Class information for:
Level 1: SELINEXOR//XPO1//CRM1 INHIBITOR

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
25640 276 41.5 87%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
5 4 CHEMISTRY, ORGANIC//CHEMISTRY, INORGANIC & NUCLEAR//CHEMISTRY, MULTIDISCIPLINARY 1745167
1 3       CHEMISTRY, ORGANIC//TETRAHEDRON LETTERS//JOURNAL OF ORGANIC CHEMISTRY 237069
288 2             CHEMISTRY, ORGANIC//ALLYLATION//TETRAHEDRON LETTERS 18901
25640 1                   SELINEXOR//XPO1//CRM1 INHIBITOR 276

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 SELINEXOR authKW 885080 3% 100% 8
2 XPO1 authKW 779043 5% 54% 13
3 CRM1 INHIBITOR authKW 774445 3% 100% 7
4 CRM1 authKW 629338 12% 18% 32
5 KPT 330 authKW 553175 2% 100% 5
6 EXPORTIN 1 authKW 448062 3% 45% 9
7 CALLYSTATIN A authKW 442540 1% 100% 4
8 S109 authKW 442540 1% 100% 4
9 LEPTOMYCIN authKW 417003 3% 54% 7
10 REV EXPORT INHIBITOR authKW 354031 1% 80% 4

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Oncology 851 30% 0% 82
2 Chemistry, Organic 372 18% 0% 49
3 Biotechnology & Applied Microbiology 259 14% 0% 39
4 Hematology 226 9% 0% 26
5 Pharmacology & Pharmacy 190 17% 0% 48
6 Microbiology 158 11% 0% 31
7 Cell Biology 144 13% 0% 37
8 Immunology 85 10% 0% 28
9 Chemistry, Medicinal 59 5% 0% 14
10 Biochemistry & Molecular Biology 37 14% 0% 39

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 INSITITUTE NERVOUS SYST DIS 165950 1% 50% 3
2 CREAT FUNCT NEW MOL MOL ASSEMBLIES 147512 1% 67% 2
3 BEIJING CLIN STUDY ANTICANCER 110635 0% 100% 1
4 BIOFIS CSIC 110635 0% 100% 1
5 BLOOD DISORDERS CANC THER EUT 110635 0% 100% 1
6 FUJIAN MED UNIV CLIN TEACHING HOSP 110635 0% 100% 1
7 INSERM U309EQUIPE ASSEMBLAGE REGULAT PAREIL 110635 0% 100% 1
8 LURIE FAMILY IMAGING PEDIAT ONCOL 110635 0% 100% 1
9 M2GEN BIOTECHNOL 110635 0% 100% 1
10 MEDMED SERV Y MEM HOSP 110635 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF ANTIBIOTICS 13039 10% 0% 28
2 JOURNAL OF HEMATOLOGY & ONCOLOGY 5897 2% 1% 6
3 SEMINARS IN CANCER BIOLOGY 893 1% 0% 3
4 ONCOTARGET 889 4% 0% 10
5 JOURNAL OF BIOMOLECULAR SCREENING 576 1% 0% 3
6 JOURNAL OF NATURAL TOXINS 467 0% 0% 1
7 CURRENT CANCER DRUG TARGETS 462 1% 0% 2
8 MOLECULAR CANCER THERAPEUTICS 429 1% 0% 4
9 NIPPON NOGEIKAGAKU KAISHI-JOURNAL OF THE JAPAN SOCIETY FOR BIOSCIENCE BIOTECHNOLOGY AND AGROCHEMISTRY 426 1% 0% 2
10 BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS 419 1% 0% 2

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 SELINEXOR 885080 3% 100% 8 Search SELINEXOR Search SELINEXOR
2 XPO1 779043 5% 54% 13 Search XPO1 Search XPO1
3 CRM1 INHIBITOR 774445 3% 100% 7 Search CRM1+INHIBITOR Search CRM1+INHIBITOR
4 CRM1 629338 12% 18% 32 Search CRM1 Search CRM1
5 KPT 330 553175 2% 100% 5 Search KPT+330 Search KPT+330
6 EXPORTIN 1 448062 3% 45% 9 Search EXPORTIN+1 Search EXPORTIN+1
7 CALLYSTATIN A 442540 1% 100% 4 Search CALLYSTATIN+A Search CALLYSTATIN+A
8 S109 442540 1% 100% 4 Search S109 Search S109
9 LEPTOMYCIN 417003 3% 54% 7 Search LEPTOMYCIN Search LEPTOMYCIN
10 REV EXPORT INHIBITOR 354031 1% 80% 4 Search REV+EXPORT+INHIBITOR Search REV+EXPORT+INHIBITOR

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 GRAVINA, GL , SENAPEDIS, W , MCCAULEY, D , BALOGLU, E , SHACHAM, S , FESTUCCIA, C , (2014) NUCLEO-CYTOPLASMIC TRANSPORT AS A THERAPEUTIC TARGET OF CANCER.JOURNAL OF HEMATOLOGY & ONCOLOGY. VOL. 7. ISSUE . P. - 45 51% 21
2 CROCHIERE, ML , BALOGLU, E , KLEBANOV, B , DONOVAN, S , DEL ALAMO, D , LEE, M , KAUFFMAN, M , SHACHAM, S , LANDESMAN, Y , (2016) A METHOD FOR QUANTIFICATION OF EXPORTIN-1 (XPO1) OCCUPANCY BY SELECTIVE INHIBITOR OF NUCLEAR EXPORT (SINE) COMPOUNDS.ONCOTARGET. VOL. 7. ISSUE 2. P. 1863 -1877 28 74% 0
3 CROCHIERE, M , KASHYAP, T , KALID, O , SHECHTER, S , KLEBANOV, B , SENAPEDIS, W , SAINT-MARTIN, JR , LANDESMAN, Y , (2015) DECIPHERING MECHANISMS OF DRUG SENSITIVITY AND RESISTANCE TO SELECTIVE INHIBITOR OF NUCLEAR EXPORT (SINE) COMPOUNDS.BMC CANCER. VOL. 15. ISSUE . P. - 41 47% 1
4 REICHARD, HA , RIEGER, JC , MICALIZIO, GC , (2008) TOTAL SYNTHESIS OF CALLYSTATIN A BY TITANIUM-MEDIATED REDUCTIVE ALKYNE-ALKYNE CROSS-COUPLING.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. VOL. 47. ISSUE 41. P. 7837 -7840 31 72% 17
5 BONAZZI, S , EIDAM, O , GUTTINGER, S , WACH, JY , ZEMP, I , KUTAY, U , GADEMANN, K , (2010) ANGUINOMYCINS AND DERIVATIVES: TOTAL SYNTHESES, MODELING, AND BIOLOGICAL EVALUATION OF THE INHIBITION OF NUCLEOCYTOPLASMIC TRANSPORT.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. VOL. 132. ISSUE 4. P. 1432 -1442 35 51% 46
6 ISHIZAWA, J , KOJIMA, K , HAIL, N , TABE, Y , ANDREEFF, M , (2015) EXPRESSION, FUNCTION, AND TARGETING OF THE NUCLEAR EXPORTER CHROMOSOME REGION MAINTENANCE 1 (CRM1) PROTEIN.PHARMACOLOGY & THERAPEUTICS. VOL. 153. ISSUE . P. 25 -35 35 43% 8
7 SENAPEDIS, WT , BALOGLU, E , LANDESMAN, Y , (2014) CLINICAL TRANSLATION OF NUCLEAR EXPORT INHIBITORS IN CANCER.SEMINARS IN CANCER BIOLOGY. VOL. 27. ISSUE . P. 74 -86 50 30% 17
8 TURNER, JG , DAWSON, JL , GRANT, S , SHAIN, KH , DALTON, WS , DAI, Y , MEADS, M , BAZ, R , KAUFFMAN, M , SHACHAM, S , ET AL (2016) TREATMENT OF ACQUIRED DRUG RESISTANCE IN MULTIPLE MYELOMA BY COMBINATION THERAPY WITH XPO1 AND TOPOISOMERASE II INHIBITORS.JOURNAL OF HEMATOLOGY & ONCOLOGY. VOL. 9. ISSUE . P. - 26 58% 1
9 RIAZ, W , BURKE, N , MAHIPAL, A , (2014) SELINEXOR EXPORTIN-1(XPO1) INHIBITOR ONCOLYTIC.DRUGS OF THE FUTURE. VOL. 39. ISSUE 10. P. 685 -692 23 72% 1
10 DE CESARE, M , COMINETTI, D , DOLDI, V , LOPERGOLO, A , DERACO, M , GANDELLINI, P , FRIEDLANDER, S , LANDESMAN, Y , KAUFFMAN, MG , SHACHAM, S , ET AL (2015) ANTI-TUMOR ACTIVITY OF SELECTIVE INHIBITORS OF XPO1/CRM1-MEDIATED NUCLEAR EXPORT IN DIFFUSE MALIGNANT PERITONEAL MESOTHELIOMA: THE ROLE OF SURVIVIN.ONCOTARGET. VOL. 6. ISSUE 15. P. 13119 -13132 25 61% 2

Classes with closest relation at Level 1


Rank Class id link
1 884 NUCLEAR PORE COMPLEX//NUCLEOPORIN//NUCLEAR TRANSPORT
2 9001 STYRYL LACTONES//GONIOTHALAMIN//ALTHOLACTONE
3 29565 OLIGOMYCIN A//APOPTOLIDIN//OSSAMYCIN
4 12194 REV//RRE//REV PROTEIN
5 24831 CROCACIN//HYDROAMIDATION//AMATHASPIRAMIDE
6 22715 BORRELIDIN//HERBERT C BROWN S CHEM//DEOXYPROPIONATES
7 26224 PRELACTONE B//ELAIOPHYLIN//HALICHOBLELIDE
8 17351 DISCODERMOLIDE//LAULIMALIDE//ELEUTHEROBIN
9 19472 VINYLOGOUS MUKAIYAMA ALDOL REACTION//VINYLOGOUS MANNICH REACTION//LYNGBOUILLOSIDE
10 30546 NUCLEAR EGFR//EGFR FAMILY RECEPTORS//P TYR

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