Class information for:
Level 1: POLG//MNGIE//DEOXYRIBONUCLEOSIDE KINASE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
8598 1237 33.5 84%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
236 3       ADENOSINE//NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS//ADENOSINE RECEPTORS 48331
2341 2             RIBONUCLEOTIDE REDUCTASE//POLG//HYDROXYUREA 4410
8598 1                   POLG//MNGIE//DEOXYRIBONUCLEOSIDE KINASE 1237

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 POLG authKW 1020461 5% 66% 63
2 MNGIE authKW 657313 3% 76% 35
3 DEOXYRIBONUCLEOSIDE KINASE authKW 568703 2% 96% 24
4 MITOCHONDRIAL DNA DEPLETION authKW 559984 3% 69% 33
5 MITOCHONDRIAL DNA DEPLETION SYNDROME authKW 483605 2% 85% 23
6 ALPERS SYNDROME authKW 467476 2% 76% 25
7 MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOMYOPATHY authKW 399867 1% 90% 18
8 MTDNA DEPLETION authKW 382562 3% 50% 31
9 DNA POLYMERASE GAMMA authKW 358276 2% 48% 30
10 POLYMERASE GAMMA authKW 323106 2% 55% 24

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Clinical Neurology 2849 22% 0% 270
2 Biochemistry & Molecular Biology 2498 39% 0% 481
3 Genetics & Heredity 2359 19% 0% 236
4 Biophysics 276 6% 0% 80
5 Neurosciences 266 11% 0% 136
6 Pediatrics 252 6% 0% 73
7 Medicine, Research & Experimental 245 6% 0% 79
8 Cell Biology 199 8% 0% 105
9 Endocrinology & Metabolism 83 4% 0% 55
10 Gastroenterology & Hepatology 54 3% 0% 35

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 SECT VET MED BIOCHEM 274727 1% 70% 16
2 VET MED CHEM 170605 3% 22% 31
3 EXPT TECHNOL MED 143608 1% 73% 8
4 UNIT MOL NEUROGENET 83663 2% 15% 23
5 LUND PROT PROD PLATFORM 74050 0% 100% 3
6 PIERFRANCO LUISA MARIANI STUDY CHILDRENS MI 72584 1% 29% 10
7 MITOCHONDRIAL GRP 66986 3% 8% 32
8 MITOCHONDRIAL DNA REPLICAT GRP 55536 0% 75% 3
9 PATOL MITOCONDRIAL 55536 0% 75% 3
10 GRP NEUROMUSCULAR MITOCHONDRIAL DIS 49367 0% 100% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS 16543 5% 1% 56
2 MITOCHONDRION 15661 2% 2% 26
3 NEUROMUSCULAR DISORDERS 8187 2% 1% 28
4 MOLECULAR GENETICS AND METABOLISM 4520 2% 1% 24
5 HUMAN MOLECULAR GENETICS 2876 3% 0% 34
6 ARCHIVES OF NEUROLOGY 1778 2% 0% 22
7 BRAIN 1691 2% 0% 21
8 NEUROLOGY 1218 3% 0% 33
9 JOURNAL OF INHERITED METABOLIC DISEASE 1201 1% 0% 15
10 JOURNAL OF BIOLOGICAL CHEMISTRY 1115 7% 0% 87

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 POLG 1020461 5% 66% 63 Search POLG Search POLG
2 MNGIE 657313 3% 76% 35 Search MNGIE Search MNGIE
3 DEOXYRIBONUCLEOSIDE KINASE 568703 2% 96% 24 Search DEOXYRIBONUCLEOSIDE+KINASE Search DEOXYRIBONUCLEOSIDE+KINASE
4 MITOCHONDRIAL DNA DEPLETION 559984 3% 69% 33 Search MITOCHONDRIAL+DNA+DEPLETION Search MITOCHONDRIAL+DNA+DEPLETION
5 MITOCHONDRIAL DNA DEPLETION SYNDROME 483605 2% 85% 23 Search MITOCHONDRIAL+DNA+DEPLETION+SYNDROME Search MITOCHONDRIAL+DNA+DEPLETION+SYNDROME
6 ALPERS SYNDROME 467476 2% 76% 25 Search ALPERS+SYNDROME Search ALPERS+SYNDROME
7 MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOMYOPATHY 399867 1% 90% 18 Search MITOCHONDRIAL+NEUROGASTROINTESTINAL+ENCEPHALOMYOPATHY Search MITOCHONDRIAL+NEUROGASTROINTESTINAL+ENCEPHALOMYOPATHY
8 MTDNA DEPLETION 382562 3% 50% 31 Search MTDNA+DEPLETION Search MTDNA+DEPLETION
9 DNA POLYMERASE GAMMA 358276 2% 48% 30 Search DNA+POLYMERASE+GAMMA Search DNA+POLYMERASE+GAMMA
10 POLYMERASE GAMMA 323106 2% 55% 24 Search POLYMERASE+GAMMA Search POLYMERASE+GAMMA

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 EL-HATTAB, A , SCAGLIA, F , (2013) MITOCHONDRIAL DNA DEPLETION SYNDROMES: REVIEW AND UPDATES OF GENETIC BASIS, MANIFESTATIONS, AND THERAPEUTIC OPTIONS.NEUROTHERAPEUTICS. VOL. 10. ISSUE 2. P. 186-198 102 84% 46
2 COPELAND, WC , (2012) DEFECTS IN MITOCHONDRIAL DNA REPLICATION AND HUMAN DISEASE.CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY. VOL. 47. ISSUE 1. P. 64 -74 92 90% 69
3 SUOMALAINEN, A , ISOHANNI, P , (2010) MITOCHONDRIAL DNA DEPLETION SYNDROMES - MANY GENES, COMMON MECHANISMS.NEUROMUSCULAR DISORDERS. VOL. 20. ISSUE 7. P. 429 -437 73 91% 71
4 FINSTERER, J , AHTING, U , (2013) MITOCHONDRIAL DEPLETION SYNDROMES IN CHILDREN AND ADULTS.CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES. VOL. 40. ISSUE 5. P. 635-644 80 90% 6
5 COPELAND, WC , (2008) INHERITED MITOCHONDRIAL DISEASES OF DNA REPLICATION.ANNUAL REVIEW OF MEDICINE. VOL. 59. ISSUE . P. 131-146 65 82% 137
6 COPELAND, WC , (2014) DEFECTS OF MITOCHONDRIAL DNA REPLICATION.JOURNAL OF CHILD NEUROLOGY. VOL. 29. ISSUE 9. P. 1216 -1224 61 81% 6
7 SUN, R , WANG, LY , (2014) THYMIDINE KINASE 2 ENZYME KINETICS ELUCIDATE THE MECHANISM OF THYMIDINE-INDUCED MITOCHONDRIAL DNA DEPLETION.BIOCHEMISTRY. VOL. 53. ISSUE 39. P. 6142 -6150 59 88% 1
8 STUMPF, JD , SANETO, RP , COPELAND, WC , (2013) CLINICAL AND MOLECULAR FEATURES OF POLG-RELATED MITOCHONDRIAL DISEASE.COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY. VOL. 5. ISSUE 4. P. - 65 76% 12
9 LIBERNINI, L , LUPIS, C , MASTRANGELO, M , CARROZZO, R , SANTORELLI, FM , INGHILLERI, M , LEUZZI, V , (2012) MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOMYOPATHY: NOVEL PATHOGENIC MUTATIONS IN THYMIDINE PHOSPHORYLASE GENE IN TWO ITALIAN BROTHERS.NEUROPEDIATRICS. VOL. 43. ISSUE 4. P. 201-208 54 98% 4
10 ANAGNOSTOU, ME , NG, YS , TAYLOR, RW , MCFARLAND, R , (2016) EPILEPSY DUE TO MUTATIONS IN THE MITOCHONDRIAL POLYMERASE GAMMA (POLG) GENE: A CLINICAL AND MOLECULAR GENETIC REVIEW.EPILEPSIA. VOL. 57. ISSUE 10. P. 1531 -1545 57 85% 0

Classes with closest relation at Level 1


Rank Class id link
1 9286 MITOCHONDRIAL NUCLEOID//MITOCHONDRIAL TRANSCRIPTION//TFAM
2 77 MELAS//MITOCHONDRIAL DISEASE//MITOCHONDRIAL ENCEPHALOMYOPATHY
3 17768 THYMIDINE KINASE 1//DNA SYNTHESIZING ENZYMES//SERUM THYMIDINE KINASE 1
4 12321 MITOCHONDRIAL TOXICITY//AZT//ZIDOVUDINE
5 33435 SUCCINYL COA SYNTHETASE//PHOSPHORYLATED HISTIDINE//OFF VP
6 8385 GEMCITABINE//DEOXYCYTIDINE KINASE//HENT1
7 13135 CLOFARABINE//CLADRIBINE//2 CHLORODEOXYADENOSINE
8 22052 DCMP HYDROXYMETHYLASE//ACTIVE OXYGEN QUENCHING//ADENINE PHOSPHORIBOSYLTRANFERASE
9 8603 MITOCHONDRIAL METABOLIC COMPETENCE//4977 BP DELETION//MITOCHONDRIAL DNA DELETION
10 15518 ADENYLATE KINASE//CHIM STRUCT MACROMOL//THYMIDYLATE KINASE

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