Class information for:
Level 1: DIPHTHERIA TOXIN//PSEUDOMONAS EXOTOXIN//IMMUNOTOXIN

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
7843 1321 38.6 74%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
103 3       O GLCNACYLATION//O GLCNAC TRANSFERASE//O GLCNACASE 73436
1876 2             RIBOSOME INACTIVATING PROTEIN//RICIN//TRICHOSANTHIN 6016
7843 1                   DIPHTHERIA TOXIN//PSEUDOMONAS EXOTOXIN//IMMUNOTOXIN 1321

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DIPHTHERIA TOXIN authKW 486742 6% 25% 85
2 PSEUDOMONAS EXOTOXIN authKW 370125 2% 49% 33
3 IMMUNOTOXIN authKW 345584 8% 14% 105
4 PSEUDOMONAS EXOTOXIN A authKW 312814 2% 44% 31
5 RECOMBINANT IMMUNOTOXIN authKW 295584 2% 47% 27
6 EXOTOXIN A authKW 126012 1% 32% 17
7 BIOTHER Y SECT address 124807 1% 60% 9
8 PHARMACEUT PROD DEV address 114112 2% 25% 20
9 EXPT MED IMMUNOTHER Y address 112729 1% 26% 19
10 ANTIBODY REFOLDING authKW 92455 0% 100% 4

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biochemistry & Molecular Biology 3873 46% 0% 604
2 Oncology 1531 19% 0% 253
3 Immunology 722 13% 0% 169
4 Microbiology 464 9% 0% 121
5 Biochemical Research Methods 324 6% 0% 81
6 Cell Biology 261 9% 0% 121
7 Biophysics 235 6% 0% 78
8 Infectious Diseases 163 4% 0% 54
9 Hematology 83 3% 0% 43
10 Medicine, Research & Experimental 74 4% 0% 53

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOTHER Y SECT 124807 1% 60% 9
2 PHARMACEUT PROD DEV 114112 2% 25% 20
3 EXPT MED IMMUNOTHER Y 112729 1% 26% 19
4 SECT MOL CANC THER EUT 87384 1% 34% 11
5 SECT EXPT CANC IMMUNOL 52828 0% 57% 4
6 CANC NIHHHS 46227 0% 100% 2
7 INNOVAT PENZBERG 46227 0% 100% 2
8 CLIN IMMUNOTHER Y SECT 38516 0% 33% 5
9 IMMUNTHER IE 34668 0% 50% 3
10 DCBDC 30817 0% 67% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF BIOLOGICAL CHEMISTRY 3604 12% 0% 157
2 PROTEIN ENGINEERING 3282 1% 1% 18
3 CLINICAL CANCER RESEARCH 2313 3% 0% 39
4 BIOCONJUGATE CHEMISTRY 2011 2% 0% 21
5 TOXINS 1945 1% 1% 11
6 MOLECULAR CANCER THERAPEUTICS 1811 1% 0% 18
7 BIOCHEMISTRY 1797 5% 0% 66
8 INFECTION AND IMMUNITY 1774 3% 0% 46
9 FEMS MICROBIOLOGY IMMUNOLOGY 1632 0% 2% 3
10 JOURNAL OF IMMUNOTHERAPY 1097 1% 1% 9

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 DIPHTHERIA TOXIN 486742 6% 25% 85 Search DIPHTHERIA+TOXIN Search DIPHTHERIA+TOXIN
2 PSEUDOMONAS EXOTOXIN 370125 2% 49% 33 Search PSEUDOMONAS+EXOTOXIN Search PSEUDOMONAS+EXOTOXIN
3 IMMUNOTOXIN 345584 8% 14% 105 Search IMMUNOTOXIN Search IMMUNOTOXIN
4 PSEUDOMONAS EXOTOXIN A 312814 2% 44% 31 Search PSEUDOMONAS+EXOTOXIN+A Search PSEUDOMONAS+EXOTOXIN+A
5 RECOMBINANT IMMUNOTOXIN 295584 2% 47% 27 Search RECOMBINANT+IMMUNOTOXIN Search RECOMBINANT+IMMUNOTOXIN
6 EXOTOXIN A 126012 1% 32% 17 Search EXOTOXIN+A Search EXOTOXIN+A
7 ANTIBODY REFOLDING 92455 0% 100% 4 Search ANTIBODY+REFOLDING Search ANTIBODY+REFOLDING
8 B3 ANTIBODY 92455 0% 100% 4 Search B3+ANTIBODY Search B3+ANTIBODY
9 MOXETUMOMAB PASUDOTOX 87114 1% 54% 7 Search MOXETUMOMAB+PASUDOTOX Search MOXETUMOMAB+PASUDOTOX
10 DIVALENT ANTIBODY TOXIN 69341 0% 100% 3 Search DIVALENT+ANTIBODY+TOXIN Search DIVALENT+ANTIBODY+TOXIN

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 CHENAL, A , NIZARD, P , GILLET, D , (2002) STRUCTURE AND FUNCTION OF DIPHTHERIA TOXIN: FROM PATHOLOGY TO ENGINEERING.JOURNAL OF TOXICOLOGY-TOXIN REVIEWS. VOL. 21. ISSUE 4. P. 321-358 120 70% 18
2 LONDON, E , (1992) DIPHTHERIA-TOXIN - MEMBRANE INTERACTION AND MEMBRANE TRANSLOCATION.BIOCHIMICA ET BIOPHYSICA ACTA. VOL. 1113. ISSUE 1. P. 25-51 127 72% 125
3 KREITMAN, RJ , (2006) IMMUNOTOXINS FOR TARGETED CANCER THERAPY.AAPS JOURNAL. VOL. 8. ISSUE 3. P. E532-E551 108 41% 135
4 KREITMAN, RJ , (2009) RECOMBINANT IMMUNOTOXINS CONTAINING TRUNCATED BACTERIAL TOXINS FOR THE TREATMENT OF HEMATOLOGIC MALIGNANCIES.BIODRUGS. VOL. 23. ISSUE 1. P. 1 -13 78 53% 63
5 WELDON, JE , PASTAN, I , (2011) A GUIDE TO TAMING A TOXIN - RECOMBINANT IMMUNOTOXINS CONSTRUCTED FROM PSEUDOMONAS EXOTOXIN A FOR THE TREATMENT OF CANCER.FEBS JOURNAL. VOL. 278. ISSUE 23. P. 4683-4700 74 50% 64
6 COLLIER, RJ , (2001) UNDERSTANDING THE MODE OF ACTION OF DIPHTHERIA TOXIN: A PERSPECTIVE ON PROGRESS DURING THE 20TH CENTURY.TOXICON. VOL. 39. ISSUE 11. P. 1793-1803 56 76% 156
7 KREITMAN, RJ , (2009) RECOMBINANT IMMUNOTOXINS FOR THE TREATMENT OF CHEMORESISTANT HEMATOLOGIC MALIGNANCIES.CURRENT PHARMACEUTICAL DESIGN. VOL. 15. ISSUE 23. P. 2652-2664 79 47% 28
8 LAI, B , ZHAO, G , LONDON, E , (2008) BEHAVIOR OF THE DEEPLY INSERTED HELICES IN DIPHTHERIA TOXIN T DOMAIN: HELICES 5, 8, AND 9 INTERACT STRONGLY AND PROMOTE PORE FORMATION, WHILE HELICES 6/7 LIMIT PORE FORMATION.BIOCHEMISTRY. VOL. 47. ISSUE 15. P. 4565-4574 43 91% 8
9 WANG, J , LONDON, E , (2009) THE MEMBRANE TOPOGRAPHY OF THE DIPHTHERIA TOXIN T DOMAIN LINKED TO THE A CHAIN REVEALS A TRANSIENT TRANSMEMBRANE HAIRPIN AND POTENTIAL TRANSLOCATION MECHANISMS.BIOCHEMISTRY. VOL. 48. ISSUE 43. P. 10446 -10456 43 88% 9
10 KREITMAN, RJ , PASTAN, I , (2006) IMMUNOTOXINS IN THE TREATMENT OF HEMATOLOGIC MALIGNANCIES.CURRENT DRUG TARGETS. VOL. 7. ISSUE 10. P. 1301-1311 87 41% 45

Classes with closest relation at Level 1


Rank Class id link
1 28347 MESOTHELIN//ERC MESOTHELIN//MORAB 009
2 6520 IMMUNOTOXIN//GELONIN//RICIN A CHAIN
3 25493 LEUKEMIA STEM CELLS//LEUKEMIC STEM CELLS//CD123
4 20385 ELONGATION FACTOR 2//EEF2K//ELONGATION FACTOR 2 KINASE
5 11014 ADP RIBOSYLTRANSFERASE//ADP RIBOSYLATION//MONO ADP RIBOSYLATION
6 2245 RIBOSOME INACTIVATING PROTEIN//RICIN//TRICHOSANTHIN
7 13436 DIPHTHERIA//CORYNEBACTERIUM DIPHTHERIAE//CORYNEBACTERIUM ULCERANS
8 11281 ANTIBODY DRUG CONJUGATE//GEMTUZUMAB OZOGAMICIN//MYLOTARG
9 26972 GYPSOPHILA TRICHOTOMA//GYPSOGENIN//GYPSOPHILA OLDHAMIANA
10 10314 EXOU//EXOS//EXOENZYME S

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