Class information for:
Level 1: NITRIC OXIDE SYNTHASE//MOL INNOVAT DRUG DISCOVERY//HEME REDUCTION

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
3477 1975 43.2 86%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
343 3       NITRIC OXIDE//PEROXYNITRITE//NITRIC OXIDE SYNTHASE 36678
295 2             NITRIC OXIDE//PEROXYNITRITE//NITRIC OXIDE-BIOLOGY AND CHEMISTRY 18821
3477 1                   NITRIC OXIDE SYNTHASE//MOL INNOVAT DRUG DISCOVERY//HEME REDUCTION 1975

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 NITRIC OXIDE SYNTHASE authKW 205313 15% 4% 296
2 MOL INNOVAT DRUG DISCOVERY address 175800 2% 25% 46
3 HEME REDUCTION authKW 113832 0% 82% 9
4 N G HYDROXY L ARGININE authKW 89436 0% 64% 9
5 N HYDROXYGUANIDINES authKW 79503 0% 86% 6
6 SELECTIVE NEURONAL NITRIC OXIDE SYNTHASE INHIBITORS authKW 77296 0% 100% 5
7 TETRAHYDROBIOPTERIN authKW 64961 3% 7% 59
8 LERNER FDN address 64412 0% 83% 5
9 IMMUNOL NB3 address 61837 0% 100% 4
10 N OMEGA HYDROXY L ARGININE authKW 61833 0% 67% 6

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Biochemistry & Molecular Biology 8447 54% 0% 1068
2 Chemistry, Medicinal 3098 12% 0% 243
3 Biophysics 1971 12% 0% 243
4 Cell Biology 385 9% 0% 180
5 Pharmacology & Pharmacy 373 11% 0% 208
6 Chemistry, Organic 316 7% 0% 145
7 Immunology 177 6% 0% 127
8 Medicine, Research & Experimental 51 3% 0% 62
9 Biochemical Research Methods 47 3% 0% 52
10 Chemistry, Inorganic & Nuclear 30 3% 0% 50

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MOL INNOVAT DRUG DISCOVERY 175800 2% 25% 46
2 LERNER FDN 64412 0% 83% 5
3 IMMUNOL NB3 61837 0% 100% 4
4 CHEM LIFE PROC 59206 2% 9% 42
5 LOW FREQUENCY EPR IN VIVO PHYSIOL 48306 0% 63% 5
6 LSOD 46378 0% 100% 3
7 DRUG DISCOVERY CHEM BIOL 45992 1% 19% 16
8 LERNER 36520 6% 2% 110
9 TECHNOPORT 34782 0% 75% 3
10 BIOCHEM INTEGRATED BIOL 30918 0% 100% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 NITRIC OXIDE-BIOLOGY AND CHEMISTRY 9503 1% 2% 29
2 BIOCHEMISTRY 6274 8% 0% 149
3 JOURNAL OF BIOLOGICAL CHEMISTRY 5354 12% 0% 234
4 JOURNAL OF MEDICINAL CHEMISTRY 3233 3% 0% 68
5 JOURNAL OF INORGANIC BIOCHEMISTRY 2591 2% 1% 31
6 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2496 3% 0% 65
7 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2479 5% 0% 107
8 BIOORGANIC & MEDICINAL CHEMISTRY 1400 2% 0% 35
9 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 1119 2% 0% 36
10 RESEARCH IN IMMUNOLOGY 1085 0% 1% 8

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 NITRIC OXIDE SYNTHASE 205313 15% 4% 296 Search NITRIC+OXIDE+SYNTHASE Search NITRIC+OXIDE+SYNTHASE
2 HEME REDUCTION 113832 0% 82% 9 Search HEME+REDUCTION Search HEME+REDUCTION
3 N G HYDROXY L ARGININE 89436 0% 64% 9 Search N+G+HYDROXY+L+ARGININE Search N+G+HYDROXY+L+ARGININE
4 N HYDROXYGUANIDINES 79503 0% 86% 6 Search N+HYDROXYGUANIDINES Search N+HYDROXYGUANIDINES
5 SELECTIVE NEURONAL NITRIC OXIDE SYNTHASE INHIBITORS 77296 0% 100% 5 Search SELECTIVE+NEURONAL+NITRIC+OXIDE+SYNTHASE+INHIBITORS Search SELECTIVE+NEURONAL+NITRIC+OXIDE+SYNTHASE+INHIBITORS
6 TETRAHYDROBIOPTERIN 64961 3% 7% 59 Search TETRAHYDROBIOPTERIN Search TETRAHYDROBIOPTERIN
7 N OMEGA HYDROXY L ARGININE 61833 0% 67% 6 Search N+OMEGA+HYDROXY+L+ARGININE Search N+OMEGA+HYDROXY+L+ARGININE
8 NEURONAL NITRIC OXIDE SYNTHASE INHIBITOR 49468 0% 80% 4 Search NEURONAL+NITRIC+OXIDE+SYNTHASE+INHIBITOR Search NEURONAL+NITRIC+OXIDE+SYNTHASE+INHIBITOR
9 FORMAMIDOXIME 46378 0% 100% 3 Search FORMAMIDOXIME Search FORMAMIDOXIME
10 HEME FMN ELECTRON TRANSFER 46378 0% 100% 3 Search HEME+FMN+ELECTRON+TRANSFER Search HEME+FMN+ELECTRON+TRANSFER

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 SANTOLINI, J , (2011) THE MOLECULAR MECHANISM OF MAMMALIAN NO-SYNTHASES: A STORY OF ELECTRONS AND PROTONS.JOURNAL OF INORGANIC BIOCHEMISTRY. VOL. 105. ISSUE 2. P. 127 -141 180 76% 21
2 ALDERTON, WK , COOPER, CE , KNOWLES, RG , (2001) NITRIC OXIDE SYNTHASES: STRUCTURE, FUNCTION AND INHIBITION.BIOCHEMICAL JOURNAL. VOL. 357. ISSUE . P. 593-615 119 57% 2177
3 FENG, CJ , (2012) MECHANISM OF NITRIC OXIDE SYNTHASE REGULATION: ELECTRON TRANSFER AND INTERDOMAIN INTERACTIONS.COORDINATION CHEMISTRY REVIEWS. VOL. 256. ISSUE 3-4. P. 393-411 164 77% 26
4 FENG, CJ , CHEN, L , LI, WB , ELMORE, BO , FAN, WH , SUN, X , (2014) DISSECTING REGULATION MECHANISM OF THE FMN TO HEME INTERDOMAIN ELECTRON TRANSFER IN NITRIC OXIDE SYNTHASES.JOURNAL OF INORGANIC BIOCHEMISTRY. VOL. 130. ISSUE . P. 130 -140 125 83% 7
5 MUKHERJEE, P , CINELLI, MA , KANG, S , SILVERMAN, RB , (2014) DEVELOPMENT OF NITRIC OXIDE SYNTHASE INHIBITORS FOR NEURODEGENERATION AND NEUROPATHIC PAIN.CHEMICAL SOCIETY REVIEWS. VOL. 43. ISSUE 19. P. 6814 -6838 140 60% 23
6 GORREN, ACF , MAYER, B , (2002) TETRAHYDROBIOPTERIN IN NITRIC OXIDE SYNTHESIS: A NOVEL BIOLOGICAL ROLE FOR PTERIDINES.CURRENT DRUG METABOLISM. VOL. 3. ISSUE 2. P. 133 -157 177 69% 63
7 DAFF, S , (2010) NO SYNTHASE: STRUCTURES AND MECHANISMS.NITRIC OXIDE-BIOLOGY AND CHEMISTRY. VOL. 23. ISSUE 1. P. 1 -11 93 74% 109
8 STUEHR, DJ , (1999) MAMMALIAN NITRIC OXIDE SYNTHASES.BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS. VOL. 1411. ISSUE 2-3. P. 217-230 94 76% 581
9 LI, HY , POULOS, TL , (2005) STRUCTURE-FUNCTION STUDIES ON NITRIC OXIDE SYNTHASES.JOURNAL OF INORGANIC BIOCHEMISTRY. VOL. 99. ISSUE 1. P. 293 -305 94 83% 165
10 ERDAL, EP , LITZINGER, EA , SEO, JW , ZHU, YQ , JI, HT , SILVERMAN, RB , (2005) SELECTIVE NEURONAL NITRIC OXIDE SYNTHASE INHIBITORS.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 5. ISSUE 7. P. 603 -624 125 66% 48

Classes with closest relation at Level 1


Rank Class id link
1 27663 ASCITES TUMOR GROWTH//BIOL MEDAWAR GOWER ST//CD56 SURFACE MARKER
2 14124 TYPE I INTERLEUKIN 1 RECEPTOR//INDUCIBLE NITRIC OXIDE SYNTHASE//INOS PROMOTER
3 20641 MOL CARDIOBIOL PROGRAM//CARDIOVASC HYPERTENS//ENDOTHELIAL NITRIC OXIDE SYNTHASE
4 20869 ZENTRUM PHARMAKOL//SURG 497 SCAIFE HALL//SKIN XENOGRAFTS
5 5995 SEPTIC SHOCK//VASCULAR HYPOREACTIVITY//SHOCK
6 28208 NITRIC OXIDE SYNTHASE I//CENT ULTRASTRUCT TEAM//NOS I
7 7175 NITRIC OXIDE//INOS//RADIAT BIOL BRANCH
8 15115 DY 9760E//ARL 17477//CALCIUM INDEPENDENT NITRIC OXIDE SYNTHASE
9 23960 GRP IMMUNOBIOL//HUBEI BIOINORGAN CHEM MED//NG L MONOMETHYL ARGININE
10 24651 GEA 3175//MESOIONIC 3 ARYL SUBSTITUTED OXATRIAZOLES//NEUTROPHIL DERIVED RELAXING FACTOR

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