Class information for:
Level 1: GLUTAMATE CYSTEINE LIGASE//GAMMA GLUTAMYLCYSTEINE SYNTHETASE//GLUTATHIONE SYNTHETASE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
16464 652 38.8 76%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
285 3       ERDOSTEINE//PEROXIREDOXIN//GLUTATHIONE 42405
870 2             PEROXIREDOXIN//THIOREDOXIN//GLUTATHIONE 11539
16464 1                   GLUTAMATE CYSTEINE LIGASE//GAMMA GLUTAMYLCYSTEINE SYNTHETASE//GLUTATHIONE SYNTHETASE 652

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 GLUTAMATE CYSTEINE LIGASE authKW 1322854 10% 44% 64
2 GAMMA GLUTAMYLCYSTEINE SYNTHETASE authKW 902201 10% 28% 68
3 GLUTATHIONE SYNTHETASE authKW 754230 6% 44% 37
4 GLUTATHIONE SYNTHETASE DEFICIENCY authKW 611937 2% 93% 14
5 PYROGLUTAMIC ACIDURIA authKW 234160 1% 100% 5
6 5 OXOPROLINURIA authKW 229473 1% 70% 7
7 5 OXOPROLINE authKW 202368 2% 39% 11
8 GAMMA GLUTAMYLCYSTEINE LIGASE authKW 199643 1% 47% 9
9 GCLC authKW 195389 2% 38% 11
10 CYSTEINE AVAILABILITY authKW 187328 1% 100% 4

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biochemistry & Molecular Biology 1767 44% 0% 288
2 Endocrinology & Metabolism 556 12% 0% 80
3 Toxicology 457 9% 0% 56
4 Biophysics 420 10% 0% 66
5 Genetics & Heredity 217 9% 0% 58
6 Medicine, Research & Experimental 165 7% 0% 46
7 Cell Biology 136 9% 0% 61
8 Pharmacology & Pharmacy 92 10% 0% 62
9 Medical Laboratory Technology 85 2% 0% 14
10 Respiratory System 44 3% 0% 18

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOCHEM MOL BIOL DIS 88524 2% 17% 11
2 DOCTORAL TRAINING ISBML 83253 1% 44% 4
3 USC LIVER DIS MED 62441 0% 67% 2
4 BARNEAVDELINGA 46832 0% 100% 1
5 BIOL GENOMICA MOL 46832 0% 100% 1
6 CANC PREVENT CONTROL PROGRAMPENN STATE CANC IN 46832 0% 100% 1
7 COLT SMRC INFLAMMAT 46832 0% 100% 1
8 DEP ANIM MED 46832 0% 100% 1
9 DIPARTIMENTO MED SCI INVECCHIAMENTOPOLICLIN CO 46832 0% 100% 1
10 ERITROPATOL 46832 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF INHERITED METABOLIC DISEASE 7513 4% 1% 27
2 FREE RADICAL BIOLOGY AND MEDICINE 4245 4% 0% 28
3 ENVIRONMENTAL SCIENCE AND TECHNOLOGY LIBRARY 3120 0% 7% 1
4 FREE RADICAL RESEARCH 996 1% 0% 8
5 BIOCHEMICAL JOURNAL 816 4% 0% 23
6 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 666 5% 0% 32
7 AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY 579 1% 0% 8
8 COSMETICS & TOILETRIES 562 0% 1% 1
9 TOXICOLOGY AND APPLIED PHARMACOLOGY 559 2% 0% 11
10 JOURNAL OF BIOLOGICAL CHEMISTRY 462 6% 0% 41

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 GLUTAMATE CYSTEINE LIGASE 1322854 10% 44% 64 Search GLUTAMATE+CYSTEINE+LIGASE Search GLUTAMATE+CYSTEINE+LIGASE
2 GAMMA GLUTAMYLCYSTEINE SYNTHETASE 902201 10% 28% 68 Search GAMMA+GLUTAMYLCYSTEINE+SYNTHETASE Search GAMMA+GLUTAMYLCYSTEINE+SYNTHETASE
3 GLUTATHIONE SYNTHETASE 754230 6% 44% 37 Search GLUTATHIONE+SYNTHETASE Search GLUTATHIONE+SYNTHETASE
4 GLUTATHIONE SYNTHETASE DEFICIENCY 611937 2% 93% 14 Search GLUTATHIONE+SYNTHETASE+DEFICIENCY Search GLUTATHIONE+SYNTHETASE+DEFICIENCY
5 PYROGLUTAMIC ACIDURIA 234160 1% 100% 5 Search PYROGLUTAMIC+ACIDURIA Search PYROGLUTAMIC+ACIDURIA
6 5 OXOPROLINURIA 229473 1% 70% 7 Search 5+OXOPROLINURIA Search 5+OXOPROLINURIA
7 5 OXOPROLINE 202368 2% 39% 11 Search 5+OXOPROLINE Search 5+OXOPROLINE
8 GAMMA GLUTAMYLCYSTEINE LIGASE 199643 1% 47% 9 Search GAMMA+GLUTAMYLCYSTEINE+LIGASE Search GAMMA+GLUTAMYLCYSTEINE+LIGASE
9 GCLC 195389 2% 38% 11 Search GCLC Search GCLC
10 CYSTEINE AVAILABILITY 187328 1% 100% 4 Search CYSTEINE+AVAILABILITY Search CYSTEINE+AVAILABILITY

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 LU, SC , (2009) REGULATION OF GLUTATHIONE SYNTHESIS.MOLECULAR ASPECTS OF MEDICINE. VOL. 30. ISSUE 1-2. P. 42-59 70 40% 442
2 LU, SC , (2013) GLUTATHIONE SYNTHESIS.BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS. VOL. 1830. ISSUE 5. P. 3143-3153 60 39% 178
3 FRANKLIN, CC , BACKOS, DS , MOHAR, I , WHITE, CC , FORMAN, HJ , KAVANAGH, TJ , (2009) STRUCTURE, FUNCTION, AND POST-TRANSLATIONAL REGULATION OF THE CATALYTIC AND MODIFIER SUBUNITS OF GLUTAMATE CYSTEINE LIGASE.MOLECULAR ASPECTS OF MEDICINE. VOL. 30. ISSUE 1-2. P. 86 -98 65 54% 104
4 FERGUSON, G , BRIDGE, W , (2016) GLUTAMATE CYSTEINE LIGASE AND THE AGE-RELATED DECLINE IN CELLULAR GLUTATHIONE: THE THERAPEUTIC POTENTIAL OF GAMMA-GLUTAMYLCYSTEINE.ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. VOL. 593. ISSUE . P. 12 -23 58 42% 4
5 LU, SC , (1999) REGULATION OF HEPATIC GLUTATHIONE SYNTHESIS: CURRENT CONCEPTS AND CONTROVERSIES.FASEB JOURNAL. VOL. 13. ISSUE 10. P. 1169 -1183 50 48% 539
6 RISTOFF, E , LARSSON, A , (2007) INBORN ERRORS IN THE METABOLISM OF GLUTATHIONE.ORPHANET JOURNAL OF RARE DISEASES. VOL. 2. ISSUE . P. - 37 77% 46
7 WILD, AC , MULCAHY, RT , (2000) REGULATION OF GAMMA-GLUTAMYLCYSTEINE SYNTHETASE SUBUNIT GENE EXPRESSION: INSIGHTS INTO TRANSCRIPTIONAL CONTROL OF ANTIOXIDANT DEFENSES.FREE RADICAL RESEARCH. VOL. 32. ISSUE 4. P. 281 -301 67 48% 136
8 BACKOS, DS , BROCKER, CN , FRANKLIN, CC , (2010) MANIPULATION OF CELLULAR GSH BIOSYNTHETIC CAPACITY VIA TAT-MEDIATED PROTEIN TRANSDUCTION OF WILD-TYPE OR A DOMINANT-NEGATIVE MUTANT OF GLUTAMATE CYSTEINE LIGASE ALTERS CELL SENSITIVITY TO OXIDANT-INDUCED CYTOTOXICITY.TOXICOLOGY AND APPLIED PHARMACOLOGY. VOL. 243. ISSUE 1. P. 35-45 40 67% 3
9 GRIFFITH, OW , (1999) BIOLOGIC AND PHARMACOLOGIC REGULATION OF MAMMALIAN GLUTATHIONE SYNTHESIS.FREE RADICAL BIOLOGY AND MEDICINE. VOL. 27. ISSUE 9-10. P. 922 -935 47 45% 594
10 KREJSA, CM , FRANKLIN, CC , WHITE, CC , LEDBETTER, JA , SCHIEVEN, GL , KAVANAGH, TJ , (2010) RAPID ACTIVATION OF GLUTAMATE CYSTEINE LIGASE FOLLOWING OXIDATIVE STRESS.JOURNAL OF BIOLOGICAL CHEMISTRY. VOL. 285. ISSUE 21. P. 16116-16124 28 78% 25

Classes with closest relation at Level 1


Rank Class id link
1 14974 MITOCHONDRIAL APOPTOSIS SIGNALING//APOPTOSIS IN UNDIFFERENTIATED CELLS//GSH COMPARTMENTATION
2 13407 YAP1//BIFUNCTIONAL GLUTATHIONE SYNTHETASE//YAP1P
3 14435 BUTHIONINE SULFOXIMINE//L 2 OXOTHIAZOLIDINE 4 CARBOXYLATE//5 OXO L PROLINASE
4 35897 MEDTAYSIDE CHILD HLTH//CHEMIOXYEXCITATION//GLUTATHIONE DISEQUILIBRIUM
5 17747 BIOMOL INTERACT BREMEN//BIOL CHEM 2//GLUTATHIONE
6 18669 XCT//SYSTEM XC//CYSTINE GLUTAMATE ANTIPORTER
7 10382 GAMMA GLUTAMYL TRANSPEPTIDASE//GAMMA GLUTAMYLTRANSFERASE//GAMMA GLUTAMYL TRANSFERASE
8 1613 NRF2//KEAP1//ANTIOXIDANT RESPONSE ELEMENT
9 10007 PHYTOCHELATINS//PHYTOCHELATIN SYNTHASE//METAL BINDING PEPTIDES
10 3889 CYSTEINE//BIOTHIOLS//THIOLS

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