Class information for:
Level 1: GLUCOKINASE//GLUCOKINASE ACTIVATOR//GLUCOKINASE REGULATORY PROTEIN

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
10494 1058 37.9 77%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
297 3       DIABETES//ISLET TRANSPLANTATION//BETA CELL 41297
457 2             BETA CELL//INSULIN SECRETION//PANCREATIC ISLETS 16005
10494 1                   GLUCOKINASE//GLUCOKINASE ACTIVATOR//GLUCOKINASE REGULATORY PROTEIN 1058

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 GLUCOKINASE authKW 2230294 20% 36% 213
2 GLUCOKINASE ACTIVATOR authKW 1904038 7% 89% 74
3 GLUCOKINASE REGULATORY PROTEIN authKW 701985 3% 81% 30
4 GKA authKW 144299 0% 100% 5
5 GLUT2 GLUCOSE TRANSPORTER authKW 120248 0% 83% 5
6 GLUCOKINASE REGULATORY PROTEIN GKRP authKW 115439 0% 100% 4
7 THER EUT DISCOVERY MOL STRUCT CHARACTERIZ address 115439 0% 100% 4
8 LIVER GLUCOKINASE authKW 103891 1% 60% 6
9 THER EUT DISCOVERY MED CHEM address 103068 0% 71% 5
10 GCKR authKW 101626 1% 39% 9

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Endocrinology & Metabolism 8736 35% 0% 373
2 Biochemistry & Molecular Biology 2084 38% 0% 407
3 Chemistry, Medicinal 449 7% 0% 72
4 Biophysics 149 5% 0% 57
5 Medicine, Research & Experimental 129 5% 0% 56
6 Cell Biology 105 7% 0% 76
7 Pharmacology & Pharmacy 41 6% 0% 68
8 Physiology 35 3% 0% 32
9 Genetics & Heredity 34 4% 0% 41
10 Biology 27 2% 0% 23

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 THER EUT DISCOVERY MOL STRUCT CHARACTERIZ 115439 0% 100% 4
2 THER EUT DISCOVERY MED CHEM 103068 0% 71% 5
3 BIOPHARMACEUT COORDINAT 57720 0% 100% 2
4 CHEM SCI 4005 57720 0% 100% 2
5 DIABET CARE GUANGDONG PROV 57720 0% 100% 2
6 DIABET OBES DRUG DISCOVERY 43287 0% 50% 3
7 CARDIOVASC GASTROINTESTINAL AREA 32464 0% 38% 3
8 GIFFORD S DIABET 32458 1% 19% 6
9 501 MED EDUC BLDG 28860 0% 100% 1
10 9 RUE JULES HETZEL 28860 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DIABETES 28569 10% 1% 109
2 DIABETOLOGIA 11254 5% 1% 57
3 ARCHIVOS DE BIOLOGIA Y MEDICINA EXPERIMENTALES 9563 1% 4% 9
4 BIOCHEMICAL JOURNAL 2925 5% 0% 55
5 MEDCHEMCOMM 1354 1% 1% 8
6 DIABETES OBESITY & METABOLISM 1293 1% 0% 10
7 JOURNAL OF BIOLOGICAL CHEMISTRY 1267 8% 0% 85
8 BIOCHEMICAL MEDICINE AND METABOLIC BIOLOGY 1039 0% 1% 5
9 BIOCHEMICAL SOCIETY TRANSACTIONS 953 2% 0% 19
10 EUROPEAN JOURNAL OF BIOCHEMISTRY 803 2% 0% 24

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 GLUCOKINASE 2230294 20% 36% 213 Search GLUCOKINASE Search GLUCOKINASE
2 GLUCOKINASE ACTIVATOR 1904038 7% 89% 74 Search GLUCOKINASE+ACTIVATOR Search GLUCOKINASE+ACTIVATOR
3 GLUCOKINASE REGULATORY PROTEIN 701985 3% 81% 30 Search GLUCOKINASE+REGULATORY+PROTEIN Search GLUCOKINASE+REGULATORY+PROTEIN
4 GKA 144299 0% 100% 5 Search GKA Search GKA
5 GLUT2 GLUCOSE TRANSPORTER 120248 0% 83% 5 Search GLUT2+GLUCOSE+TRANSPORTER Search GLUT2+GLUCOSE+TRANSPORTER
6 GLUCOKINASE REGULATORY PROTEIN GKRP 115439 0% 100% 4 Search GLUCOKINASE+REGULATORY+PROTEIN+GKRP Search GLUCOKINASE+REGULATORY+PROTEIN+GKRP
7 LIVER GLUCOKINASE 103891 1% 60% 6 Search LIVER+GLUCOKINASE Search LIVER+GLUCOKINASE
8 GCKR 101626 1% 39% 9 Search GCKR Search GCKR
9 AZD1656 86580 0% 100% 3 Search AZD1656 Search AZD1656
10 PIRAGLIATIN 86580 0% 100% 3 Search PIRAGLIATIN Search PIRAGLIATIN

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 IYNEDJIAN, P , (2009) MOLECULAR PHYSIOLOGY OF MAMMALIAN GLUCOKINASE.CELLULAR AND MOLECULAR LIFE SCIENCES. VOL. 66. ISSUE 1. P. 27-42 77 61% 123
2 AGIUS, L , (2008) GLUCOKINASE AND MOLECULAR ASPECTS OF LIVER GLYCOGEN METABOLISM.BIOCHEMICAL JOURNAL. VOL. 414. ISSUE . P. 1-18 91 51% 130
3 MATSCHINSKY, FM , (2009) ASSESSING THE POTENTIAL OF GLUCOKINASE ACTIVATORS IN DIABETES THERAPY.NATURE REVIEWS DRUG DISCOVERY. VOL. 8. ISSUE 5. P. 399 -416 63 64% 193
4 GREWALA, AS , SEKHON, BS , LATHER, V , (2014) RECENT UPDATES ON GLUCOKINASE ACTIVATORS FOR THE TREATMENT OF TYPE 2 DIABETES MELLITUS.MINI-REVIEWS IN MEDICINAL CHEMISTRY. VOL. 14. ISSUE 7. P. 585 -602 60 77% 8
5 AGIUS, L , (2016) HORMONAL AND METABOLITE REGULATION OF HEPATIC GLUCOKINASE.ANNUAL REVIEW OF NUTRITION, VOL 36. VOL. 36. ISSUE . P. 389 -415 79 56% 0
6 LARION, M , MILLER, BG , (2012) HOMOTROPIC ALLOSTERIC REGULATION IN MONOMERIC MAMMALIAN GLUCOKINASE.ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. VOL. 519. ISSUE 2. P. 103-111 50 75% 17
7 BALTRUSCH, S , TIEDGE, M , (2006) GLUCOKINASE REGULATORY NETWORK IN PANCREATIC BETA-CELLS AND LIVER.DIABETES. VOL. 55. ISSUE . P. S55-S64 55 82% 20
8 NAKAMURA, A , TERAUCHI, Y , (2015) PRESENT STATUS OF CLINICAL DEPLOYMENT OF GLUCOKINASE ACTIVATORS.JOURNAL OF DIABETES INVESTIGATION. VOL. 6. ISSUE 2. P. 124 -132 40 73% 12
9 FILIPSKI, KJ , PFEFFERKORN, JA , (2014) A PATENT REVIEW OF GLUCOKINASE ACTIVATORS AND DISRUPTORS OF THE GLUCOKINASE - GLUCOKINASE REGULATORY PROTEIN INTERACTION: 2011-2014.EXPERT OPINION ON THERAPEUTIC PATENTS. VOL. 24. ISSUE 8. P. 875 -891 36 84% 9
10 KAMINSKI, MT , SCHULTZ, J , WATERSTRADT, R , TIEDGE, M , LENZEN, S , BALTRUSCH, S , (2014) GLUCOSE-INDUCED DISSOCIATION OF GLUCOKINASE FROM ITS REGULATORY PROTEIN IN THE NUCLEUS OF HEPATOCYTES PRIOR TO NUCLEAR EXPORT.BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH. VOL. 1843. ISSUE 3. P. 554 -564 39 81% 3

Classes with closest relation at Level 1


Rank Class id link
1 15197 HEXOKINASE//HEXOKINASE II//BRAIN HEXOKINASE
2 6916 MODY//MATURITY ONSET DIABETES OF THE YOUNG//MONOGENIC DIABETES
3 25097 INSULIN GENE THERAPY//ENDOCRINOL METAB SECT 111//INSULIN STORAGE
4 4912 D GLUCOSE METABOLISM//CHILDRENS DIABET//PANCREATIC ISLETS
5 19466 E2A GENE//RAT INSULIN II GENE//UNITE DIABETOL CLIN
6 22680 GK RAT//INSULIN GLUCOSE CLAMP//PHOSPHORYLATIVE SYSTEM
7 18644 A2 NORADRENERGIC NEURONS//LASER CATAPULT MICRODISSECTION//GLUCOSE SENSING
8 31620 FANCONI BICKEL SYNDROME//GLYCOGEN STORAGE DISEASE TYPE XI//FANCONI BICKEL
9 7510 GLUCONEOGENESIS//GLYCOGENOLYSIS//ENDOGENOUS GLUCOSE PRODUCTION
10 12692 CHREBP//CARBOHYDRATE RESPONSE ELEMENT BINDING PROTEIN CHREBP//CARBOHYDRATE RESPONSE ELEMENT BINDING PROTEIN

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