Class information for:
Level 1: FASUDIL//RHO KINASE//Y 27632

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
7347 1378 44.9 92%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
180 3       DUCHENNE MUSCULAR DYSTROPHY//DYSTROPHIN//MUSCULAR DYSTROPHY 56784
420 2             JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY//RHO KINASE//MYOSIN 16501
7347 1                   FASUDIL//RHO KINASE//Y 27632 1378

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 FASUDIL authKW 2836035 14% 67% 192
2 RHO KINASE authKW 2394202 25% 31% 349
3 Y 27632 authKW 625231 6% 33% 85
4 RHO KINASE INHIBITOR authKW 609488 4% 51% 54
5 RHO ASSOCIATED KINASE authKW 369872 3% 35% 48
6 ROCK2 authKW 356611 2% 62% 26
7 HYDROXYFASUDIL authKW 256130 1% 68% 17
8 ROCK authKW 253227 7% 12% 99
9 ROCK INHIBITOR authKW 158242 1% 36% 20
10 FASUDIL HYDROCHLORIDE authKW 155089 1% 50% 14

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Peripheral Vascular Diseases 2189 12% 0% 169
2 Cell Biology 1270 17% 0% 235
3 Cardiac & Cardiovascular System 1209 13% 0% 175
4 Pharmacology & Pharmacy 841 17% 0% 228
5 Biochemistry & Molecular Biology 403 18% 0% 251
6 Physiology 372 7% 0% 91
7 Chemistry, Medicinal 257 5% 0% 66
8 Neurosciences 215 10% 0% 135
9 Medicine, Research & Experimental 207 6% 0% 79
10 Hematology 179 4% 0% 59

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CELL PHARMACOL 99717 3% 12% 37
2 VASC MED UNIT 82673 2% 13% 28
3 GHOSH SCI TECHNOL 69239 0% 63% 5
4 ABORAT INNOVAT 2011 63858 1% 41% 7
5 TECHNOL AGCY 56970 0% 43% 6
6 DRUG DISCOVERY S OSAKA 44315 0% 100% 2
7 INITIAT TEAM MICROENVIRONM 44315 0% 100% 2
8 COE PROGRAM LIFESTYLE RELATED DIS 41748 1% 27% 7
9 MAJOR CLIN 39881 0% 60% 3
10 SCI AFFAIRS SALES PROMOT 33233 0% 50% 3

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF CARDIOVASCULAR PHARMACOLOGY 1218 2% 0% 25
2 CIRCULATION RESEARCH 1124 2% 0% 23
3 HYPERTENSION 1072 2% 0% 24
4 ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 1039 1% 0% 19
5 AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 752 2% 0% 21
6 AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 736 1% 0% 14
7 EUROPEAN JOURNAL OF PHARMACOLOGY 661 2% 0% 30
8 CARDIOVASCULAR DIABETOLOGY 634 0% 0% 6
9 DRUG NEWS & PERSPECTIVES 517 0% 1% 4
10 JOURNAL OF HYPERTENSION 490 1% 0% 15

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 FASUDIL 2836035 14% 67% 192 Search FASUDIL Search FASUDIL
2 RHO KINASE 2394202 25% 31% 349 Search RHO+KINASE Search RHO+KINASE
3 Y 27632 625231 6% 33% 85 Search Y+27632 Search Y+27632
4 RHO KINASE INHIBITOR 609488 4% 51% 54 Search RHO+KINASE+INHIBITOR Search RHO+KINASE+INHIBITOR
5 RHO ASSOCIATED KINASE 369872 3% 35% 48 Search RHO+ASSOCIATED+KINASE Search RHO+ASSOCIATED+KINASE
6 ROCK2 356611 2% 62% 26 Search ROCK2 Search ROCK2
7 HYDROXYFASUDIL 256130 1% 68% 17 Search HYDROXYFASUDIL Search HYDROXYFASUDIL
8 ROCK 253227 7% 12% 99 Search ROCK Search ROCK
9 ROCK INHIBITOR 158242 1% 36% 20 Search ROCK+INHIBITOR Search ROCK+INHIBITOR
10 FASUDIL HYDROCHLORIDE 155089 1% 50% 14 Search FASUDIL+HYDROCHLORIDE Search FASUDIL+HYDROCHLORIDE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 SHI, JJ , WEI, L , (2013) RHO KINASES IN CARDIOVASCULAR PHYSIOLOGY AND PATHOPHYSIOLOGY: THE EFFECT OF FASUDIL.JOURNAL OF CARDIOVASCULAR PHARMACOLOGY. VOL. 62. ISSUE 4. P. 341-354 185 68% 40
2 LOIRAND, G , (2015) RHO KINASES IN HEALTH AND DISEASE: FROM BASIC SCIENCE TO TRANSLATIONAL RESEARCH.PHARMACOLOGICAL REVIEWS. VOL. 67. ISSUE 4. P. 1074 -1095 150 74% 5
3 FENG, YB , LOGRASSO, PV , DEFERT, O , LI, RS , (2016) RHO KINASE (ROCK) INHIBITORS AND THEIR THERAPEUTIC POTENTIAL.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 59. ISSUE 6. P. 2269 -2300 108 57% 7
4 WEI, L , SURMA, M , SHI, S , LAMBERT-CHEATHAM, N , SHI, JJ , (2016) NOVEL INSIGHTS INTO THE ROLES OF RHO KINASE IN CANCER.ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS. VOL. 64. ISSUE 4. P. 259 -278 123 51% 2
5 DONG, M , YAN, BP , LIAO, JK , LAM, YY , YIP, GWK , YU, CM , (2010) RHO-KINASE INHIBITION: A NOVEL THERAPEUTIC TARGET FOR THE TREATMENT OF CARDIOVASCULAR DISEASES.DRUG DISCOVERY TODAY. VOL. 15. ISSUE 15-16. P. 622-629 79 71% 59
6 GUAN, RG , XU, XY , CHEN, MH , HU, HY , GE, H , WEN, SJ , ZHOU, SY , PI, RB , (2013) ADVANCES IN THE STUDIES OF ROLES OF RHO/RHO-KINASE IN DISEASES AND THE DEVELOPMENT OF ITS INHIBITORS.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. VOL. 70. ISSUE . P. 613-622 58 87% 26
7 ZHOU, H , LI, YJ , (2012) RHO KINASE INHIBITORS: POTENTIAL TREATMENTS FOR DIABETES AND DIABETIC COMPLICATIONS.CURRENT PHARMACEUTICAL DESIGN. VOL. 18. ISSUE 20. P. 2964-2973 87 64% 10
8 HARTMANN, S , RIDLEY, AJ , LUTZ, S , (2015) THE FUNCTION OF RHO-ASSOCIATED KINASES ROCK1 AND ROCK2 IN THE PATHOGENESIS OF CARDIOVASCULAR DISEASE.FRONTIERS IN PHARMACOLOGY. VOL. 6. ISSUE . P. - 86 53% 9
9 SHIMIZU, T , LIAO, JK , (2016) RHO KINASES AND CARDIAC REMODELING.CIRCULATION JOURNAL. VOL. 80. ISSUE 7. P. 1491 -1498 61 73% 2
10 SHIN, HK , SALOMONE, S , AYATA, C , (2008) TARGETING CEREBROVASCULAR RHO-KINASE IN STROKE.EXPERT OPINION ON THERAPEUTIC TARGETS. VOL. 12. ISSUE 12. P. 1547-1564 106 56% 14

Classes with closest relation at Level 1


Rank Class id link
1 7520 MYOSIN PHOSPHATASE//CPI 17//MYPT1
2 34692 PKN//PRK1//PKN ALPHA
3 1558 RHO GTPASES//TIAM1//RHOB
4 18330 CONTRACTILE FORCES//HOF NEIDER GRP LEUKOCYTE MIGRAT//THREE DIMENSIONAL CELL MIGRATION
5 3288 PULMONARY ARTERIAL HYPERTENSION//PULMONARY HYPERTENSION//BMPR2
6 10527 COFILIN//LIM KINASE//ADF COFILIN
7 32714 ALPHA BETA ADRENOCEPTOR BLOCKADE//KMUP 1//ACHYRANTHES BIDENTATA POLYPEPTIDES
8 6899 SECT PULM CRIT MED//LUNG INJURY//MICROVASCULAR PERMEABILITY
9 5494 TRABECULAR MESHWORK//SCHLEMMS CANAL//OUTFLOW FACILITY
10 2292 STATINS//ATORVASTATIN//HMG COA REDUCTASE INHIBITORS

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