, TXK, AND THE BTK REGULATOR SH3BP5.ADVANCES IN GENETICS, VOL 64. VOL. 64. ISSUE . P. 51 -80 125 65% 12
4 FELICES, M , FALK, M , KOSAKA, Y , BERG, LJ , (2007) TEC KINASES IN T CELL AND MAST CELL SIGNALING.ADVANCES IN IMMUNOLOGY, VOL 93. VOL. 93. ISSUE . P. 145 -184 125 62% 32
5 SMITH, CIE , ISLAM, TC , MATTSSON, PT , MOHAMED, AJ , NORE, BF , VIHINEN, M , (2001) THE TEC FAMILY OF CYTOPLASMIC TYROSINE KINASES: MAMMALIAN BTK, BMX, ITK, TEC, TXK AND HOMOLOGS IN OTHER SPECIES.BIOESSAYS. VOL. 23. ISSUE 5. P. 436 -446 77 86% 152
6 SAHU, N , AUGUST, A , (2009) ITK INHIBITORS IN INFLAMMATION AND IMMUNE-MEDIATED DISORDERS.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 9. ISSUE 8. P. 690 -703 83 70% 15
7 ANDREOTTI, AH , SCHWARTZBERG, PL , JOSEPH, RE , BERG, LJ , (2010) T-CELL SIGNALING REGULATED BY THE TEC FAMILY KINASE, ITK.COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY. VOL. 2. ISSUE 7. P. - 88 59% 43
8 BOUCHERON, N , ELLMEIER, W , (2012) THE ROLE OF TEC FAMILY KINASES IN THE REGULATION OF T-HELPER-CELL DIFFERENTIATION.INTERNATIONAL REVIEWS OF IMMUNOLOGY. VOL. 31. ISSUE 2. P. 133 -154 97 56% 6
9 VARGAS, L , HAMASY, A , NORE, BF , SMITH, CIE , (2013) INHIBITORS OF BTK AND ITK: STATE OF THE NEW DRUGS FOR CANCER, AUTOIMMUNITY AND INFLAMMATORY DISEASES.SCANDINAVIAN JOURNAL OF IMMUNOLOGY. VOL. 78. ISSUE 2. P. 130 -139 65 70% 25
10 PONADER, S , BURGER, JA , (2014) BRUTON'S TYROSINE KINASE: FROM X-LINKED AGAMMAGLOBULINEMIA TOWARD TARGETED THERAPY FOR B-CELL MALIGNANCIES.JOURNAL OF CLINICAL ONCOLOGY. VOL. 32. ISSUE 17. P. 1830 -U115 66 67% 15

Classes with closest relation at Level 1


Rank Class id link
1 18972 SYK//SPLEEN TYROSINE KINASE//FOSTAMATINIB
2 3006 COMMON VARIABLE IMMUNODEFICIENCY//IGA DEFICIENCY//CVID
3 13788 SLP 76//ADAP//SECT LYMPHOCYTE SIGNALING
4 5381 RECEPTOR EDITING//SURROGATE LIGHT CHAIN//PRE B CELL RECEPTOR
5 31526 ARID3B//JUMONJI//AT RICH INTERACTION DOMAIN
6 12297 SEVERE COMBINED IMMUNODEFICIENCY//OMENN SYNDROME//PRIMARY IMMUNODEFICIENCY
7 11061 SURFACE IGM//MEMBRANE IMMUNOGLOBULIN//IG ALPHA
8 14683 SHIP2//SHIP1//DOK
9 11252 WISKOTT ALDRICH SYNDROME//X LINKED THROMBOCYTOPENIA//WISKOTT ALDRICH SYNDROME PROTEIN
10 22654 VAV//VAV1//VAV PROTO ONCOGENE

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