Class information for:
Level 1: ATLA-ALTERNATIVES TO LABORATORY ANIMALS//EYE IRRITATION//TOXICOLOGY IN VITRO

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
3833 1899 28.4 55%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
537 3       BIOARTIFICIAL LIVER//HEPATOCYTES//HEPATOCYTE TRANSPLANTATION 19236
908 2             BIOARTIFICIAL LIVER//HEPATOCYTES//HEPATOCYTE TRANSPLANTATION 11255
3833 1                   ATLA-ALTERNATIVES TO LABORATORY ANIMALS//EYE IRRITATION//TOXICOLOGY IN VITRO 1899

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ATLA-ALTERNATIVES TO LABORATORY ANIMALS journal 1627060 20% 27% 372
2 EYE IRRITATION authKW 1045395 5% 64% 102
3 TOXICOLOGY IN VITRO journal 708183 23% 10% 436
4 ALTERNATIVE METHODS authKW 544787 6% 31% 110
5 DRAIZE TEST authKW 500481 2% 76% 41
6 MEIC authKW 418599 1% 96% 27
7 SKIN CORROSION authKW 354383 1% 96% 23
8 ECVAM authKW 345508 2% 61% 35
9 SKIN IRRITATION authKW 301208 4% 24% 79
10 BASAL CYTOTOXICITY authKW 221752 1% 69% 20

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Toxicology 70547 57% 0% 1086
2 Medicine, Research & Experimental 5415 21% 0% 391
3 Medicine, Legal 780 2% 0% 43
4 Pharmacology & Pharmacy 639 13% 0% 248
5 Ophthalmology 541 5% 0% 98
6 Dermatology 343 4% 0% 71
7 Food Science & Technology 286 6% 0% 106
8 Integrative & Complementary Medicine 133 1% 0% 22
9 Environmental Sciences 111 6% 0% 107
10 CYTOLOGY & HISTOLOGY 27 0% 0% 4

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 AFDELING TOXIKOL 178092 1% 92% 12
2 FRAME ALTERNAT 164627 1% 64% 16
3 ECVAM 135749 2% 21% 41
4 BGVV 90558 1% 43% 13
5 GENET MUTAGEN 80390 0% 100% 5
6 BIOCHEM TOXIKOL 72348 0% 75% 6
7 RUSSELL BURCH HOUSE 71615 0% 64% 7
8 ASSESSMENT CHEM 68592 0% 53% 8
9 HUMAN SAFETY EVALUAT 57418 0% 71% 5
10 ZEBET 53825 1% 28% 12

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ATLA-ALTERNATIVES TO LABORATORY ANIMALS 1627060 20% 27% 372
2 TOXICOLOGY IN VITRO 708183 23% 10% 436
3 JOURNAL OF TOXICOLOGY-CUTANEOUS AND OCULAR TOXICOLOGY 166087 4% 15% 70
4 ALTEX-ALTERNATIVEN ZU TIEREXPERIMENTEN 21447 1% 6% 21
5 IN VITRO & MOLECULAR TOXICOLOGY-A JOURNAL OF BASIC AND APPLIED RESEARCH 19832 1% 11% 11
6 FOOD AND CHEMICAL TOXICOLOGY 17824 5% 1% 97
7 REGULATORY TOXICOLOGY AND PHARMACOLOGY 8347 2% 1% 39
8 TOXICOLOGY METHODS 8142 1% 5% 10
9 FUNDAMENTAL AND APPLIED TOXICOLOGY 7269 2% 1% 31
10 CELL BIOLOGY AND TOXICOLOGY 7231 1% 2% 23

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 EYE IRRITATION 1045395 5% 64% 102 Search EYE+IRRITATION Search EYE+IRRITATION
2 ALTERNATIVE METHODS 544787 6% 31% 110 Search ALTERNATIVE+METHODS Search ALTERNATIVE+METHODS
3 DRAIZE TEST 500481 2% 76% 41 Search DRAIZE+TEST Search DRAIZE+TEST
4 MEIC 418599 1% 96% 27 Search MEIC Search MEIC
5 SKIN CORROSION 354383 1% 96% 23 Search SKIN+CORROSION Search SKIN+CORROSION
6 ECVAM 345508 2% 61% 35 Search ECVAM Search ECVAM
7 SKIN IRRITATION 301208 4% 24% 79 Search SKIN+IRRITATION Search SKIN+IRRITATION
8 BASAL CYTOTOXICITY 221752 1% 69% 20 Search BASAL+CYTOTOXICITY Search BASAL+CYTOTOXICITY
9 DRAIZE EYE TEST 212793 1% 88% 15 Search DRAIZE+EYE+TEST Search DRAIZE+EYE+TEST
10 BCOP 194082 1% 93% 13 Search BCOP Search BCOP

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 VINARDELL, MP , MITJANS, M , (2008) ALTERNATIVE METHODS FOR EYE AND SKIN IRRITATION TESTS: AN OVERVIEW.JOURNAL OF PHARMACEUTICAL SCIENCES. VOL. 97. ISSUE 1. P. 46 -59 72 90% 60
2 ZUANG, V , ESKES, C , (2005) ALTERNATIVE (NON-ANIMAL) METHODS FOR COSMETICS TESTING: CURRENT STATUS AND FUTURE PROSPECTS - A REPORT PREPARED IN THE CONTEXT OF THE 7TH AMENDMENT OF THE COSMETIC DIRECTIVE FOR ESTABLISHING THE TIMETABLE FOR PHASING OUT ANIMAL TESTING - FOREWORD.ATLA-ALTERNATIVES TO LABORATORY ANIMALS. VOL. 33. ISSUE . P. 1 -+ 187 32% 7
3 WILSON, SL , AHEARNE, M , HOPKINSON, A , (2015) AN OVERVIEW OF CURRENT TECHNIQUES FOR OCULAR TOXICITY TESTING.TOXICOLOGY. VOL. 327. ISSUE . P. 32 -46 55 68% 14
4 GRINDON, C , COMBES, R , CRONIN, MTD , ROBERTS, DW , GARROD, JF , (2008) AN INTEGRATED DECISION-TREE TESTING STRATEGY FOR EYE IRRITATION WITH RESPECT TO THE REQUIREMENTS OF THE EU REACH LEGISLATION.ATLA-ALTERNATIVES TO LABORATORY ANIMALS. VOL. 36. ISSUE 1. P. 81-92 63 85% 7
5 GRINDON, C , COMBES, R , CRONIN, MTD , ROBERTS, DW , GARROD, JF , (2008) AN INTEGRATED DECISION-TREE TESTING STRATEGY FOR EYE IRRITATION WITH RESPECT TO THE REQUIREMENTS OF THE EU REACH LEGISLATION.ATLA-ALTERNATIVES TO LABORATORY ANIMALS. VOL. 36. ISSUE . P. 111-122 63 85% 2
6 UBELS, JL , CLOUSING, DP , (2005) IN VITRO ALTERNATIVES TO THE USE OF ANIMALS IN OCULAR TOXICOLOGY TESTING.OCULAR SURFACE. VOL. 3. ISSUE 3. P. 126-142 64 77% 8
7 GERNER, I , LIEBSCH, M , SPIELMANN, H , (2005) ASSESSMENT OF THE EYE IRRITATING PROPERTIES OF CHEMICALS BY APPLYING ALTERNATIVES TO THE DRAIZE RABBIT EYE TEST: THE USE OF QSARS AND IN VITRO TESTS FOR THE CLASSIFICATION OF EYE IRRITATION.ATLA-ALTERNATIVES TO LABORATORY ANIMALS. VOL. 33. ISSUE 3. P. 215-237 51 89% 26
8 HERZINGER, T , KORTING, HC , MAIBACH, HI , (1995) ASSESSMENT OF CUTANEOUS AND OCULAR IRRITANCY - A DECADE OF RESEARCH ON ALTERNATIVES TO ANIMAL EXPERIMENTATION.FUNDAMENTAL AND APPLIED TOXICOLOGY. VOL. 24. ISSUE 1. P. 29-41 81 78% 20
9 MCNAMEE, P , HIBATALLAH, J , COSTABEL-FARKAS, M , GOEBEL, C , ARAKI, D , DUFOUR, E , HEWITT, NJ , JONES, P , KIRST, A , LE VARLET, B , ET AL (2009) A TIERED APPROACH TO THE USE OF ALTERNATIVES TO ANIMAL TESTING FOR THE SAFETY ASSESSMENT OF COSMETICS: EYE IRRITATION.REGULATORY TOXICOLOGY AND PHARMACOLOGY. VOL. 54. ISSUE 2. P. 197-209 38 93% 30
10 BALLS, M , CLOTHIER, R , (2009) FRAME AND THE VALIDATION PROCESS.ATLA-ALTERNATIVES TO LABORATORY ANIMALS. VOL. 37. ISSUE 6. P. 631-640 39 95% 0

Classes with closest relation at Level 1


Rank Class id link
1 14023 COMPUTAT TOXICOL//ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION//CAAT
2 24727 ATLA-ALTERNATIVES TO LABORATORY ANIMALS//THREE RS//ANIMAL EXPERIMENTATION
3 28612 AIR LIQUID INTERFACE//DIRECT EXPOSURE METHODS//CSAT S
4 9662 SENSITIVE SKIN//BIOENGINEERING METHODS//TRANSEPIDERMAL WATER LOSS
5 15910 BENZALKONIUM CHLORIDE//BIOL PHARMACOL SCI//PRESERVATIVES
6 29177 3 4 5 DIMETHYLTHIAZOL 2 YL 2 5 DIPHENYLTETRAZOLIUM BROMIDE//POLLEN PEPTIDE//PAPAVER SOMNIFERUM POLLEN
7 15462 IN VITRO MITOGENIC STIMULATION//UMR 0938//URIDINE UPTAKE ASSAY
8 37435 AV LINER//CRYOPRESERVATION COMPUTERIZED MOTION ANALYSIS//EPIDIDYMAL BULL SPERMATOZOA
9 6210 SKIN SENSITIZATION//LOCAL LYMPH NODE ASSAY//LLNA
10 30330 CFU GM ASSAY//PYRAZINE DIAZOHYDROXIDE//SR 4987 CELLS

Go to start page