Class information for:
Level 1: CHIM BIOINORGAN//CARBONIC ANHYDRASE//POLO SCI

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
2987 2093 44.4 82%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
408 3       CHIM BIOINORGAN//POLO SCI//CARBONIC ANHYDRASE 29468
2256 2             CARBONIC ANHYDRASE//CHIM BIOINORGAN//POLO SCI 4686
2987 1                   CHIM BIOINORGAN//CARBONIC ANHYDRASE//POLO SCI 2093

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CHIM BIOINORGAN address 6756352 26% 85% 547
2 CARBONIC ANHYDRASE authKW 3863008 38% 33% 795
3 POLO SCI address 1566325 7% 70% 153
4 NEUROFARBA address 1259253 10% 42% 204
5 CARBONIC ANHYDRASE IX authKW 1134246 6% 60% 129
6 SEZ SCI FARMACEUT address 1100088 4% 93% 81
7 SEZ SCI FARMACEUT NUTRACEUT address 942751 3% 91% 71
8 DIPARTIMENTO NEUROFARBA address 780131 3% 82% 65
9 SECT PHARMACEUT NUTRICEUT SCI address 718875 3% 93% 53
10 SULFONAMIDES authKW 532617 14% 12% 293

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Medicinal 48928 45% 0% 944
2 Chemistry, Organic 4833 23% 0% 474
3 Biochemistry & Molecular Biology 3501 36% 0% 751
4 Oncology 1014 13% 0% 277
5 Pharmacology & Pharmacy 200 8% 0% 175
6 Pathology 95 3% 0% 55
7 Biophysics 83 3% 0% 72
8 Urology & Nephrology 60 2% 0% 49
9 Chemistry, Multidisciplinary 28 6% 0% 120
10 Biochemical Research Methods 20 2% 0% 43

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CHIM BIOINORGAN 6756352 26% 85% 547
2 POLO SCI 1566325 7% 70% 153
3 NEUROFARBA 1259253 10% 42% 204
4 SEZ SCI FARMACEUT 1100088 4% 93% 81
5 SEZ SCI FARMACEUT NUTRACEUT 942751 3% 91% 71
6 DIPARTIMENTO NEUROFARBA 780131 3% 82% 65
7 SECT PHARMACEUT NUTRICEUT SCI 718875 3% 93% 53
8 CHIM INORGAN BIOINORGAN 368976 3% 39% 65
9 CHIM BIOORGAN 344174 6% 18% 128
10 IST BIOSCI BIORISORSE 282137 2% 54% 36

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 407597 11% 12% 233
2 BIOORGANIC & MEDICINAL CHEMISTRY 41768 9% 1% 193
3 JOURNAL OF ENZYME INHIBITION 29822 1% 8% 27
4 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 28702 11% 1% 223
5 JOURNAL OF MEDICINAL CHEMISTRY 7800 5% 1% 108
6 EXPERT OPINION ON THERAPEUTIC PATENTS 7088 2% 1% 33
7 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 3841 2% 1% 50
8 CURRENT PHARMACEUTICAL DESIGN 1550 1% 0% 26
9 CHEMICAL BIOLOGY & DRUG DESIGN 1049 1% 1% 11
10 CURRENT TOPICS IN MEDICINAL CHEMISTRY 759 1% 0% 11

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 CARBONIC ANHYDRASE 3863008 38% 33% 795 Search CARBONIC+ANHYDRASE Search CARBONIC+ANHYDRASE
2 CARBONIC ANHYDRASE IX 1134246 6% 60% 129 Search CARBONIC+ANHYDRASE+IX Search CARBONIC+ANHYDRASE+IX
3 SULFONAMIDES 532617 14% 12% 293 Search SULFONAMIDES Search SULFONAMIDES
4 BETA CLASS ENZYME 364688 1% 100% 25 Search BETA+CLASS+ENZYME Search BETA+CLASS+ENZYME
5 CARBONIC ANHYDRASE INHIBITORS 331575 3% 32% 72 Search CARBONIC+ANHYDRASE+INHIBITORS Search CARBONIC+ANHYDRASE+INHIBITORS
6 CA IX 314360 2% 57% 38 Search CA+IX Search CA+IX
7 HYDRATASE ACTIVITY 261486 1% 81% 22 Search HYDRATASE+ACTIVITY Search HYDRATASE+ACTIVITY
8 SULFAMIDE 260392 2% 54% 33 Search SULFAMIDE Search SULFAMIDE
9 BETA CARBONIC ANHYDRASE 233392 1% 80% 20 Search BETA+CARBONIC+ANHYDRASE Search BETA+CARBONIC+ANHYDRASE
10 SULFAMATE 227844 2% 46% 34 Search SULFAMATE Search SULFAMATE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 SUPURAN, CT , (2016) HOW MANY CARBONIC ANHYDRASE INHIBITION MECHANISMS EXIST?.JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY. VOL. 31. ISSUE 3. P. 345 -360 157 96% 6
2 SUPURAN, CT , (2017) ADVANCES IN STRUCTURE-BASED DRUG DISCOVERY OF CARBONIC ANHYDRASE INHIBITORS.EXPERT OPINION ON DRUG DISCOVERY. VOL. 12. ISSUE 1. P. 61 -88 173 93% 0
3 SUPURAN, CT , DE SIMONE, G , ALTERIO, V , DI FIORE, A , D'AMBROSIO, K , (2012) MULTIPLE BINDING MODES OF INHIBITORS TO CARBONIC ANHYDRASES: HOW TO DESIGN SPECIFIC DRUGS TARGETING 15 DIFFERENT ISOFORMS?.CHEMICAL REVIEWS. VOL. 112. ISSUE 8. P. 4421 -4468 177 60% 103
4 SUPURAN, CT , (2008) CARBONIC ANHYDRASES: NOVEL THERAPEUTIC APPLICATIONS FOR INHIBITORS AND ACTIVATORS.NATURE REVIEWS DRUG DISCOVERY. VOL. 7. ISSUE 2. P. 168 -181 87 85% 607
5 PASTOREK, J , PASTOREKOVA, S , (2015) HYPOXIA-INDUCED CARBONIC ANHYDRASE IX AS A TARGET FOR CANCER THERAPY: FROM BIOLOGY TO CLINICAL USE.SEMINARS IN CANCER BIOLOGY. VOL. 31. ISSUE . P. 52 -64 122 72% 27
6 MCDONALD, PC , WINUM, JY , SUPURAN, CT , DEDHAR, S , (2012) RECENT DEVELOPMENTS IN TARGETING CARBONIC ANHYDRASE IX FOR CANCER THERAPEUTICS.ONCOTARGET. VOL. 3. ISSUE 1. P. 84-97 94 88% 85
7 CAPASSO, C , SUPURAN, CT , (2015) BACTERIAL, FUNGAL AND PROTOZOAN CARBONIC ANHYDRASES AS DRUG TARGETS.EXPERT OPINION ON THERAPEUTIC TARGETS. VOL. 19. ISSUE 12. P. 1689 -1704 123 82% 0
8 PASTOREKOVA, S , ZATOVICOVA, M , PASTOREK, J , (2008) CANCER-ASSOCIATED CARBONIC ANHYDRASES AND THEIR INHIBITION.CURRENT PHARMACEUTICAL DESIGN. VOL. 14. ISSUE 7. P. 685-698 132 72% 101
9 LICSANDRU, E , TANC, M , KOCSIS, I , BARBOIU, M , SUPURAN, CT , (2017) A CLASS OF CARBONIC ANHYDRASE I - SELECTIVE ACTIVATORS.JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY. VOL. 32. ISSUE 1. P. 37 -46 96 97% 0
10 DE SIMONE, G , ALTERIO, V , SUPURAN, CT , (2013) EXPLOITING THE HYDROPHOBIC AND HYDROPHILIC BINDING SITES FOR DESIGNING CARBONIC ANHYDRASE INHIBITORS.EXPERT OPINION ON DRUG DISCOVERY. VOL. 8. ISSUE 7. P. 793 -810 96 91% 21

Classes with closest relation at Level 1


Rank Class id link
1 11541 CARBONIC ANHYDRASE//HUMAN CARBONIC ANHYDRASE II//IMIDAZOLIDINE RING HYDROLYSIS
2 10538 CARBONIC ANHYDRASE III//CARBONIC ANHYDRASE//CARBONIC ANHYDRASE VI
3 27606 DRUG RADIAT//M PRC//ANTI BREAST CANCER ACTIVITY
4 25516 SULOFENUR//INDISULAM//E7070
5 19617 SULFATHIAZOLE COMPLEXES//N SUBSTITUTED SULFONAMIDES//SULFONAMIDE LIGANDS
6 30436 SYMPHYOCLADIA LATIUSCULA//BROMOPHENOLS//RHODOMELA CONFERVOIDES
7 35883 ENDOPEPTIDEASE//5 FLUOROURACIL5 FU//ACUTE CADMIUM
8 19000 6 PHOSPHOGLUCONATE DEHYDROGENASE//GLUCOSE 6 PHOSPHATE DEHYDROGENASE//BIOTECHNOL PLICAT
9 16621 PHLIP//TUMOR ACIDITY//TUMOR PH
10 4552 CO2 CONCENTRATING MECHANISM//CARBOXYSOME//CARBON CONCENTRATING MECHANISM

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