Class information for:
Level 1: ELASTASE INHIBITOR//PROTEINASE K INHIBITOR//HUMAN LEUKOCYTE ELASTASE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
13510 832 31.5 57%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
111 3       THROMBOSIS RESEARCH//THROMBOSIS AND HAEMOSTASIS//HEMATOLOGY 71244
1906 2             ALPHA 1 ANTITRYPSIN DEFICIENCY//ALPHA 1 ANTITRYPSIN//ALPHA1 ANTITRYPSIN DEFICIENCY 5908
13510 1                   ELASTASE INHIBITOR//PROTEINASE K INHIBITOR//HUMAN LEUKOCYTE ELASTASE 832

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ELASTASE INHIBITOR authKW 223117 3% 26% 23
2 PROTEINASE K INHIBITOR authKW 183499 1% 100% 5
3 HUMAN LEUKOCYTE ELASTASE authKW 129195 2% 27% 13
4 PORCINE PANCREATIC ELASTASE authKW 111837 1% 38% 8
5 FR134043 authKW 110099 0% 100% 3
6 PEPTIDYL CARBAMATE authKW 110099 0% 100% 3
7 HUMAN NEUTROPHIL ELASTASE authKW 110069 2% 17% 18
8 HUMAN LEUKOCYTE ELASTASE HLE authKW 83882 0% 57% 4
9 1 4 DISUBSTITUTED AZETIDIN 2 ONES authKW 73399 0% 100% 2
10 5 5 TRANS LACTAM RING authKW 73399 0% 100% 2

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Medicinal 9108 31% 0% 259
2 Chemistry, Organic 3624 30% 0% 253
3 Biochemistry & Molecular Biology 1018 31% 0% 262
4 Respiratory System 303 6% 0% 46
5 Pharmacology & Pharmacy 263 13% 0% 106
6 Biophysics 262 7% 0% 62
7 Chemistry, Multidisciplinary 139 11% 0% 94
8 Integrative & Complementary Medicine 19 1% 0% 6
9 Crystallography 7 1% 0% 12
10 Biochemical Research Methods 4 2% 0% 15

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 IST BIOSTRUTTURE GRP 73399 0% 100% 2
2 ADV TECHNOL BIOMED MICRO RUMENT 36700 0% 100% 1
3 BIOCHIM MED MEDBIOMOL IFR53 36700 0% 100% 1
4 BIOL CELLULAIRE SUPRAMOL 36700 0% 100% 1
5 CHEM EMZYMOL 36700 0% 100% 1
6 CHEM PHARMACOL S 36700 0% 100% 1
7 CHIM MOL REIMS PHARMBIOMOL IFR53 36700 0% 100% 1
8 CHIM PHYS BIOPOLYMERS 36700 0% 100% 1
9 CNRS UA 455 36700 0% 100% 1
10 CONICET QUIM ORGAN SINTESIS 36700 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF MEDICINAL CHEMISTRY 7858 8% 0% 68
2 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 7291 9% 0% 71
3 JOURNAL OF ENZYME INHIBITION 3699 1% 2% 6
4 BIOORGANIC & MEDICINAL CHEMISTRY 3418 4% 0% 35
5 CLINICAL RESPIRATORY PHYSIOLOGY-BULLETIN EUROPEEN DE PHYSIOPATHOLOGIE RESPIRATOIRE 2071 0% 2% 3
6 AMERICAN REVIEW OF RESPIRATORY DISEASE 1903 2% 0% 18
7 BIOCHEMISTRY 1334 5% 0% 45
8 BIOORGANIC CHEMISTRY 1209 1% 0% 7
9 EXPERT OPINION ON THERAPEUTIC PATENTS 1042 1% 0% 8
10 ANNUAL REPORTS IN MEDICINAL CHEMISTRY 1022 1% 1% 5

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 ELASTASE INHIBITOR 223117 3% 26% 23 Search ELASTASE+INHIBITOR Search ELASTASE+INHIBITOR
2 PROTEINASE K INHIBITOR 183499 1% 100% 5 Search PROTEINASE+K+INHIBITOR Search PROTEINASE+K+INHIBITOR
3 HUMAN LEUKOCYTE ELASTASE 129195 2% 27% 13 Search HUMAN+LEUKOCYTE+ELASTASE Search HUMAN+LEUKOCYTE+ELASTASE
4 PORCINE PANCREATIC ELASTASE 111837 1% 38% 8 Search PORCINE+PANCREATIC+ELASTASE Search PORCINE+PANCREATIC+ELASTASE
5 FR134043 110099 0% 100% 3 Search FR134043 Search FR134043
6 PEPTIDYL CARBAMATE 110099 0% 100% 3 Search PEPTIDYL+CARBAMATE Search PEPTIDYL+CARBAMATE
7 HUMAN NEUTROPHIL ELASTASE 110069 2% 17% 18 Search HUMAN+NEUTROPHIL+ELASTASE Search HUMAN+NEUTROPHIL+ELASTASE
8 HUMAN LEUKOCYTE ELASTASE HLE 83882 0% 57% 4 Search HUMAN+LEUKOCYTE+ELASTASE+HLE Search HUMAN+LEUKOCYTE+ELASTASE+HLE
9 1 4 DISUBSTITUTED AZETIDIN 2 ONES 73399 0% 100% 2 Search 1+4+DISUBSTITUTED+AZETIDIN+2+ONES Search 1+4+DISUBSTITUTED+AZETIDIN+2+ONES
10 5 5 TRANS LACTAM RING 73399 0% 100% 2 Search 5+5+TRANS+LACTAM+RING Search 5+5+TRANS+LACTAM+RING

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 EDWARDS, PD , BERNSTEIN, PR , (1994) SYNTHETIC INHIBITORS OF ELASTASE.MEDICINAL RESEARCH REVIEWS. VOL. 14. ISSUE 2. P. 127-194 119 60% 202
2 LUCAS, SD , COSTA, E , GUEDES, RC , MOREIRA, R , (2013) TARGETING COPD: ADVANCES ON LOW-MOLECULAR-WEIGHT INHIBITORS OF HUMAN NEUTROPHIL ELASTASE.MEDICINAL RESEARCH REVIEWS. VOL. 33. ISSUE . P. E73-E101 60 63% 23
3 POWERS, JC , ASGIAN, JL , EKICI, OD , JAMES, KE , (2002) IRREVERSIBLE INHIBITORS OF SERINE, CYSTEINE, AND THREONINE PROTEASES.CHEMICAL REVIEWS. VOL. 102. ISSUE 12. P. 4639-4750 139 21% 535
4 MARTYN, DC , MOORE, MJB , ABELL, AD , (1999) SUCCINIMIDE AND SACCHARIN-BASED ENZYME-ACTIVATED INHIBITORS OF SERINE PROTEASES.CURRENT PHARMACEUTICAL DESIGN. VOL. 5. ISSUE 6. P. 405-415 35 83% 22
5 WALKER, B , LYNAS, JF , (2001) STRATEGIES FOR THE INHIBITION OF SERINE PROTEASES.CELLULAR AND MOLECULAR LIFE SCIENCES. VOL. 58. ISSUE 4. P. 596 -624 69 34% 60
6 POCHET, L , DOUCET, C , DIVE, G , WOUTERS, J , MASEREEL, B , REBOUD-RAVAUX, M , PIROTTE, B , (2000) COUMARINIC DERIVATIVES AS MECHANISM-BASED INHIBITORS OF ALPHA-CHYMOTRYPSIN AND HUMAN LEUKOCYTE ELASTASE.BIOORGANIC & MEDICINAL CHEMISTRY. VOL. 8. ISSUE 6. P. 1489 -1501 27 79% 32
7 BOSCHETTI, CE , MASCARETTI, OA , CRICCO, JA , ROVERI, OA , (1995) SYNTHESIS AND ELASTASE INHIBITORY ACTIVITY OF 6-ALPHA-CHLORO-2,2-DIMETHYL-3-ALPHA-(PIVALOYLOXY)METHYLPENAM SULFONE, 6-ALPHA-CHLORO-2,2-DIMETHYL-3-EXO-METHYLENEPENAM SULFONE, BENZYL AND METHYL 6-ALPHA-SUBSTITUTED PENICILLANATE SULFONES.BIOORGANIC & MEDICINAL CHEMISTRY. VOL. 3. ISSUE 1. P. 95-100 30 86% 3
8 EDWARDS, PD , ANDISIK, DW , STRIMPLER, AM , GOMES, B , TUTHILL, PA , (1996) NONPEPTIDIC INHIBITORS OF HUMAN NEUTROPHIL ELASTASE .7. DESIGN, SYNTHESIS, AND IN VITRO ACTIVITY OF A SERIES OF PYRIDOPYRIMIDINE TRIFLUOROMETHYL KETONES.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 39. ISSUE 5. P. 1112-1124 25 93% 32
9 DOUCET, C , POCHET, L , THIERRY, N , PIROTTE, B , DELARGE, J , REBOUD-RAVAUX, M , (1999) 6-SUBSTITUTED 2-OXO-2H-1-BENZOPYRAN-3-CARBOXYLIC ACID AS A CORE STRUCTURE FOR SPECIFIC INHIBITORS OF HUMAN LEUKOCYTE ELASTASE.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 42. ISSUE 20. P. 4161-4171 25 81% 47
10 SJO, P , (2012) NEUTROPHIL ELASTASE INHIBITORS: RECENT ADVANCES IN THE DEVELOPMENT OF MECHANISM-BASED AND NONELECTROPHILIC INHIBITORS.FUTURE MEDICINAL CHEMISTRY. VOL. 4. ISSUE 5. P. 651-660 20 69% 11

Classes with closest relation at Level 1


Rank Class id link
1 7218 ELAFIN//SLPI//SECRETORY LEUKOCYTE PROTEASE INHIBITOR
2 24005 NEUTROPHIL ELASTASE INHIBITOR//SIVELESTAT//NEUTROPHIL ELASTASE
3 24378 2 ARYL 4H 3 1 BENZOXAZIN 4 ONES//ANTIOXIDANT AND ANTICORROSIVE ADDITIVES//6 BROMO 2 METHYL 3 1 BENZOXAZIN 4 ONE
4 14403 KETOSTEROID ISOMERASE//LOW BARRIER HYDROGEN BOND//JULIUS SPOKOJNY BIOORGAN CHEM
5 15727 AS 924//CEFCAPENE PIVOXIL//ORAL CEPHALOSPORIN
6 29371 BETA ACETAMIDO KETONES//DAKIN WEST REACTION//BETA AMIDO KETONES
7 4751 BETA LACTAMS//2 AZETIDINONE//STAUDINGER REACTION
8 26067 TARUMI KU//ALLIED MED SCI SUMA KU//MED FUKUSHIMA KU
9 20898 ISOTHIAZOLIUM SALTS//1 2 BENZISOTHIAZOL 32H ONE//INTERUNIV RIC REAZ PERICICLICHE SINTESI SIS
10 33485 N NITROHYDROXYLAMINES//N NITROSOAMIDE//OXIDATIVE NITRATION

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