Class information for:
Level 1: KETOSTEROID ISOMERASE//LOW BARRIER HYDROGEN BOND//JULIUS SPOKOJNY BIOORGAN CHEM

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
14403 771 42.7 62%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
278 3       CORYNEBACTERIUM GLUTAMICUM//ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY//BIOCHEMISTRY & MOLECULAR BIOLOGY 43163
2622 2             TRIOSEPHOSPHATE ISOMERASE//HISTIDINE BIOSYNTHESIS//KETOSTEROID ISOMERASE 3550
14403 1                   KETOSTEROID ISOMERASE//LOW BARRIER HYDROGEN BOND//JULIUS SPOKOJNY BIOORGAN CHEM 771

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 KETOSTEROID ISOMERASE authKW 513251 2% 72% 18
2 LOW BARRIER HYDROGEN BOND authKW 400176 3% 42% 24
3 JULIUS SPOKOJNY BIOORGAN CHEM address 159339 2% 31% 13
4 SHORT STRONG HYDROGEN BONDS authKW 126730 1% 80% 4
5 ACTIVE SITE ENVIRONMENT authKW 118810 0% 100% 3
6 GLYOXAL INHIBITOR authKW 118810 0% 100% 3
7 CRI BIOMOL RECOGNIT address 105607 1% 67% 4
8 PROT FOLDING ENGN address 99004 1% 50% 5
9 POTASSIUM HYDROGEN MALEATE authKW 79207 0% 100% 2
10 SHIFT OF PKA OF HIS57 authKW 79207 0% 100% 2

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biochemistry & Molecular Biology 2585 49% 0% 374
2 Chemistry, Multidisciplinary 1185 27% 0% 208
3 Biophysics 362 9% 0% 68
4 Chemistry, Physical 331 16% 0% 127
5 Physics, Atomic, Molecular & Chemical 222 8% 0% 61
6 Chemistry, Organic 164 8% 0% 63
7 Chemistry, Medicinal 33 3% 0% 21
8 Spectroscopy 32 2% 0% 19
9 Computer Science, Interdisciplinary Applications 11 2% 0% 13
10 Biochemical Research Methods 6 2% 0% 15

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JULIUS SPOKOJNY BIOORGAN CHEM 159339 2% 31% 13
2 CRI BIOMOL RECOGNIT 105607 1% 67% 4
3 PROT FOLDING ENGN 99004 1% 50% 5
4 HUMAN NUTR CLIN DIETET 52803 0% 67% 2
5 SEC STRATEG CLUSTERCONWAY 52803 0% 67% 2
6 A609 39603 0% 100% 1
7 ADV DEF TECHNOL TECH DEV MEGURO KU 39603 0% 100% 1
8 CREAT INIAT BIOMOL RECOGNIT 39603 0% 100% 1
9 CREAT INITIAT SUPERFUNCT MATNAM GU 39603 0% 100% 1
10 CREAT INITIATNAM GU 39603 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOCHEMISTRY 13748 18% 0% 136
2 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 6226 16% 0% 121
3 BIOORGANIC CHEMISTRY 1707 1% 1% 8
4 PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS 1372 2% 0% 15
5 CRC CRITICAL REVIEWS IN BIOCHEMISTRY 1112 0% 1% 2
6 BIOCHEMICAL JOURNAL 811 3% 0% 25
7 BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS 606 1% 0% 7
8 JOURNAL OF MOLECULAR STRUCTURE 542 2% 0% 17
9 THEORETICAL CHEMISTRY ACCOUNTS 504 1% 0% 6
10 JOURNAL OF PHYSICAL CHEMISTRY A 448 2% 0% 19

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 KETOSTEROID ISOMERASE 513251 2% 72% 18 Search KETOSTEROID+ISOMERASE Search KETOSTEROID+ISOMERASE
2 LOW BARRIER HYDROGEN BOND 400176 3% 42% 24 Search LOW+BARRIER+HYDROGEN+BOND Search LOW+BARRIER+HYDROGEN+BOND
3 SHORT STRONG HYDROGEN BONDS 126730 1% 80% 4 Search SHORT+STRONG+HYDROGEN+BONDS Search SHORT+STRONG+HYDROGEN+BONDS
4 ACTIVE SITE ENVIRONMENT 118810 0% 100% 3 Search ACTIVE+SITE+ENVIRONMENT Search ACTIVE+SITE+ENVIRONMENT
5 GLYOXAL INHIBITOR 118810 0% 100% 3 Search GLYOXAL+INHIBITOR Search GLYOXAL+INHIBITOR
6 POTASSIUM HYDROGEN MALEATE 79207 0% 100% 2 Search POTASSIUM+HYDROGEN+MALEATE Search POTASSIUM+HYDROGEN+MALEATE
7 SHIFT OF PKA OF HIS57 79207 0% 100% 2 Search SHIFT+OF+PKA+OF+HIS57 Search SHIFT+OF+PKA+OF+HIS57
8 HYDROGEN MALEATE 71284 0% 60% 3 Search HYDROGEN+MALEATE Search HYDROGEN+MALEATE
9 TETRAHEDRAL INTERMEDIATE 60335 1% 19% 8 Search TETRAHEDRAL+INTERMEDIATE Search TETRAHEDRAL+INTERMEDIATE
10 3 CYCLOHEXEN 1 ONE 39603 0% 100% 1 Search 3+CYCLOHEXEN+1+ONE Search 3+CYCLOHEXEN+1+ONE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 NATARAJAN, A , SCHWANS, JP , HERSCHLAG, D , (2014) USING UNNATURAL AMINO ACIDS TO PROBE THE ENERGETICS OF OXYANION HOLE HYDROGEN BONDS IN THE KETOSTEROID ISOMERASE ACTIVE SITE.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. VOL. 136. ISSUE 21. P. 7643 -7654 46 69% 7
2 JANG, DS , CHOI, G , CHA, HJ , SHIN, S , HONG, BH , LEE, HJ , LEE, HC , CHOI, KY , (2015) CONTRIBUTION OF A LOW-BARRIER HYDROGEN BOND TO CATALYSIS IS NOT SIGNIFICANT IN KETOSTEROID ISOMERASE.MOLECULES AND CELLS. VOL. 38. ISSUE 5. P. 409 -415 34 83% 0
3 HEDSTROM, L , (2002) SERINE PROTEASE MECHANISM AND SPECIFICITY.CHEMICAL REVIEWS. VOL. 102. ISSUE 12. P. 4501-4523 59 31% 715
4 CHAKRAVORTY, DK , HAMMES-SCHIFFER, S , (2010) IMPACT OF MUTATION ON PROTON TRANSFER REACTIONS IN KETOSTEROID ISOMERASE: INSIGHTS FROM MOLECULAR DYNAMICS SIMULATIONS.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. VOL. 132. ISSUE 21. P. 7549 -7555 39 59% 14
5 HOWE, N , ROGERS, L , HEWAGE, C , MALTHOUSE, JPG , (2009) OXYANION AND TETRAHEDRAL INTERMEDIATE STABILISATION BY SUBTILISIN: DETECTION OF A NEW TETRAHEDRAL ADDUCT.BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS. VOL. 1794. ISSUE 8. P. 1251 -1258 28 88% 1
6 POLLACK, RM , (2004) ENZYMATIC MECHANISMS FOR CATALYSIS OF ENOLIZATION: KETOSTEROID ISOMERASE.BIOORGANIC CHEMISTRY. VOL. 32. ISSUE 5. P. 341-353 36 69% 55
7 DJURDJEVIC-PAHL, A , HEWAGE, C , MALTHOUSE, JPG , (2005) IONISATIONS WITHIN A SUBTILISIN-GLYOXAL INHIBITOR COMPLEX.BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS. VOL. 1749. ISSUE 1. P. 33-41 28 90% 13
8 CHILDS, W , BOXER, SG , (2010) PROTON AFFINITY OF THE OXYANION HOLE IN THE ACTIVE SITE OF KETOSTEROID ISOMERASE.BIOCHEMISTRY. VOL. 49. ISSUE 12. P. 2725-2731 26 84% 10
9 FUHRMANN, CN , DAUGHERTY, MD , AGARD, DA , (2006) SUBANGSTROM CRYSTALLOGRAPHY REVEALS THAT SHORT IONIC HYDROGEN BONDS, AND NOT A HIS-ASP LOW-BARRIER HYDROGEN BOND, STABILIZE THE TRANSITION STATE IN SERINE PROTEASE CATALYSIS.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. VOL. 128. ISSUE 28. P. 9086 -9102 41 54% 61
10 CLELAND, WW , FREY, PA , GERLT, JA , (1998) THE LOW BARRIER HYDROGEN BOND IN ENZYMATIC CATALYSIS.JOURNAL OF BIOLOGICAL CHEMISTRY. VOL. 273. ISSUE 40. P. 25529-25532 28 74% 365

Classes with closest relation at Level 1


Rank Class id link
1 19542 CARBOXYLATE HYDRATION//POTENTIAL ENERGY SURFACE AB INITIO CALCULATIONS//VIA CHALCOPHILES
2 13510 ELASTASE INHIBITOR//PROTEINASE K INHIBITOR//HUMAN LEUKOCYTE ELASTASE
3 22346 DEUTERIUM ISOTOPE EFFECTS//LONG RANGE ISOTOPE EFFECTS//SOLVENT SUBSTRATE PROTON EXCHANGE
4 17105 HYDROGEN TUNNELLING//PROMOTING VIBRATION//HYDROGEN TUNNELING
5 25090 2 METHYLCITRIC ACID CYCLE//PROPIONATE METABOLISM//2 METHYLCITRATE SYNTHASE
6 11273 INTRAMOLECULAR HYDROGEN BOND//AIM AND NBO//RELATED ROTAMERS METHOD
7 17636 TRIOSEPHOSPHATE ISOMERASE//TRIOSEPHOSPHATE ISOMERASE DEFICIENCY//BIOQUIM BIOL ESTRUCT
8 28279 AROMATIC POLYAMIDINES//TRYPSIN ISOFORMS//DMC AZALYS ONP
9 24744 MANDELATE RACEMASE//MANDELATE RACEMASE EC 5122//ENOLASE SUPERFAMILY
10 11577 ACID PLUS BASE EQUILIBRIA//CATIONIC HETEROCONJUGATION//AM1D CALCULATIONS

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