Class information for:
Level 1: COMPUTATIONAL TOXICOLOGY//ICH M7//RODENT CARCINOGENICITY

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
10922 1024 37.1 60%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
116 3       MUTATION RESEARCH//TOXICOLOGY//CARCINOGENESIS 70215
469 2             MUTATION RESEARCH//MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS//COMET ASSAY 15922
10922 1                   COMPUTATIONAL TOXICOLOGY//ICH M7//RODENT CARCINOGENICITY 1024

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 COMPUTATIONAL TOXICOLOGY authKW 314738 3% 33% 32
2 ICH M7 authKW 271072 1% 91% 10
3 RODENT CARCINOGENICITY authKW 225981 1% 63% 12
4 MC4PC authKW 212038 1% 89% 8
5 CASE MULTICASE authKW 208727 1% 100% 7
6 INFORMAT COMPUTAT SAFETY ANAL STAFF address 208727 1% 100% 7
7 PREDICTIVE TOXICOLOGY authKW 206105 3% 22% 31
8 TOPKAT authKW 185784 1% 69% 9
9 OFF PHARMACEUT SCI INFORMAT COMPUTAT SAFETY ANA address 178909 1% 100% 6
10 DEREK authKW 175393 1% 59% 10

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Toxicology 37567 57% 0% 582
2 Genetics & Heredity 4632 29% 0% 292
3 Computer Science, Interdisciplinary Applications 2538 14% 0% 142
4 Medicine, Legal 1982 5% 0% 49
5 Environmental Sciences 1911 22% 0% 225
6 Mathematical & Computational Biology 1829 8% 0% 82
7 Chemistry, Medicinal 1499 12% 0% 122
8 Pharmacology & Pharmacy 621 17% 0% 169
9 Chemistry, Multidisciplinary 510 17% 0% 173
10 Public, Environmental & Occupational Health 165 7% 0% 67

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 INFORMAT COMPUTAT SAFETY ANAL STAFF 208727 1% 100% 7
2 OFF PHARMACEUT SCI INFORMAT COMPUTAT SAFETY ANA 178909 1% 100% 6
3 ICSAS 149091 0% 100% 5
4 FOOD CONTACT NOTIFICAT 132821 1% 64% 7
5 OFF FOOD ADDIT SAFETY 75311 1% 21% 12
6 RD DSAR PRECLIN SAFETY FF 67089 0% 75% 3
7 CONSUMERS PROTECT UNIT 59636 0% 100% 2
8 PREDICT COMPOUND SAFETY ADME 59636 0% 100% 2
9 EXISTING SUBST RISK ASSESSMENT BUR 53006 0% 44% 4
10 OFF PHARMACEUT SCI 49495 2% 10% 17

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 SAR AND QSAR IN ENVIRONMENTAL RESEARCH 114510 5% 7% 55
2 MUTATION RESEARCH 38982 10% 1% 103
3 ENVIRONMENTAL AND MOLECULAR MUTAGENESIS 31401 5% 2% 49
4 JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS 25427 1% 7% 13
5 REGULATORY TOXICOLOGY AND PHARMACOLOGY 24566 5% 2% 49
6 QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS 24106 2% 4% 20
7 MUTAGENESIS 19036 4% 2% 38
8 ENVIRONMENTAL MUTAGENESIS 12514 1% 3% 14
9 MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS 9330 3% 1% 35
10 ATLA-ALTERNATIVES TO LABORATORY ANIMALS 7837 2% 1% 19

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 COMPUTATIONAL TOXICOLOGY 314738 3% 33% 32 Search COMPUTATIONAL+TOXICOLOGY Search COMPUTATIONAL+TOXICOLOGY
2 ICH M7 271072 1% 91% 10 Search ICH+M7 Search ICH+M7
3 RODENT CARCINOGENICITY 225981 1% 63% 12 Search RODENT+CARCINOGENICITY Search RODENT+CARCINOGENICITY
4 MC4PC 212038 1% 89% 8 Search MC4PC Search MC4PC
5 CASE MULTICASE 208727 1% 100% 7 Search CASE+MULTICASE Search CASE+MULTICASE
6 PREDICTIVE TOXICOLOGY 206105 3% 22% 31 Search PREDICTIVE+TOXICOLOGY Search PREDICTIVE+TOXICOLOGY
7 TOPKAT 185784 1% 69% 9 Search TOPKAT Search TOPKAT
8 DEREK 175393 1% 59% 10 Search DEREK Search DEREK
9 MULTICASE 165647 1% 56% 10 Search MULTICASE Search MULTICASE
10 CARCINOGENICITY 159632 7% 7% 74 Search CARCINOGENICITY Search CARCINOGENICITY

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 BENIGNI, R , (2005) STRUCTURE-ACTIVITY RELATIONSHIP STUDIES OF CHEMICAL MUTAGENS AND CARCINOGENS: MECHANISTIC INVESTIGATIONS AND PREDICTION APPROACHES.CHEMICAL REVIEWS. VOL. 105. ISSUE 5. P. 1767 -1800 91 65% 100
2 VALERIO, LG , (2009) IN SILICO TOXICOLOGY FOR THE PHARMACEUTICAL SCIENCES.TOXICOLOGY AND APPLIED PHARMACOLOGY. VOL. 241. ISSUE 3. P. 356 -370 55 51% 85
3 RICHARD, AM , (1994) APPLICATION OF SAR METHODS TO NONCONGENERIC DATA-BASES ASSOCIATED WITH CARCINOGENICITY AND MUTAGENICITY - ISSUES AND APPROACHES.MUTATION RESEARCH. VOL. 305. ISSUE 1. P. 73-97 51 85% 44
4 SAIAKHOV, RD , KLOPMAN, G , (2008) MULTICASE EXPERT SYSTEMS AND THE REACH INITIATIVE.TOXICOLOGY MECHANISMS AND METHODS. VOL. 18. ISSUE 2-3. P. 159-175 34 74% 18
5 FJODOROVA, N , VRACKO, M , TUSAR, M , JEZIERSKA, A , NOVIC, M , KUHNE, R , SCHUURMANN, G , (2010) QUANTITATIVE AND QUALITATIVE MODELS FOR CARCINOGENICITY PREDICTION FOR NON-CONGENERIC CHEMICALS USING CP ANN METHOD FOR REGULATORY USES.MOLECULAR DIVERSITY. VOL. 14. ISSUE 3. P. 581 -594 37 64% 14
6 KRUHLAK, NL , BENZ, RD , ZHOU, H , COLATSKY, TJ , (2012) (Q)SAR MODELLING AND SAFETY ASSESSMENT IN REGULATORY REVIEW.CLINICAL PHARMACOLOGY & THERAPEUTICS. VOL. 91. ISSUE 3. P. 529 -534 24 86% 27
7 KAZIUS, J , MCGUIRE, R , BURSI, R , (2005) DERIVATION AND VALIDATION OF TOXICOPHORES FOR MUTAGENICITY PREDICTION.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 48. ISSUE 1. P. 312-320 26 79% 212
8 VALERIO, LG , CROSS, KP , (2012) CHARACTERIZATION AND VALIDATION OF AN IN SILICO TOXICOLOGY MODEL TO PREDICT THE MUTAGENIC POTENTIAL OF DRUG IMPURITIES.TOXICOLOGY AND APPLIED PHARMACOLOGY. VOL. 260. ISSUE 3. P. 209 -221 25 81% 12
9 MODI, S , LI, J , MALCOMBER, S , MOORE, C , SCOTT, A , WHITE, A , CARMICHAEL, P , (2012) INTEGRATED IN SILICO APPROACHES FOR THE PREDICTION OF AMES TEST MUTAGENICITY.JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN. VOL. 26. ISSUE 9. P. 1017 -1033 28 72% 8
10 FIORAVANZO, E , BASSAN, A , PAVAN, M , MOSTRAG-SZLICHTYNG, A , WORTH, AP , (2012) ROLE OF IN SILICO GENOTOXICITY TOOLS IN THE REGULATORY ASSESSMENT OF PHARMACEUTICAL IMPURITIES.SAR AND QSAR IN ENVIRONMENTAL RESEARCH. VOL. 23. ISSUE 3-4. P. 257-277 34 59% 2

Classes with closest relation at Level 1


Rank Class id link
1 8645 POLY 3 TEST//HISTORICAL CONTROL DATA//NATIONAL TOXICOLOGY PROGRAM
2 21276 THRESHOLD OF TOXICOLOGICAL CONCERN//THRESHOLD OF TOXICOLOGICAL CONCERN TTC//GENOTOXIC IMPURITY
3 21702 GREENSCREEN HC//MISLEADING POSITIVE RESULTS//VIRACEPT
4 7733 TETRAHYMENA PYRIFORMIS//SAR AND QSAR IN ENVIRONMENTAL RESEARCH//QSAR
5 14023 COMPUTAT TOXICOL//ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION//CAAT
6 3807 QSPR//QSAR//CORAL SOFTWARE
7 5400 3 CHLORO 4 DICHLOROMETHYL 5 HYDROXY 25H FURANONE//MX//SOS CHROMOTEST
8 11300 LIVER MICRONUCLEUS ASSAY//MUTATION RESEARCH//MICRONUCLEUS TEST
9 33802 GRP PHARMACOCHEM//FLAGGED OBSERVATIONS//GENERALIZED REGRESSION GENETIC NEURAL NETWORK
10 7367 CHEM BIOACT//UNIDAD INVEST DISENO FARMACOS CONECTIVIDAD MOL//UNIV CIENCIA MOL

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