Class information for:
Level 1: TANKYRASE//TANKYRASE 1//TANKYRASE INHIBITORS

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
31664 149 37.6 93%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
364 3       TELOMERASE//TELOMERE//C ELEGANS 34320
700 2             TELOMERASE//TELOMERE//TELOMERE LENGTH 12973
31664 1                   TANKYRASE//TANKYRASE 1//TANKYRASE INHIBITORS 149

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 TANKYRASE authKW 4618251 27% 56% 40
2 TANKYRASE 1 authKW 1653148 7% 73% 11
3 TANKYRASE INHIBITORS authKW 731913 3% 71% 5
4 TNKS authKW 640423 3% 63% 5
5 PARSYLATION authKW 468423 3% 57% 4
6 TNKS1 authKW 461105 2% 75% 3
7 TANKYRASE 2 authKW 409873 1% 100% 2
8 BIOASSAY PROFILING address 273247 1% 67% 2
9 UNIT CELL SIGNALING address 269646 3% 26% 5
10 SFI CAST BIOMED INNOVAT address 234207 3% 29% 4

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Medicinal 757 21% 0% 32
2 Cell Biology 402 28% 0% 41
3 Biochemistry & Molecular Biology 352 42% 0% 62
4 Oncology 116 16% 0% 24
5 Andrology 63 1% 0% 2
6 Biophysics 46 7% 0% 11
7 Chemistry, Organic 10 5% 0% 8
8 Genetics & Heredity 9 5% 0% 7
9 Multidisciplinary Sciences 6 1% 0% 2
10 Biochemical Research Methods 4 3% 0% 4

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOASSAY PROFILING 273247 1% 67% 2
2 UNIT CELL SIGNALING 269646 3% 26% 5
3 SFI CAST BIOMED INNOVAT 234207 3% 29% 4
4 07 01 204936 1% 100% 1
5 CHEM BIOMINIST EDUC 204936 1% 100% 1
6 CRUK DNA REPAIR ENZYMES GRP 204936 1% 100% 1
7 DIRECTORS ROOM 204936 1% 100% 1
8 DISCOVERY ONCOL SMALL MOL PHARMA EARLY 204936 1% 100% 1
9 EARLY CLIN DRUG DEV GRP 204936 1% 100% 1
10 PEDIAT INTERNAL MED MOL BIOL 204936 1% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ACS MEDICINAL CHEMISTRY LETTERS 3724 3% 0% 5
2 JOURNAL OF MEDICINAL CHEMISTRY 1864 9% 0% 14
3 MOLECULAR BIOSYSTEMS 678 2% 0% 3
4 MOLECULAR AND CELLULAR BIOLOGY 442 5% 0% 7
5 ONCOLOGY REPORTS 325 3% 0% 4
6 ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS 265 1% 0% 2
7 BIOCHEMISTRY-MOSCOW 250 2% 0% 3
8 BMC BIOLOGY 242 1% 0% 1
9 FAMILIAL CANCER 232 1% 0% 1
10 AGING-US 225 1% 0% 1

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 TANKYRASE 4618251 27% 56% 40 Search TANKYRASE Search TANKYRASE
2 TANKYRASE 1 1653148 7% 73% 11 Search TANKYRASE+1 Search TANKYRASE+1
3 TANKYRASE INHIBITORS 731913 3% 71% 5 Search TANKYRASE+INHIBITORS Search TANKYRASE+INHIBITORS
4 TNKS 640423 3% 63% 5 Search TNKS Search TNKS
5 PARSYLATION 468423 3% 57% 4 Search PARSYLATION Search PARSYLATION
6 TNKS1 461105 2% 75% 3 Search TNKS1 Search TNKS1
7 TANKYRASE 2 409873 1% 100% 2 Search TANKYRASE+2 Search TANKYRASE+2
8 2 AMINOPYRIDINE OXAZOLIDINONE 204936 1% 100% 1 Search 2+AMINOPYRIDINE+OXAZOLIDINONE Search 2+AMINOPYRIDINE+OXAZOLIDINONE
9 2 ARYLQUINAZOLIN 4 ONE 204936 1% 100% 1 Search 2+ARYLQUINAZOLIN+4+ONE Search 2+ARYLQUINAZOLIN+4+ONE
10 7 ARYL 1 METHYL 1 2 3 4 TETRAHYDRO 1 6 NAPHTHYRIDIN 5 ONE 204936 1% 100% 1 Search 7+ARYL+1+METHYL+1+2+3+4+TETRAHYDRO+1+6+NAPHTHYRIDIN+5+ONE Search 7+ARYL+1+METHYL+1+2+3+4+TETRAHYDRO+1+6+NAPHTHYRIDIN+5+ONE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 LEHTIO, L , CHI, NW , KRAUSS, S , (2013) TANKYRASES AS DRUG TARGETS.FEBS JOURNAL. VOL. 280. ISSUE 15. P. 3576-3593 58 61% 49
2 HAIKARAINEN, T , KRAUSS, S , LEHTIO, L , (2014) TANKYRASES: STRUCTURE, FUNCTION AND THERAPEUTIC IMPLICATIONS IN CANCER.CURRENT PHARMACEUTICAL DESIGN. VOL. 20. ISSUE 41. P. 6472 -6488 68 40% 14
3 WAALER, J , IGNATEV, A , NKIZINKIKO, Y , VENKANNAGARI, H , OBAJI, E , KRAUSS, S , LEHTIO, L , HAIKARAINEN, T , (2016) DEVELOPMENT AND STRUCTURAL ANALYSIS OF ADENOSINE SITE BINDING TANKYRASE INHIBITORS.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. VOL. 26. ISSUE 2. P. 328 -333 22 85% 0
4 PAINE, HA , NATHUBHAI, A , WOON, ECY , SUNDERLAND, PT , WOOD, PJ , MAHON, MF , LLOYD, MD , THOMPSON, AS , HAIKARAINEN, T , NARWAL, M , ET AL (2015) EXPLORATION OF THE NICOTINAMIDE-BINDING SITE OF THE TANKYRASES, IDENTIFYING 3-ARYLISOQUINOLIN-1-ONES AS POTENT AND SELECTIVE INHIBITORS IN VITRO.BIOORGANIC & MEDICINAL CHEMISTRY. VOL. 23. ISSUE 17. P. 5891 -5908 33 50% 4
5 ZHAN, P , SONG, YN , ITOH, Y , SUZUKI, T , LIU, XY , (2014) RECENT ADVANCES IN THE STRUCTURE-BASED RATIONAL DESIGN OF TNKSIS.MOLECULAR BIOSYSTEMS. VOL. 10. ISSUE 11. P. 2783 -2799 26 60% 3
6 KAMAL, A , RIYAZ, S , SRIVASTAVA, AK , RAHIM, A , (2014) TANKYRASE INHIBITORS AS THERAPEUTIC TARGETS FOR CANCER.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 14. ISSUE 17. P. 1967 -1976 25 63% 3
7 NKIZINKIKO, Y , KUMAR, BVSS , JEANKUMAR, VU , HAIKARAINEN, T , KOIVUNEN, J , MADHURI, C , YOGEESWARI, P , VENKANNAGARI, H , OBAJI, E , PIHLAJANIEMI, T , ET AL (2015) DISCOVERY OF POTENT AND SELECTIVE NONPLANAR TANKYRASE INHIBITING NICOTINAMIDE MIMICS.BIOORGANIC & MEDICINAL CHEMISTRY. VOL. 23. ISSUE 15. P. 4139 -4149 24 59% 2
8 HAIKARAINEN, T , NATHUBHAI, A , HAYWARD, PC , MUNOZ-DESCALZO, S , THOMPSON, AS , LLOYD, MD , LEHTIO, L , THREADGILL, MD , (2016) STRUCTURE-ACTIVITY RELATIONSHIPS OF 2-ARYLQUINAZOLIN-4-ONES AS HIGHLY SELECTIVE AND POTENT INHIBITORS OF THE TANKYRASES.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. VOL. 118. ISSUE . P. 316 -327 27 47% 0
9 HAIKARAINEN, T , KOIVUNEN, J , NARWAL, M , VENKANNAGARI, H , OBAJI, E , JOENSUU, P , PIHLAJANIEMI, T , LEHTIO, L , (2013) PARA-SUBSTITUTED 2-PHENYL-3,4-DIHYDROQUINAZOLIN-4-ONES AS POTENT AND SELECTIVE TANKYRASE INHIBITORS.CHEMMEDCHEM. VOL. 8. ISSUE 12. P. 1978-1985 20 61% 8
10 MARIOTTI, L , TEMPLETON, CM , RANES, M , PARACUELLOS, P , CRONIN, N , BEURON, F , MORRIS, E , GUETTLER, S , (2016) TANKYRASE REQUIRES SAM DOMAIN-DEPENDENT POLYMERIZATION TO SUPPORT WNT-BETA-CATENIN SIGNALING.MOLECULAR CELL. VOL. 63. ISSUE 3. P. 498 -513 26 39% 2

Classes with closest relation at Level 1


Rank Class id link
1 495 POLYADP RIBOSE POLYMERASE//POLYADP RIBOSE//POLYADP RIBOSYLATION
2 981 BETA CATENIN//AXIN//WNT
3 1312 TELOMERE//TELOMERASE//TRF2
4 10345 PARP INHIBITORS//OLAPARIB//SYNTHETIC LETHALITY
5 37412 T OLIGO//DNA N METHYL TRANSFERASE//HAIR FOLLICLE PIGMENTATION
6 217 TELOMERASE//HTERT//TELOMERASE ACTIVITY
7 21034 GRB7//GRB14//GRB10
8 21062 DNA ENCODED LIBRARY//DNA ENCODED CHEMICAL LIBRARY//TEMPLATED REACTIONS
9 29981 CHEM HETEROCYCLES NAT PROD//ORGAN MED CHEM//1 3 DISUBSTITUTED ISOQUINOLINES
10 32500 PYRIDAZINO4 5 BINDOLES//AZACARBOLINES//1 HYDRAZINO 4 3 5 DIMETHYL 1 PYRAZOLYL 5H PYRIDAZINO4 5 BINDOLE

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