Class information for:
Level 1: STAT3//GRIM 19//STAT3 INHIBITOR

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
5366 1633 47.5 93%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
422 3       C REACTIVE PROTEIN//STAT3//HAPTOGLOBIN 28303
1051 2             STAT3//GP130//ONCOSTATIN M 10071
5366 1                   STAT3//GRIM 19//STAT3 INHIBITOR 1633

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 STAT3 authKW 2125046 35% 20% 577
2 GRIM 19 authKW 485612 2% 84% 31
3 STAT3 INHIBITOR authKW 343686 2% 74% 25
4 SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3 authKW 215624 4% 18% 64
5 PSTAT3 authKW 99872 1% 23% 23
6 OPB 31121 authKW 93486 0% 100% 5
7 S3I 201 authKW 77903 0% 83% 5
8 GALIELLALACTONE authKW 76341 0% 58% 7
9 CO EXPRESSION PLASMID authKW 74789 0% 100% 4
10 STAT3 DECOY authKW 74789 0% 100% 4

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Oncology 16077 51% 0% 836
2 Cell Biology 2343 21% 0% 338
3 Biochemistry & Molecular Biology 840 22% 0% 365
4 Chemistry, Medicinal 483 6% 0% 95
5 Medicine, Research & Experimental 321 6% 0% 104
6 Genetics & Heredity 226 6% 0% 103
7 Pathology 119 3% 0% 51
8 Hematology 64 3% 0% 45
9 Pharmacology & Pharmacy 55 6% 0% 101
10 Immunology 46 5% 0% 74

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CHINESE MED PLANTS OURCE LINGNAN 56092 0% 100% 3
2 CHILDHOOD CANC 42366 2% 9% 26
3 MED PLANTS OURCE SCI ENGN 42067 0% 75% 3
4 H LEE MOFFIT CANC INTERDISCIP 37394 0% 100% 2
5 NATIONWIDE CHILDRENS HOSP CHILDHOOD 37394 0% 100% 2
6 ONCOLMOL ONCOL PROGRAM 37394 0% 100% 2
7 UNIT 064 37394 0% 100% 2
8 MOL ONCOL PROGRAM 32234 2% 6% 29
9 CANC IMMUNOTHER EUT TUMOR IMMUNOL 30262 1% 12% 14
10 COSMETOL PLAST SURG 24928 0% 67% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MOLECULAR CANCER THERAPEUTICS 4658 2% 1% 32
2 ONCOGENE 4425 4% 0% 66
3 ONCOTARGET 3893 3% 0% 51
4 NEOPLASIA 3179 1% 1% 17
5 CANCER RESEARCH 2385 4% 0% 72
6 MOLECULAR CANCER 1502 1% 1% 12
7 ONCOLOGY REPORTS 1433 2% 0% 28
8 INTERNATIONAL JOURNAL OF ONCOLOGY 1387 2% 0% 27
9 CURRENT CANCER DRUG TARGETS 1244 0% 1% 8
10 CLINICAL CANCER RESEARCH 1238 2% 0% 32

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 STAT3 2125046 35% 20% 577 Search STAT3 Search STAT3
2 GRIM 19 485612 2% 84% 31 Search GRIM+19 Search GRIM+19
3 STAT3 INHIBITOR 343686 2% 74% 25 Search STAT3+INHIBITOR Search STAT3+INHIBITOR
4 SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3 215624 4% 18% 64 Search SIGNAL+TRANSDUCER+AND+ACTIVATOR+OF+TRANSCRIPTION+3 Search SIGNAL+TRANSDUCER+AND+ACTIVATOR+OF+TRANSCRIPTION+3
5 PSTAT3 99872 1% 23% 23 Search PSTAT3 Search PSTAT3
6 OPB 31121 93486 0% 100% 5 Search OPB+31121 Search OPB+31121
7 S3I 201 77903 0% 83% 5 Search S3I+201 Search S3I+201
8 GALIELLALACTONE 76341 0% 58% 7 Search GALIELLALACTONE Search GALIELLALACTONE
9 CO EXPRESSION PLASMID 74789 0% 100% 4 Search CO+EXPRESSION+PLASMID Search CO+EXPRESSION+PLASMID
10 STAT3 DECOY 74789 0% 100% 4 Search STAT3+DECOY Search STAT3+DECOY

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 WANG, XC , CROWE, PJ , GOLDSTEIN, D , YANG, JL , (2012) STAT3 INHIBITION, A NOVEL APPROACH TO ENHANCING TARGETED THERAPY IN HUMAN CANCERS.INTERNATIONAL JOURNAL OF ONCOLOGY. VOL. 41. ISSUE 4. P. 1181-1191 86 66% 54
2 SIVEEN, KS , SIKKA, S , SURANA, R , DAI, XY , ZHANG, JW , KUMAR, AP , TAN, BKH , SETHI, G , BISHAYEE, A , (2014) TARGETING THE STAT3 SIGNALING PATHWAY IN CANCER: ROLE OF SYNTHETIC AND NATURAL INHIBITORS.BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER. VOL. 1845. ISSUE 2. P. 136 -154 100 36% 105
3 ZHAO, CG , LI, HM , LIN, HJ , YANG, SL , LIN, JY , LIANG, G , (2016) FEEDBACK ACTIVATION OF STAT3 AS A CANCER DRUG-RESISTANCE MECHANISM.TRENDS IN PHARMACOLOGICAL SCIENCES. VOL. 37. ISSUE 1. P. 47 -61 56 64% 8
4 WU, P , WU, D , ZHAO, LF , HUANG, LJ , SHEN, G , HUANG, J , CHAI, Y , (2016) PROGNOSTIC ROLE OF STAT3 IN SOLID TUMORS: A SYSTEMATIC REVIEW AND META-ANALYSIS.ONCOTARGET. VOL. 7. ISSUE 15. P. 19863 -19883 64 73% 2
5 SIDDIQUEE, KAZ , TURKSON, J , (2008) STAT3 AS A TARGET FOR INDUCING APOPTOSIS IN SOLID AND HEMATOLOGICAL TUMORS.CELL RESEARCH. VOL. 18. ISSUE 2. P. 254-267 88 57% 97
6 MASCIOCCHI, D , GELAIN, A , VILLA, S , MENEGHETTI, F , BARLOCCO, D , (2011) SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3 (STAT3): A PROMISING TARGET FOR ANTICANCER THERAPY.FUTURE MEDICINAL CHEMISTRY. VOL. 3. ISSUE 5. P. 567 -597 93 56% 23
7 DEVARAJAN, E , HUANG, S , (2009) STAT3 AS A CENTRAL REGULATOR OF TUMOR METASTASES.CURRENT MOLECULAR MEDICINE. VOL. 9. ISSUE 5. P. 626-633 71 65% 84
8 FURTEK, SL , BACKOS, DS , MATHESON, CJ , REIGAN, P , (2016) STRATEGIES AND APPROACHES OF TARGETING STAT3 FOR CANCER TREATMENT.ACS CHEMICAL BIOLOGY. VOL. 11. ISSUE 2. P. 308 -318 51 53% 11
9 FURQAN, M , AKINLEYE, A , MUKHI, N , MITTAL, V , CHEN, YM , LIU, DL , (2013) STAT INHIBITORS FOR CANCER THERAPY.JOURNAL OF HEMATOLOGY & ONCOLOGY. VOL. 6. ISSUE . P. - 57 69% 39
10 YUE, PB , LOPEZ-TAPIA, F , PALADINO, D , LI, YF , CHEN, CH , NAMANJA, AT , HILLIARD, T , CHEN, Y , TIUS, MA , TURKSON, J , (2016) HYDROXAMIC ACID AND BENZOIC ACID-BASED STAT3 INHIBITORS SUPPRESS HUMAN GLIOMA AND BREAST CANCER PHENOTYPES IN VITRO AND IN VIVO.CANCER RESEARCH. VOL. 76. ISSUE 3. P. 652 -663 41 93% 2

Classes with closest relation at Level 1


Rank Class id link
1 3696 STAT1//STAT5//STAT
2 36997 NICLOSAMIDE//WNT SIGNALING INHIBITOR//50 GROWTH INHIBITION VALUE
3 20921 BASAL CELL CARCINOMA CELLS//NIJMEGEN MOL LIFE SCI 278//SILTUXIMAB
4 7798 SOCS1//SOCS//SOCS3
5 16985 CUCURBITACINS//CUCURBITACIN B//CUCURBITACIN E
6 22506 CARDIOTROPHIN 1//HSP 56//INTERLEUKIN 6 CYTOKINE FAMILY
7 13676 TOFACITINIB//JAK3//JANUS KINASE
8 20517 INTERLEUKIN 11//IL 11//RECOMBINANT HUMAN INTERLEUKIN 11
9 36855 ARHI//APLASIA RAS HOMOLOG MEMBER I//APLASIA RAS HOMOLOGUE MEMBER I ARHI
10 30546 NUCLEAR EGFR//EGFR FAMILY RECEPTORS//P TYR

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