Class information for:
Level 1: TUBULYSIN//PYRROLO 1 5 BENZOXAZEPINES//PBOX

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
33929 118 36.6 88%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
3 4 PLANT SCIENCES//AGRONOMY//FOOD SCIENCE & TECHNOLOGY 1882812
354 3       MICROCYSTIN//HARMFUL ALGAE//MICROCYSTIN LR 34996
1803 2             LANTIBIOTIC//OXAZOLE//DOLASTATIN 10 6283
33929 1                   TUBULYSIN//PYRROLO 1 5 BENZOXAZEPINES//PBOX 118

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 TUBULYSIN authKW 5831083 22% 87% 26
2 PYRROLO 1 5 BENZOXAZEPINES authKW 1811433 6% 100% 7
3 PBOX authKW 1585002 6% 88% 7
4 PRETUBULYSIN authKW 1035105 3% 100% 4
5 KEMOTECH address 776329 3% 100% 3
6 JOHN DURKAN LEUKAEMIA S address 517552 2% 100% 2
7 JOHN DURKAN S address 517552 2% 100% 2
8 PBOX 6 authKW 517552 2% 100% 2
9 EUROPEAN DRUG DISCOVERY DEV address 455531 11% 14% 13
10 5 BENZOXAZEPINE authKW 258776 1% 100% 1

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Medicinal 446 19% 0% 22
2 Chemistry, Organic 430 28% 0% 33
3 Pharmacology & Pharmacy 118 20% 0% 24
4 Oncology 115 18% 0% 21
5 Chemistry, Multidisciplinary 45 15% 0% 18
6 Biochemistry & Molecular Biology 11 13% 0% 15
7 Integrative & Complementary Medicine 4 1% 0% 1
8 Biophysics 2 3% 0% 3
9 Medicine, Research & Experimental 1 3% 0% 3
10 Multidisciplinary Sciences 1 1% 0% 1

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 KEMOTECH 776329 3% 100% 3
2 JOHN DURKAN LEUKAEMIA S 517552 2% 100% 2
3 JOHN DURKAN S 517552 2% 100% 2
4 EUROPEAN DRUG DISCOVERY DEV 455531 11% 14% 13
5 CHIM ORGAN FINE IRCOF ASSOCIE CNRS UMR 6014 258776 1% 100% 1
6 JOHN DURKAN LEUKEMIA S 258776 1% 100% 1
7 SIR PATRICK DUN S 258774 2% 50% 2
8 EUROPEAN DRUG DISCOVERY DEV NATSYNDRUGS 154025 4% 12% 5
9 SEZ A QUILICO 153342 3% 15% 4
10 BEREICH NATURSTOFFE 129387 1% 50% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CANCER BIOLOGY & THERAPY 826 3% 0% 3
2 CHEMICAL BIOLOGY & DRUG DESIGN 624 2% 0% 2
3 MINI-REVIEWS IN ORGANIC CHEMISTRY 610 1% 0% 1
4 CHEMMEDCHEM 449 2% 0% 2
5 BANGLADESH JOURNAL OF PHARMACOLOGY 434 1% 0% 1
6 INVESTIGATIONAL NEW DRUGS 402 2% 0% 2
7 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 362 5% 0% 6
8 JOURNAL OF CANCER 344 1% 0% 1
9 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 301 4% 0% 5
10 NACHRICHTEN AUS DER CHEMIE 276 1% 0% 1

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 TUBULYSIN 5831083 22% 87% 26 Search TUBULYSIN Search TUBULYSIN
2 PYRROLO 1 5 BENZOXAZEPINES 1811433 6% 100% 7 Search PYRROLO+1+5+BENZOXAZEPINES Search PYRROLO+1+5+BENZOXAZEPINES
3 PBOX 1585002 6% 88% 7 Search PBOX Search PBOX
4 PRETUBULYSIN 1035105 3% 100% 4 Search PRETUBULYSIN Search PRETUBULYSIN
5 PBOX 6 517552 2% 100% 2 Search PBOX+6 Search PBOX+6
6 5 BENZOXAZEPINE 258776 1% 100% 1 Search 5+BENZOXAZEPINE Search 5+BENZOXAZEPINE
7 BENZOXAZEPINES DERIVATIVES 258776 1% 100% 1 Search BENZOXAZEPINES+DERIVATIVES Search BENZOXAZEPINES+DERIVATIVES
8 CAPASASE 258776 1% 100% 1 Search CAPASASE Search CAPASASE
9 DEACETOXYTUBUVALINE 258776 1% 100% 1 Search DEACETOXYTUBUVALINE Search DEACETOXYTUBUVALINE
10 DRUG RESISTANCE AND G2 M ARREST 258776 1% 100% 1 Search DRUG+RESISTANCE+AND+G2+M+ARREST Search DRUG+RESISTANCE+AND+G2+M+ARREST

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 NICOLAOU, KC , YUN, J , MANDAL, D , ERANDE, RD , KLAHN, P , JIN, M , AUJAY, M , SANDOVAL, J , GAVRILYUK, J , VOURLOUMIS, D , (2016) TOTAL SYNTHESIS AND BIOLOGICAL EVALUATION OF NATURAL AND DESIGNED TUBULYSINS.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. VOL. 138. ISSUE 5. P. 1698 -1708 40 63% 8
2 MURRAY, BC , PETERSON, MT , FECIK, RA , (2015) CHEMISTRY AND BIOLOGY OF TUBULYSINS: ANTIMITOTIC TETRAPEPTIDES WITH ACTIVITY AGAINST DRUG RESISTANT CANCERS.NATURAL PRODUCT REPORTS. VOL. 32. ISSUE 5. P. 654 -662 35 80% 14
3 SHANKAR, PS , BIGOTTI, S , LAZZARI, P , MANCA, I , SPIGA, M , SANI, M , ZANDA, M , (2013) SYNTHESIS AND CYTOTOXICITY EVALUATION OF DIASTEREOISOMERS AND N-TERMINAL ANALOGUES OF TUBULYSIN-U.TETRAHEDRON LETTERS. VOL. 54. ISSUE 45. P. 6137 -6141 29 94% 6
4 TAO, W , ZHOU, W , ZHOU, Z , SI, CM , SUN, X , WEI, BG , (2016) AN ENANTIOSELECTIVE TOTAL SYNTHESIS OF TUBULYSIN V.TETRAHEDRON. VOL. 72. ISSUE 39. P. 5928 -5933 39 61% 0
5 COLOMBO, R , WANG, ZY , HAN, JY , BALACHANDRAN, R , DAGHESTANI, HT , CAMARCO, DP , VOGT, A , DAY, BW , MENDEL, D , WIPF, P , (2016) TOTAL SYNTHESIS AND BIOLOGICAL EVALUATION OF TUBULYSIN ANALOGUES.JOURNAL OF ORGANIC CHEMISTRY. VOL. 81. ISSUE 21. P. 10302 -10320 39 61% 0
6 SHANKAR, SP , JAGODZINSKA, M , MALPEZZI, L , LAZZARI, P , MANCA, I , GREIG, IR , SANI, M , ZANDA, M , (2013) SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIP STUDIES OF NOVEL TUBULYSIN U ANALOGUES - EFFECT ON CYTOTOXICITY OF STRUCTURAL VARIATIONS IN THE TUBUVALINE FRAGMENT.ORGANIC & BIOMOLECULAR CHEMISTRY. VOL. 11. ISSUE 14. P. 2273 -2287 26 87% 6
7 YANG, XD , DONG, CM , CHEN, J , LIU, Q , HAN, B , ZHANG, Q , CHEN, Y , (2013) DESIGN, SYNTHESIS, AND BIOLOGICAL ACTIVITIES OF TRIAZOLE TUBULYSIN V ANALOGUE.TETRAHEDRON LETTERS. VOL. 54. ISSUE 23. P. 2986 -2988 27 73% 9
8 PARK, Y , SIM, M , CHANG, TS , RYU, JS , (2016) A CONCISE SYNTHESIS OF TUBUPHENYLALANINE AND EPI-TUBUPHENYLALANINE VIA A DIASTEREOSELECTIVE MUKAIYAMA ALDOL REACTION OF SILYL KETENE ACETAL.ORGANIC & BIOMOLECULAR CHEMISTRY. VOL. 14. ISSUE 3. P. 913 -919 22 85% 0
9 WANG, R , TIAN, P , LIN, GQ , (2013) STEREOSELECTIVE TOTAL SYNTHESIS OF TUBULYSIN V.CHINESE JOURNAL OF CHEMISTRY. VOL. 31. ISSUE 1. P. 40 -48 24 67% 5
10 TOADER, D , WANG, FJ , GINGIPALLI, L , VASBINDER, M , ROTH, M , MAO, SL , BLOCK, M , HARPER, J , THOTA, S , SU, M , ET AL (2016) STRUCTURE-CYTOTOXICITY RELATIONSHIPS OF ANALOGUES OF N-14-DESACETOXYTUBULYSIN H.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 59. ISSUE 23. P. 10781 -10787 18 86% 0

Classes with closest relation at Level 1


Rank Class id link
1 14510 DOLASTATIN 10//DIDEMNIN B//CRYPTOPHYCIN
2 5476 COMBRETASTATIN//COMBRETASTATIN A 4//VASCULAR DISRUPTING AGENTS
3 15859 TAXOL//PACLITAXEL//BCL 2 PHOSPHORYLATION
4 14678 SULFINYLIMINE//N SULFONYLIMINES//SULFINIMINES
5 10553 FOLATE RECEPTOR//FOLATE BINDING PROTEIN//FOLATE RECEPTOR ALPHA
6 11281 ANTIBODY DRUG CONJUGATE//GEMTUZUMAB OZOGAMICIN//MYLOTARG
7 12492 OXAZOLE//PHORBOXAZOLE//DIAZONAMIDE A
8 10628 EPOTHILONES//IXABEPILONE//PATUPILONE
9 29842 HEX 2 ENOPYRANOSIDES//MODIFIED TETRAHYDROFURAN//SULFONYL SUGARS
10 20833 THIOPEPTIDES//NOSIHEPTIDE//NOCATHIACIN

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