Class information for:
Level 1: METHADONE//EDDP//2 ETHYLIDENE 1 5 DIMETHYL 3 3 DIPHENYLPYRROLIDINE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
14642 758 33.4 67%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
1 4 ECONOMICS//EDUCATION & EDUCATIONAL RESEARCH//PSYCHOL 3876184
25 3       SUBSTANCE ABUSE//ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH//ALCOHOL 112030
1436 2             BUPRENORPHINE//METHADONE//SUBSTANCE ABUSE 7862
14642 1                   METHADONE//EDDP//2 ETHYLIDENE 1 5 DIMETHYL 3 3 DIPHENYLPYRROLIDINE 758

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 METHADONE authKW 1898998 42% 15% 319
2 EDDP authKW 352763 2% 52% 17
3 2 ETHYLIDENE 1 5 DIMETHYL 3 3 DIPHENYLPYRROLIDINE authKW 281979 1% 100% 7
4 METHADONE ENANTIOMERS authKW 161131 1% 100% 4
5 EMDP authKW 128903 1% 80% 4
6 CLINICAL OPIOID WITHDRAWAL SCALE authKW 120848 0% 100% 3
7 S METHADONE authKW 107418 1% 67% 4
8 6 DIMETHYLAMINO 4 4 DIPHENYL 3 HEPTANONE METHADONE authKW 80565 0% 100% 2
9 ADULT ACTG PHARMACOL SUPPORT address 80565 0% 100% 2
10 METHADONE DETERMINATION authKW 80565 0% 100% 2

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Substance Abuse 9613 17% 0% 127
2 Pharmacology & Pharmacy 2348 34% 0% 254
3 Medicine, Legal 1528 5% 0% 37
4 Psychiatry 586 11% 0% 83
5 Chemistry, Analytical 551 13% 0% 97
6 Toxicology 476 8% 0% 62
7 Medical Laboratory Technology 280 3% 0% 26
8 Anesthesiology 279 4% 0% 30
9 Medicine, General & Internal 180 9% 0% 66
10 Biochemical Research Methods 154 6% 0% 43

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ADULT ACTG PHARMACOL SUPPORT 80565 0% 100% 2
2 S BIOCHIM NUTR 80565 0% 100% 2
3 DRUG ABUSE ADDICT 69409 1% 19% 9
4 SONG DE BRANCH 64448 1% 40% 4
5 UNIT BIOCHEM CLIN PSYCHOPHARMACOL 61672 1% 22% 7
6 TOXICOL CLIN TOXICOL 60421 0% 50% 3
7 ST MARTIN 58588 1% 36% 4
8 ADDICT FORENS PSYCHIAT 53709 0% 67% 2
9 UNIT BIOCHEM CLIN PSYCHOPHARMACOL PSYCHIAT 53709 0% 67% 2
10 UNIT DRUG ADDICT 53709 0% 67% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF ADDICTIVE DISEASES 18655 3% 2% 19
2 HEROIN ADDICTION AND RELATED CLINICAL PROBLEMS 12203 1% 4% 8
3 AMERICAN JOURNAL ON ADDICTIONS 9712 2% 1% 18
4 JOURNAL OF ANALYTICAL TOXICOLOGY 8146 3% 1% 26
5 DRUG AND ALCOHOL DEPENDENCE 4850 4% 0% 27
6 CLINICAL PHARMACOLOGY & THERAPEUTICS 4291 3% 0% 25
7 THERAPEUTIC DRUG MONITORING 2403 2% 0% 15
8 JOURNAL OF ADDICTION MEDICINE 2124 1% 1% 5
9 ADDICTION BIOLOGY 1648 1% 1% 7
10 JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY 1472 1% 0% 10

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 METHADONE 1898998 42% 15% 319 Search METHADONE Search METHADONE
2 EDDP 352763 2% 52% 17 Search EDDP Search EDDP
3 2 ETHYLIDENE 1 5 DIMETHYL 3 3 DIPHENYLPYRROLIDINE 281979 1% 100% 7 Search 2+ETHYLIDENE+1+5+DIMETHYL+3+3+DIPHENYLPYRROLIDINE Search 2+ETHYLIDENE+1+5+DIMETHYL+3+3+DIPHENYLPYRROLIDINE
4 METHADONE ENANTIOMERS 161131 1% 100% 4 Search METHADONE+ENANTIOMERS Search METHADONE+ENANTIOMERS
5 EMDP 128903 1% 80% 4 Search EMDP Search EMDP
6 CLINICAL OPIOID WITHDRAWAL SCALE 120848 0% 100% 3 Search CLINICAL+OPIOID+WITHDRAWAL+SCALE Search CLINICAL+OPIOID+WITHDRAWAL+SCALE
7 S METHADONE 107418 1% 67% 4 Search S+METHADONE Search S+METHADONE
8 6 DIMETHYLAMINO 4 4 DIPHENYL 3 HEPTANONE METHADONE 80565 0% 100% 2 Search 6+DIMETHYLAMINO+4+4+DIPHENYL+3+HEPTANONE+METHADONE Search 6+DIMETHYLAMINO+4+4+DIPHENYL+3+HEPTANONE+METHADONE
9 METHADONE DETERMINATION 80565 0% 100% 2 Search METHADONE+DETERMINATION Search METHADONE+DETERMINATION
10 METHADONE OVERDOSE 80565 0% 100% 2 Search METHADONE+OVERDOSE Search METHADONE+OVERDOSE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 EAP, CB , BUCLIN, T , BAUMANN, P , (2002) INTERINDIVIDUAL VARIABILITY OF THE CLINICAL PHARMACOKINETICS OF METHADONE - IMPLICATIONS FOR THE TREATMENT OF OPIOID DEPENDENCE.CLINICAL PHARMACOKINETICS. VOL. 41. ISSUE 14. P. 1153-1193 90 53% 275
2 KAPUR, BM , HUTSON, JR , CHIBBER, T , LUK, A , SELBY, P , (2011) METHADONE: A REVIEW OF DRUG-DRUG AND PATHOPHYSIOLOGICAL INTERACTIONS.CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES. VOL. 48. ISSUE 4. P. 171 -195 86 48% 20
3 ALINEJAD, S , KAZEMI, T , ZAMANI, N , HOFFMAN, RS , MEHRPOUR, O , (2015) A SYSTEMATIC REVIEW OF THE CARDIOTOXICITY OF METHADONE.EXCLI JOURNAL. VOL. 14. ISSUE . P. 577 -600 64 54% 0
4 WESCHULES, DJ , BAIN, KT , RICHEIMER, S , (2008) ACTUAL AND POTENTIAL DRUG INTERACTIONS ASSOCIATED WITH METHADONE.PAIN MEDICINE. VOL. 9. ISSUE 3. P. 315-344 68 50% 42
5 BRUCE, RD , MOODY, DE , ALTICE, FL , GOUREVITCH, MN , FRIEDLAND, GH , (2013) A REVIEW OF PHARMACOLOGICAL INTERACTIONS BETWEEN HIV OR HEPATITIS C VIRUS MEDICATIONS AND OPIOID AGONIST THERAPY: IMPLICATIONS AND MANAGEMENT FOR CLINICAL PRACTICE.EXPERT REVIEW OF CLINICAL PHARMACOLOGY. VOL. 6. ISSUE 3. P. 249-269 67 44% 14
6 KHARASCH, ED , REGINA, KJ , BLOOD, J , FRIEDEL, C , (2015) METHADONE PHARMACOGENETICS.ANESTHESIOLOGY. VOL. 123. ISSUE 5. P. 1142 -1153 35 71% 11
7 DINIS-OLIVEIRA, RJ , (2016) METABOLOMICS OF METHADONE: CLINICAL AND FORENSIC TOXICOLOGICAL IMPLICATIONS AND VARIABILITY OF DOSE RESPONSE.DRUG METABOLISM REVIEWS. VOL. 48. ISSUE 4. P. 568 -576 44 63% 0
8 KRANTZ, MJ , MARTIN, J , STIMMEL, B , MEHTA, D , HAIGNEY, MCP , (2009) QTC INTERVAL SCREENING IN METHADONE TREATMENT.ANNALS OF INTERNAL MEDICINE. VOL. 150. ISSUE 6. P. 387-W69 36 63% 121
9 MOODY, DE , (2013) METABOLIC AND TOXICOLOGICAL CONSIDERATIONS OF THE OPIOID REPLACEMENT THERAPY AND ANALGESIC DRUGS: METHADONE AND BUPRENORPHINE.EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY. VOL. 9. ISSUE 6. P. 675-697 56 43% 5
10 RODRIGUEZ-ROSASA, ME , MEDRANO, JG , EPSTEIN, DH , MOOLCHAN, ET , PRESTON, KL , WAINER, IW , (2005) DETERMINATION OF TOTAL AND FREE CONCENTRATIONS OF THE ENANTIOMERS OF METHADONE AND ITS METABOLITE (2-ETHYLIDENE-1,5-DIMETHYL-3,3-DIPHENYL-PYRROLIDINE) IN HUMAN PLASMA BY ENANTIOSELECTIVE LIQUID CHROMATOGRAPHY WITH MASS SPECTROMETRIC DETECTION.JOURNAL OF CHROMATOGRAPHY A. VOL. 1073. ISSUE 1-2. P. 237-248 32 91% 25

Classes with closest relation at Level 1


Rank Class id link
1 1986 METHADONE MAINTENANCE TREATMENT//METHADONE//METHADONE MAINTENANCE
2 5388 BUPRENORPHINE//BUPRENORPHINE NALOXONE//NORBUPRENORPHINE
3 12122 NEONATAL ABSTINENCE SYNDROME//METHADONE//BUPRENORPHINE
4 5211 BREAKTHROUGH PAIN//CANCER PAIN//FENTANYL
5 11030 OVERDOSE//DRUG RELATED DEATHS//OVERDOSE PREVENTION
6 16064 OPRM1//A118G//OPRM1 GENE
7 7391 MORPHINE 6 GLUCURONIDE//OXYCODONE//MORPHINE 3 GLUCURONIDE
8 12818 LOFEXIDINE//NALTREXONE//6 BETA NALTREXOL
9 11919 SERTINDOLE//TORSADES DE POINTES//TORSADE DE POINTES
10 25029 DEXTROPROPOXYPHENE//CO PROXAMOL//DEXTROPROPOXYPHENE DXP

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