The course comprises approximately 100 full-time study hours, whereof 30 hours Zoom lectures, in addition to self-studies. The lectures treat basic principles such as spin algebra, density operator formalism of quantum statistical mechanics, and the design and operation of the most common multidimensional NMR pulse sequences. The course also includes a short treatment of the application of those methods in structural biochemistry.
For participants without sufficient entry-level knowledge in quantum mechanics, a short additional introduction of ”Quantum mechanics for pedestrians” will be given with the intention of facilitating the understanding of the actual course material.
After completing the course, the student should be able to:
- explain the basic quantum mechanical principles for NMR spectroscopy
- explain the operation of the most common multidimensional NMR experiments
- explain how suitable combinations of NMR experiments can be used for structure determination of biomolecules
- define and compare the different methods, choose technique/method for specific analysis problems and motivate the choices
- use the above listed knowledge to plan, perform and evaluate a laboratory project within the subject area, in group (or individually, depending on the number of participants) including to perform a smaller literature study, and present the laboratory project in a written report and perform an opposition on another laboratory project in the course