Class information for:
Level 1: LI FRAUMENI SYNDROME//LI FRAUMENI//GERMLINE TP53 MUTATION

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
19114 521 34.7 83%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
304 3       P53//RETINOBLASTOMA//MDM2 40663
936 2             P53//MDM2//P73 10991
19114 1                   LI FRAUMENI SYNDROME//LI FRAUMENI//GERMLINE TP53 MUTATION 521

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 LI FRAUMENI SYNDROME authKW 4048663 24% 56% 123
2 LI FRAUMENI authKW 689490 4% 59% 20
3 GERMLINE TP53 MUTATION authKW 410256 1% 100% 7
4 LI FRAUMENI LIKE SYNDROME authKW 375088 2% 80% 8
5 GERMLINE P53 MUTATION authKW 301411 1% 86% 6
6 PR337H authKW 234432 1% 100% 4
7 TP53 GERMLINE MUTATIONS authKW 234432 1% 100% 4
8 R337H authKW 175824 1% 100% 3
9 TP53 authKW 158757 11% 5% 55
10 CRC PAEDIAT FAMILIAL CANC GRP address 133958 1% 57% 4

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Oncology 7603 62% 0% 322
2 Genetics & Heredity 2439 29% 0% 151
3 Pediatrics 263 9% 0% 45
4 Hematology 118 5% 0% 28
5 Cell Biology 77 8% 0% 43
6 Medical Laboratory Technology 41 2% 0% 9
7 Pathology 36 3% 0% 16
8 Medicine, Research & Experimental 34 4% 0% 22
9 Medicine, General & Internal 22 5% 0% 25
10 Biochemistry & Molecular Biology 17 10% 0% 51

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CRC PAEDIAT FAMILIAL CANC GRP 133958 1% 57% 4
2 CRC CANC GENET GRP 117216 0% 100% 2
3 PROT MOL ANAL 117216 0% 100% 2
4 CRC CANC GENET 105492 1% 60% 3
5 PAEDIAT FAMILIAL CANC GRP 91473 2% 20% 8
6 BARTS CANC CRUK 58608 0% 100% 1
7 BIOL 11 TSUKIJI 5 CHOME CHUO KU 58608 0% 100% 1
8 BIOMED U614 58608 0% 100% 1
9 BREAST PATHOL UNIV 58608 0% 100% 1
10 CANC GENET CLIN SERV 58608 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 FAMILIAL CANCER 13116 3% 2% 14
2 CANCER GENETICS AND CYTOGENETICS 4215 4% 0% 21
3 PEDIATRIC BLOOD & CANCER 2899 3% 0% 15
4 HEREDITARY CANCER IN CLINICAL PRACTICE 2892 1% 2% 3
5 BRITISH JOURNAL OF CANCER 2723 6% 0% 29
6 ONCOGENE 2164 5% 0% 26
7 JOURNAL OF MEDICAL GENETICS 1966 3% 0% 14
8 HUMAN MUTATION 1770 2% 0% 11
9 CANCER 1407 5% 0% 26
10 ONCOGENESIS 887 0% 1% 2

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 LI FRAUMENI SYNDROME 4048663 24% 56% 123 Search LI+FRAUMENI+SYNDROME Search LI+FRAUMENI+SYNDROME
2 LI FRAUMENI 689490 4% 59% 20 Search LI+FRAUMENI Search LI+FRAUMENI
3 GERMLINE TP53 MUTATION 410256 1% 100% 7 Search GERMLINE+TP53+MUTATION Search GERMLINE+TP53+MUTATION
4 LI FRAUMENI LIKE SYNDROME 375088 2% 80% 8 Search LI+FRAUMENI+LIKE+SYNDROME Search LI+FRAUMENI+LIKE+SYNDROME
5 GERMLINE P53 MUTATION 301411 1% 86% 6 Search GERMLINE+P53+MUTATION Search GERMLINE+P53+MUTATION
6 PR337H 234432 1% 100% 4 Search PR337H Search PR337H
7 TP53 GERMLINE MUTATIONS 234432 1% 100% 4 Search TP53+GERMLINE+MUTATIONS Search TP53+GERMLINE+MUTATIONS
8 R337H 175824 1% 100% 3 Search R337H Search R337H
9 TP53 158757 11% 5% 55 Search TP53 Search TP53
10 LI FRAUMENI SYNDROME LFS 133958 1% 57% 4 Search LI+FRAUMENI+SYNDROME+LFS Search LI+FRAUMENI+SYNDROME+LFS

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 NICHOLS, KE , MALKIN, D , GARBER, JE , FRAUMENI, JF , LI, FP , (2001) GERM-LINE P53 MUTATIONS PREDISPOSE TO A WIDE SPECTRUM OF EARLY-ONSET CANCERS.CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION. VOL. 10. ISSUE 2. P. 83-87 69 80% 161
2 KAMIHARA, J , RANA, HQ , GARBER, JE , (2014) GERMLINE TP53 MUTATIONS AND THE CHANGING LANDSCAPE OF LI-FRAUMENI SYNDROME.HUMAN MUTATION. VOL. 35. ISSUE 6. P. 654 -662 46 66% 27
3 CHOMPRET, A , (2002) THE LI-FRAUMENI SYNDROME.BIOCHIMIE. VOL. 84. ISSUE 1. P. 75-82 60 71% 41
4 BIRCH, JM , ALSTON, RD , MCNALLY, RJQ , EVANS, DGR , KELSEY, AM , HARRIS, M , EDEN, OB , VARLEY, JM , (2001) RELATIVE FREQUENCY AND MORPHOLOGY OF CANCERS IN CARRIERS OF GERMLINE TP53 MUTATIONS.ONCOGENE. VOL. 20. ISSUE 34. P. 4621-4628 39 87% 213
5 VARLEY, JM , (2003) GERMLINE TP53 MUTATIONS AND LI-FRAUMENI SYNDROME.HUMAN MUTATION. VOL. 21. ISSUE 3. P. 313-320 42 74% 190
6 FREBOURG, T , (1997) THE LI-FRAUMENI SYNDROME.BULLETIN DU CANCER. VOL. 84. ISSUE 7. P. 735-740 52 87% 7
7 BOUGEARD, G , RENAUX-PETEL, M , FLAMAN, JM , CHARBONNIER, C , FERMEY, P , BELOTTI, M , GAUTHIER-VILLARS, M , STOPPA-LYONNET, D , CONSOLINO, E , BRUGIERES, L , ET AL (2015) REVISITING LI-FRAUMENI SYNDROME FROM TP53 MUTATION CARRIERS.JOURNAL OF CLINICAL ONCOLOGY. VOL. 33. ISSUE 21. P. 2345 -U33 27 71% 23
8 VARLEY, JM , EVANS, DGR , BIRCH, JM , (1997) LI-FRAUMENI SYNDROME - A MOLECULAR AND CLINICAL REVIEW.BRITISH JOURNAL OF CANCER. VOL. 76. ISSUE 1. P. 1-14 65 52% 177
9 FREBOURG, T , (1997) GERMLINE MUTATIONS OF THE P53 GENE..PATHOLOGIE BIOLOGIE. VOL. 45. ISSUE 10. P. 845 -851 52 74% 3
10 BALLINGER, ML , MITCHELL, G , THOMAS, DM , (2015) SURVEILLANCE RECOMMENDATIONS FOR PATIENTS WITH GERMLINE TP53 MUTATIONS.CURRENT OPINION IN ONCOLOGY. VOL. 27. ISSUE 4. P. 332 -337 31 69% 4

Classes with closest relation at Level 1


Rank Class id link
1 8010 MUTANT P53//PRIMA 1//CP 31398
2 15199 CHEK2//PALB2//CHK2
3 1581 P53//P53 GENE//ONCOGENE
4 23203 HEREDITARY DIFFUSE GASTRIC CANCER//PROPHYLACTIC GASTRECTOMY//HDGC
5 9053 P53 POLYMORPHISM//P53 CODON 72//CODON 72
6 6039 ADRENOCORTICAL CARCINOMA//MITOTANE//ADRENOCORTICAL TUMORS
7 19058 CHOROID PLEXUS PAPILLOMA//CHOROID PLEXUS CARCINOMA//CHOROID PLEXUS TUMOR
8 471 BRCA2//BRCA1//HEREDITARY BREAST CANCER
9 8325 RETINOBLASTOMA//RB1 GENE//RB1
10 13947 P53//AREA BIOPATOL//BCL 2

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