Class information for:
Level 1: HERG//I KR//HERG CHANNEL

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
3490 1973 42.7 88%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
8 4 CARDIAC & CARDIOVASCULAR SYSTEM//PERIPHERAL VASCULAR DISEASES//CARDIOL 1276458
11 3       ATRIAL FIBRILLATION//CARDIAC & CARDIOVASCULAR SYSTEM//CATHETER ABLATION 130936
1064 2             LONG QT SYNDROME//BRUGADA SYNDROME//QT INTERVAL 10012
3490 1                   HERG//I KR//HERG CHANNEL 1973

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 HERG authKW 2725427 16% 55% 321
2 I KR authKW 749637 4% 66% 73
3 HERG CHANNEL authKW 729731 4% 65% 73
4 HUMAN ETHER A GO GO RELATED GENE authKW 647027 3% 75% 56
5 LONG QT SYNDROME authKW 488574 11% 14% 224
6 TORSADES DE POINTES authKW 375292 6% 22% 112
7 TORSADE DE POINTES authKW 288321 5% 20% 94
8 QT PROLONGATION authKW 259819 4% 21% 80
9 RAPID DELAYED RECTIFIER authKW 248455 1% 94% 17
10 HUMAN ETHER A GO GO RELATED GENE HERG authKW 186333 1% 71% 17

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Pharmacology & Pharmacy 8475 39% 0% 768
2 Cardiac & Cardiovascular System 5802 22% 0% 435
3 Physiology 2837 14% 0% 272
4 Chemistry, Medicinal 1159 8% 0% 155
5 Toxicology 900 7% 0% 140
6 Peripheral Vascular Diseases 688 6% 0% 122
7 Biophysics 572 7% 0% 142
8 Biochemistry & Molecular Biology 350 15% 0% 304
9 Cell Biology 265 8% 0% 157
10 Biochemical Research Methods 99 3% 0% 66

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 QT PRODACT 99036 0% 80% 8
2 SAFETY PHARMACOL 95345 2% 21% 30
3 MARK COWLEY LIDWILL PROGRAM CARDIAC ELE OPH 94782 0% 88% 7
4 EXCELLENCE CARDIOVASC SAFETY 91020 1% 59% 10
5 ELECT ENGN CYBERNET 79583 0% 86% 6
6 NORA ECCLES HARRISON CARDIOVASC TRAINING IN 53929 2% 12% 30
7 MOL CARDIOL BIOPHYS 50628 1% 27% 12
8 SAFETY ASSESSMENT UK 48411 1% 24% 13
9 GLOBAL PRECLIN TOXICOL PATHOL 46425 0% 100% 3
10 ECCLES PROGRAM HUMAN MOL BIOL GENET 42852 1% 21% 13

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS 22760 2% 4% 41
2 BRITISH JOURNAL OF PHARMACOLOGY 11031 6% 1% 113
3 ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES 10924 1% 3% 22
4 JOURNAL OF PHARMACOLOGICAL SCIENCES 7190 2% 1% 33
5 HEART RHYTHM 5028 2% 1% 31
6 JOURNAL OF GENERAL PHYSIOLOGY 4737 2% 1% 32
7 MOLECULAR PHARMACOLOGY 4378 3% 1% 53
8 CARDIOVASCULAR RESEARCH 3767 2% 1% 44
9 JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 3754 2% 1% 40
10 JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY 3702 2% 1% 32

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 HERG 2725427 16% 55% 321 Search HERG Search HERG
2 I KR 749637 4% 66% 73 Search I+KR Search I+KR
3 HERG CHANNEL 729731 4% 65% 73 Search HERG+CHANNEL Search HERG+CHANNEL
4 HUMAN ETHER A GO GO RELATED GENE 647027 3% 75% 56 Search HUMAN+ETHER+A+GO+GO+RELATED+GENE Search HUMAN+ETHER+A+GO+GO+RELATED+GENE
5 LONG QT SYNDROME 488574 11% 14% 224 Search LONG+QT+SYNDROME Search LONG+QT+SYNDROME
6 TORSADES DE POINTES 375292 6% 22% 112 Search TORSADES+DE+POINTES Search TORSADES+DE+POINTES
7 TORSADE DE POINTES 288321 5% 20% 94 Search TORSADE+DE+POINTES Search TORSADE+DE+POINTES
8 QT PROLONGATION 259819 4% 21% 80 Search QT+PROLONGATION Search QT+PROLONGATION
9 RAPID DELAYED RECTIFIER 248455 1% 94% 17 Search RAPID+DELAYED+RECTIFIER Search RAPID+DELAYED+RECTIFIER
10 HUMAN ETHER A GO GO RELATED GENE HERG 186333 1% 71% 17 Search HUMAN+ETHER+A+GO+GO+RELATED+GENE+HERG Search HUMAN+ETHER+A+GO+GO+RELATED+GENE+HERG

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 VANDENBERG, JI , PERRY, MD , PERRIN, MJ , MANN, SA , KE, Y , HILL, AP , (2012) HERG K+ CHANNELS: STRUCTURE, FUNCTION, AND CLINICAL SIGNIFICANCE.PHYSIOLOGICAL REVIEWS. VOL. 92. ISSUE 3. P. 1393 -1478 351 54% 144
2 POLAK, S , WISNIOWSKA, B , BRANDYS, J , (2009) COLLATION, ASSESSMENT AND ANALYSIS OF LITERATURE IN VITRO DATA ON HERG RECEPTOR BLOCKING POTENCY FOR SUBSEQUENT MODELING OF DRUGS' CARDIOTOXIC PROPERTIES.JOURNAL OF APPLIED TOXICOLOGY. VOL. 29. ISSUE 3. P. 183-206 177 73% 39
3 VILLOUTREIX, BO , TABOUREAU, O , (2015) COMPUTATIONAL INVESTIGATIONS OF HERG CHANNEL BLOCKERS: NEW INSIGHTS AND CURRENT PREDICTIVE MODELS.ADVANCED DRUG DELIVERY REVIEWS. VOL. 86. ISSUE . P. 72 -82 118 73% 11
4 HANCOX, JC , MCPATE, MJ , EL HARCHI, A , ZHANG, YH , (2008) THE HERG POTASSIUM CHANNEL AND HERG SCREENING FOR DRUG-INDUCED TORSADES DE POINTES.PHARMACOLOGY & THERAPEUTICS. VOL. 119. ISSUE 2. P. 118 -132 144 69% 94
5 WANG, SC , LI, YY , XU, L , LI, D , HOU, TJ , (2013) RECENT DEVELOPMENTS IN COMPUTATIONAL PREDICTION OF HERG BLOCKAGE.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 13. ISSUE 11. P. 1317-1326 84 88% 20
6 RASCHI, E , CECCARINI, L , DE PONTI, F , RECANATINI, M , (2009) HERG-RELATED DRUG TOXICITY AND MODELS FOR PREDICTING HERG LIABILITY AND QT PROLONGATION.EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY. VOL. 5. ISSUE 9. P. 1005-1021 97 77% 33
7 DURDAGI, S , SUBBOTINA, J , LEES-MILLER, J , GUO, J , DUFF, HJ , NOSKOV, SY , (2010) INSIGHTS INTO THE MOLECULAR MECHANISM OF HERG1 CHANNEL ACTIVATION AND BLOCKADE BY DRUGS.CURRENT MEDICINAL CHEMISTRY. VOL. 17. ISSUE 30. P. 3514 -3532 99 66% 21
8 HE, FZ , MCLEOD, HL , ZHANG, W , (2013) CURRENT PHARMACOGENOMIC STUDIES ON HERG POTASSIUM CHANNELS.TRENDS IN MOLECULAR MEDICINE. VOL. 19. ISSUE 4. P. 227-238 79 75% 12
9 ZHANG, KP , YANG, BF , LI, BX , (2014) TRANSLATIONAL TOXICOLOGY AND RESCUE STRATEGIES OF THE HERG CHANNEL DYSFUNCTION: BIOCHEMICAL AND MOLECULAR MECHANISTIC ASPECTS.ACTA PHARMACOLOGICA SINICA. VOL. 35. ISSUE 12. P. 1473 -1484 74 80% 6
10 TAN, YY , CHEN, YD , YOU, QD , SUN, HP , LI, MH , (2012) PREDICTING THE POTENCY OF HERG K+ CHANNEL INHIBITION BY COMBINING 3D-QSAR PHARMACOPHORE AND 2D-QSAR MODELS.JOURNAL OF MOLECULAR MODELING. VOL. 18. ISSUE 3. P. 1023-1036 73 83% 16

Classes with closest relation at Level 1


Rank Class id link
1 11919 SERTINDOLE//TORSADES DE POINTES//TORSADE DE POINTES
2 1859 LONG QT SYNDROME//KCNQ1//SHORT QT SYNDROME
3 7162 SOTALOL//DOFETILIDE//CLASS III ANTIARRHYTHMIC AGENT
4 13321 NEUROSCI SOLUT CANC GRP//EAG1//ETHER A GO GO
5 7026 TRANSIENT OUTWARD CURRENT//KV43//KCHIP
6 27113 SAFETY PHARMACOLOGY//TAIL CUFF METHOD//JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
7 18583 RANOLAZINE//LATE SODIUM CURRENT//LATE I NA
8 2028 QT DISPERSION//QT INTERVAL//REPOLARIZATION
9 20894 PLANAR PATCH CLAMP//ION CHANNEL RECORDING//PLANAR PATCH CLAMP CHIP
10 7460 CARDIOMYOCYTES//CARDIAC DIFFERENTIATION//STEM CELL REGENERAT MED CONSORTIUM

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