Class information for:
Level 1: SYK//SPLEEN TYROSINE KINASE//FOSTAMATINIB

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
18972 528 47.2 92%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
269 3       CELL BIOLOGY//CAVEOLIN 1//CAVEOLAE 44007
536 2             X LINKED AGAMMAGLOBULINEMIA//BTK//SH2 DOMAIN 14793
18972 1                   SYK//SPLEEN TYROSINE KINASE//FOSTAMATINIB 528

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 SYK authKW 1751302 20% 29% 106
2 SPLEEN TYROSINE KINASE authKW 1360697 8% 59% 40
3 FOSTAMATINIB authKW 1003995 5% 69% 25
4 SYK INHIBITOR authKW 514383 2% 68% 13
5 R788 authKW 346986 1% 100% 6
6 SPLEEN TYROSINE KINASE SYK authKW 333094 2% 48% 12
7 R406 authKW 236137 1% 58% 7
8 SYK KINASE authKW 191617 2% 25% 13
9 SYK GENE authKW 173493 1% 100% 3
10 MTA SE LENDULET INFLAMMAT PHYSIOL GRP address 120475 1% 42% 5

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Immunology 764 20% 0% 103
2 Chemistry, Medicinal 449 9% 0% 49
3 Biochemistry & Molecular Biology 422 27% 0% 140
4 Cell Biology 326 14% 0% 76
5 Oncology 275 14% 0% 72
6 Rheumatology 266 4% 0% 23
7 Hematology 223 7% 0% 37
8 Pharmacology & Pharmacy 192 13% 0% 71
9 Biophysics 42 4% 0% 23
10 Allergy 30 1% 0% 7

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MTA SE LENDULET INFLAMMAT PHYSIOL GRP 120475 1% 42% 5
2 CARDIOVASC PHYSIOL PATHOPHYSIOL 84113 1% 36% 4
3 MOL ONCOL DRUG DISCOVERY PROGRAM 84113 1% 36% 4
4 ANEXPLO CREFREUS006 57831 0% 100% 1
5 ASTRA CHAIR ASTHMA 57831 0% 100% 1
6 BIOCHEM MOL BIOL PATHOPHYSIOL FU 57831 0% 100% 1
7 BIOL IMMUNOL PLATFORM PCS 57831 0% 100% 1
8 C3MTEAM 2 57831 0% 100% 1
9 CANADIAN BLOOD SERV LI KA SHING 57831 0% 100% 1
10 CARDIOVASC MOLEC BIOL 57831 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF IMMUNOLOGY 999 6% 0% 31
2 EXPERT OPINION ON INVESTIGATIONAL DRUGS 960 1% 0% 6
3 IMMUNITY 815 1% 0% 7
4 EXPERT OPINION ON THERAPEUTIC PATENTS 641 1% 0% 5
5 CANCER CELL 598 1% 0% 4
6 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 563 3% 0% 16
7 BLOOD 518 3% 0% 18
8 ARTHRITIS & RHEUMATOLOGY 514 1% 0% 3
9 FORMULARY 383 0% 0% 2
10 VOIX & IMAGES 374 0% 1% 1

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 SYK 1751302 20% 29% 106 Search SYK Search SYK
2 SPLEEN TYROSINE KINASE 1360697 8% 59% 40 Search SPLEEN+TYROSINE+KINASE Search SPLEEN+TYROSINE+KINASE
3 FOSTAMATINIB 1003995 5% 69% 25 Search FOSTAMATINIB Search FOSTAMATINIB
4 SYK INHIBITOR 514383 2% 68% 13 Search SYK+INHIBITOR Search SYK+INHIBITOR
5 R788 346986 1% 100% 6 Search R788 Search R788
6 SPLEEN TYROSINE KINASE SYK 333094 2% 48% 12 Search SPLEEN+TYROSINE+KINASE+SYK Search SPLEEN+TYROSINE+KINASE+SYK
7 R406 236137 1% 58% 7 Search R406 Search R406
8 SYK KINASE 191617 2% 25% 13 Search SYK+KINASE Search SYK+KINASE
9 SYK GENE 173493 1% 100% 3 Search SYK+GENE Search SYK+GENE
10 BIIB 057 115662 0% 100% 2 Search BIIB+057 Search BIIB+057

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 SINGH, R , MASUDA, ES , PAYAN, DG , (2012) DISCOVERY AND DEVELOPMENT OF SPLEEN TYROSINE KINASE (SYK) INHIBITORS.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 55. ISSUE 8. P. 3614 -3643 82 45% 28
2 GEAHLEN, RL , (2014) GETTING SYK: SPLEEN TYROSINE KINASE AS A THERAPEUTIC TARGET.TRENDS IN PHARMACOLOGICAL SCIENCES. VOL. 35. ISSUE 8. P. 414 -422 56 54% 29
3 KRISENKO, MO , GEAHLEN, RL , (2015) CALLING IN SYK: SYK'S DUAL ROLE AS A TUMOR PROMOTER AND TUMOR SUPPRESSOR IN CANCER.BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH. VOL. 1853. ISSUE 1. P. 254 -263 58 52% 9
4 TYBULEWICZ, VLJ , MOCSAI, A , RULAND, J , (2010) THE SYK TYROSINE KINASE: A CRUCIAL PLAYER IN DIVERSE BIOLOGICAL FUNCTIONS.NATURE REVIEWS IMMUNOLOGY. VOL. 10. ISSUE 6. P. 387 -402 55 30% 362
5 CURRIE, KS , KROPF, JE , LEE, T , BLOMGREN, P , XU, JJ , ZHAO, ZD , GALLION, S , WHITNEY, JA , MACLIN, D , LANSDON, EB , ET AL (2014) DISCOVERY OF GS-9973, A SELECTIVE AND ORALLY EFFICACIOUS INHIBITOR OF SPLEEN TYROSINE KINASE.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 57. ISSUE 9. P. 3856 -3873 28 64% 37
6 RICCABONI, M , BIANCHI, I , PETRILLO, P , (2010) SPLEEN TYROSINE KINASES: BIOLOGY, THERAPEUTIC TARGETS AND DRUGS.DRUG DISCOVERY TODAY. VOL. 15. ISSUE 13-14. P. 517-530 37 57% 54
7 COOPMAN, PJ , MUELLER, SC , (2006) THE SYK TYROSINE KINASE: A NEW NEGATIVE REGULATOR IN TUMOR GROWTH AND PROGRESSION.CANCER LETTERS. VOL. 241. ISSUE 2. P. 159-173 47 50% 62
8 KAUR, M , SINGH, M , SILAKARI, O , (2013) INHIBITORS OF SWITCH KINASE 'SPLEEN TYROSINE KINASE' IN INFLAMMATION AND IMMUNE-MEDIATED DISORDERS: A REVIEW.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. VOL. 67. ISSUE . P. 434-446 35 57% 14
9 DENYER, J , PATEL, V , (2009) SYK KINASE INHIBITORS IN ALLERGIC DISEASES.DRUG NEWS & PERSPECTIVES. VOL. 22. ISSUE 3. P. 146-150 28 80% 16
10 THOMA, G , SMITH, AB , VAN EIS, MJ , VANGREVELINGHE, E , BLANZ, J , AICHHOLZ, R , LITTLEWOOD-EVANS, A , LEE, CC , LIU, H , ZERWES, HG , (2015) DISCOVERY AND PROFILING OF A SELECTIVE AND EFFICACIOUS SYK INHIBITOR.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 58. ISSUE 4. P. 1950 -1963 22 81% 7

Classes with closest relation at Level 1


Rank Class id link
1 11061 SURFACE IGM//MEMBRANE IMMUNOGLOBULIN//IG ALPHA
2 8654 X LINKED AGAMMAGLOBULINEMIA//BRUTONS TYROSINE KINASE//BTK
3 37469 AML CELL DEATH//ARSENIC TRIOXIDE 1//ATPASE BINDING CASSETTE ABC TRANSPORTERS
4 13788 SLP 76//ADAP//SECT LYMPHOCYTE SIGNALING
5 4882 P56LCK//LCK//LCK INHIBITOR
6 3910 RBL 2H3 CELLS//MAST CELLS//FC EPSILON RI
7 13676 TOFACITINIB//JAK3//JANUS KINASE
8 22654 VAV//VAV1//VAV PROTO ONCOGENE
9 14390 CBL//CBL B//C CBL
10 26350 SYST BIOL SCI//SORBUS COMMIXTA//3 4 5 TRIHYDROXYCINNAMIC ACID

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