Class information for:
Level 1: ADDICT NIH HLTH HUMAN SERV//CITDHHS//DRUG DESIGN SYNTH SECT

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
30821 162 20.4 35%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
5 4 CHEMISTRY, ORGANIC//CHEMISTRY, INORGANIC & NUCLEAR//CHEMISTRY, MULTIDISCIPLINARY 1745167
721 3       STOBADINE//KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII//PIPERIDIN 4 ONE 5066
4156 2             ADDICT NIH HLTH HUMAN SERV//CITDHHS//DRUG DESIGN SYNTH SECT 524
30821 1                   ADDICT NIH HLTH HUMAN SERV//CITDHHS//DRUG DESIGN SYNTH SECT 162

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ADDICT NIH HLTH HUMAN SERV address 1130945 4% 100% 6
2 CITDHHS address 785376 3% 83% 5
3 DRUG DESIGN SYNTH SECT address 744020 9% 26% 15
4 PHENYLMORPHAN authKW 603169 2% 80% 4
5 OXIDE BRIDGED PHENYLMORPHANS authKW 565472 2% 100% 3
6 CIT HLTH HUMAN SERV address 376982 1% 100% 2
7 LIGAND MODEL authKW 376982 1% 100% 2
8 OPIOID LIGAND MODEL authKW 376982 1% 100% 2
9 MM2 87 authKW 251320 1% 67% 2
10 1 3 DIMETHYL 4 PROPIONYL 4 PYRIDYLPIPERIDINES authKW 188491 1% 100% 1

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Medicinal 2199 35% 0% 56
2 Chemistry, Organic 728 31% 0% 50
3 Pharmacology & Pharmacy 140 19% 0% 31
4 Chemistry, Multidisciplinary 128 20% 0% 33
5 Crystallography 41 5% 0% 8
6 Spectroscopy 40 5% 0% 8
7 Chemistry, Physical 13 9% 0% 15
8 Chemistry, Analytical 10 5% 0% 8
9 Education, Scientific Disciplines 7 1% 0% 2
10 Mathematics, Interdisciplinary Applications 6 2% 0% 3

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ADDICT NIH HLTH HUMAN SERV 1130945 4% 100% 6
2 CITDHHS 785376 3% 83% 5
3 DRUG DESIGN SYNTH SECT 744020 9% 26% 15
4 CIT HLTH HUMAN SERV 376982 1% 100% 2
5 ADDICT CHEM BIOL BRANCH 188491 1% 100% 1
6 ADDICT HLTH HLTH HUMAN S 188491 1% 100% 1
7 ADDICT NIHUS HHS 188491 1% 100% 1
8 CHEM BIOL BRANCH HLTH HUMAN SERV 188491 1% 100% 1
9 CHEM BIOL BRANCHNIH HLTH HUMAN SERV 188491 1% 100% 1
10 CNRSUMR 7081ULP 188491 1% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF MEDICINAL CHEMISTRY 4650 14% 0% 23
2 ORGANIC REACTIVITY 2885 1% 1% 2
3 ORGANIC MAGNETIC RESONANCE 1814 2% 0% 3
4 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 984 4% 0% 7
5 MEDICINAL RESEARCH REVIEWS 883 1% 0% 2
6 IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENII MATEMATIKA 880 1% 0% 2
7 JOURNAL OF PHARMACEUTICAL SCIENCES 816 4% 0% 7
8 INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY 681 4% 0% 6
9 JOURNAL OF PHARMACY AND PHARMACOLOGY 582 3% 0% 5
10 CHIRALITY 552 2% 0% 3

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 PHENYLMORPHAN 603169 2% 80% 4 Search PHENYLMORPHAN Search PHENYLMORPHAN
2 OXIDE BRIDGED PHENYLMORPHANS 565472 2% 100% 3 Search OXIDE+BRIDGED+PHENYLMORPHANS Search OXIDE+BRIDGED+PHENYLMORPHANS
3 LIGAND MODEL 376982 1% 100% 2 Search LIGAND+MODEL Search LIGAND+MODEL
4 OPIOID LIGAND MODEL 376982 1% 100% 2 Search OPIOID+LIGAND+MODEL Search OPIOID+LIGAND+MODEL
5 MM2 87 251320 1% 67% 2 Search MM2+87 Search MM2+87
6 1 3 DIMETHYL 4 PROPIONYL 4 PYRIDYLPIPERIDINES 188491 1% 100% 1 Search 1+3+DIMETHYL+4+PROPIONYL+4+PYRIDYLPIPERIDINES Search 1+3+DIMETHYL+4+PROPIONYL+4+PYRIDYLPIPERIDINES
7 2 3 5 TRISUBSTITUTED N METHYLPIPERIDINES 188491 1% 100% 1 Search 2+3+5+TRISUBSTITUTED+N+METHYLPIPERIDINES Search 2+3+5+TRISUBSTITUTED+N+METHYLPIPERIDINES
8 2 AZABICYCLO331NON 5 YL PHENOLS 188491 1% 100% 1 Search 2+AZABICYCLO331NON+5+YL+PHENOLS Search 2+AZABICYCLO331NON+5+YL+PHENOLS
9 4 HYDROXYBENZOTHIOPHENE 6 CARBOXYLIC ACID 188491 1% 100% 1 Search 4+HYDROXYBENZOTHIOPHENE+6+CARBOXYLIC+ACID Search 4+HYDROXYBENZOTHIOPHENE+6+CARBOXYLIC+ACID
10 5 3 HYDROXYPHENYL 2 PHENETHYL 2 AZABICYCLO331NONAN 4 OL SYNTHESIS 188491 1% 100% 1 Search 5+3+HYDROXYPHENYL+2+PHENETHYL+2+AZABICYCLO331NONAN+4+OL+SYNTHESIS Search 5+3+HYDROXYPHENYL+2+PHENETHYL+2+AZABICYCLO331NONAN+4+OL+SYNTHESIS

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 LI, FY , DECK, JA , DERSCH, CM , ROTHMAN, RB , DESCHAMPS, JR , JACOBSON, AE , RICE, KC , (2012) PROBES FOR NARCOTIC RECEPTOR MEDIATED PHENOMENA. 46. N-SUBSTITUTED-2,3,4,9,10,10A-HEXAHYDRO-1H-1,4A-(EPIMINOETHANO)PHENANTHREN-6-AND 8-OLS - CARBOCYCLIC RELATIVES OF F-OXIDE-BRIDGED PHENYLMORPHANS.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. VOL. 58. ISSUE . P. 557 -567 19 68% 1
2 LI, F , FOLK, JE , CHENG, KJ , KURIMURA, M , DECK, JA , DESCHAMPS, JR , ROTHMAN, RB , DERSCH, CM , JACOBSON, AE , RICE, KC , (2011) PROBES FOR NARCOTIC RECEPTOR MEDIATED PHENOMENA. 43. SYNTHESIS OF THE ORTHO-A AND PARA-A, AND IMPROVED SYNTHESIS AND OPTICAL RESOLUTION OF THE ORTHO-B AND PARA-B OXIDE-BRIDGED PHENYLMORPHANS: COMPOUNDS WITH MODERATE TO LOW OPIOID-RECEPTOR AFFINITY.BIOORGANIC & MEDICINAL CHEMISTRY. VOL. 19. ISSUE 14. P. 4330 -4337 12 86% 1
3 ZHANG, Y , LEE, YS , ROTHMAN, RB , DERSCH, CM , DESCHAMPS, JR , JACOBSON, AE , RICE, KC , (2009) PROBES FOR NARCOTIC RECEPTOR MEDIATED PHENOMENA. 39. ENANTIOMERIC N-SUBSTITUTED BENZOFURO[2,3-C]PYRIDIN-6-OLS: SYNTHESIS AND TOPOLOGICAL RELATIONSHIP TO OXIDE-BRIDGED PHENYLMORPHANS.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 52. ISSUE 23. P. 7570 -7579 14 74% 3
4 ZEZULA, J , SINGER, L , PRZYBYL, AK , HASHIMOTO, A , DERSCH, CM , ROTHMAN, RB , DESCHAMPS, J , LEE, YS , JACOBSON, AE , RICE, KC , (2008) SYNTHESIS AND PHARMACOLOGICAL EFFECTS OF THE ENANTIOMERS OF THE N-PHENETHYL ANALOGUES OF THE ORTHO AND PARA E- AND F-OXIDE-BRIDGED PHENYLMORPHANS.ORGANIC & BIOMOLECULAR CHEMISTRY. VOL. 6. ISSUE 16. P. 2868 -2883 13 81% 0
5 IYER, MR , LEE, YS , DESCHAMPS, JR , ROTHMAN, RB , DERSCH, CM , JACOBSON, AE , RICE, KC , (2010) PROBES FOR NARCOTIC RECEPTOR MEDIATED PHENOMENA. 40. N-SUBSTITUTED CIS-4A-ETHYL-1,2,3,4,4A,9A-HEXAHYDROBENZOFURO[2,3-C]PYRIDIN-8-OLS.BIOORGANIC & MEDICINAL CHEMISTRY. VOL. 18. ISSUE 1. P. 91 -99 14 64% 2
6 IYER, MR , ROTHMAN, RB , DERSCH, CM , JACOBSON, AE , RICE, KC , (2015) PROBES FOR NARCOTIC RECEPTOR MEDIATED PHENOMENA 49. N-SUBSTITUTED RAC-CIS-4A-ARYLALKYL-1,2,3,4,4A,9A-HEXAHYDROBENZOFURO[2,3-C]PYRIDIN-6-OLS.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. VOL. 92. ISSUE . P. 531 -539 11 65% 1
7 KODATO, S , LINDERS, JTM , GU, XH , YAMADA, K , FLIPPEN-ANDERSON, JL , DESCHAMPS, JR , JACOBSON, AE , RICE, KC , (2004) SYNTHESIS OF RAC-(1R,4AR,9AR)-2-METHYL-1,3,4,9A-TETRAHYDRO-2H-1,4A-PROPANOBENZOFURO[2,3-C]PYRIDIN-6-OL. AN UNUSUAL DOUBLE REARRANGEMENT LEADING TO THE ORTHO- AND PARA-F OXIDE-BRIDGED PHENYLMORPHAN ISOMERS.ORGANIC & BIOMOLECULAR CHEMISTRY. VOL. 2. ISSUE 3. P. 330 -336 10 83% 11
8 KIM, JH , DESCHAMPS, JR , ROTHMAN, RB , DERSCH, CM , FOLK, JE , CHENG, KJ , JACOBSON, AE , RICE, KC , (2011) PROBES FOR NARCOTIC RECEPTOR MEDIATED PHENOMENA. PART 42: SYNTHESIS AND IN VITRO PHARMACOLOGICAL CHARACTERIZATION OF THE N-METHYL AND N-PHENETHYL ANALOGUES OF THE RACEMIC ORTHO-C AND PARA-C OXIDE-BRIDGED PHENYLMORPHANS.BIOORGANIC & MEDICINAL CHEMISTRY. VOL. 19. ISSUE 11. P. 3434-3443 10 67% 2
9 KURIMURA, M , LIU, H , SULIMA, A , HASHIMOTO, A , PRZYBYL, AK , OHSHIMA, E , KODATO, S , DESCHAMPS, JR , DERSCH, CM , ROTHMAN, RB , ET AL (2008) PROBES FOR NARCOTIC RECEPTOR MEDIATED PHENOMENA. 37.(1) SYNTHESIS AND OPIOID BINDING AFFINITY OF THE FINAL PAIR OF OXIDE-BRIDGED PHENYLMORPHANS, THE ORTHO- AND PARA-B-ISOMERS AND THEIR N-PHENETHYL ANALOGUES, AND THE SYNTHESIS OF THE N-PHENETHYL ANALOGUES OF THE ORTHO- AND PARA-D-ISOMERS.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 51. ISSUE 24. P. 7866 -7881 11 65% 3
10 LINDERS, JTM , MIRSADEGHI, S , FLIPPEN-ANDERSON, JL , GEORGE, C , JACOBSON, AE , RICE, KC , (2003) PROBES FOR NARCOTIC RECEPTOR MEDIATED PHENOMENA - SYNTHESIS OF RAC-(3R,6AS,11AR)-1,3,4,5,6,11A-HEXAHYDRO-2-METHYL-2H-3,6A-METHANOBENZOFURO[2,3-C]AZOCIN-8-OL, AN EPOXY ISOMER OF 5-PHENYLMORPHAN.HELVETICA CHIMICA ACTA. VOL. 86. ISSUE 2. P. 484 -493 11 73% 12

Classes with closest relation at Level 1


Rank Class id link
1 33770 O AZAXYLYLENE//SECT ORGAN CHEM A MARCHESINI//1 2 3 4 TETRAHYDROQUINOLINE 8 OL
2 1629 ENDOMORPHIN//DELTA OPIOID RECEPTOR//ENDOMORPHIN 2
3 28236 TETRADECAHYDROACRIDINES//SATURATED AMINE OXIDES//TETRADECAHYDRO
4 28728 OHMEFENTANYL//FENTANYL ANALOGS//1 SUBSTITUTED ANALOGS
5 31267 HERBICIDINS//2 3 DIHYDRO 1 4 DIOXIN//2 AMINOBENZOBTHIOPHENE 3 CARBOXYLATES
6 12456 DIHYDROETORPHINE//MORPHINE ALKALOIDS//APOMORPHINE DERIVATIVES
7 30141 MEPTAZINOL//CHEMOREFLEX CENTRAL//CIENCIAS C14 QUIM
8 31963 TARTRAMIDES//R R TARTARIC ACID DERIVATIVES//TARTRADIAMIDES
9 35207 1 3 AECTONEDICARBOXYLATE//2 4 DIACETYL 3 4 FLUOROPHENYL 5 HYDROXY 5 METHYLCYCLOHEXANONE//2 4 DIACETYL 5 HYDROXY 5 METHYL 3 4 NITROPHENYL CYCLOHEXANONE
10 35310 TRIPHENYLPHOSPHONIUM YLIDES//YLIDIC CONFORMATION//ACYL STRETCHING FREQUENCIES

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