Class information for:
Level 1: MITOCHONDRIAL TOXICITY//AZT//ZIDOVUDINE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
12321 915 38.5 82%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
7 4 INFECTIOUS DISEASES//MICROBIOLOGY//VIROLOGY 1353914
29 3       HIV//VIROLOGY//HIV 1 108954
571 2             LIPODYSTROPHY//HIV//JOURNAL OF NEUROVIROLOGY 14362
12321 1                   MITOCHONDRIAL TOXICITY//AZT//ZIDOVUDINE 915

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MITOCHONDRIAL TOXICITY authKW 1051855 9% 40% 78
2 AZT authKW 448473 8% 19% 71
3 ZIDOVUDINE authKW 336860 11% 10% 101
4 NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS authKW 276269 4% 20% 41
5 CARCINOGEN DNA INTERACT SECT address 261705 2% 39% 20
6 HYPERLACTATEMIA authKW 213252 2% 30% 21
7 HYPERLACTATAEMIA authKW 208917 1% 52% 12
8 METACAVIR authKW 166852 1% 100% 5
9 NRTI authKW 156774 2% 21% 22
10 LACTIC ACIDOSIS authKW 131019 6% 8% 51

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Infectious Diseases 8723 29% 0% 268
2 Virology 3291 15% 0% 135
3 Toxicology 1879 14% 0% 129
4 Pharmacology & Pharmacy 1320 24% 0% 218
5 Immunology 1156 18% 0% 168
6 Genetics & Heredity 257 8% 0% 76
7 Pathology 253 5% 0% 49
8 Microbiology 198 8% 0% 69
9 Medicine, Research & Experimental 135 6% 0% 52
10 Medicine, General & Internal 59 5% 0% 50

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CARCINOGEN DNA INTERACT SECT 261705 2% 39% 20
2 MUSCLE MITOCHONDRIAL FUNCT 119177 1% 71% 5
3 SECT COMPARAT PSYCHOL 118745 1% 32% 11
4 MITOCHONDRIAL FUNCTIONALISM 66741 0% 100% 2
5 HAWAII AIDS CLIN PROGRAM 52078 1% 20% 8
6 MITOCHONDRIAL 49539 1% 21% 7
7 CHAIR IMMUNOLSECT GEN PATHOL 44493 0% 67% 2
8 GENET ABIL 2 44493 0% 67% 2
9 PHYSIOL INVEST 44493 0% 67% 2
10 TOXICIDADE GENET 42901 0% 43% 3

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ANTIVIRAL THERAPY 37671 5% 2% 46
2 ENVIRONMENTAL AND MOLECULAR MUTAGENESIS 11455 3% 1% 28
3 MITOCHONDRION 8013 2% 2% 16
4 MILITARY OPERATIONS RESEARCH 7055 1% 4% 6
5 AIDS 6790 5% 0% 42
6 JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES 4910 3% 1% 25
7 HIV MEDICINE 4381 1% 1% 12
8 CARDIOVASCULAR TOXICOLOGY 3907 1% 2% 7
9 AIDS RESEARCH AND HUMAN RETROVIRUSES 1994 2% 0% 18
10 LABORATORY INVESTIGATION 1676 2% 0% 17

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 MITOCHONDRIAL TOXICITY 1051855 9% 40% 78 Search MITOCHONDRIAL+TOXICITY Search MITOCHONDRIAL+TOXICITY
2 AZT 448473 8% 19% 71 Search AZT Search AZT
3 ZIDOVUDINE 336860 11% 10% 101 Search ZIDOVUDINE Search ZIDOVUDINE
4 NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS 276269 4% 20% 41 Search NUCLEOSIDE+REVERSE+TRANSCRIPTASE+INHIBITORS Search NUCLEOSIDE+REVERSE+TRANSCRIPTASE+INHIBITORS
5 HYPERLACTATEMIA 213252 2% 30% 21 Search HYPERLACTATEMIA Search HYPERLACTATEMIA
6 HYPERLACTATAEMIA 208917 1% 52% 12 Search HYPERLACTATAEMIA Search HYPERLACTATAEMIA
7 METACAVIR 166852 1% 100% 5 Search METACAVIR Search METACAVIR
8 NRTI 156774 2% 21% 22 Search NRTI Search NRTI
9 LACTIC ACIDOSIS 131019 6% 8% 51 Search LACTIC+ACIDOSIS Search LACTIC+ACIDOSIS
10 AZIDOTHYMIDINE 123562 2% 19% 20 Search AZIDOTHYMIDINE Search AZIDOTHYMIDINE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 LEWIS, W , (2005) NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS, MITOCHONDRIAL DNA AND AIDS THERAPY.ANTIVIRAL THERAPY. VOL. 10. ISSUE . P. M13-M27 140 62% 31
2 LEWIS, W , (2004) CARDIOMYOPATHY, NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS AND MITOCHONDRIA ARE LINKED THROUGH AIDS AND ITS THERAPY.MITOCHONDRION. VOL. 4. ISSUE 2-3. P. 141-152 69 63% 17
3 ROSS, AC , LEONG, T , AVERY, A , CASTILLO-DURAN, M , BONILLA, H , LEBRECHT, D , WALKER, UA , STORER, N , LABBATO, D , KHAITAN, A , ET AL (2012) EFFECTS OF IN UTERO ANTIRETROVIRAL EXPOSURE ON MITOCHONDRIAL DNA LEVELS, MITOCHONDRIAL FUNCTION AND OXIDATIVE STRESS.HIV MEDICINE. VOL. 13. ISSUE 2. P. 98-106 38 83% 17
4 MIRO, O , LOPEZ, S , CARDELLACH, F , CASADEMONT, J , (2005) MITOCHONDRIAL STUDIES IN HAART-RELATED LIPODYSTROPHY: FROM EXPERIMENTAL HYPOTHESIS TO CLINICAL FINDINGS.ANTIVIRAL THERAPY. VOL. 10. ISSUE . P. M73-M81 45 85% 23
5 LEUNG, GPH , (2012) IATROGENIC MITOCHONDRIOPATHIES: A RECENT LESSON FROM NUCLEOSIDE/NUCLEOTIDE REVERSE TRANSCRIPTASE INHIBITORS.ADVANCES IN MITOCHONDRIAL MEDICINE. VOL. 942. ISSUE . P. 347-369 74 43% 6
6 PINTI, M , SALOMONI, P , COSSARIZZA, A , (2006) ANTI-HIV DRUGS AND THE MITOCHONDRIA.BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS. VOL. 1757. ISSUE 5-6. P. 700-707 58 56% 46
7 COTE, HCF , (2005) POSSIBLE WAYS NUCLEOSIDE ANALOGUES CAN AFFECT MITOCHONDRIAL DNA CONTENT AND GENE EXPRESSION DURING HIV THERAPY.ANTIVIRAL THERAPY. VOL. 10. ISSUE . P. M3-M11 51 66% 25
8 FALCO, V , CRESPO, M , RIBERA, E , (2003) LACTIC ACIDOSIS RELATED TO NUCLEOSIDE THERAPY IN HIV-INFECTED PATIENTS.EXPERT OPINION ON PHARMACOTHERAPY. VOL. 4. ISSUE 8. P. 1321-1329 41 87% 12
9 DAY, L , SHIKUMA, C , GERSCHENSON, M , (2004) MITOCHONDRIAL INJURY IN THE PATHOGENESIS OF ANTIRETROVIRAL-INDUCED HEPATIC STEATOSIS AND LACTIC ACIDEMIA.MITOCHONDRION. VOL. 4. ISSUE 2-3. P. 95-109 53 65% 14
10 ZHANG, PH , ZHANG, LY , JIANG, ZZ , XIONG, YT , CHEN, HK , TAO, YQ , HU, MZ , LI, Z , (2011) EVALUATION OF MITOCHONDRIAL TOXICITY IN MARMOTA HIMALAYANA TREATED WITH METACAVIR, A NOVEL 2 ',3 '-DIDEOXYGUANOSINE PRODRUG FOR TREATMENT OF HEPATITIS B VIRUS.ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. VOL. 55. ISSUE 5. P. 1930-1936 33 85% 4

Classes with closest relation at Level 1


Rank Class id link
1 22767 DISTAL SENSORY POLYNEUROPATHY//ANTIRETROVIRAL TOXIC NEUROPATHY//NEURO AIDS PROGRAM
2 5405 ZIDOVUDINE//DIDANOSINE//ZALCITABINE
3 859 LIPODYSTROPHY//LIPOATROPHY//PROGRAM NUTR METAB
4 8598 POLG//MNGIE//DEOXYRIBONUCLEOSIDE KINASE
5 16538 HIV ASSOCIATED CARDIOMYOPATHY//HIV RELATED PULMONARY HYPERTENSION//HIV ASSOCIATED PULMONARY HYPERTENSION
6 18817 HIV ARTHRITIS//HIV ASSOCIATED ARTHRITIS//RHEUMATIC MANIFESTATIONS
7 1229 MOTHER TO CHILD TRANSMISSION//VERTICAL TRANSMISSION//PERINATAL TRANSMISSION
8 29519 EXTRACELLULAR FLUX//COMPOUND SAFETY PREDICT//UAB MITOCHONDRIAL MED
9 3304 CO INFECTION//HIV HCV COINFECTION//HIV
10 11702 I TECH SERV//LAMIVUDINE//EMTRICITABINE

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