Class information for:
Level 1: PRONUCLEOTIDES//PHOSPHORAMIDATE//PROTIDE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
12489 902 28.5 73%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
236 3       ADENOSINE//NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS//ADENOSINE RECEPTORS 48331
793 2             NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS//NUCLEOSIDES//CARBOCYCLIC NUCLEOSIDES 12112
12489 1                   PRONUCLEOTIDES//PHOSPHORAMIDATE//PROTIDE 902

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PRONUCLEOTIDES authKW 825316 4% 76% 32
2 PHOSPHORAMIDATE authKW 688167 8% 29% 70
3 PROTIDE authKW 436430 2% 68% 19
4 AZT authKW 263137 6% 14% 54
5 PRODRUG authKW 222852 14% 5% 126
6 UMR 5625 address 215630 3% 22% 29
7 NUCLEOTIDE PRODRUG authKW 210915 1% 69% 9
8 HYDROGENPHOSPHONATE METHOD authKW 174092 1% 86% 6
9 CYCLOSAL authKW 152329 1% 75% 6
10 REGA MED address 145605 13% 4% 115

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Medicinal 8496 29% 0% 261
2 Chemistry, Organic 3592 29% 0% 263
3 Biochemistry & Molecular Biology 1011 30% 0% 274
4 Pharmacology & Pharmacy 920 21% 0% 185
5 Virology 861 8% 0% 71
6 Chemistry, Multidisciplinary 218 13% 0% 116
7 Biochemical Research Methods 10 2% 0% 19
8 Biophysics 4 2% 0% 18
9 Chemistry, Analytical 4 3% 0% 23
10 Chemistry, Inorganic & Nuclear 1 2% 0% 14

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 UMR 5625 215630 3% 22% 29
2 REGA MED 145605 13% 4% 115
3 UMR CNRS USTL 5625 138221 1% 58% 7
4 MINIST EDUC BIOORGAN PHOSPHORUS CHEM 113346 1% 28% 12
5 U74INSERM 101554 0% 100% 3
6 BIOORGAN PHOSPHORUS CHEMMINIST EDUC 76930 1% 45% 5
7 WELSH PHARM 72864 5% 5% 47
8 COOPERATIF NOVIRIO 67703 0% 100% 2
9 LIFE SCI ENGNMINIST EDUC 67703 0% 100% 2
10 ORGAN FUNCT MOL 67703 0% 100% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS 120946 14% 3% 129
2 ANTIVIRAL CHEMISTRY & CHEMOTHERAPY 98680 4% 8% 38
3 JOURNAL OF MEDICINAL CHEMISTRY 14201 11% 0% 95
4 ANTIVIRAL RESEARCH 8183 3% 1% 29
5 NUCLEOSIDES & NUCLEOTIDES 6138 1% 2% 11
6 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 5273 7% 0% 63
7 BIOORGANIC & MEDICINAL CHEMISTRY 2794 4% 0% 33
8 ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH 1290 1% 0% 9
9 CHEMMEDCHEM 1181 1% 0% 9
10 RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY 842 1% 0% 6

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 PRONUCLEOTIDES 825316 4% 76% 32 Search PRONUCLEOTIDES Search PRONUCLEOTIDES
2 PHOSPHORAMIDATE 688167 8% 29% 70 Search PHOSPHORAMIDATE Search PHOSPHORAMIDATE
3 PROTIDE 436430 2% 68% 19 Search PROTIDE Search PROTIDE
4 AZT 263137 6% 14% 54 Search AZT Search AZT
5 PRODRUG 222852 14% 5% 126 Search PRODRUG Search PRODRUG
6 NUCLEOTIDE PRODRUG 210915 1% 69% 9 Search NUCLEOTIDE+PRODRUG Search NUCLEOTIDE+PRODRUG
7 HYDROGENPHOSPHONATE METHOD 174092 1% 86% 6 Search HYDROGENPHOSPHONATE+METHOD Search HYDROGENPHOSPHONATE+METHOD
8 CYCLOSAL 152329 1% 75% 6 Search CYCLOSAL Search CYCLOSAL
9 N P 4 BROMOPHENYL 2 3 DIDEHYDRO 3 DEOXY 5 THYMIDYLYL L ALANINE METHYL ESTER 141046 1% 83% 5 Search N+P+4+BROMOPHENYL+2+3+DIDEHYDRO+3+DEOXY+5+THYMIDYLYL+L+ALANINE+METHYL+ESTER Search N+P+4+BROMOPHENYL+2+3+DIDEHYDRO+3+DEOXY+5+THYMIDYLYL+L+ALANINE+METHYL+ESTER
10 D4T 138461 2% 27% 15 Search D4T Search D4T

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 PRADERE, U , GARNIER-AMBLARD, EC , COATS, SJ , AMBLARD, F , SCHINAZI, RF , (2014) SYNTHESIS OF NUCLEOSIDE PHOSPHATE AND PHOSPHONATE PRODRUGS.CHEMICAL REVIEWS. VOL. 114. ISSUE 18. P. 9154 -9218 202 60% 76
2 WAGNER, CR , IYER, VV , MCINTEE, EJ , (2000) PRONUCLEOTIDES: TOWARD THE IN VIVO DELIVERY OF ANTIVIRAL AND ANTICANCER NUCLEOTIDES.MEDICINAL RESEARCH REVIEWS. VOL. 20. ISSUE 6. P. 417 -451 101 78% 180
3 HECKER, SJ , ERION, MD , (2008) PRODRUGS OF PHOSPHATES AND PHOSPHONATES.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 51. ISSUE 8. P. 2328-2345 89 57% 189
4 PETERSON, LW , MCKENNA, CE , (2009) PRODRUG APPROACHES TO IMPROVING THE ORAL ABSORPTION OF ANTIVIRAL NUCLEOTIDE ANALOGUES.EXPERT OPINION ON DRUG DELIVERY. VOL. 6. ISSUE 4. P. 405-420 62 70% 14
5 CAHARD, D , MCGUIGAN, C , BALZARINI, J , (2004) ARYLOXY PHOSPHORAMIDATE TRIESTERS AS PRO-TIDES.MINI-REVIEWS IN MEDICINAL CHEMISTRY. VOL. 4. ISSUE 4. P. 371-381 54 79% 105
6 PARANG, K , WIEBE, LI , KNAUS, EE , (2000) NOVEL APPROACHES FOR DESIGNING 5 '-O-ESTER PRODRUGS OF 3'-AZIDO-2 ',3 '-DIDEOXYTHYMIDINE (AZT).CURRENT MEDICINAL CHEMISTRY. VOL. 7. ISSUE 10. P. 995 -1039 98 47% 116
7 MEHELLOU, Y , BALZARINI, J , MCGUIGAN, C , (2009) ARYLOXY PHOSPHORAMIDATE TRIESTERS: A TECHNOLOGY FOR DELIVERING MONOPHOSPHORYLATED NUCLEOSIDES AND SUGARS INTO CELLS.CHEMMEDCHEM. VOL. 4. ISSUE 11. P. 1779 -1791 57 62% 54
8 PERTENBREITER, F , BALZARINI, J , MEIER, C , (2015) NUCLEOSIDE MONO- AND DIPHOSPHATE PRODRUGS OF 2 ', 3 '-DIDEOXYURIDINE AND 2 ', 3 '-DIDEOXY-2 ', 3 '-DIDEHYDROURIDINE.CHEMMEDCHEM. VOL. 10. ISSUE 1. P. 94 -106 28 78% 5
9 VENKATACHALAM, TK , SAMUEL, P , UCKUN, FM , (2005) STEREOCHEMICAL INFLUENCE ON LIPASE-MEDIATED HYDROLYSIS AND BIOLOGICAL ACTIVITY OF STAMPIDINE AND OTHER STAVUDINE PHOSPHORAMIDATES.BIOORGANIC & MEDICINAL CHEMISTRY. VOL. 13. ISSUE 5. P. 1763 -1773 35 83% 11
10 ORA, M , TAHERPOUR, S , LINNA, R , LEISVUORI, A , HIETAMAKI, E , POIJARVI-VIRTA, P , BEIGELMAN, L , LONNBERG, H , (2009) BIODEGRADABLE PROTECTIONS FOR NUCLEOSIDE 5 '-MONOPHOSPHATES: COMPARATIVE STUDY ON THE REMOVAL OF O-ACETYL AND O-ACETYLOXYMETHYL PROTECTED 3-HYDROXY-2,2-BIS(ETHOXYCARBONYL)PROPYL GROUPS.JOURNAL OF ORGANIC CHEMISTRY. VOL. 74. ISSUE 14. P. 4992 -5001 39 66% 6

Classes with closest relation at Level 1


Rank Class id link
1 10470 ACYCLIC NUCLEOSIDE PHOSPHONATES//PMEA//CIDOFOVIR
2 5405 ZIDOVUDINE//DIDANOSINE//ZALCITABINE
3 5118 NUCLEOSIDES & NUCLEOTIDES//NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS//KETONUCLEOSIDES
4 22326 N PHOSPHORYL AMINO ACID//BIOORGAN PHOSPHORUS CHEM//SERYL HISTIDINE DIPEPTIDE
5 14958 ISONUCLEOSIDES//TROXACITABINE//L NUCLEOSIDES
6 1458 NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS//H PHOSPHONATES//BORANOPHOSPHATE
7 17844 GILEAD IOCB//REVERSIBLE TERMINATOR//LIFE SCI SOLUT GRP
8 21088 LOTEPREDNOL ETABONATE//CHEMICAL DELIVERY SYSTEM//NBP ASSAY
9 26650 NANOART//PHARMACEUT NANOMAT SCI//PHARMACOL EXPT NEUROSCI
10 4553 NS5B POLYMERASE//NS5B//HCV NS5B POLYMERASE

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