Class information for:
Level 1: NS5B POLYMERASE//NS5B//HCV NS5B POLYMERASE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
4553 1767 40.8 86%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
7 4 INFECTIOUS DISEASES//MICROBIOLOGY//VIROLOGY 1353914
99 3       HEPATITIS C VIRUS//HEPATITIS C//HEPATITIS B VIRUS 74452
26 2             HEPATITIS C VIRUS//HEPATITIS C//HCV 34145
4553 1                   NS5B POLYMERASE//NS5B//HCV NS5B POLYMERASE 1767

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 NS5B POLYMERASE authKW 1053804 4% 85% 72
2 NS5B authKW 687497 4% 52% 77
3 HCV NS5B POLYMERASE authKW 605236 2% 97% 36
4 NS3 PROTEASE authKW 592646 3% 70% 49
5 HCV authKW 287375 15% 6% 261
6 NS3 authKW 259228 3% 31% 49
7 NS3 HELICASE authKW 238930 1% 63% 22
8 NS3 4A PROTEASE authKW 208060 1% 71% 17
9 NON NUCLEOSIDE INHIBITORS authKW 175044 2% 35% 29
10 ANTIVIRAL THER Y address 173254 1% 53% 19

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Medicinal 19849 32% 0% 557
2 Virology 10743 19% 0% 336
3 Chemistry, Organic 3644 22% 0% 380
4 Biochemistry & Molecular Biology 1479 27% 0% 477
5 Pharmacology & Pharmacy 1177 17% 0% 303
6 Gastroenterology & Hepatology 304 5% 0% 84
7 Microbiology 232 6% 0% 110
8 Biophysics 202 5% 0% 88
9 Biochemical Research Methods 178 4% 0% 76
10 Infectious Diseases 82 3% 0% 50

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ANTIVIRAL THER Y 173254 1% 53% 19
2 METAB VIRAL DIS EXCELLENCE DRUG DISCOVERY 88851 1% 43% 12
3 MRL ROME 76966 0% 64% 7
4 IST RIC BIOL MOL P ANGELETTI SPA 69117 0% 100% 4
5 IRBM 66349 1% 30% 13
6 MED CHEM ORGAN PHARMACEUT CHEM 56545 0% 55% 6
7 METAB ANTIVIRAL DIS EXCELLENCE DRUG DISCOVE 51838 0% 100% 3
8 R4CQ 51838 0% 100% 3
9 VIROL DISCOVERY BIOL 51838 0% 100% 3
10 ANTIVIRAL 35047 2% 6% 32

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 40175 14% 1% 242
2 JOURNAL OF MEDICINAL CHEMISTRY 9279 6% 1% 108
3 ANTIVIRAL RESEARCH 8739 2% 1% 42
4 JOURNAL OF VIROLOGY 5428 6% 0% 113
5 ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 4806 5% 0% 82
6 BIOORGANIC & MEDICINAL CHEMISTRY 3385 3% 0% 51
7 ACS MEDICINAL CHEMISTRY LETTERS 2441 1% 1% 14
8 ANTIVIRAL THERAPY 2334 1% 1% 16
9 JOURNAL OF VIRAL HEPATITIS 1734 1% 1% 15
10 ANNUAL REPORTS IN MEDICINAL CHEMISTRY 1557 1% 1% 9

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 NS5B POLYMERASE 1053804 4% 85% 72 Search NS5B+POLYMERASE Search NS5B+POLYMERASE
2 NS5B 687497 4% 52% 77 Search NS5B Search NS5B
3 HCV NS5B POLYMERASE 605236 2% 97% 36 Search HCV+NS5B+POLYMERASE Search HCV+NS5B+POLYMERASE
4 NS3 PROTEASE 592646 3% 70% 49 Search NS3+PROTEASE Search NS3+PROTEASE
5 HCV 287375 15% 6% 261 Search HCV Search HCV
6 NS3 259228 3% 31% 49 Search NS3 Search NS3
7 NS3 HELICASE 238930 1% 63% 22 Search NS3+HELICASE Search NS3+HELICASE
8 NS3 4A PROTEASE 208060 1% 71% 17 Search NS3+4A+PROTEASE Search NS3+4A+PROTEASE
9 NON NUCLEOSIDE INHIBITORS 175044 2% 35% 29 Search NON+NUCLEOSIDE+INHIBITORS Search NON+NUCLEOSIDE+INHIBITORS
10 RNA DEPENDENT RNA POLYMERASE 168477 3% 16% 60 Search RNA+DEPENDENT+RNA+POLYMERASE Search RNA+DEPENDENT+RNA+POLYMERASE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 SOFIA, MJ , CHANG, WS , FURMAN, PA , MOSLEY, RT , ROSS, BS , (2012) NUCLEOSIDE, NUCLEOTIDE, AND NON-NUCLEOSIDE INHIBITORS OF HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA-POLYMERASE.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 55. ISSUE 6. P. 2481-2531 176 54% 112
2 GEMMA, S , BROGI, S , NOVELLINO, E , CAMPIANI, G , MAGA, G , BRINDISI, M , BUTINI, S , (2014) HCV-TARGETED ANTIVIRALS: CURRENT STATUS AND FUTURE CHALLENGES.CURRENT PHARMACEUTICAL DESIGN. VOL. 20. ISSUE 21. P. 3445 -3464 169 68% 3
3 HAUDECOEUR, R , PEUCHMAUR, M , AHMED-BELKACEM, A , PAWLOTSKY, JM , BOUMENDJEL, A , (2013) STRUCTURE-ACTIVITY RELATIONSHIPS IN THE DEVELOPMENT OF ALLOSTERIC HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE INHIBITORS: TEN YEARS OF RESEARCH.MEDICINAL RESEARCH REVIEWS. VOL. 33. ISSUE 5. P. 934-984 109 95% 19
4 DE FRANCESCO, R , CARFI, A , (2007) ADVANCES IN THE DEVELOPMENT OF NEW THERAPEUTIC AGENTS TARGETING THE NS34A SERINE PROTEASE OR THE NS5B RNA-DEPENDENT RNA POLYMERASE OF THE HEPATITIS C VIRUS.ADVANCED DRUG DELIVERY REVIEWS. VOL. 59. ISSUE 12. P. 1242-1262 99 86% 89
5 KOCH, U , NARJES, F , (2007) RECENT PROGRESS IN THE DEVELOPMENT OF INHIBITORS OF THE HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 7. ISSUE 13. P. 1302 -1329 97 76% 78
6 ZAPF, CW , BLOOM, JD , LEVIN, JI , (2007) RECENT PROGRESS ON NOVEL HCV INHIBITORS.ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 42. VOL. 42. ISSUE . P. 281-300 94 80% 9
7 DAS, D , HONG, J , CHEN, SH , WANG, GY , BEIGELMAN, L , SEIWERT, SD , BUCKMAN, BO , (2011) RECENT ADVANCES IN DRUG DISCOVERY OF BENZOTHIADIAZINE AND RELATED ANALOGS AS HCV NS5B POLYMERASE INHIBITORS.BIOORGANIC & MEDICINAL CHEMISTRY. VOL. 19. ISSUE 16. P. 4690 -4703 86 75% 11
8 LI, H , SHI, ST , (2010) NON-NUCLEOSIDE INHIBITORS OF HEPATITIS C VIRUS POLYMERASE: CURRENT PROGRESS AND FUTURE CHALLENGES.FUTURE MEDICINAL CHEMISTRY. VOL. 2. ISSUE 1. P. 121 -141 69 93% 20
9 WATKINS, WJ , RAY, AS , CHONG, LS , (2010) HCV NS5B POLYMERASE INHIBITORS.CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT. VOL. 13. ISSUE 4. P. 441-465 68 83% 36
10 ZHAO, C , WANG, YH , MA, ST , (2015) RECENT ADVANCES ON THE SYNTHESIS OF HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA-POLYMERASE INHIBITORS.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. VOL. 102. ISSUE . P. 188 -214 72 76% 1

Classes with closest relation at Level 1


Rank Class id link
1 835 HEPATITIS C VIRUS//STUDY HEPATITIS C//VIROL 2
2 1329 DIRECT ACTING ANTIVIRALS//SOFOSBUVIR//TELAPREVIR
3 11392 INTERFERON SENSITIVITY DETERMINING REGION//ISDR//CORE PROTEIN
4 13276 UVRB//UVRD//UVRABC
5 27147 BACTERIOPHAGE PHI 6//CYSTOVIRUS//GENOMIC PACKAGING
6 4086 RIBA//ANTI HCV//HEPATITIS C VIRUS
7 12489 PRONUCLEOTIDES//PHOSPHORAMIDATE//PROTIDE
8 1075 RIBAVIRIN//IL28B//INTERLEUKIN 28B
9 6218 HCV GENOTYPES//HEPATITIS C VIRUS//HCV GENOTYPING
10 5844 IRES//INTERNAL RIBOSOME ENTRY SITE//INTERNAL RIBOSOME ENTRY SITE IRES

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