Class information for:
Level 1: HERBOXIDIENE//SPLICEOSTATIN A//FR901464

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
30236 172 37.4 85%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
5 4 CHEMISTRY, ORGANIC//CHEMISTRY, INORGANIC & NUCLEAR//CHEMISTRY, MULTIDISCIPLINARY 1745167
1 3       CHEMISTRY, ORGANIC//TETRAHEDRON LETTERS//JOURNAL OF ORGANIC CHEMISTRY 237069
288 2             CHEMISTRY, ORGANIC//ALLYLATION//TETRAHEDRON LETTERS 18901
30236 1                   HERBOXIDIENE//SPLICEOSTATIN A//FR901464 172

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 HERBOXIDIENE authKW 1065191 3% 100% 6
2 SPLICEOSTATIN A authKW 913019 3% 86% 6
3 FR901464 authKW 634040 3% 71% 5
4 E7107 authKW 532596 2% 100% 3
5 PLADIENOLIDE authKW 399445 2% 75% 3
6 PLADIENOLIDE B authKW 355064 1% 100% 2
7 SUDEMYCIN authKW 355064 1% 100% 2
8 THAILANSTATIN authKW 355064 1% 100% 2
9 SF3B authKW 199720 2% 38% 3
10 17S U2 SNRNP authKW 177532 1% 100% 1

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Organic 569 27% 0% 46
2 Chemistry, Medicinal 322 13% 0% 23
3 Biotechnology & Applied Microbiology 278 18% 0% 31
4 Oncology 126 16% 0% 27
5 Biochemistry & Molecular Biology 105 24% 0% 41
6 Microbiology 73 10% 0% 17
7 Cell Biology 55 11% 0% 19
8 Pharmacology & Pharmacy 55 13% 0% 22
9 Immunology 36 9% 0% 15
10 Chemistry, Applied 21 4% 0% 7

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CENT HOSP SHENLI OIL FIELD 177532 1% 100% 1
2 CNRS UMR 3215 INSERM U934 177532 1% 100% 1
3 DEPATMENT DEV BIOL GENET 177532 1% 100% 1
4 HIGH THROUGHPUT CHEM IL 177532 1% 100% 1
5 INTER PROGRAM MOL BIOMED SCI 177532 1% 100% 1
6 KOIDE GRP 177532 1% 100% 1
7 MED EDUC S PORT 177532 1% 100% 1
8 NIHR EXPT CANC MED 177532 1% 100% 1
9 PRECLIN PK SHARED OURCE 177532 1% 100% 1
10 TSUKUBA CHEM 177532 1% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF ANTIBIOTICS 6000 9% 0% 15
2 ACS CHEMICAL BIOLOGY 2966 3% 0% 6
3 ORGANIC LETTERS 1563 9% 0% 15
4 NATURE CHEMICAL BIOLOGY 1161 2% 0% 3
5 CURRENT HEMATOLOGIC MALIGNANCY REPORTS 565 1% 0% 1
6 MEDCHEMCOMM 523 1% 0% 2
7 CANCER CELL 461 1% 0% 2
8 CANCER SCIENCE 449 2% 0% 3
9 GENES & DEVELOPMENT 376 2% 0% 4
10 BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 362 3% 0% 5

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 HERBOXIDIENE 1065191 3% 100% 6 Search HERBOXIDIENE Search HERBOXIDIENE
2 SPLICEOSTATIN A 913019 3% 86% 6 Search SPLICEOSTATIN+A Search SPLICEOSTATIN+A
3 FR901464 634040 3% 71% 5 Search FR901464 Search FR901464
4 E7107 532596 2% 100% 3 Search E7107 Search E7107
5 PLADIENOLIDE 399445 2% 75% 3 Search PLADIENOLIDE Search PLADIENOLIDE
6 PLADIENOLIDE B 355064 1% 100% 2 Search PLADIENOLIDE+B Search PLADIENOLIDE+B
7 SUDEMYCIN 355064 1% 100% 2 Search SUDEMYCIN Search SUDEMYCIN
8 THAILANSTATIN 355064 1% 100% 2 Search THAILANSTATIN Search THAILANSTATIN
9 SF3B 199720 2% 38% 3 Search SF3B Search SF3B
10 17S U2 SNRNP 177532 1% 100% 1 Search 17S+U2+SNRNP Search 17S+U2+SNRNP

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 EFFENBERGER, KA , URABE, VK , PRICHARD, BE , GHOSH, AK , JURICA, MS , (2016) INTERCHANGEABLE SF3B1 INHIBITORS INTERFERE WITH PRE-MRNA SPLICING AT MULTIPLE STAGES.RNA. VOL. 22. ISSUE 3. P. 350 -359 34 65% 6
2 LAGISETTI, C , YERMOLINA, MV , SHARMA, LK , PALACIOS, G , PRIGARO, BJ , WEBB, TR , (2014) PRE-MRNA SPLICING-MODULATORY PHARMACOPHORES: THE TOTAL SYNTHESIS OF HERBOXIDIENE, A PLADIENOLIDE-HERBOXIDIENE HYBRID ANALOG AND RELATED DERIVATIVES.ACS CHEMICAL BIOLOGY. VOL. 9. ISSUE 3. P. 643-648 36 78% 15
3 KUMAR, D , KASHYAP, MK , LA CLAIR, JJ , VILLA, R , SPAANDERMAN, I , CHIEN, S , RASSENTI, LZ , KIPPS, TJ , BURKART, MD , CASTRO, JE , (2016) SELECTIVITY IN SMALL MOLECULE SPLICING MODULATION.ACS CHEMICAL BIOLOGY. VOL. 11. ISSUE 10. P. 2716 -2723 38 78% 0
4 PHAM, D , KOIDE, K , (2016) DISCOVERIES, TARGET IDENTIFICATIONS, AND BIOLOGICAL APPLICATIONS OF NATURAL PRODUCTS THAT INHIBIT SPLICING FACTOR 3B SUBUNIT 1.NATURAL PRODUCT REPORTS. VOL. 33. ISSUE 5. P. 637 -647 43 58% 2
5 DHAR, S , LA CLAIR, JJ , LEON, B , HAMMONS, JC , YU, Z , KASHYAP, MK , CASTRO, JE , BURKART, MD , (2016) A CARBOHYDRATE-DERIVED SPLICE MODULATOR.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. VOL. 138. ISSUE 15. P. 5063 -5068 35 70% 0
6 MARTINEZ-MONTIEL, N , ROSAS-MURRIETA, NH , MARTINEZ-MONTIEL, M , GASPARIANO-CHOLULA, MP , MARTINEZ-CONTRERAS, RD , (2016) MICROBIAL AND NATURAL METABOLITES THAT INHIBIT SPLICING: A POWERFUL ALTERNATIVE FOR CANCER TREATMENT.BIOMED RESEARCH INTERNATIONAL. VOL. . ISSUE . P. - 47 51% 0
7 GAO, Y , VOGT, A , FORSYTH, CJ , KOIDE, K , (2013) COMPARISON OF SPLICING FACTOR 3B INHIBITORS IN HUMAN CELLS.CHEMBIOCHEM. VOL. 14. ISSUE 1. P. 49-52 29 71% 19
8 MAKOWSKI, K , VIGEVANI, L , ALBERICIO, F , VALCARCEL, J , ALVAREZ, M , (2017) SUDEMYCIN K: A SYNTHETIC ANTITUMOR SPLICING INHIBITOR VARIANT WITH IMPROVED ACTIVITY AND VERSATILE CHEMISTRY.ACS CHEMICAL BIOLOGY. VOL. 12. ISSUE 1. P. 163 -173 33 63% 0
9 EFFENBERGER, KA , ANDERSON, DD , BRAY, WM , PRICHARD, BE , MA, NC , ADAMS, MS , GHOSH, AK , JURICA, MS , (2014) COHERENCE BETWEEN CELLULAR RESPONSES AND IN VITRO SPLICING INHIBITION FOR THE ANTI-TUMOR DRUG PLADIENOLIDE B AND ITS ANALOGS.JOURNAL OF BIOLOGICAL CHEMISTRY. VOL. 289. ISSUE 4. P. 1938-1947 26 72% 10
10 WEBB, TR , JOYNER, AS , POTTER, PM , (2013) THE DEVELOPMENT AND APPLICATION OF SMALL MOLECULE MODULATORS OF SF3B AS THERAPEUTIC AGENTS FOR CANCER.DRUG DISCOVERY TODAY. VOL. 18. ISSUE 1-2. P. 43 -49 27 51% 32

Classes with closest relation at Level 1


Rank Class id link
1 3668 SPLICEOSOME//PRE MRNA SPLICING//SNRNP
2 785 SR PROTEINS//ALTERNATIVE SPLICING//POLYPYRIMIDINE TRACT BINDING PROTEIN
3 9655 PRINS CYCLIZATION//TETRAHYDROPYRAN//CENTROLOBINE
4 36622 FINE CHEM BIOCHEM//NAMALWA KJM 1//NAMALWA KJM 1 CELLS
5 1137 MYELODYSPLASTIC SYNDROME//AZACITIDINE//MDS
6 5889 P TEFB//CDK9//RNA POLYMERASE II
7 27919 GENE THER Y SCI//RECOMBINANT SENDAI VIRUS//HVJ E
8 33778 ALPHA BETA UNSATURATED HYDROXY ESTERS//DIOL DESYMMETRIZATION//IODOYLIDES
9 27406 MIGRASTATIN//CYCLOHEXYLAMINOGLUTETHIMIDE//GLUTARIMIDE
10 24831 CROCACIN//HYDROAMIDATION//AMATHASPIRAMIDE

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