Class information for:
Level 1: N SUBSTITUTED AZEPINES//1 PHENETHYLAMINE//1 PHENYL 2 AMINOETHANOL

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
22659 373 28.9 36%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
5 4 CHEMISTRY, ORGANIC//CHEMISTRY, INORGANIC & NUCLEAR//CHEMISTRY, MULTIDISCIPLINARY 1745167
721 3       STOBADINE//KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII//PIPERIDIN 4 ONE 5066
3679 2             ADRENERGIC DRUG//FARMACO-EDIZIONE SCIENTIFICA//1 2 4TRIAZOLO1 5 AQUINOLINES 1142
22659 1                   N SUBSTITUTED AZEPINES//1 PHENETHYLAMINE//1 PHENYL 2 AMINOETHANOL 373

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 N SUBSTITUTED AZEPINES authKW 163727 1% 100% 2
2 1 PHENETHYLAMINE authKW 81863 0% 100% 1
3 1 PHENYL 2 AMINOETHANOL authKW 81863 0% 100% 1
4 2 AMINO 1 2 3 4 TETRAHYDRO 1 4 EPOXYNAPHTHALENES authKW 81863 0% 100% 1
5 2 ARYLATED 1 BENZAZOCINES authKW 81863 0% 100% 1
6 3 HYDROXYBENZYL ALCOHOL authKW 81863 0% 100% 1
7 3 PHENYL 3 PIPERIDINOL authKW 81863 0% 100% 1
8 3 PHENYLPIPERIDINE authKW 81863 0% 100% 1
9 3 PHENYLPIPERIDINE DERIVATIVES authKW 81863 0% 100% 1
10 3 PIPERIDINOL DERIVATIVE authKW 81863 0% 100% 1

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Medicinal 4148 31% 0% 117
2 Pharmacology & Pharmacy 1302 35% 0% 132
3 Chemistry, Organic 359 15% 0% 57
4 Neurosciences 91 12% 0% 43
5 Chemistry, Multidisciplinary 90 13% 0% 48
6 Pathology 29 3% 0% 12
7 Biophysics 24 4% 0% 15
8 Substance Abuse 13 1% 0% 4
9 Biochemistry & Molecular Biology 12 10% 0% 36
10 Crystallography 11 2% 0% 8

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CENT 21785 JUSOHONMACHI YODOGAWA KU 81863 0% 100% 1
2 DEV SPECIAL FUNCT PL GENOM 81863 0% 100% 1
3 DIPARTIMENTO PSICHIAT NEURBIOL FARMACOL BIOTECN 81863 0% 100% 1
4 MED THORNDIKE MEM 81863 0% 100% 1
5 SPECIAL STRUCT FUNCT GENOM 81863 0% 100% 1
6 TECNOL AGRIND 81863 0% 100% 1
7 CHEM MOL BIOSCI SCMB 27286 0% 33% 1
8 UMR CHIM ORGAN MACROMOL 8009 23386 1% 14% 2
9 LCOP 17231 1% 11% 2
10 MOL BIOSCI IMB 16371 0% 20% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF MEDICINAL CHEMISTRY 10725 14% 0% 53
2 RESEARCH COMMUNICATIONS IN CHEMICAL PATHOLOGY AND PHARMACOLOGY 5137 3% 1% 12
3 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2232 4% 0% 16
4 INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS 2035 2% 0% 8
5 ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH 1180 2% 0% 8
6 DOKLADY CHEMISTRY 1066 1% 0% 4
7 ARCHIV DER PHARMAZIE 921 2% 0% 7
8 BRAIN RESEARCH 666 5% 0% 20
9 PROGRESS IN NEURO-PSYCHOPHARMACOLOGY 587 0% 1% 1
10 ALDRICHIMICA ACTA 583 0% 1% 1

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 N SUBSTITUTED AZEPINES 163727 1% 100% 2 Search N+SUBSTITUTED+AZEPINES Search N+SUBSTITUTED+AZEPINES
2 1 PHENETHYLAMINE 81863 0% 100% 1 Search 1+PHENETHYLAMINE Search 1+PHENETHYLAMINE
3 1 PHENYL 2 AMINOETHANOL 81863 0% 100% 1 Search 1+PHENYL+2+AMINOETHANOL Search 1+PHENYL+2+AMINOETHANOL
4 2 AMINO 1 2 3 4 TETRAHYDRO 1 4 EPOXYNAPHTHALENES 81863 0% 100% 1 Search 2+AMINO+1+2+3+4+TETRAHYDRO+1+4+EPOXYNAPHTHALENES Search 2+AMINO+1+2+3+4+TETRAHYDRO+1+4+EPOXYNAPHTHALENES
5 2 ARYLATED 1 BENZAZOCINES 81863 0% 100% 1 Search 2+ARYLATED+1+BENZAZOCINES Search 2+ARYLATED+1+BENZAZOCINES
6 3 HYDROXYBENZYL ALCOHOL 81863 0% 100% 1 Search 3+HYDROXYBENZYL+ALCOHOL Search 3+HYDROXYBENZYL+ALCOHOL
7 3 PHENYL 3 PIPERIDINOL 81863 0% 100% 1 Search 3+PHENYL+3+PIPERIDINOL Search 3+PHENYL+3+PIPERIDINOL
8 3 PHENYLPIPERIDINE 81863 0% 100% 1 Search 3+PHENYLPIPERIDINE Search 3+PHENYLPIPERIDINE
9 3 PHENYLPIPERIDINE DERIVATIVES 81863 0% 100% 1 Search 3+PHENYLPIPERIDINE+DERIVATIVES Search 3+PHENYLPIPERIDINE+DERIVATIVES
10 3 PIPERIDINOL DERIVATIVE 81863 0% 100% 1 Search 3+PIPERIDINOL+DERIVATIVE Search 3+PIPERIDINOL+DERIVATIVE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 GRUNEWALD, GL , LU, J , CRISCIONE, KR , MORO, CO , (2005) INHIBITORS OF PHENYLETHANOLAMINE N-METHYLTRANSFERASE DEVOID OF ALPHA(2)-ADRENOCEPTOR AFFINITY.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. VOL. 15. ISSUE 23. P. 5319-5323 19 90% 23
2 GRUNEWALD, GL , SEIM, MR , BHAT, SR , WILSON, ME , CRISCIONE, KR , (2008) SYNTHESIS OF 4,5,6,7-TETRAHYDROTHIENO[3,2-C]PYRIDINES AND COMPARISON WITH THEIR ISOSTERIC 1,2,3,4-TETRAHYDROISOQUINOLINES AS INHIBITORS OF PHENYLETHANOLAMINE N-METHYLTRANSFERASE.BIOORGANIC & MEDICINAL CHEMISTRY. VOL. 16. ISSUE 1. P. 542-559 24 63% 11
3 GRUNEWALD, GL , SEIM, MR , REGIER, RC , MARTIN, JL , GEE, CL , DRINKWATER, N , CRISCIONE, KR , (2006) COMPARISON OF THE BINDING OF 3-FLUOROMETHYL-7-SULFONYL-1,2,3,4-TETRAHYDROISOQUINOLINES WITH THEIR ISOSTERIC SULFONAMIDES TO THE ACTIVE SITE OF PHENYLETHANOLAMINE N-METHYLTRANSFERASE.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 49. ISSUE 18. P. 5424 -5433 22 67% 20
4 WU, Q , MCLEISH, MJ , (2013) KINETIC AND PH STUDIES ON HUMAN PHENYLETHANOLAMINE N-METHYLTRANSFERASE.ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. VOL. 539. ISSUE 1. P. 1 -8 21 55% 2
5 NAIR, PC , MALDE, AK , MARK, AE , (2011) USING THEORY TO RECONCILE EXPERIMENT: THE STRUCTURAL AND THERMODYNAMIC BASIS OF LIGAND RECOGNITION BY PHENYLETHANOLAMINE N-METHYLTRANSFERASE (PNMT).JOURNAL OF CHEMICAL THEORY AND COMPUTATION. VOL. 7. ISSUE 5. P. 1458-1468 19 63% 5
6 GRUNEWALD, GL , SEIM, MR , LU, J , MAKBOUL, M , CRISCIONE, KR , (2006) APPLICATION OF THE GOLDILOCKS EFFECT TO THE DESIGN OF POTENT AND SELECTIVE INHIBITORS OF PHENYLETHANOLAMINE N-METHYLTRANSFERASE: BALANCING PK(A) AND STERIC EFFECTS IN THE OPTIMIZATION OF 3-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE INHIBITORS BY BETA-FLUORINATION.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 49. ISSUE 10. P. 2939 -2952 22 59% 16
7 GRUNEWALD, GL , MCLEISH, MJ , CRISCIONE, KR , (2001) PHENYLETHANOLAMINE N-METHYLTRANSFERASE KINETICS: BOVINE VERSUS RECOMBINANT HUMAN ENZYME.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. VOL. 11. ISSUE 12. P. 1579-1582 15 100% 5
8 WU, Q , GEE, CL , LIN, F , TYNDALL, JD , MARTIN, JL , GRUNEWALD, GL , MCLEISH, MJ , (2005) STRUCTURAL, MUTAGENIC, AND KINETIC ANALYSIS OF THE BINDING OF SUBSTRATES AND INHIBITORS OF HUMAN PHENYLETHANOLAMINE N-METHYLTRANSFERASE.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 48. ISSUE 23. P. 7243-7252 22 55% 17
9 DRINKWATER, N , GEE, CL , PURI, M , CRISCIONE, KR , MCLEISH, MJ , GRUNEWALD, GL , MARTIN, JL , (2009) MOLECULAR RECOGNITION OF PHYSIOLOGICAL SUBSTRATE NORADRENALINE BY THE ADRENALINE-SYNTHESIZING ENZYME PNMT AND FACTORS INFLUENCING ITS METHYLTRANSFERASE ACTIVITY.BIOCHEMICAL JOURNAL. VOL. 422. ISSUE . P. 463-471 20 53% 7
10 GRUNEWALD, GL , CALDWELL, TM , LI, QF , CRISCIONE, KR , (2001) SYNTHESIS AND EVALUATION OF 4-FLUORO-8-SUBSTITUTED-2,3,4,5-TETRAHYDRO-1H-2-BENZAZAPINES AS SELECTIVE INHIBITORS OF PHENYLETHANOLAMINE N-METHYLTRANSFERASE VERSUS THE ALPHA(2)-ADRENOCEPTOR.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 44. ISSUE 17. P. 2849-2856 17 74% 23

Classes with closest relation at Level 1


Rank Class id link
1 16385 PHENYLETHANOLAMINE N METHYLTRANSFERASE//TYROSINE HYDROXYLASE//PNMT
2 21076 ADRENERGIC DRUG//2 5ISOXAZOLIDINYL ETHANOLAMINES//ETHANOL DIESEL FUEL ADDITIVE BLENDS
3 12452 OSU6162//ROXINDOLE//TERGURIDE
4 26754 FARMACO-EDIZIONE SCIENTIFICA//1 2 4TRIAZOLO1 5 AQUINOLINES//L RHAMNOPYRANOSYL BROMIDE
5 30884 FINE ORGAN SYNTH//SINTESIS ORGAN FINA//GRP PROD NAT
6 37456 BIINDENYLIDENES//DIMERS OF INDENE//5 6 DIMETHOXY INDENE
7 29898 3 4 DIHYDROXYPHENYLACETALDEHYDE//3 4 DIHYDROXYPHENYLGLYCOLALDEHYDE//DOPAL
8 30821 ADDICT NIH HLTH HUMAN SERV//CITDHHS//DRUG DESIGN SYNTH SECT
9 2592 ROSTRAL VENTROLATERAL MEDULLA//CAUDAL VENTROLATERAL MEDULLA//VENTROLATERAL MEDULLA
10 30945 IMIDAZOLE N OXIDES//ORGAN PL CHEM//1 SUBSTITUTED 1H IMIDAZOLE 3 OXIDES

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