Class information for:
Level 1: PYRUVATE DEHYDROGENASE COMPLEX//DIHYDROLIPOAMIDE DEHYDROGENASE//LIPOYL DOMAIN

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
4028 1860 34.3 64%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
389 3       PEROXISOME//CARNITINE//JOURNAL OF INHERITED METABOLIC DISEASE 30841
2868 2             PYRUVATE DEHYDROGENASE COMPLEX//NONKETOTIC HYPERGLYCINEMIA//DIHYDROLIPOAMIDE DEHYDROGENASE 2878
4028 1                   PYRUVATE DEHYDROGENASE COMPLEX//DIHYDROLIPOAMIDE DEHYDROGENASE//LIPOYL DOMAIN 1860

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PYRUVATE DEHYDROGENASE COMPLEX authKW 1080894 7% 48% 137
2 DIHYDROLIPOAMIDE DEHYDROGENASE authKW 629652 3% 63% 61
3 LIPOYL DOMAIN authKW 509364 2% 97% 32
4 PYRUVATE DEHYDROGENASE KINASE authKW 468397 3% 52% 55
5 PYRUVATE DEHYDROGENASE authKW 436084 6% 23% 114
6 PYRUVATE DEHYDROGENASE DEFICIENCY authKW 284969 1% 69% 25
7 PYRUVATE DEHYDROGENASE COMPLEX DEFICIENCY authKW 257639 1% 83% 19
8 PYRIDINE NUCLEOTIDE DISULFIDE OXIDOREDUCTASE authKW 213396 1% 100% 13
9 ALPHA KETO ACID DEHYDROGENASE COMPLEX authKW 201082 1% 88% 14
10 2 OXOACID DEHYDROGENASE authKW 136789 1% 83% 10

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Biochemistry & Molecular Biology 10535 61% 0% 1142
2 Biophysics 1718 12% 0% 221
3 Genetics & Heredity 747 10% 0% 179
4 Endocrinology & Metabolism 496 7% 0% 139
5 Cell Biology 354 9% 0% 168
6 Medicine, Research & Experimental 296 6% 0% 109
7 Microbiology 223 6% 0% 112
8 Pediatrics 191 5% 0% 84
9 Biochemical Research Methods 68 3% 0% 56
10 Clinical Neurology 58 4% 0% 76

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 FUNDAMENTAL MED PHARMACEUT SCI 53717 0% 55% 6
2 CHEM BIOL INTER E TRAINING PROGRAM 52527 0% 80% 4
3 GEN DEV MED 49233 0% 33% 9
4 PROT CHEM ENGN 38928 1% 22% 11
5 METAB PROGRAMME 37509 0% 29% 8
6 INHERITED DISORDERS ENERGY METAB 37302 0% 45% 5
7 CAMBRIDGE MOL RECOGNIT 36604 1% 9% 24
8 DMPK BIOTRANSFORMAT 32830 0% 100% 2
9 EXTREMOPHILE 25632 1% 16% 10
10 BIOL PHYS SPACE 24620 0% 50% 3

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOCHEMICAL JOURNAL 11063 8% 0% 141
2 JOURNAL OF INHERITED METABOLIC DISEASE 9362 3% 1% 51
3 EUROPEAN JOURNAL OF BIOCHEMISTRY 7078 5% 0% 93
4 MOLECULAR GENETICS AND METABOLISM 2509 1% 1% 22
5 JOURNAL OF BIOLOGICAL CHEMISTRY 2245 8% 0% 150
6 FEBS LETTERS 1934 4% 0% 71
7 BIOCHEMISTRY INTERNATIONAL 1796 1% 1% 19
8 BIOCHEMISTRY 1712 4% 0% 77
9 ADVANCES IN ENZYME REGULATION 1336 0% 1% 7
10 BIOCHEMISTRY-MOSCOW 1060 1% 0% 22

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 PYRUVATE DEHYDROGENASE COMPLEX 1080894 7% 48% 137 Search PYRUVATE+DEHYDROGENASE+COMPLEX Search PYRUVATE+DEHYDROGENASE+COMPLEX
2 DIHYDROLIPOAMIDE DEHYDROGENASE 629652 3% 63% 61 Search DIHYDROLIPOAMIDE+DEHYDROGENASE Search DIHYDROLIPOAMIDE+DEHYDROGENASE
3 LIPOYL DOMAIN 509364 2% 97% 32 Search LIPOYL+DOMAIN Search LIPOYL+DOMAIN
4 PYRUVATE DEHYDROGENASE KINASE 468397 3% 52% 55 Search PYRUVATE+DEHYDROGENASE+KINASE Search PYRUVATE+DEHYDROGENASE+KINASE
5 PYRUVATE DEHYDROGENASE 436084 6% 23% 114 Search PYRUVATE+DEHYDROGENASE Search PYRUVATE+DEHYDROGENASE
6 PYRUVATE DEHYDROGENASE DEFICIENCY 284969 1% 69% 25 Search PYRUVATE+DEHYDROGENASE+DEFICIENCY Search PYRUVATE+DEHYDROGENASE+DEFICIENCY
7 PYRUVATE DEHYDROGENASE COMPLEX DEFICIENCY 257639 1% 83% 19 Search PYRUVATE+DEHYDROGENASE+COMPLEX+DEFICIENCY Search PYRUVATE+DEHYDROGENASE+COMPLEX+DEFICIENCY
8 PYRIDINE NUCLEOTIDE DISULFIDE OXIDOREDUCTASE 213396 1% 100% 13 Search PYRIDINE+NUCLEOTIDE+DISULFIDE+OXIDOREDUCTASE Search PYRIDINE+NUCLEOTIDE+DISULFIDE+OXIDOREDUCTASE
9 ALPHA KETO ACID DEHYDROGENASE COMPLEX 201082 1% 88% 14 Search ALPHA+KETO+ACID+DEHYDROGENASE+COMPLEX Search ALPHA+KETO+ACID+DEHYDROGENASE+COMPLEX
10 2 OXOACID DEHYDROGENASE 136789 1% 83% 10 Search 2+OXOACID+DEHYDROGENASE Search 2+OXOACID+DEHYDROGENASE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 PATEL, KP , O'BRIEN, TW , SUBRAMONY, SH , SHUSTER, J , STACPOOLE, PW , (2012) THE SPECTRUM OF PYRUVATE DEHYDROGENASE COMPLEX DEFICIENCY: CLINICAL, BIOCHEMICAL AND GENETIC FEATURES IN 371 PATIENTS.MOLECULAR GENETICS AND METABOLISM. VOL. 105. ISSUE 1. P. 34-43 137 88% 19
2 BERG, A , DEKOK, A , (1997) 2-OXO ACID DEHYDROGENASE MULTIENZYME COMPLEXES. THE CENTRAL ROLE OF THE LIPOYL DOMAIN.BIOLOGICAL CHEMISTRY. VOL. 378. ISSUE 7. P. 617-634 133 88% 66
3 ROCHE, TE , BAKER, JC , YAN, YH , HIROMASA, Y , GONG, XM , PENG, T , DONG, JC , TURKAN, A , KASTEN, SA , (2001) DISTINCT REGULATORY PROPERTIES OF PYRUVATE DEHYDROGENASE KINASE AND PHOSPHATASE ISOFORMS.PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY, VOL 70. VOL. 70. ISSUE . P. 33 -75 108 75% 112
4 HENGEVELD, AF , DE KOK, A , (2002) STRUCTURAL BASIS OF THE DYSFUNCTIONING OF HUMAN 2-OXO ACID DEHYDROGENASE COMPLEXES.CURRENT MEDICINAL CHEMISTRY. VOL. 9. ISSUE 4. P. 499 -520 107 71% 10
5 DE KOK, A , HENGEVELD, AF , MARTIN, A , WESTPHAL, AH , (1998) THE PYRUVATE DEHYDROGENASE MULTI-ENZYME COMPLEX FROM GRAM-NEGATIVE BACTERIA.BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY. VOL. 1385. ISSUE 2. P. 353 -366 77 91% 98
6 PERHAM, RN , (1991) DOMAINS, MOTIFS, AND LINKERS IN 2-OXO ACID DEHYDROGENASE MULTIENZYME COMPLEXES - A PARADIGM IN THE DESIGN OF A MULTIFUNCTIONAL PROTEIN.BIOCHEMISTRY. VOL. 30. ISSUE 35. P. 8501-8512 77 93% 297
7 PATEL, MS , NEMERIA, NS , FUREY, W , JORDAN, F , (2014) THE PYRUVATE DEHYDROGENASE COMPLEXES: STRUCTURE-BASED FUNCTION AND REGULATION.JOURNAL OF BIOLOGICAL CHEMISTRY. VOL. 289. ISSUE 24. P. 16615-16623 59 66% 32
8 ROCHE, TE , HIROMASA, Y , (2007) PYRUVATE DEHYDROGENASE KINASE REGULATORY MECHANISMS AND INHIBITION IN TREATING DIABETES, HEART ISCHEMIA, AND CANCER.CELLULAR AND MOLECULAR LIFE SCIENCES. VOL. 64. ISSUE 7-8. P. 830-849 84 56% 114
9 PERHAM, RN , (2000) SWINGING ARMS AND SWINGING DOMAINS IN MULTIFUNCTIONAL ENZYMES: CATALYTIC MACHINES FOR MULTISTEP REACTIONS.ANNUAL REVIEW OF BIOCHEMISTRY. VOL. 69. ISSUE . P. 961 -1004 109 47% 292
10 CRONAN, JE , (2016) ASSEMBLY OF LIPOIC ACID ON ITS COGNATE ENZYMES: AN EXTRAORDINARY AND ESSENTIAL BIOSYNTHETIC PATHWAY.MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS. VOL. 80. ISSUE 2. P. 429 -450 70 51% 4

Classes with closest relation at Level 1


Rank Class id link
1 21684 NONKETOTIC HYPERGLYCINEMIA//GLYCINE CLEAVAGE SYSTEM//NKH
2 9764 MAPLE SYRUP URINE DISEASE//BRANCHED CHAIN ALPHA KETO ACID DEHYDROGENASE COMPLEX//BRANCHED CHAIN ALPHA KETOACID DEHYDROGENASE
3 9264 TRANSKETOLASE//THIAMINE DIPHOSPHATE//THIAMIN DIPHOSPHATE
4 14422 TRYPANOTHIONE REDUCTASE//TRYPANOTHIONE//TRYPAREDOXIN
5 14819 BIOTIN PROTEIN LIGASE//PYRUVATE CARBOXYLASE//BIRA
6 19276 LACTIC ACIDOSIS//TYPE B LACTIC ACIDOSIS//FLUORESCENT INTRACELLULAR H PROBE
7 24529 AIST TSUKUBA 6 10//LEUCINE RESPONSIVE REGULATORY PROTEIN//FFRP
8 8390 ALPHA LIPOIC ACID//LIPOIC ACID//THIOCTIC ACID
9 21137 AMPLEX RED//REVERSE ELECTRON TRANSPORT//NEUROBIOCHEM GRP
10 14459 BIOTIN SYNTHASE//BIOTIN BIOSYNTHESIS//RADICAL SAM

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