Class information for:
Level 1: NATIVE CHEMICAL LIGATION//PEPTIDE THIOESTER//DIFFICULT SEQUENCE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
5605 1598 40.6 81%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
5 4 CHEMISTRY, ORGANIC//CHEMISTRY, INORGANIC & NUCLEAR//CHEMISTRY, MULTIDISCIPLINARY 1745167
534 3       PYRIMIDINOPHANES//SOLID PHASE SYNTHESIS//INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH 19564
1347 2             SOLID PHASE SYNTHESIS//JOURNAL OF COMBINATORIAL CHEMISTRY//NATIVE CHEMICAL LIGATION 8307
5605 1                   NATIVE CHEMICAL LIGATION//PEPTIDE THIOESTER//DIFFICULT SEQUENCE 1598

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 NATIVE CHEMICAL LIGATION authKW 1923582 10% 60% 167
2 PEPTIDE THIOESTER authKW 959316 4% 87% 58
3 DIFFICULT SEQUENCE authKW 360007 2% 61% 31
4 CHEMICAL PROTEIN SYNTHESIS authKW 296335 2% 57% 27
5 CHEMICAL LIGATION authKW 286720 3% 37% 41
6 PEPTIDE LIGATION authKW 256863 1% 61% 22
7 PROTEIN CHEMICAL SYNTHESIS authKW 196523 1% 86% 12
8 PEPTIDE HYDRAZIDES authKW 183420 1% 80% 12
9 THIOESTER authKW 178682 3% 18% 51
10 ASPARTIMIDE FORMATION authKW 178321 1% 67% 14

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Organic 10389 37% 0% 587
2 Chemistry, Multidisciplinary 3926 33% 0% 530
3 Biochemistry & Molecular Biology 2297 34% 0% 538
4 Chemistry, Medicinal 522 6% 0% 97
5 Biochemical Research Methods 463 7% 0% 105
6 Chemistry, Analytical 333 8% 0% 122
7 Biophysics 173 5% 0% 78
8 Chemistry, Applied 1 1% 0% 18
9 Biotechnology & Applied Microbiology 0 2% 0% 27
10 Medicine, Research & Experimental -2 1% 0% 15

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 21ST CENTURY COE PROGRAMYAMASHINA KU 146971 1% 77% 10
2 UMR CNRS 8161 119410 1% 63% 10
3 PROT 32 YAMADAOKA 79610 0% 83% 5
4 SYNTHET PROT CHEM 69529 1% 20% 18
5 MED CHEMYAMASHINA KU 59705 0% 63% 5
6 CHEM PROT SYNTH 38214 0% 100% 2
7 CUMMINGS LIFE SCI 325 38214 0% 100% 2
8 FRONTIER MED SCIYAMASHINA KU 38214 0% 100% 2
9 GENEVA BRANCH 38214 0% 100% 2
10 IFR MOL CELLULAR MED 142 38214 0% 100% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF PEPTIDE SCIENCE 130796 7% 6% 111
2 JOURNAL OF PEPTIDE RESEARCH 12988 2% 3% 25
3 INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS 10193 1% 3% 17
4 ORGANIC LETTERS 8034 7% 0% 104
5 TETRAHEDRON LETTERS 7955 11% 0% 176
6 BIOPOLYMERS 7887 3% 1% 52
7 INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH 7284 2% 1% 31
8 ORGANIC & BIOMOLECULAR CHEMISTRY 6621 4% 1% 64
9 CHEMBIOCHEM 6479 2% 1% 39
10 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 5959 7% 0% 111

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 NATIVE CHEMICAL LIGATION 1923582 10% 60% 167 Search NATIVE+CHEMICAL+LIGATION Search NATIVE+CHEMICAL+LIGATION
2 PEPTIDE THIOESTER 959316 4% 87% 58 Search PEPTIDE+THIOESTER Search PEPTIDE+THIOESTER
3 DIFFICULT SEQUENCE 360007 2% 61% 31 Search DIFFICULT+SEQUENCE Search DIFFICULT+SEQUENCE
4 CHEMICAL PROTEIN SYNTHESIS 296335 2% 57% 27 Search CHEMICAL+PROTEIN+SYNTHESIS Search CHEMICAL+PROTEIN+SYNTHESIS
5 CHEMICAL LIGATION 286720 3% 37% 41 Search CHEMICAL+LIGATION Search CHEMICAL+LIGATION
6 PEPTIDE LIGATION 256863 1% 61% 22 Search PEPTIDE+LIGATION Search PEPTIDE+LIGATION
7 PROTEIN CHEMICAL SYNTHESIS 196523 1% 86% 12 Search PROTEIN+CHEMICAL+SYNTHESIS Search PROTEIN+CHEMICAL+SYNTHESIS
8 PEPTIDE HYDRAZIDES 183420 1% 80% 12 Search PEPTIDE+HYDRAZIDES Search PEPTIDE+HYDRAZIDES
9 THIOESTER 178682 3% 18% 51 Search THIOESTER Search THIOESTER
10 ASPARTIMIDE FORMATION 178321 1% 67% 14 Search ASPARTIMIDE+FORMATION Search ASPARTIMIDE+FORMATION

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 BONDALAPATI, S , JBARA, M , BRIK, A , (2016) EXPANDING THE CHEMICAL TOOLBOX FOR THE SYNTHESIS OF LARGE AND UNIQUELY MODIFIED PROTEINS.NATURE CHEMISTRY. VOL. 8. ISSUE 5. P. 407 -418 80 79% 18
2 MONBALIU, JCM , KATRITZKY, AR , (2012) RECENT TRENDS IN CYS- AND SER/THR-BASED SYNTHETIC STRATEGIES FOR THE ELABORATION OF PEPTIDE CONSTRUCTS.CHEMICAL COMMUNICATIONS. VOL. 48. ISSUE 95. P. 11601 -11622 160 73% 15
3 MALINS, LR , PAYNE, RJ , (2015) MODERN EXTENSIONS OF NATIVE CHEMICAL LIGATION FOR CHEMICAL PROTEIN SYNTHESIS.PROTEIN LIGATION AND TOTAL SYNTHESIS I. VOL. 362. ISSUE . P. 27 -87 110 83% 2
4 OTAKA, A , SATO, K , DING, H , SHIGENAGA, A , (2012) ONE-POT/SEQUENTIAL NATIVE CHEMICAL LIGATION USING N-SULFANYLETHYLANILIDE PEPTIDE.CHEMICAL RECORD. VOL. 12. ISSUE 5. P. 479 -490 105 92% 8
5 HACKENBERGER, CPR , SCHWARZER, D , (2008) CHEMOSELECTIVE LIGATION AND MODIFICATION STRATEGIES FOR PEPTIDES AND PROTEINS.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. VOL. 47. ISSUE 52. P. 10030 -10074 166 38% 398
6 GUAN, XY , CHAFFEY, PK , ZENG, C , TAN, ZP , (2015) NEW METHODS FOR CHEMICAL PROTEIN SYNTHESIS.PROTEIN LIGATION AND TOTAL SYNTHESIS II. VOL. 363. ISSUE . P. 155 -192 117 72% 2
7 OTAKA, A , SATO, K , SHIGENAGA, A , (2015) CHEMICAL SYNTHESIS OF PROTEINS USING N-SULFANYLETHYLANILIDE PEPTIDES, BASED ON N-S ACYL TRANSFER CHEMISTRY.PROTEIN LIGATION AND TOTAL SYNTHESIS II. VOL. 363. ISSUE . P. 33 -56 93 89% 0
8 DE FIGUEIREDO, RM , SUPPO, JS , CAMPAGNE, JM , (2016) NONCLASSICAL ROUTES FOR AMIDE BOND FORMATION.CHEMICAL REVIEWS. VOL. 116. ISSUE 19. P. 12029 -12122 224 34% 1
9 TAILHADES, J , PATIL, NA , HOSSAIN, MA , WADE, JD , (2015) INTRAMOLECULAR ACYL TRANSFER IN PEPTIDE AND PROTEIN LIGATION AND SYNTHESIS.JOURNAL OF PEPTIDE SCIENCE. VOL. 21. ISSUE 3. P. 139 -147 79 85% 9
10 WANG, YH , XIAO, H , WANG, F , TIAN, CL , LI, YM , HUANG, YC , CHEN, CC , GAO, S , (2016) SYNTHESIS OF L- AND D-UBIQUITIN BY ONE-POT LIGATION AND METAL-FREE DESULFURIZATION.CHEMISTRY-A EUROPEAN JOURNAL. VOL. 22. ISSUE 22. P. 7623 -7628 67 86% 4

Classes with closest relation at Level 1


Rank Class id link
1 6167 INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH//PHARMACEUT SCI SAKYO KU//MED SAKYO KU
2 37505 14 RESIDUE PEPTIDES//AMIDE TO E OLEFIN MUTATION//AMIDE TO ESTER MUTATION
3 13640 COUPLING REAGENTS//RACEMIZATION FREE COUPLING//PEPTIDE COUPLING REAGENTS
4 10684 GLYCOPEPTIDES//TUMOR VACCINOL//ANTITUMOR VACCINES
5 22821 ENDO BETA N ACETYLGLUCOSAMINIDASE//ENDO M//SUGAR OXAZOLINE
6 11925 INTEIN//PROTEIN SPLICING//HOMING ENDONUCLEASE
7 16343 CYCLOTIDES//KALATA B1//CIRCULAR PROTEINS
8 3192 BIOORTHOGONAL REACTIONS//BIOORTHOGONAL CHEMISTRY//NONCANONICAL AMINO ACIDS
9 26683 HETEROCYCL CPDS//N ACYLSULFONAMIDE//N ACYLBENZOTRIAZOLES
10 17280 LIPOAMINO ACIDS//LIPOPEPTIDE//LIPIDIC AMINO ACID

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