Class information for:
Level 1: FACTOR VIII//HEMOPHILIA A//FACTOR VIIIA

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
7211 1392 35.5 74%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
8 4 CARDIAC & CARDIOVASCULAR SYSTEM//PERIPHERAL VASCULAR DISEASES//CARDIOL 1276458
131 3       HEMATOLOGY//HAEMOPHILIA//TRANSFUSION 66936
1253 2             HAEMOPHILIA//FACTOR VIII//HAEMOPHILIA A 8891
7211 1                   FACTOR VIII//HEMOPHILIA A//FACTOR VIIIA 1392

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 FACTOR VIII authKW 658333 15% 14% 214
2 HEMOPHILIA A authKW 225720 6% 13% 82
3 FACTOR VIIIA authKW 214568 1% 65% 15
4 ASSAY DISCREPANCY authKW 204158 1% 85% 11
5 ONE STAGE ASSAY authKW 182785 1% 83% 10
6 COAGULATION FACTOR VIII authKW 181274 2% 36% 23
7 FACTOR VIII ASSAY authKW 109673 0% 100% 5
8 INTRINSIC FACTOR XASE authKW 109673 0% 100% 5
9 FVIII authKW 101509 2% 19% 25
10 DUAL VECTOR GENE DELIVERY authKW 87739 0% 100% 4

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Hematology 45799 55% 0% 765
2 Peripheral Vascular Diseases 7461 22% 0% 304
3 BIOLOGY, MISCELLANEOUS 896 1% 1% 8
4 Medicine, Research & Experimental 726 10% 0% 133
5 Biochemistry & Molecular Biology 679 22% 0% 305
6 Biotechnology & Applied Microbiology 524 10% 0% 133
7 Genetics & Heredity 194 6% 0% 88
8 Medical Laboratory Technology 98 2% 0% 23
9 Biochemical Research Methods 37 3% 0% 38
10 Biophysics 26 3% 0% 38

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 HAEMOSTASIS SECT 71717 1% 30% 11
2 RETROVIRAL GENE TRANSFER SECT 43869 0% 100% 2
3 RICHARDSON 29802 1% 12% 11
4 NUCEL NUCLEO TER IA CELULAR MOL 29245 0% 67% 2
5 PROGRAM MOL SYST PHARMACOL 24190 1% 14% 8
6 PLASMA PROT 22173 1% 8% 13
7 ABRAMSON 310HEMATOL 21935 0% 100% 1
8 BEOCHEM CELL BIOL 21935 0% 100% 1
9 BIOCHEM MOL BIOLSUH DAE MOON KU 21935 0% 100% 1
10 BIOL CHIM PROT UMS 3444 21935 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 HAEMOPHILIA 66994 7% 3% 97
2 THROMBOSIS AND HAEMOSTASIS 32187 9% 1% 121
3 JOURNAL OF THROMBOSIS AND HAEMOSTASIS 30661 5% 2% 74
4 THROMBOSIS RESEARCH 12968 6% 1% 78
5 BLOOD 8053 8% 0% 113
6 SCANDINAVIAN JOURNAL OF HAEMATOLOGY 6338 1% 2% 18
7 BRITISH JOURNAL OF HAEMATOLOGY 6185 4% 0% 62
8 HUMAN GENE THERAPY 5487 2% 1% 29
9 MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT 4327 0% 3% 6
10 SEMINARS IN THROMBOSIS AND HEMOSTASIS 3984 2% 1% 22

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 FACTOR VIII 658333 15% 14% 214 Search FACTOR+VIII Search FACTOR+VIII
2 HEMOPHILIA A 225720 6% 13% 82 Search HEMOPHILIA+A Search HEMOPHILIA+A
3 FACTOR VIIIA 214568 1% 65% 15 Search FACTOR+VIIIA Search FACTOR+VIIIA
4 ASSAY DISCREPANCY 204158 1% 85% 11 Search ASSAY+DISCREPANCY Search ASSAY+DISCREPANCY
5 ONE STAGE ASSAY 182785 1% 83% 10 Search ONE+STAGE+ASSAY Search ONE+STAGE+ASSAY
6 COAGULATION FACTOR VIII 181274 2% 36% 23 Search COAGULATION+FACTOR+VIII Search COAGULATION+FACTOR+VIII
7 FACTOR VIII ASSAY 109673 0% 100% 5 Search FACTOR+VIII+ASSAY Search FACTOR+VIII+ASSAY
8 INTRINSIC FACTOR XASE 109673 0% 100% 5 Search INTRINSIC+FACTOR+XASE Search INTRINSIC+FACTOR+XASE
9 FVIII 101509 2% 19% 25 Search FVIII Search FVIII
10 DUAL VECTOR GENE DELIVERY 87739 0% 100% 4 Search DUAL+VECTOR+GENE+DELIVERY Search DUAL+VECTOR+GENE+DELIVERY

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 FAY, PJ , (2004) ACTIVATION OF FACTOR VIII AND MECHANISMS OF COFACTOR ACTION.BLOOD REVIEWS. VOL. 18. ISSUE 1. P. 1-15 83 78% 108
2 LENTING, PJ , VAN MOURIK, JA , MERTENS, K , (1998) THE LIFE CYCLE OF COAGULATION FACTOR VIII IN VIEW OF ITS STRUCTURE AND FUNCTION.BLOOD. VOL. 92. ISSUE 11. P. 3983-3996 106 59% 225
3 ORLOVA, NA , KOVNIR, SV , VOROBIEV, II , GABIBOV, AG , VOROBIEV, AI , (2013) BLOOD CLOTTING FACTOR VIII: FROM EVOLUTION TO THERAPY.ACTA NATURAE. VOL. 5. ISSUE 2. P. 19-39 93 53% 9
4 PEYVANDI, F , OLDENBURG, J , FRIEDMAN, KD , (2016) A CRITICAL APPRAISAL OF ONE-STAGE AND CHROMOGENIC ASSAYS OF FACTOR VIII ACTIVITY.JOURNAL OF THROMBOSIS AND HAEMOSTASIS. VOL. 14. ISSUE 2. P. 248 -261 48 87% 2
5 ROGERS, GL , HERZOG, RW , (2015) GENE THERAPY FOR HEMOPHILIA.FRONTIERS IN BIOSCIENCE-LANDMARK. VOL. 20. ISSUE . P. 556 -603 106 30% 5
6 MONAGHAN, M , WAKABAYASHI, H , GRIFFITHS, AE , FAY, PJ , (2016) STABILIZING INTERACTIONS BETWEEN D666-S1787 AND T657-Y1792 AT THE A2-A3 INTERFACE SUPPORT FACTOR VIIIA STABILITY IN THE BLOOD CLOTTING PATHWAY.JOURNAL OF THROMBOSIS AND HAEMOSTASIS. VOL. 14. ISSUE 5. P. 1021 -1030 35 90% 0
7 FAY, PJ , (2006) FACTOR VIII STRUCTURE AND FUNCTION.INTERNATIONAL JOURNAL OF HEMATOLOGY. VOL. 83. ISSUE 2. P. 103-108 46 79% 39
8 VLOT, AJ , KOPPELMAN, SJ , BOUMA, BN , SIXMA, JJ , (1998) FACTOR VIII AND VON WILLEBRAND FACTOR.THROMBOSIS AND HAEMOSTASIS. VOL. 79. ISSUE 3. P. 456-465 82 51% 89
9 NOGAMI, K , WAKABAYASHI, H , SCHMIDT, K , FAY, PJ , (2003) ALTERED INTERACTIONS BETWEEN THE A1 AND A2 SUBUNITS OF FACTOR VIIIA FOLLOWING CLEAVAGE OF A1 SUBUNIT BY FACTOR XA.JOURNAL OF BIOLOGICAL CHEMISTRY. VOL. 278. ISSUE 3. P. 1634-1641 39 98% 33
10 WANG, W , WANG, YJ , KELNER, DN , (2003) COAGULATION FACTOR VIII: STRUCTURE AND STABILITY.INTERNATIONAL JOURNAL OF PHARMACEUTICS. VOL. 259. ISSUE 1-2. P. 1-15 62 63% 17

Classes with closest relation at Level 1


Rank Class id link
1 2067 FACTOR VIII INHIBITOR//HAEMOPHILIA//ACQUIRED HAEMOPHILIA
2 8500 HEMOPHILIA A//FACTOR VIII GENE//HAEMOPHILIA A
3 3016 FACTOR VA//FACTOR V DEFICIENCY//PROTHROMBINASE
4 14295 HAEMOPHILIA//HEMOPHILIA//ANTIVIRAL HEAT TREATMENT
5 1342 HAEMOPHILIA//HEMOPHILIA//VAN CREVELDKLIN
6 639 VON WILLEBRAND DISEASE//VON WILLEBRAND FACTOR//VWD
7 17915 THROMBIN GENERATION//THROMBIN GENERATION ASSAY//ENDOGENOUS THROMBIN POTENTIAL
8 16469 COMPARAT COAGULAT SECT//ASO HOKUBU VET CLIN//CANINE HEREDITARY DISEASE
9 1257 ADENO ASSOCIATED VIRUS//AAV//POWELL GENE THER Y
10 22520 SKIN GENE THERAPY//MOUSE GROWTH HORMONE//LITTLE MICE

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