Class information for:
Level 1: 5 HT4 RECEPTOR//5 HT4//GR 113808

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
7516 1360 34.6 71%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
6 4 GASTROENTEROLOGY & HEPATOLOGY//ONCOLOGY//SURGERY 1371034
337 3       IRRITABLE BOWEL SYNDROME//CONSTIPATION//ENTERIC NERVOUS SYSTEM 37464
111 2             IRRITABLE BOWEL SYNDROME//NEUROGASTROENTEROLOGY AND MOTILITY//FUNCTIONAL DYSPEPSIA 25141
7516 1                   5 HT4 RECEPTOR//5 HT4//GR 113808 1360

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 5 HT4 RECEPTOR authKW 2884127 14% 68% 190
2 5 HT4 authKW 514290 3% 55% 42
3 GR 113808 authKW 424152 2% 82% 23
4 5 HT4 RECEPTOR AGONIST authKW 391122 2% 62% 28
5 MOSAPRIDE authKW 317481 2% 43% 33
6 SEROTONIN 5 HT4 RECEPTOR authKW 246959 1% 100% 11
7 CISAPRIDE authKW 237512 5% 17% 64
8 MOSAPRIDE CITRATE authKW 202599 1% 48% 19
9 GR 125487 authKW 202057 1% 100% 9
10 GASTROPROKINETIC AGENT authKW 194034 1% 79% 11

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Pharmacology & Pharmacy 11289 53% 0% 720
2 Chemistry, Medicinal 2235 13% 0% 171
3 Gastroenterology & Hepatology 1971 12% 0% 165
4 Neurosciences 439 13% 0% 174
5 Veterinary Sciences 94 4% 0% 55
6 Chemistry, Organic 82 5% 0% 71
7 Medicine, Research & Experimental 74 4% 0% 54
8 Physiology 51 3% 0% 43
9 Chemistry, Analytical 23 3% 0% 46
10 Clinical Neurology 21 3% 0% 46

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 RECONNAISSANCE MOL CELLULAIRE 71841 0% 80% 4
2 DISCOVERY PHARMACOL GRP 2 59866 0% 67% 4
3 RECONNAISSANCE MOL SYNTH 50513 0% 75% 3
4 CARDIOL CELLULAIRE MOL 46615 1% 23% 9
5 GI PHARMACOL 44902 0% 100% 2
6 GASTROINTESTINAL PHARMACOL 41041 1% 23% 8
7 HEYMANS PHARMACOL 31419 2% 6% 24
8 BIOMED BIOTECNOL IBBTEC 29933 0% 67% 2
9 DRUG DISCOVERY AS 29933 0% 67% 2
10 CNRS UPR 9023 28862 0% 43% 3

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 10354 4% 1% 53
2 BRITISH JOURNAL OF PHARMACOLOGY 9728 6% 1% 88
3 NEUROGASTROENTEROLOGY AND MOTILITY 4977 2% 1% 24
4 JAPANESE JOURNAL OF PHARMACOLOGY 4268 2% 1% 29
5 EUROPEAN JOURNAL OF PHARMACOLOGY 3830 5% 0% 70
6 JOURNAL OF GASTROINTESTINAL MOTILITY 3322 0% 7% 2
7 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 2388 4% 0% 48
8 JOURNAL OF PHARMACY AND PHARMACOLOGY 1714 2% 0% 25
9 CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL 1661 1% 0% 19
10 SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY 1638 2% 0% 27

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 5 HT4 RECEPTOR 2884127 14% 68% 190 Search 5+HT4+RECEPTOR Search 5+HT4+RECEPTOR
2 5 HT4 514290 3% 55% 42 Search 5+HT4 Search 5+HT4
3 GR 113808 424152 2% 82% 23 Search GR+113808 Search GR+113808
4 5 HT4 RECEPTOR AGONIST 391122 2% 62% 28 Search 5+HT4+RECEPTOR+AGONIST Search 5+HT4+RECEPTOR+AGONIST
5 MOSAPRIDE 317481 2% 43% 33 Search MOSAPRIDE Search MOSAPRIDE
6 SEROTONIN 5 HT4 RECEPTOR 246959 1% 100% 11 Search SEROTONIN+5+HT4+RECEPTOR Search SEROTONIN+5+HT4+RECEPTOR
7 CISAPRIDE 237512 5% 17% 64 Search CISAPRIDE Search CISAPRIDE
8 MOSAPRIDE CITRATE 202599 1% 48% 19 Search MOSAPRIDE+CITRATE Search MOSAPRIDE+CITRATE
9 GR 125487 202057 1% 100% 9 Search GR+125487 Search GR+125487
10 GASTROPROKINETIC AGENT 194034 1% 79% 11 Search GASTROPROKINETIC+AGENT Search GASTROPROKINETIC+AGENT

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 LANGLOIS, M , FISCHMEISTER, R , (2003) 5-HT4 RECEPTOR LIGANDS: APPLICATIONS AND NEW PROSPECTS.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 46. ISSUE 3. P. 319-344 159 76% 69
2 BUREAU, R , BOULOUARD, M , DAUPHIN, F , LEZOUALC'H, F , RAULT, S , (2010) REVIEW OF 5-HT4R LIGANDS: STATE OF ART AND CLINICAL APPLICATIONS.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 10. ISSUE 5. P. 527-553 84 76% 7
3 LUCAS, G , (2009) SEROTONIN RECEPTORS, TYPE 4: A NEW HOPE?.CURRENT DRUG TARGETS. VOL. 10. ISSUE 11. P. 1085-1095 71 72% 10
4 DE MAEYER, JH , LEFEBVRE, RA , SCHUURKES, JAJ , (2008) 5-HT4 RECEPTOR AGONISTS: SIMILAR BUT NOT THE SAME.NEUROGASTROENTEROLOGY AND MOTILITY. VOL. 20. ISSUE 2. P. 99-112 66 59% 124
5 BRIEJER, MR , AKKERMANS, LMA , SCHUURKES, JAJ , (1995) GASTROINTESTINAL PROKINETIC BENZAMIDES: THE PHARMACOLOGY UNDERLYING STIMULATION OF MOTILITY.PHARMACOLOGICAL REVIEWS. VOL. 47. ISSUE 4. P. 631-651 87 68% 123
6 STANGHELLINI, V , TACK, J , CAMILLERI, M , CHANG, L , CHEY, WD , GALLIGAN, JJ , LACY, BE , MULLER-LISSNER, S , QUIGLEY, EMM , SCHUURKES, J , ET AL (2012) SYSTEMATIC REVIEW: CARDIOVASCULAR SAFETY PROFILE OF 5-HT4 AGONISTS DEVELOPED FOR GASTROINTESTINAL DISORDERS.ALIMENTARY PHARMACOLOGY & THERAPEUTICS. VOL. 35. ISSUE 7. P. 745 -767 73 38% 72
7 NIROGI, R , KANDIKERE, V , BHYRAPUNENI, G , SARALAYA, R , AJJALA, DR , ALETI, RR , RASHEED, MA , (2013) IN-VIVO RAT STRIATAL 5-HT4 RECEPTOR OCCUPANCY USING NON-RADIOLABELLED SB207145.JOURNAL OF PHARMACY AND PHARMACOLOGY. VOL. 65. ISSUE 5. P. 704-712 35 78% 4
8 NIROGI, R , MOHAMMED, AR , SHINDE, AK , BOGARAJU, N , GAGGINAPALLI, SR , RAVELLA, SR , KOTA, L , BHYRAPUNENI, G , MUDDANA, NR , BENADE, V , ET AL (2015) SYNTHESIS AND SAR OF IMIDAZO[1,5-A]PYRIDINE DERIVATIVES AS 5-HT4 RECEPTOR PARTIAL AGONISTS FOR THE TREATMENT OF COGNITIVE DISORDERS ASSOCIATED WITH ALZHEIMER'S DISEASE.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. VOL. 103. ISSUE . P. 289 -301 30 79% 2
9 DE MAEYER, JH , STRAETEMANS, R , SCHUURKES, JAJ , LEFEBVRE, RA , (2006) PORCINE LEFT ATRIAL AND SINOATRIAL 5-HT4 RECEPTOR-INDUCED RESPONSES: FADING OF THE RESPONSE AND INFLUENCE OF DEVELOPMENT.BRITISH JOURNAL OF PHARMACOLOGY. VOL. 147. ISSUE 2. P. 140-157 43 64% 24
10 VICKERY, RG , MAI, N , KAUFMAN, E , BEATTIE, DT , PULIDO-RIOS, T , O'KEEFE, M , HUMPHREY, PPA , SMITH, JAM , (2007) A COMPARISON OF THE PHARMACOLOGICAL PROPERTIES OF GUINEA-PIG AND HUMAN RECOMBINANT 5-HT4 RECEPTORS.BRITISH JOURNAL OF PHARMACOLOGY. VOL. 150. ISSUE 6. P. 782 -791 37 74% 10

Classes with closest relation at Level 1


Rank Class id link
1 8376 5 HT3 RECEPTOR//5 HT3 RECEPTOR ANTAGONIST//5 HT3
2 31784 TRIMEBUTINE//CAS 39133 31 8//CAS 34140 59 5
3 11145 5 HT7 RECEPTOR//5 HT6 RECEPTOR//5 HT6
4 28884 METOCLOPRAMIDE//BROMOPRIDE//METOCLOPRAMIDE HYDROCHLORIDE
5 12805 EMESIS//SUNCUS MURINUS//EMESIS GRP
6 27176 SMOOTH MUSCLE INSUFFICIENCY//8 OH DPAT 8 HYDROXY 2 N DIPROPYLAMINOTETRALIN//ACUTE AND CHRONIC SEROTONIN INSUFFICIENCY
7 30562 GALACTOGOGUE//DOMPERIDONE//RELACTATION
8 3994 ENTERIC NERVOUS SYSTEM//MYENTERIC PLEXUS//ENTERIC GLIA
9 7648 MOTILIN//MIGRATING MOTOR COMPLEX//GUT HORMONE
10 5760 INTESTINAL SECRETION//SORBIN//E COLI STA

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