Class information for:
Level 1: TRAIL//DR5//TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
1157 2815 47.9 94%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
441 3       TRAIL//SURVIVIN//APOPTOSIS 26474
306 2             TRAIL//SURVIVIN//APOPTOSIS 18497
1157 1                   TRAIL//DR5//TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND 2815

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 TRAIL authKW 6060479 38% 53% 1062
2 DR5 authKW 763068 4% 57% 123
3 TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND authKW 698167 4% 62% 104
4 DEATH RECEPTOR authKW 572467 6% 30% 178
5 TRAIL RECEPTORS authKW 547133 2% 86% 59
6 DR4 authKW 402469 2% 62% 60
7 DEATH RECEPTOR 5 authKW 390545 2% 68% 53
8 TNF RELATED APOPTOSIS INDUCING LIGAND authKW 362962 2% 57% 59
9 TRAIL RESISTANCE authKW 308488 1% 89% 32
10 APO2L TRAIL authKW 301152 1% 73% 38

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Oncology 18438 42% 0% 1188
2 Cell Biology 5143 23% 0% 649
3 Biochemistry & Molecular Biology 2129 26% 0% 730
4 Medicine, Research & Experimental 818 7% 0% 210
5 Immunology 532 8% 0% 236
6 Hematology 376 4% 0% 122
7 Genetics & Heredity 324 6% 0% 166
8 Pharmacology & Pharmacy 201 8% 0% 215
9 Biophysics 120 4% 0% 99
10 Gastroenterology & Hepatology 91 3% 0% 72

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MORPHOL EMBRYOL 119302 2% 18% 60
2 OPTOSIS REGULAT 100922 1% 42% 22
3 HUMAN GENE THER Y UNIT 76359 0% 54% 13
4 CELL SIGNALING OPTOSIS 74359 0% 57% 12
5 HUMAN NORMAL MORPHOL 57838 0% 67% 8
6 TRANSLAT ONCOL EXPT CANC THER EUT 54488 0% 36% 14
7 MOL TARGETING CANC PREVENT 49832 1% 18% 26
8 PROGRAM GENE THER Y VIROL 48796 0% 50% 9
9 MOL ONCOL CELL CYCLE REGULAT 46825 1% 24% 18
10 SURG PHARMACOL 45492 1% 26% 16

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PEZCOLLER FOUNDATION SYMPOSIA 17377 2% 3% 57
2 VITAMINS AND HORMONES 11396 1% 7% 16
3 MOLECULAR CANCER THERAPEUTICS 8883 2% 1% 58
4 CANCER BIOLOGY & THERAPY 7415 2% 2% 44
5 CELL DEATH AND DIFFERENTIATION 6870 2% 1% 45
6 ONCOGENE 5516 3% 1% 97
7 CELL DEATH & DISEASE 4369 1% 1% 31
8 CLINICAL CANCER RESEARCH 3892 3% 1% 74
9 CANCER RESEARCH 3576 4% 0% 116
10 INTERNATIONAL JOURNAL OF ONCOLOGY 2996 2% 1% 52

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class		 LCSH search Wikipedia search
1 TRAIL 6060479 38% 53% 1062 Search TRAIL Search TRAIL
2 DR5 763068 4% 57% 123 Search DR5 Search DR5
3 TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND 698167 4% 62% 104 Search TUMOR+NECROSIS+FACTOR+RELATED+APOPTOSIS+INDUCING+LIGAND Search TUMOR+NECROSIS+FACTOR+RELATED+APOPTOSIS+INDUCING+LIGAND
4 DEATH RECEPTOR 572467 6% 30% 178 Search DEATH+RECEPTOR Search DEATH+RECEPTOR
5 TRAIL RECEPTORS 547133 2% 86% 59 Search TRAIL+RECEPTORS Search TRAIL+RECEPTORS
6 DR4 402469 2% 62% 60 Search DR4 Search DR4
7 DEATH RECEPTOR 5 390545 2% 68% 53 Search DEATH+RECEPTOR+5 Search DEATH+RECEPTOR+5
8 TNF RELATED APOPTOSIS INDUCING LIGAND 362962 2% 57% 59 Search TNF+RELATED+APOPTOSIS+INDUCING+LIGAND Search TNF+RELATED+APOPTOSIS+INDUCING+LIGAND
9 TRAIL RESISTANCE 308488 1% 89% 32 Search TRAIL+RESISTANCE Search TRAIL+RESISTANCE
10 APO2L TRAIL 301152 1% 73% 38 Search APO2L+TRAIL Search APO2L+TRAIL

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 JOHNSTONE, RW , FREW, AJ , SMYTH, MJ , (2008) THE TRAIL APOPTOTIC PATHWAY IN CANCER ONSET, PROGRESSION AND THERAPY.NATURE REVIEWS CANCER. VOL. 8. ISSUE 10. P. 782 -798 141 73% 462
2 DE MIGUEL, D , LEMKE, J , ANEL, A , WALCZAK, H , MARTINEZ-LOSTAO, L , (2016) ONTO BETTER TRAILS FOR CANCER TREATMENT.CELL DEATH AND DIFFERENTIATION. VOL. 23. ISSUE 5. P. 733 -747 136 68% 10
3 MELLIER, G , HUANG, SN , SHENOY, K , PERVAIZ, S , (2010) TRAILING DEATH IN CANCER.MOLECULAR ASPECTS OF MEDICINE. VOL. 31. ISSUE 1. P. 93-112 150 75% 65
4 MERINO, D , LALAOUI, N , MORIZOT, A , SOLARY, E , MICHEAU, O , (2007) TRAIL IN CANCER THERAPY: PRESENT AND FUTURE CHALLENGES.EXPERT OPINION ON THERAPEUTIC TARGETS. VOL. 11. ISSUE 10. P. 1299-1314 157 80% 54
5 AMM, HM , OLIVER, PG , LEE, CH , LI, YF , BUCHSBAUM, DJ , (2011) COMBINED MODALITY THERAPY WITH TRAIL OR AGONISTIC DEATH RECEPTOR ANTIBODIES.CANCER BIOLOGY & THERAPY. VOL. 11. ISSUE 5. P. 431 -449 140 75% 25
6 AMARANTE-MENDES, GP , GRIFFITH, TS , (2015) THERAPEUTIC APPLICATIONS OF TRAIL RECEPTOR AGONISTS IN CANCER AND BEYOND.PHARMACOLOGY & THERAPEUTICS. VOL. 155. ISSUE . P. 117 -131 162 56% 8
7 MICHEAU, O , SHIRLEY, S , DUFOUR, F , (2013) DEATH RECEPTORS AS TARGETS IN CANCER.BRITISH JOURNAL OF PHARMACOLOGY. VOL. 169. ISSUE 8. P. 1723 -1744 103 78% 52
8 PENNARUN, B , MEIJER, A , DE VRIES, EGE , KLEIBEUKER, JH , KRUYT, F , DE JONG, S , (2010) PLAYING THE DISC: TURNING ON TRAIL DEATH RECEPTOR-MEDIATED APOPTOSIS IN CANCER.BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER. VOL. 1805. ISSUE 2. P. 123 -140 139 63% 84
9 PRASAD, S , KIM, JH , GUPTA, SC , AGGARWAL, BB , (2014) TARGETING DEATH RECEPTORS FOR TRAIL BY AGENTS DESIGNED BY MOTHER NATURE.TRENDS IN PHARMACOLOGICAL SCIENCES. VOL. 35. ISSUE 10. P. 520 -536 133 63% 16
10 MAHALINGAM, D , SZEGEZDI, E , KEANE, M , DE JONG, S , SAMALI, A , (2009) TRAIL RECEPTOR SIGNALLING AND MODULATION: ARE WE ON THE RIGHT TRAIL?.CANCER TREATMENT REVIEWS. VOL. 35. ISSUE 3. P. 280-288 99 80% 147

Classes with closest relation at Level 1


Rank Class id link
1 14699 C FLIP//FADD//DEATH EFFECTOR DOMAIN
2 6794 XIAP//LIVIN//SMAC
3 1319 FAS//FAS LIGAND//FASL
4 28260 CASP8 652 6N DEL//CASPASE8//CASP8
5 34188 IG20//MADD//HUWE1
6 31962 PEA 15//IST ENDOCRINOL ONCOL SPERIMENTALE GAETANO SALVA//BIKDD
7 22230 DCR3//DECOY RECEPTOR 3//TL1A
8 32156 CYTOTOXIC DENDRITIC CELLS//IKDCS//INTERFERON PRODUCING KILLER DENDRITIC CELLS
9 1845 APAF 1//CASPASE 2//CASPASE
10 10122 TUMOR TROPISM//MESENCHYMAL STEM CELLS//VET BIOCHEM IMMUNOL

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