Class information for:
Level 1: ACYCLIC NUCLEOSIDE PHOSPHONATES//PMEA//CIDOFOVIR

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
10470 1061 30.8 77%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
236 3       ADENOSINE//NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS//ADENOSINE RECEPTORS 48331
793 2             NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS//NUCLEOSIDES//CARBOCYCLIC NUCLEOSIDES 12112
10470 1                   ACYCLIC NUCLEOSIDE PHOSPHONATES//PMEA//CIDOFOVIR 1061

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ACYCLIC NUCLEOSIDE PHOSPHONATES authKW 1523400 7% 69% 77
2 PMEA authKW 553094 3% 62% 31
3 CIDOFOVIR authKW 406216 7% 18% 79
4 ACYCLIC NUCLEOTIDE ANALOGUES authKW 332665 2% 68% 17
5 PMEDAP authKW 287782 1% 100% 10
6 PMEG authKW 287782 1% 100% 10
7 ACYCLIC NUCLEOTIDE ANALOGS authKW 267856 1% 85% 11
8 HPMPC authKW 266387 2% 51% 18
9 BK PROJECT TEAM 21 address 245230 1% 61% 14
10 HPMPA authKW 239815 1% 83% 10

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Pharmacology & Pharmacy 2497 30% 0% 314
2 Virology 1822 10% 0% 110
3 Chemistry, Medicinal 1788 13% 0% 135
4 Chemistry, Organic 1107 16% 0% 168
5 Chemistry, Multidisciplinary 580 18% 0% 186
6 Microbiology 429 10% 0% 103
7 Biochemistry & Molecular Biology 220 16% 0% 172
8 Oncology 77 7% 0% 70
9 Infectious Diseases 54 3% 0% 31
10 Dermatology 33 2% 0% 20

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BK PROJECT TEAM 21 245230 1% 61% 14
2 REGA MED 175679 13% 4% 137
3 ORGAN CHEM BIOCHEM 170383 18% 3% 188
4 MED 0676 148001 1% 86% 6
5 PROJECT TEAM BK 21 110991 1% 43% 9
6 SAN DIEGO VET MED FDN 86335 0% 100% 3
7 EQUIPE REPLICASES VIRALES STRUCT MECANISME DRUG 57556 0% 100% 2
8 GRP ENZYMOL MOL FONCT 57556 0% 100% 2
9 NUCLEOSIDES PHOSPHORYLATED EFFECTORS TEAM 57556 0% 100% 2
10 NEW ANTIVIRALS ANTINEOPLAST 55981 1% 16% 12

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS 55693 9% 2% 95
2 COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS 34884 9% 1% 94
3 ANTIVIRAL RESEARCH 33992 6% 2% 64
4 ANTIVIRAL CHEMISTRY & CHEMOTHERAPY 14852 2% 3% 16
5 ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 7913 8% 0% 81
6 FOLIA BIOLOGICA 5197 2% 1% 16
7 JOURNAL OF MEDICINAL CHEMISTRY 1984 4% 0% 39
8 MEDICINAL RESEARCH REVIEWS 1645 1% 1% 7
9 NEOPLASMA 1105 1% 0% 11
10 NUCLEOSIDES & NUCLEOTIDES 1072 0% 1% 5

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 ACYCLIC NUCLEOSIDE PHOSPHONATES 1523400 7% 69% 77 Search ACYCLIC+NUCLEOSIDE+PHOSPHONATES Search ACYCLIC+NUCLEOSIDE+PHOSPHONATES
2 PMEA 553094 3% 62% 31 Search PMEA Search PMEA
3 CIDOFOVIR 406216 7% 18% 79 Search CIDOFOVIR Search CIDOFOVIR
4 ACYCLIC NUCLEOTIDE ANALOGUES 332665 2% 68% 17 Search ACYCLIC+NUCLEOTIDE+ANALOGUES Search ACYCLIC+NUCLEOTIDE+ANALOGUES
5 PMEDAP 287782 1% 100% 10 Search PMEDAP Search PMEDAP
6 PMEG 287782 1% 100% 10 Search PMEG Search PMEG
7 ACYCLIC NUCLEOTIDE ANALOGS 267856 1% 85% 11 Search ACYCLIC+NUCLEOTIDE+ANALOGS Search ACYCLIC+NUCLEOTIDE+ANALOGS
8 HPMPC 266387 2% 51% 18 Search HPMPC Search HPMPC
9 HPMPA 239815 1% 83% 10 Search HPMPA Search HPMPA
10 PHOSPHONIC ACID NUCLEOSIDE 230226 1% 100% 8 Search PHOSPHONIC+ACID+NUCLEOSIDE Search PHOSPHONIC+ACID+NUCLEOSIDE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 HOLY, A , (2003) PHOSPHONOMETHOXYALKYL ANALOGS OF NUCLEOTIDES.CURRENT PHARMACEUTICAL DESIGN. VOL. 9. ISSUE 31. P. 2567 -2592 217 65% 156
2 HOLY, A , GUNTER, J , DVORAKOVA, H , MASOJIDKOVA, M , ANDREI, G , SNOECK, R , BALZARINI, J , DE CLERCQ, E , (1999) STRUCTURE-ANTIVIRAL ACTIVITY RELATIONSHIP IN THE SERIES OF PYRIMIDINE AND PURINE N-[2-(2-PHOSPHONOMETHOXY)ETHYL] NUCLEOTIDE ANALOGUES. 1. DERIVATIVES SUBSTITUTED AT THE CARBON ATOMS OF THE BASE.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 42. ISSUE 12. P. 2064 -2086 82 79% 112
3 NAESENS, L , SNOECK, R , ANDREI, G , BALZARINI, J , NEYTS, J , DECLERCQ, E , (1997) HPMPC (CIDOFOVIR), PMEA (ADEFOVIR) AND RELATED ACYCLIC NUCLEOSIDE PHOSPHONATE ANALOGUES: A REVIEW OF THEIR PHARMACOLOGY AND CLINICAL POTENTIAL IN THE TREATMENT OF VIRAL INFECTIONS.ANTIVIRAL CHEMISTRY & CHEMOTHERAPY. VOL. 8. ISSUE 1. P. 1-23 89 69% 172
4 HOLY, A , VOTRUBA, I , TLOUSTOVA, E , MASOJIDKOVA, M , (2001) SYNTHESIS AND CYTOSTATIC ACTIVITY OF N-[2-(PHOSPHONOMETHOXY)ALKYL] DERIVATIVES OF N-6-SUBSTITUTED ADENINES, 2,6-DIAMINOPURINES AND RELATED COMPOUNDS.COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS. VOL. 66. ISSUE 10. P. 1545 -1592 70 77% 36
5 DE CLERCQ, E , (2013) THE ACYCLIC NUCLEOSIDE PHOSPHONATES (ANPS): ANTONIN HOLY'S LEGACY.MEDICINAL RESEARCH REVIEWS. VOL. 33. ISSUE 6. P. 1278-1303 55 65% 18
6 DE CLERCQ, E , HOLY, A , (2005) ACYCLIC NUCLEOSIDE PHOSPHONATES: A KEY CLASS OF ANTIVIRAL DRUGS.NATURE REVIEWS DRUG DISCOVERY. VOL. 4. ISSUE 11. P. 928-940 64 52% 320
7 DE CLERCQ, E , (2007) THE ACYCLIC NUCLEOSIDE PHOSPHONATES FROM INCEPTION TO CLINICAL USE: HISTORICAL PERSPECTIVE.ANTIVIRAL RESEARCH. VOL. 75. ISSUE 1. P. 1-13 62 60% 80
8 HOLY, A , VOTRUBA, I , MASOJIDKOVA, M , ANDREI, G , SNOECK, R , NAESENS, L , DE CLERCQ, E , BALZARINI, J , (2002) 6-[2-(PHOSPHONOMETHOXY)ALKOXY]PYRIMIDINES WITH ANTIVIRAL ACTIVITY.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 45. ISSUE 9. P. 1918-1929 57 79% 70
9 DE CLERCQ, E , (2011) THE CLINICAL POTENTIAL OF THE ACYCLIC (AND CYCLIC) NUCLEOSIDE PHOSPHONATES. THE MAGIC OF THE PHOSPHONATE BOND.BIOCHEMICAL PHARMACOLOGY. VOL. 82. ISSUE 2. P. 99-109 47 69% 54
10 KHANDAZHINSKAYA, A , YASKO, M , SHIROKOVA, E , (2006) THE SYNTHESIS AND ANTIVIRAL PROPERTIES OF ACYCLIC NUCLEOSIDE ANALOGUES WITH A PHOSPHONOMETHOXY FRAGMENT IN THE SIDE CHAIN.CURRENT MEDICINAL CHEMISTRY. VOL. 13. ISSUE 24. P. 2953 -2980 60 70% 11

Classes with closest relation at Level 1


Rank Class id link
1 13094 POLYMETHYLENE ANALOGUES//TRICYCLIC ANALOGUES//ACYCLONUCLEOSIDES
2 12489 PRONUCLEOTIDES//PHOSPHORAMIDATE//PROTIDE
3 15771 UL97//GANCICLOVIR RESISTANCE//MARIBAVIR
4 5617 CARBOCYCLIC NUCLEOSIDES//CARBANUCLEOSIDES//MOLETTE DRUG DISCOVERY
5 14958 ISONUCLEOSIDES//TROXACITABINE//L NUCLEOSIDES
6 26418 TAS 106//DUPLEX DRUG//3 C ETHYNYLCYTIDINE
7 16093 DIFLUOROPHOSPHONATE//DIFLUOROMETHYLENEPHOSPHONATES//PHOSPHONODITHIOFORMATE
8 13474 RECURRENT RESPIRATORY PAPILLOMATOSIS//LARYNGEAL PAPILLOMATOSIS//LARYNGEAL PAPILLOMA
9 14088 COMBINATORIAL CHEM DRUG DISCOVERY//PURINES//GILEAD SCI IOCB
10 4078 SMALLPOX//ORTHOPOXVIRUS//SMALLPOX VACCINE

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