Class information for:
Level 1: CYP2A6//COTININE//CYP2A5

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
6598 1465 33.7 72%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
1 4 ECONOMICS//EDUCATION & EDUCATIONAL RESEARCH//PSYCHOL 3876184
341 3       SMOKING CESSATION//SMOKING//TOBACCO CONTROL 36872
18 2             SMOKING CESSATION//SMOKING//TOBACCO CONTROL 36872
6598 1                   CYP2A6//COTININE//CYP2A5 1465

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CYP2A6 authKW 1280019 8% 56% 110
2 COTININE authKW 952395 13% 23% 197
3 CYP2A5 authKW 380766 2% 70% 26
4 NICOTINE METABOLISM authKW 372909 2% 62% 29
5 TRANS 3 HYDROXYCOTININE authKW 297725 1% 71% 20
6 CYP2A13 authKW 281352 1% 75% 18
7 CLIN PHARMACOL EXPT THER EUT address 201851 3% 21% 47
8 COUMARIN 7 HYDROXYLASE authKW 187568 1% 75% 12
9 NICOTINE METABOLITES authKW 187562 1% 60% 15
10 NICOTINE authKW 182769 18% 3% 262

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Pharmacology & Pharmacy 4704 34% 0% 499
2 Chemistry, Analytical 2540 19% 0% 276
3 Toxicology 2110 12% 0% 175
4 Substance Abuse 1414 5% 0% 70
5 Biochemical Research Methods 1057 10% 0% 143
6 Medical Laboratory Technology 766 4% 0% 59
7 Public, Environmental & Occupational Health 637 10% 0% 143
8 Chemistry, Medicinal 142 4% 0% 54
9 Oncology 75 6% 0% 87
10 Genetics & Heredity 54 4% 0% 59

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CLIN PHARMACOL EXPT THER EUT 201851 3% 21% 47
2 CLIN PHARMACOL EXPT THER EUTMED SERV 65126 0% 63% 5
3 WORLDWIDE SCI AFFAIRS 46892 0% 75% 3
4 MECANISMES ACT NICOTIANEES 41683 0% 100% 2
5 CAMPBELL FAMILY MENTAL HLTH 40789 2% 8% 26
6 ADDICT MENTAL HLTH 35471 4% 3% 56
7 PHARMACOBIODYNAM 35156 1% 19% 9
8 BIO FOOD CHEM 27787 0% 67% 2
9 MED SERVSAN FRANCISCO GEN HOSPMED 27787 0% 67% 2
10 SAN FRANCISCO GEN HOSP MED 27416 0% 26% 5

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DRUG METABOLISM AND DISPOSITION 14724 5% 1% 73
2 NICOTINE & TOBACCO RESEARCH 11713 3% 2% 37
3 PHARMACOGENETICS 7110 1% 2% 18
4 PHARMACOGENETICS AND GENOMICS 5283 1% 2% 17
5 CLINICAL PHARMACOLOGY & THERAPEUTICS 4846 3% 1% 37
6 DRUG METABOLISM AND PHARMACOKINETICS 2871 1% 1% 10
7 JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS 2780 2% 1% 22
8 JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 2322 3% 0% 37
9 CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION 2198 2% 0% 26
10 XENOBIOTICA 2120 1% 1% 20

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 CYP2A6 1280019 8% 56% 110 Search CYP2A6 Search CYP2A6
2 COTININE 952395 13% 23% 197 Search COTININE Search COTININE
3 CYP2A5 380766 2% 70% 26 Search CYP2A5 Search CYP2A5
4 NICOTINE METABOLISM 372909 2% 62% 29 Search NICOTINE+METABOLISM Search NICOTINE+METABOLISM
5 TRANS 3 HYDROXYCOTININE 297725 1% 71% 20 Search TRANS+3+HYDROXYCOTININE Search TRANS+3+HYDROXYCOTININE
6 CYP2A13 281352 1% 75% 18 Search CYP2A13 Search CYP2A13
7 COUMARIN 7 HYDROXYLASE 187568 1% 75% 12 Search COUMARIN+7+HYDROXYLASE Search COUMARIN+7+HYDROXYLASE
8 NICOTINE METABOLITES 187562 1% 60% 15 Search NICOTINE+METABOLITES Search NICOTINE+METABOLITES
9 NICOTINE 182769 18% 3% 262 Search NICOTINE Search NICOTINE
10 NICOTINE METABOLITE RATIO 168815 1% 90% 9 Search NICOTINE+METABOLITE+RATIO Search NICOTINE+METABOLITE+RATIO

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 HUKKANEN, J , JACOB, P , BENOWITZ, NL , (2005) METABOLISM AND DISPOSITION KINETICS OF NICOTINE.PHARMACOLOGICAL REVIEWS. VOL. 57. ISSUE 1. P. 79 -115 160 43% 626
2 MWENIFIUMBO, JC , TYNDALE, RF , (2007) GENETIC VARIABILITY IN CYP2A6 AND THE PHARMACOKINETICS OF NICOTINE.PHARMACOGENOMICS. VOL. 8. ISSUE 10. P. 1385 -1402 90 76% 57
3 ROSSINI, A , SIMAO, TD , ALBANO, RM , PINTO, LFR , (2008) CYP2A6 POLYMORPHISMS AND RISK FOR TOBACCO-RELATED CANCERS.PHARMACOGENOMICS. VOL. 9. ISSUE 11. P. 1737-1752 81 79% 31
4 ALLENBY, CE , BOYLAN, KA , LERMAN, C , FALCONE, M , (2016) PRECISION MEDICINE FOR TOBACCO DEPENDENCE: DEVELOPMENT AND VALIDATION OF THE NICOTINE METABOLITE RATIO.JOURNAL OF NEUROIMMUNE PHARMACOLOGY. VOL. 11. ISSUE 3. P. 471 -483 66 69% 2
5 ABU-BAKAR, A , HAKKOLA, J , JUVONEN, R , RAHNASTO-RILLA, M , RAUNIO, H , LANG, MA , (2013) FUNCTION AND REGULATION OF THE CYP2A5/CYP2A6 GENES IN RESPONSE TO TOXIC INSULTS IN THE LIVER.CURRENT DRUG METABOLISM. VOL. 14. ISSUE 1. P. 137-150 93 56% 14
6 DI, YM , CHOW, VDW , YANG, LP , ZHOU, SF , (2009) STRUCTURE, FUNCTION, REGULATION AND POLYMORPHISM OF HUMAN CYTOCHROME P450 2A6.CURRENT DRUG METABOLISM. VOL. 10. ISSUE 7. P. 754-780 111 45% 51
7 NAKAJIMA, M , (2007) SMOKING BEHAVIOR AND RELATED CANCERS: THE ROLE OF CYP2A6 POLYMORPHISMS.CURRENT OPINION IN MOLECULAR THERAPEUTICS. VOL. 9. ISSUE 6. P. 538-544 58 81% 12
8 TRICKER, AR , (2003) NICOTINE METABOLISM, HUMAN DRUG METABOLISM POLYMORPHISMS, AND SMOKING BEHAVIOUR.TOXICOLOGY. VOL. 183. ISSUE 1-3. P. 151 -173 75 61% 71
9 WASSENAAR, CA , ZHOU, Q , TYNDALE, RF , (2016) CYP2A6 GENOTYPING METHODS AND STRATEGIES USING REAL-TIME AND END POINT PCR PLATFORMS.PHARMACOGENOMICS. VOL. 17. ISSUE 2. P. 147 -162 41 84% 0
10 CHENOWETH, MJ , NOVALEN, M , HAWK, LW , SCHNOLL, RA , GEORGE, TP , CINCIRIPINI, PM , LERMAN, C , TYNDALE, RF , (2014) KNOWN AND NOVEL SOURCES OF VARIABILITY IN THE NICOTINE METABOLITE RATIO IN A LARGE SAMPLE OF TREATMENT-SEEKING SMOKERS.CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION. VOL. 23. ISSUE 9. P. 1773 -1782 41 77% 11

Classes with closest relation at Level 1


Rank Class id link
1 13179 NNK//TOBACCO SPECIFIC NITROSAMINES//TOBACCO SPECIFIC N NITROSAMINES
2 21487 MENTHOL//MENTHOL CIGARETTES//COMMUNITY MED HLTH CARE ADJUNCT
3 6260 BEITRAGE ZUR TABAKFORSCHUNG INTERNATIONAL//PHILIP MORRIS INT RD//SMOKE CHEMISTRY
4 8079 ENVIRONMENTAL TOBACCO SMOKE//PASSIVE SMOKING//SECONDHAND SMOKE
5 31116 EXHALED CARBON MONOXIDE//CARBOXYHEMOGLOBIN DIFFERENCE//EXHALED CO
6 26985 PUTRESCINE N METHYLTRANSFERASE//METHYLPUTRESCINE OXIDASE//NICOTINE N DEMETHYLASE
7 18117 COOKING OIL FUMES//COOKING FUMES//TRANS TRANS 2 4 DECADIENAL
8 4044 MATERNAL SMOKING//SMOKING//SMOKING CESSATION
9 27533 PHARMACOKINET BIOANAL//HUMANIZED LIVER//PL DEV BIOL
10 5382 GABRA2//VIRGINIA PSYCHIAT BEHAV GENET//CHRNA3

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