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Publications

50 latest publications

[1]
Ek, M., Nilvebrant, J., Nygren, P.-Å., Ståhl, S., Lindberg, H. & Löfblom, J. (2025). Drug Development. Alzheimer's & Dementia : Journal of the Alzheimer's Association, 21(S5), 100961.
[2]
Jönsson, M., Möller, M., Schierholz, L., Dorka, N., Tegel, H., Lundberg, E. ... Hober, S. (2025). Engineered calcium-regulated affinity protein for efficient internalization and lysosomal toxin delivery. Proceedings of the National Academy of Sciences of the United States of America, 122(48).
[3]
Oroujeni, M., Westerlund, K., Papalanis, E., Van Deventer, A., Liu, Y., Clinton, J. ... Eriksson Karlström, A. (2025). Designed Ankyrin Repeat Protein-Mediated Peptide Nucleic Acid-Based Pretargeting : A Proof-of-Principle Study. Journal of Nuclear Medicine, 66(7), 1105-1111.
[4]
Rinne, S. S., Yin, W., Li, R., Ding, H., Mestre Borras, A., Mahmod, C. ... Gräslund, T. (2025). Affibody-Derived Drug Conjugates Targeting The Epidermal Growth Factor Receptor Are Potent And Specific Cytotoxic Agents. ACS Pharmacology & Translational Science, 8(11), 3872-3885.
[5]
Ahmadiharchegani, F., Tobin, R. A., Degan, C., Naveed, A., Guglieri, M., Jimenez-Requena, A. ... Hathout, Y. (2025). Circulating protein biomarkers identified in two independent clinical trial cohorts of glucocorticoid-naive Duchenne muscular dystrophy patients. Scientific Reports, 15(1), 39997.
[6]
Wegrzyniak, O., Lechi, F., Rokka, J., Mitran, B., Zhang, B., Thelander, U. ... Eriksson, O. (2025). PET imaging of platelet derived growth factor receptor β in lung fibrosis. EJNMMI Radiopharmacy and Chemistry, 10(1).
[7]
Zhang, Q., Clinton, J., Westerlund, K. & Mim, C. (2025). SMCT1 has a low affinity to PDZ domain containing 1 protein. microPublication biology, 2025.
[8]
Masson, H. O., Di Giusto, P., Kuo, C. C., Malm, M., Lundqvist, M., Sivertsson, Å. ... Lewis, N. E. (2025). Deciphering the determinants of recombinant protein expression across the human secretome. Proceedings of the National Academy of Sciences of the United States of America, 122(41).
[9]
Visentin, C., Rizzi, G., Yin, W., Hotot, M., Roy, D., Gräslund, T. ... Ricagno, S. (2025). Affibodies as valuable tool to prevent β2m aggregation under lysosomal-like conditions (vol 20, 67, 2025). Biology Direct, 20(1).
[10]
Mestre Borras, A., Mehari, H., Ståhl, S. & Löfblom, J. (2025). Engineering high-efficiency matriptase substrates using E. coli display for applications in prodrug activation. CELL REPORTS METHODS, 5(6).
[11]
Keller, G., Widhe, M., Jansson, R., Vaisbourd, E., Pires, R. S. & Hedhammar, M. (2025). Recombinant spider silk functionalized with a CD40 agonist shows improved capability to activate human B cells in vitro - A novel module for cancer immunotherapy. International Journal of Biological Macromolecules, 327.
[12]
Nilvebrant, J., Moro, C. F., Papalanis, E., Novin, M. O., Ding, H., Li, R. ... Nygren, P.-Å. (2025). An anti-CEA affibody showing high-definition staining in human pancreatic cancer tissue sections and selective tumor targeting in vivo. Translational Oncology, 61.
[13]
Dahlsson Leitao, C., Löfblom, J., Nygren, P.-Å., Hober, S., Uhlén, M. & Ståhl, S. (2025). The many virtues of staphylococcal protein A : A journey from N to C terminus. Journal of Biotechnology, 406, 272-280.
[14]
Källén, A., Taebnia, N., Widhe, M., Lauschke, V. M. & Hedhammar, M. (2025). 3D Culture in Functionalized FN-Silk Networks Facilitate Proliferation, Differentiation and Phenotypic Stability of Mature Human Primary Cells and Stem Cells. Biotechnology and Bioengineering, 122(9), 2522-2534.
[15]
Möller, M., Jönsson, M., Lundqvist, M., Rockberg, J., Löfblom, J., Tegel, H. & Hober, S. (2025). Deep sequencing combined with high-throughput screening enables efficient development of a pH-dependent high-affinity binding domain targeting HER3. Protein Science, 34(8).
[16]
Zhang, Y., Sundäng Peters, E., Daramola, O., Tucker, T. A., Rockberg, J., Hatton, D. & Chotteau, V. (2025). Intensification of rAAV Production Based on HEK293 Cell Transient Transfection. Biotechnology Journal, 20(6).
[17]
Giang, K. A., Nilvebrant, J., Liu, H., Káradóttir, H., Diao, Y., Svensson Gelius, S. & Nygren, P.-Å. (2025). An Anti-BCMA Affibody Affinity Protein for Therapeutic and Diagnostic Use in Multiple Myeloma. International Journal of Molecular Sciences, 26(11).
[18]
Thorell, H., Karlander, M., Thalén, N., Fresk, M., Villacañas González, M. D. C., Jung, T. ... Rockberg, J. (2025). Selective DNA delivery through amodular AAV platform utilising Affibody binding domains. Human Gene Therapy, 36(3-4), E211-E212.
[19]
Esnal, M. R., Arrías, P. N., Rockberg, J. & Malm, M. (2025). Understanding recombinant AAV production kinetics in HEK293 cells. Human Gene Therapy, 36(3-4), E189-E189.
[20]
Arrías, P. N., Esnal, M. R. & Malm, M. (2025). Imaging the rAAV manufacturing process : assessing the subcellular localisation of capsids during production. Human Gene Therapy, 36(3-4), E187-E188.
[21]
Cristina, V., Giulia, R., Yin, W., Mathilde, H., Dipambita, R., Gräslund, T. ... Stefano, R. (2025). Affibodies as valuable tool to prevent β2m aggregation under lysosomal-like conditions. Biology Direct, 20(1).
[22]
Johansson, C., Schrama, E. J., Kotol, D., Hober, A., Koeks, Z., van de Velde, N. M. ... Al-Khalili Szigyarto, C. (2025). Contrasting Becker and Duchenne muscular dystrophy serum biomarker candidates by using data independent acquisition LC-MS/MS. Skeletal Muscle, 15(1).
[23]
Rönning, S., Thorell, H., Malm, M. & Rockberg, J. (2025). Automated plasmid purification can reducemanual labour and increase titres in AAV production. Human Gene Therapy, 36(3-4), E179-E180.
[24]
Hanitrarimalala, V., Prgomet, Z., Hedhammar, M., Tassidis, H. & Wingren, A. G. (2025). In vitro 3D modeling of colorectal cancer: the pivotal role of the extracellular matrix, stroma and immune modulation. Frontiers in Genetics, 16.
[25]
Zimmermann, I., Dölle, M., Friberg, O., Atallah, E., Eilts, F., Chotteau, V. ... Berensmeier, S. (2025). Calcium-dependent magnetic separation: A novel approach for the integrated processing of high-quality mAbs. Separation and Purification Technology, 371.
[26]
Sadler, C. J., Creamer, A., Giang, K. A., Darmawan, K. K., Shamsabadi, A., Richards, D. A. ... Stevens, M. M. (2025). Adding a Twist to Lateral Flow Immunoassays : A Direct Replacement of Antibodies with Helical Affibodies, from Selection to Application. Journal of the American Chemical Society, 147(14), 11925-11940.
[27]
Westerberg, C., Mestre Borras, A., Ståhl, S. & Löfblom, J. (2025). Affibody-based HER2 prodrug shows conditional cytotoxic effect on HER2-positive cancer cells. Biochemical and Biophysical Research Communications - BBRC, 758.
[28]
Teworte, S., Behrens, M. C., Widhe, M., Gurzeler, L.-A., Hedhammar, M. & Luciani, P. (2025). A Fibronectin (FN)-Silk 3D Cell Culture Model as a Screening Tool for Repurposed Antifibrotic Drug Candidates for Endometriosis. Small.
[29]
Zimmermann, I., Eilts, F., Galler, A. S., Bayer, J., Hober, S. & Berensmeier, S. (2025). Immobilizing calcium-dependent affinity ligand onto iron oxide nanoparticles for mild magnetic mAb separation. Biotechnology Reports, 45.
[30]
Gkouma, S., Bhalla, N., Frapard, S., Jönsson, A., Gürbüz, H., Dogan, A. A. ... Hedhammar, M. (2025). Standalone single- and bi-layered human skin 3D models supported by recombinant silk feature native spatial organization. Biofabrication, 17(1).
[31]
Davoodi, S., Ornithopoulou, E., J. Gavillet, C., Davydok, A., Roth, S. V., Lendel, C. & Lundell, F. (2025). Confinement induced self-assembly of protein nanofibrils probed by microfocus X-ray scattering. Journal of Physical Chemistry B, 129(3), 1070-1081.
[32]
Ståhl, S., Lindberg, H., Hjelm, L. C., Löfblom, J. & Dahlsson Leitao, C. (2024). Engineering of Affibody Molecules. Cold Spring Harbor Protocols, 2024(11).
[33]
Gkouma, S., Widhe, M. & Hedhammar, M. (2024). Functionalized Silk Matrices For Single- Or Bi-layered Models Of Barrier Tissue. Tissue Engineering. Part A, 30(15-16), S61-S62.
[34]
Nhi, P., Åstrand, C., Hedhammar, M. & Al-Khalili Szigyarto, C. (2024). Generation of cardiomyocyte cell models for personalized medicine. Neuromuscular Disorders, 43.
[35]
Johansson, C., Boehler, J., Brown, K., Koeks, Z., Schrama, E., van de Velde, N. ... Al-Khalili Szigyarto, C. (2024). Identification of Gene‐Therapy Responsive Blood Biomarkers in mdx Mouse Model. Journal of Cachexia, Sarcopenia and Muscle, 7(2), 187-198.
[36]
Costa, M., van der Geer, L., Joaquim, M., Hammarström, B., Tanriverdi, S., Jönsson, H. ... Russom, A. (2024). EchoTilt: An Acoustofluidic Method for the Capture and Enrichment of Nanoplastics Directed Toward Drinking Water Monitoring. Micromachines, 15(12).
[37]
Arrias, P. N., Osmanli, Z., Peralta, E., Chinestrad, P. M., Monzon, A. M. & Tosatto, S. C. E. (2024). Diversity and structural-functional insights of alpha-solenoid proteins. Protein Science, 33(11).
[38]
Möller, M. (2024). Engineering conditional binding for enhanced protein therapeutics (Doctoral thesis , Kungliga Tekniska högskolan, TRITA-CBH-FOU 2024:60). Retrieved from https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-356757.
[39]
Mebrahtu, A., Laurén, I., Veerman, R., Akpinar, G. G., Lord, M., Kostakis, A. ... Mangsbo, S. (2024). A bispecific CD40 agonistic antibody allowing for antibody-peptide conjugate formation to enable cancer-specific peptide delivery, resulting in improved T proliferation and anti-tumor immunity in mice. Nature Communications, 15(1).
[40]
Clinton, J., Westerlund, K., Eriksson Karlström, A. & Gräslund, T. (2024). Affibody-mediated peptide nucleic acid pretargeting for delivery of cytotoxic payloads to HER2 positive carcinoma. Journal of Peptide Science, 30.
[41]
Jönsson, M., Mushtaq, A. U., Nagy, T. M., von Witting, E., Löfblom, J., Nam, K. ... Hober, S. (2024). Cooperative folding as a molecular switch in an evolved antibody binder. Journal of Biological Chemistry, 300(11).
[42]
Ek, M., Nilvebrant, J., Nygren, P.-Å., Ståhl, S., Lindberg, H. & Löfblom, J. (2024). An anti-sortilin affibody-peptide fusion inhibits sortilin-mediated progranulin degradation. Frontiers in Immunology, 15.
[43]
Lee, S., Portlock, T. J., Garcia-Guevara, J. F., von Feilitzen, K., Johansson, F., Zhang, C. ... Shoaie, S. (2024). Global compositional and functional states of the human gut microbiome in health and disease. Genome Research, 34(6), 967-978.
[44]
Mamand, D. R., Bazaz, S., Mohammad, D. K., Liang, X., Pavlova, S., Mim, C. ... EL-Andaloussi, S. (2024). Extracellular vesicles originating from melanoma cells promote dysregulation in haematopoiesis as a component of cancer immunoediting. Journal of Extracellular Vesicles, 13(7).
[45]
Dannemeyer, M., Berling, A., Kanje, S., Enstedt, H., Xu, L., Afshari, D. ... Tegel, H. (2024). Fast and robust recombinant protein production utilizing episomal stable pools in WAVE bioreactors. Protein Expression and Purification, 221.
[46]
Aniander, G. (2024). Improved candidate screening through tailored co-culture assays and precise tuning of protein expression (Licentiate thesis , KTH Royal Institute of Technology, Stockholm, TRITA-CBH-FOU 2024:17). Retrieved from https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-346648.
[47]
Bragina, O., Tashireva, L., Loos, D., Chernov, V., Hober, S. & Tolmachev, V. (2024). Evaluation of Approaches for the Assessment of HER2 Expression in Breast Cancer by Radionuclide Imaging Using the Scaffold Protein [<sup>99m</sup>Tc]Tc-ADAPT6. Pharmaceutics, 16(4).
[48]
Yan, J., Bangalore, C. R., Nikouyan, N., Appelberg, S., Silva, D. N., Yao, H. ... Saellberg, M. (2024). Distinct roles of vaccine-induced SARS-CoV-2-specific neutralizing antibodies and T cells in protection and disease. Molecular Therapy, 32(2), 540-555.
[49]
Mebrahtu, A., Aniander, G., Mega, A., Moradi, M., Thalén, N., Gudmundsdotter, L. ... Rockberg, J. (2024). Co-culture platform for tuning of cancer receptor density allows for evaluation of bispecific immune cell engagers. New Biotechnology, 79, 120-126.
[50]
Marking, U., Bladh, O., Aguilera, K., Yang, Y., Greilert Norin, N., Blom, K. ... Thålin, C. (2024). Humoral immune responses to the monovalent xbb.1.5-adapted bnt162b2 mrna booster in sweden. The Lancet - Infectious diseases, 24(2), e80-e81.