Class information for:
Level 1: THRESHOLD OF TOXICOLOGICAL CONCERN//THRESHOLD OF TOXICOLOGICAL CONCERN TTC//GENOTOXIC IMPURITY

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
21276 426 33.2 52%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
116 3       MUTATION RESEARCH//TOXICOLOGY//CARCINOGENESIS 70215
469 2             MUTATION RESEARCH//MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS//COMET ASSAY 15922
21276 1                   THRESHOLD OF TOXICOLOGICAL CONCERN//THRESHOLD OF TOXICOLOGICAL CONCERN TTC//GENOTOXIC IMPURITY 426

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 THRESHOLD OF TOXICOLOGICAL CONCERN authKW 1101219 6% 59% 26
2 THRESHOLD OF TOXICOLOGICAL CONCERN TTC authKW 834067 4% 73% 16
3 GENOTOXIC IMPURITY authKW 829408 4% 64% 18
4 GENOTOXIC IMPURITIES authKW 703735 4% 55% 18
5 CRAMER CLASSIFICATION authKW 286713 1% 100% 4
6 TTC authKW 266731 4% 20% 19
7 EXPOSURE BASED WAIVING authKW 255991 1% 71% 5
8 TTC CONCEPT authKW 229369 1% 80% 4
9 CHICAGO PHARMACEUT SCI GRP address 215035 1% 100% 3
10 ACCEPTABLE DAILY EXPOSURE ADE authKW 163833 1% 57% 4

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Medicine, Legal 5741 12% 0% 53
2 Toxicology 3347 27% 0% 114
3 Chemistry, Analytical 1639 27% 0% 116
4 Chemistry, Applied 1578 19% 0% 79
5 Pharmacology & Pharmacy 1407 35% 0% 147
6 Chemistry, Organic 652 19% 0% 80
7 Biochemical Research Methods 157 7% 0% 31
8 Food Science & Technology 134 8% 0% 32
9 Environmental Sciences 13 5% 0% 20
10 Biotechnology & Applied Microbiology 11 4% 0% 16

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CHICAGO PHARMACEUT SCI GRP 215035 1% 100% 3
2 CTO 3 143357 0% 100% 2
3 R45T 143357 0% 100% 2
4 US I PROC DEV 143357 0% 100% 2
5 PHARM SCI TECH 95570 0% 67% 2
6 ADM TOXICOL 71678 0% 100% 1
7 ADV POLYMER TECHNOL 71678 0% 100% 1
8 ANAL SCI DEV 71678 0% 100% 1
9 ANALYT DEV COMMERCIALIZAT ACTIVE PHARMACEUT IN 71678 0% 100% 1
10 ANALYT DEV IND 71678 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ORGANIC PROCESS RESEARCH & DEVELOPMENT 128548 17% 2% 74
2 REGULATORY TOXICOLOGY AND PHARMACOLOGY 69253 12% 2% 53
3 JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 12682 10% 0% 44
4 JOURNAL OF PHARMACEUTICAL INNOVATION 12515 1% 3% 6
5 ELELMISZERVIZSGALATI KOZLEMENYEK 4214 0% 6% 1
6 LC GC NORTH AMERICA 2649 2% 1% 7
7 FOOD AND CHEMICAL TOXICOLOGY 2153 4% 0% 16
8 CHIMICA OGGI-CHEMISTRY TODAY 1883 1% 0% 6
9 CURRENT PHARMACEUTICAL ANALYSIS 1457 1% 1% 3
10 BIOPHARM INTERNATIONAL 1228 1% 1% 3

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 THRESHOLD OF TOXICOLOGICAL CONCERN 1101219 6% 59% 26 Search THRESHOLD+OF+TOXICOLOGICAL+CONCERN Search THRESHOLD+OF+TOXICOLOGICAL+CONCERN
2 THRESHOLD OF TOXICOLOGICAL CONCERN TTC 834067 4% 73% 16 Search THRESHOLD+OF+TOXICOLOGICAL+CONCERN+TTC Search THRESHOLD+OF+TOXICOLOGICAL+CONCERN+TTC
3 GENOTOXIC IMPURITY 829408 4% 64% 18 Search GENOTOXIC+IMPURITY Search GENOTOXIC+IMPURITY
4 GENOTOXIC IMPURITIES 703735 4% 55% 18 Search GENOTOXIC+IMPURITIES Search GENOTOXIC+IMPURITIES
5 CRAMER CLASSIFICATION 286713 1% 100% 4 Search CRAMER+CLASSIFICATION Search CRAMER+CLASSIFICATION
6 TTC 266731 4% 20% 19 Search TTC Search TTC
7 EXPOSURE BASED WAIVING 255991 1% 71% 5 Search EXPOSURE+BASED+WAIVING Search EXPOSURE+BASED+WAIVING
8 TTC CONCEPT 229369 1% 80% 4 Search TTC+CONCEPT Search TTC+CONCEPT
9 ACCEPTABLE DAILY EXPOSURE ADE 163833 1% 57% 4 Search ACCEPTABLE+DAILY+EXPOSURE+ADE Search ACCEPTABLE+DAILY+EXPOSURE+ADE
10 PERMITTED DAILY EXPOSURE PDE 163833 1% 57% 4 Search PERMITTED+DAILY+EXPOSURE+PDE Search PERMITTED+DAILY+EXPOSURE+PDE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 KUMAR, A , ZHANG, K , WIGMAN, L , (2015) ANALYTICAL TECHNOLOGIES FOR GENOTOXIC IMPURITIES IN PHARMACEUTICAL COMPOUNDS.LC GC NORTH AMERICA. VOL. 33. ISSUE 5. P. 344 -+ 33 57% 1
2 RAMAN, NVVSS , PRASAD, AVSS , REDDY, KR , (2011) STRATEGIES FOR THE IDENTIFICATION, CONTROL AND DETERMINATION OF GENOTOXIC IMPURITIES IN DRUG SUBSTANCES: A PHARMACEUTICAL INDUSTRY PERSPECTIVE.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. VOL. 55. ISSUE 4. P. 662-667 25 69% 32
3 HENNES, EC , (2012) AN OVERVIEW OF VALUES FOR THE THRESHOLD OF TOXICOLOGICAL CONCERN.TOXICOLOGY LETTERS. VOL. 211. ISSUE 3. P. 296-303 27 63% 11
4 ELDER, DP , WHITE, A , HARVEY, J , TEASDALE, A , WILLIAMS, R , COVEY-CRUMP, E , (2015) MUTAGENIC IMPURITIES: PRECOMPETITIVE/COMPETITIVE COLLABORATIVE AND DATA SHARING INITIATIVES.ORGANIC PROCESS RESEARCH & DEVELOPMENT. VOL. 19. ISSUE 11. P. 1486 -1494 23 70% 2
5 ROBINSON, DI , (2010) CONTROL OF GENOTOXIC IMPURITIES IN ACTIVE PHARMACEUTICAL INGREDIENTS: A REVIEW AND PERSPECTIVE.ORGANIC PROCESS RESEARCH & DEVELOPMENT. VOL. 14. ISSUE 4. P. 946-959 25 61% 47
6 KALKHOF, H , HERZLER, M , STAHLMANN, R , GUNDERT-REMY, U , (2012) THRESHOLD OF TOXICOLOGICAL CONCERN VALUES FOR NON-GENOTOXIC EFFECTS IN INDUSTRIAL CHEMICALS: RE-EVALUATION OF THE CRAMER CLASSIFICATION.ARCHIVES OF TOXICOLOGY. VOL. 86. ISSUE 1. P. 17-25 18 75% 12
7 SNODIN, DJ , MCCROSSEN, SD , (2012) GUIDELINES AND PHARMACOPOEIAL STANDARDS FOR PHARMACEUTICAL IMPURITIES: OVERVIEW AND CRITICAL ASSESSMENT.REGULATORY TOXICOLOGY AND PHARMACOLOGY. VOL. 63. ISSUE 2. P. 298-312 19 70% 7
8 DEWHURST, I , RENWICK, AG , (2013) EVALUATION OF THE THRESHOLD OF TOXICOLOGICAL CONCERN (TTC) - CHALLENGES AND APPROACHES.REGULATORY TOXICOLOGY AND PHARMACOLOGY. VOL. 65. ISSUE 1. P. 168-177 17 74% 11
9 HO, TD , YEHL, PM , CHETWYN, NP , WANG, J , ANDERSON, JL , ZHONG, QQ , (2014) DETERMINATION OF TRACE LEVEL GENOTOXIC IMPURITIES IN SMALL MOLECULE DRUG SUBSTANCES USING CONVENTIONAL HEADSPACE GAS CHROMATOGRAPHY WITH CONTEMPORARY IONIC LIQUID DILUENTS AND ELECTRON CAPTURE DETECTION.JOURNAL OF CHROMATOGRAPHY A. VOL. 1361. ISSUE . P. 217 -228 22 56% 6
10 ZARN, JA , HANGGI, E , ENGELI, BE , (2015) IMPACT OF STUDY DESIGN AND DATABASE PARAMETERS ON NOAEL DISTRIBUTIONS USED FOR TOXICOLOGICAL CONCERN (TTC) VALUES.REGULATORY TOXICOLOGY AND PHARMACOLOGY. VOL. 72. ISSUE 3. P. 491 -500 16 80% 0

Classes with closest relation at Level 1


Rank Class id link
1 10922 COMPUTATIONAL TOXICOLOGY//ICH M7//RODENT CARCINOGENICITY
2 21702 GREENSCREEN HC//MISLEADING POSITIVE RESULTS//VIRACEPT
3 25905 RESIDUAL SOLVENTS//P CYCLOHEXYLPHENOL//P PHENYLPHENOL
4 15067 BENCHMARK DOSE//UNCERTAINTY FACTORS//NONCANCER RISK ASSESSMENT
5 23137 METHYLEUGENOL//SAFROLE//ESTRAGOLE
6 30377 SUCCINYLMONOCHOLINE//MAZIPREDONE//PIPECURONIUM BROMIDE
7 14023 COMPUTAT TOXICOL//ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION//CAAT
8 35165 2 6 DICHLOROQUINONE 4 CHLORO IMIDE//CELLULAR POROUS AND FIBROUS MATERIALS//SHIFT OF EQUILIBRIUM
9 23377 PHMAX//DICALCIUM PHOSPHATE ANHYDROUS DICAFOS ANR//EQUIVALENT PH
10 18346 ACCURACY PROFILE//TOTAL ERROR//ROBUSTNESS TESTING

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