Class information for:
Level 1: ANTISICKLING ACTIVITY//ANTISICKLING AGENTS THERAPEUTIC USE//ANTISICKLING

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
13096 860 31.1 45%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
455 3       HEMOGLOBIN//SICKLE CELL DISEASE//SICKLE CELL ANEMIA 25359
1642 2             SICKLE CELL DISEASE//SICKLE CELL ANEMIA//ACUTE CHEST SYNDROME 6938
13096 1                   ANTISICKLING ACTIVITY//ANTISICKLING AGENTS THERAPEUTIC USE//ANTISICKLING 860

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ANTISICKLING ACTIVITY authKW 393282 1% 92% 12
2 ANTISICKLING AGENTS THERAPEUTIC USE authKW 284038 1% 100% 8
3 ANTISICKLING authKW 252477 1% 89% 8
4 ANTI SICKLING AGENT authKW 147935 1% 83% 5
5 HEMOGLOBIN S POLYMERIZATION authKW 147935 1% 83% 5
6 ERYTHROCYTES DRUG EFFECTS authKW 142019 0% 100% 4
7 SICKLE HEMOGLOBIN authKW 138569 1% 35% 11
8 ANTISICKLING AGENT authKW 113614 0% 80% 4
9 DEHYDRATION PREVENTION CONTROL authKW 113614 0% 80% 4
10 PIRACETAM THERAPEUTIC USE authKW 113614 0% 80% 4

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Hematology 6824 27% 0% 236
2 Biochemistry & Molecular Biology 1303 34% 0% 296
3 Biophysics 1283 15% 0% 127
4 Integrative & Complementary Medicine 280 2% 0% 20
5 Medicine, Research & Experimental 204 7% 0% 59
6 Chemistry, Medicinal 198 5% 0% 45
7 Pharmacology & Pharmacy 62 8% 0% 66
8 Biology 51 3% 0% 25
9 Medicine, General & Internal 30 5% 0% 39
10 Microscopy 25 1% 0% 6

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CNRS UA 607 71010 0% 100% 2
2 MED CHEM QUAL CONTROL 41222 1% 19% 6
3 ABOJUPA LAYOUT 35505 0% 100% 1
4 ALBERT E EIN MED HEMATOL 35505 0% 100% 1
5 ATWATER S 35505 0% 100% 1
6 BIOL PL TECH 35505 0% 100% 1
7 CARDEZA FDN HERMATOLOGIC 35505 0% 100% 1
8 CARDIOVASC HLTH UNIT MONTPELLIER 35505 0% 100% 1
9 CARNDEZA FDN 35505 0% 100% 1
10 CELL MOLEC BIOL BIOPHYS CELL PHYSIOL 35505 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BLOOD CELLS 28157 3% 3% 23
2 CLINICAL HEMORHEOLOGY 14816 2% 2% 20
3 TEXAS REPORTS ON BIOLOGY AND MEDICINE 12153 1% 5% 7
4 HEMOGLOBIN 5084 2% 1% 18
5 AMERICAN JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY 4318 1% 1% 11
6 BIOPHYSICAL JOURNAL 3971 5% 0% 47
7 JOURNAL OF MOLECULAR BIOLOGY 2896 5% 0% 44
8 AMERICAN JOURNAL OF HEMATOLOGY 2863 3% 0% 22
9 BLOOD 2842 6% 0% 53
10 JOURNAL OF LABORATORY AND CLINICAL MEDICINE 2534 2% 0% 17

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 ANTISICKLING ACTIVITY 393282 1% 92% 12 Search ANTISICKLING+ACTIVITY Search ANTISICKLING+ACTIVITY
2 ANTISICKLING AGENTS THERAPEUTIC USE 284038 1% 100% 8 Search ANTISICKLING+AGENTS+THERAPEUTIC+USE Search ANTISICKLING+AGENTS+THERAPEUTIC+USE
3 ANTISICKLING 252477 1% 89% 8 Search ANTISICKLING Search ANTISICKLING
4 ANTI SICKLING AGENT 147935 1% 83% 5 Search ANTI+SICKLING+AGENT Search ANTI+SICKLING+AGENT
5 HEMOGLOBIN S POLYMERIZATION 147935 1% 83% 5 Search HEMOGLOBIN+S+POLYMERIZATION Search HEMOGLOBIN+S+POLYMERIZATION
6 ERYTHROCYTES DRUG EFFECTS 142019 0% 100% 4 Search ERYTHROCYTES+DRUG+EFFECTS Search ERYTHROCYTES+DRUG+EFFECTS
7 SICKLE HEMOGLOBIN 138569 1% 35% 11 Search SICKLE+HEMOGLOBIN Search SICKLE+HEMOGLOBIN
8 ANTISICKLING AGENT 113614 0% 80% 4 Search ANTISICKLING+AGENT Search ANTISICKLING+AGENT
9 DEHYDRATION PREVENTION CONTROL 113614 0% 80% 4 Search DEHYDRATION+PREVENTION+CONTROL Search DEHYDRATION+PREVENTION+CONTROL
10 PIRACETAM THERAPEUTIC USE 113614 0% 80% 4 Search PIRACETAM+THERAPEUTIC+USE Search PIRACETAM+THERAPEUTIC+USE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 FERRONE, FA , (2016) SICKLE CELL DISEASE: ITS MOLECULAR MECHANISM AND THE ONE DRUG THAT TREATS IT.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. VOL. 93. ISSUE . P. 1168 -1173 28 70% 0
2 LU, L , LI, XJ , VEKILOV, PG , KARNIADAKIS, GE , (2016) PROBING THE TWISTED STRUCTURE OF SICKLE HEMOGLOBIN FIBERS VIA PARTICLE SIMULATIONS.BIOPHYSICAL JOURNAL. VOL. 110. ISSUE 9. P. 2085 -2093 28 62% 0
3 EATON, WA , HOFRICHTER, J , (1987) HEMOGLOBIN-S GELATION AND SICKLE-CELL DISEASE.BLOOD. VOL. 70. ISSUE 5. P. 1245-1266 56 57% 249
4 WANG, JC , KWONG, S , FERRONE, FA , TURNER, MS , BRIEHL, RW , (2009) FIBER DEPOLYMERIZATION: FRACTURE, FRAGMENTS, VANISHING TIMES, AND STOCHASTICS IN SICKLE HEMOGLOBIN.BIOPHYSICAL JOURNAL. VOL. 96. ISSUE 2. P. 655 -670 19 100% 3
5 TAM, MF , TAM, TCS , SIMPLACEANU, V , HO, NT , ZOU, M , HO, C , (2015) SICKLE CELL HEMOGLOBIN WITH MUTATION AT HIS-50 HAS IMPROVED SOLUBILITY.JOURNAL OF BIOLOGICAL CHEMISTRY. VOL. 290. ISSUE 35. P. 21762 -21772 27 59% 1
6 SAFO, MK , KO, TP , SCHREITER, ER , RUSSELL, JE , (2015) STRUCTURAL BASIS FOR THE ANTIPOLYMER ACTIVITY OF HB ZETA(2)BETA(S)(2) TRAPPED IN A TENSE CONFORMATION.JOURNAL OF MOLECULAR STRUCTURE. VOL. 1099. ISSUE . P. 99 -107 22 71% 0
7 SRINIVASULU, S , ACHARYA, AS , PRABHAKARAN, M , FABRY, ME , ALAMI, R , FIERING, SN , BOUHASIRRA, EE , NAGEL, RL , (2007) HBS-SAVARIA: THE ANTI-POLYMERIZATION EFFECT OF A SINGLE MUTATION IN HUMAN ALPHA-CHAINS.PROTEIN JOURNAL. VOL. 26. ISSUE 8. P. 523 -532 24 77% 3
8 FERRONE, FA , (2004) POLYMERIZATION AND SICKLE CELL DISEASE: A MOLECULAR VIEW.MICROCIRCULATION. VOL. 11. ISSUE 2. P. 115-128 24 75% 30
9 ADACHI, K , DING, M , ASAKURA, T , SURREY, S , (2009) RELATIONSHIP BETWEEN BETA 4 HYDROGEN BOND AND BETA 6 HYDROPHOBIC INTERACTIONS DURING AGGREGATE, FIBER OR CRYSTAL FORMATION IN OVERSATURATED SOLUTIONS OF HEMOGLOBIN A AND S.ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. VOL. 481. ISSUE 2. P. 137-144 19 83% 3
10 ODER, E , SAFO, MK , ABDULMALIK, O , KATO, GJ , (2016) NEW DEVELOPMENTS IN ANTI-SICKLING AGENTS: CAN DRUGS DIRECTLY PREVENT THE POLYMERIZATION OF SICKLE HAEMOGLOBIN INVIVO?.BRITISH JOURNAL OF HAEMATOLOGY. VOL. 175. ISSUE 1. P. 24 -30 20 65% 0

Classes with closest relation at Level 1


Rank Class id link
1 8467 AHSP//RECOMBINANT MUTANT HEMOGLOBIN//5 5 DITHIOBIS2 NITROBENZOATE
2 103 SICKLE CELL DISEASE//SICKLE CELL ANEMIA//ACUTE CHEST SYNDROME
3 7677 K CL COTRANSPORT//POTASSIUM CHLORIDE COTRANSPORT//BUMETANIDE
4 30040 LONG HELIX//CIRCULAR EXTINCTION//CYLINDRICAL SHAPED
5 36392 26 KDA HELICOBACTER SPECIES SPECIFIC ANTIGEN GENE//AMOL THALASSEMIA//CANCER ADVERSE EFFECTS
6 23858 SICKLE CELL TRAIT//UMR S 458//CARIBEEN DREPANOCYTOSE GUY MERAULT
7 9383 FETAL HEMOGLOBIN//HEMOGLOBINOPATHY THALASSEMIA UNIT//GAMMA GLOBIN
8 20249 RSR13//OXYHEMOGLOBIN DISSOCIATION CURVE//ALLOSTERIC MODIFIER
9 9537 SENESCENT CELL ANTIGEN//ERYTHROCYTE AGING//SENESCENT ERYTHROCYTES
10 25320 SICKLE CELL NEPHROPATHY//SICKLE NEPHROPATHY//REFERENCE SYNDROMES DREPANOCYTAI MAJEURS

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