Class information for:
Level 1: TRIPLE REUPTAKE INHIBITOR//DOV 216 303//TRIPLE UPTAKE INHIBITORS

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
30745 164 38.2 76%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
1 4 ECONOMICS//EDUCATION & EDUCATIONAL RESEARCH//PSYCHOL 3876184
154 3       PSYCHIATRY//ALEXITHYMIA//PSYCHIAT 62481
207 2             PSYCHIATRY//ANTIDEPRESSANTS//DEPRESSION 21074
30745 1                   TRIPLE REUPTAKE INHIBITOR//DOV 216 303//TRIPLE UPTAKE INHIBITORS 164

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 TRIPLE REUPTAKE INHIBITOR authKW 3154298 15% 71% 24
2 DOV 216 303 authKW 1140425 4% 88% 7
3 TRIPLE UPTAKE INHIBITORS authKW 775799 3% 83% 5
4 DISCOVERY EARLY CLIN address 664969 3% 71% 5
5 DOV 21 947 authKW 558576 2% 100% 3
6 PERIPHERAL SELECTIVE NORADRENALINE REUPTAKE INHIBITOR authKW 558576 2% 100% 3
7 7 ARYL 1 4 OXAZEPANE DERIVATIVES authKW 372384 1% 100% 2
8 BICIFADINE authKW 372384 1% 100% 2
9 BROAD SPECTRUM ANTIDEPRESSANT authKW 372384 1% 100% 2
10 CONFORMATIONALLY RESTRICTED ANALOG authKW 372384 1% 100% 2

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Medicinal 2674 38% 0% 62
2 Chemistry, Organic 1020 36% 0% 59
3 Pharmacology & Pharmacy 431 31% 0% 51
4 Psychiatry 60 8% 0% 13
5 Neurosciences 41 12% 0% 19
6 Behavioral Sciences 13 2% 0% 4
7 Biochemistry & Molecular Biology 11 12% 0% 19
8 Substance Abuse 8 1% 0% 2
9 Psychology, Clinical 6 2% 0% 3
10 Chemistry, Multidisciplinary 5 7% 0% 11

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DISCOVERY EARLY CLIN 664969 3% 71% 5
2 AFDELING FARM 186192 1% 100% 1
3 ANIM PHYSIOL BIOPHY 186192 1% 100% 1
4 DREPT PHARMACOKINET PHARMACODYNAM 186192 1% 100% 1
5 GENOME PSYCHIAT 186192 1% 100% 1
6 INTER CLIN PHARMACOL 186192 1% 100% 1
7 NEUROPHARMACOL SEROTONINE 186192 1% 100% 1
8 NEUROSCI MDC US CLIN 186192 1% 100% 1
9 UIPSRUDOLF MAGNUS NEUROSCI 186192 1% 100% 1
10 PLEBAUM PHARM HLTH SCI 135406 2% 18% 4

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ACTA PHARMACEUTICA JUGOSLAVICA 4061 2% 1% 3
2 BIOORGANIC & MEDICINAL CHEMISTRY 2803 9% 0% 14
3 JOURNAL OF MEDICINAL CHEMISTRY 2213 10% 0% 16
4 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2128 10% 0% 17
5 CNS DRUG REVIEWS 1140 1% 1% 1
6 EXPERT OPINION ON INVESTIGATIONAL DRUGS 776 2% 0% 3
7 BMB REPORTS 706 1% 0% 2
8 INDIAN JOURNAL OF PHARMACOLOGY 693 1% 0% 2
9 ACS MEDICINAL CHEMISTRY LETTERS 539 1% 0% 2
10 IDRUGS 497 1% 0% 1

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 TRIPLE REUPTAKE INHIBITOR 3154298 15% 71% 24 Search TRIPLE+REUPTAKE+INHIBITOR Search TRIPLE+REUPTAKE+INHIBITOR
2 DOV 216 303 1140425 4% 88% 7 Search DOV+216+303 Search DOV+216+303
3 TRIPLE UPTAKE INHIBITORS 775799 3% 83% 5 Search TRIPLE+UPTAKE+INHIBITORS Search TRIPLE+UPTAKE+INHIBITORS
4 DOV 21 947 558576 2% 100% 3 Search DOV+21+947 Search DOV+21+947
5 PERIPHERAL SELECTIVE NORADRENALINE REUPTAKE INHIBITOR 558576 2% 100% 3 Search PERIPHERAL+SELECTIVE+NORADRENALINE+REUPTAKE+INHIBITOR Search PERIPHERAL+SELECTIVE+NORADRENALINE+REUPTAKE+INHIBITOR
6 7 ARYL 1 4 OXAZEPANE DERIVATIVES 372384 1% 100% 2 Search 7+ARYL+1+4+OXAZEPANE+DERIVATIVES Search 7+ARYL+1+4+OXAZEPANE+DERIVATIVES
7 BICIFADINE 372384 1% 100% 2 Search BICIFADINE Search BICIFADINE
8 BROAD SPECTRUM ANTIDEPRESSANT 372384 1% 100% 2 Search BROAD+SPECTRUM+ANTIDEPRESSANT Search BROAD+SPECTRUM+ANTIDEPRESSANT
9 CONFORMATIONALLY RESTRICTED ANALOG 372384 1% 100% 2 Search CONFORMATIONALLY+RESTRICTED+ANALOG Search CONFORMATIONALLY+RESTRICTED+ANALOG
10 MDR1 EFFLUX RATIO 372384 1% 100% 2 Search MDR1+EFFLUX+RATIO Search MDR1+EFFLUX+RATIO

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 PARK, JE , SONG, C , CHOI, K , SIM, T , MOON, B , ROH, EJ , (2013) SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL 3,4-DIARYL LACTAM DERIVATIVES AS TRIPLE REUPTAKE INHIBITORS.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. VOL. 23. ISSUE 20. P. 5515 -5518 16 57% 3
2 SHARMA, H , SANTRA, S , DUTTA, A , (2015) TRIPLE REUPTAKE INHIBITORS AS POTENTIAL NEXT-GENERATION ANTIDEPRESSANTS: A NEW HOPE?.FUTURE MEDICINAL CHEMISTRY. VOL. 7. ISSUE 17. P. 2385 -2405 33 23% 0
3 LAPA, GB , (2011) MOLECULAR-BIOLOGICAL PROBLEMS OF DRUG DESIGN AND MECHANISM OF DRUG ACTION TRIPLE INHIBITORS OF MONOAMINE REUPTAKE TRANSPORTERS: FIRST RESULTS AND OUTLOOK.PHARMACEUTICAL CHEMISTRY JOURNAL. VOL. 45. ISSUE 6. P. 323 -328 19 38% 0
4 ZHANG, MZ , JOVIC, F , VICKERS, T , DYCK, B , TAMIYA, J , GREY, J , TRAN, JA , FLECK, BA , PICK, R , FOSTER, AC , ET AL (2008) STUDIES ON THE STRUCTURE-ACTIVITY RELATIONSHIP OF BICIFADINE ANALOGS AS MONOAMINE TRANSPORTER INHIBITORS.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. VOL. 18. ISSUE 13. P. 3682 -3686 14 52% 9
5 YAMAGUCHI, K , KAZUTA, Y , HIRANO, K , YAMADA, S , MATSUDA, A , SHUTO, S , (2008) SYNTHESIS OF 1-ARYLPIPERAZYL-2-PHENYLCYCLOPROPANES DESIGNED AS ANTIDOPAMINERGIC AGENTS: CYCLOPROPANE-BASED CONFORMATIONALLY RESTRICTED ANALOGS OF HALOPERIDOL.BIOORGANIC & MEDICINAL CHEMISTRY. VOL. 16. ISSUE 19. P. 8875-8881 15 47% 14
6 MICHELI, F , CAVANNI, P , BETTATI, M , BONANOMI, G , DI FABIO, R , FAZZOLARI, E , MARCHIORO, C , ROSCIC, M , TARSI, L , VISENTINI, F , ET AL (2011) 1-HETEROARYL-6-(3,4-DICHLOROPHENYL)-3-AZABICYCLO[4.1.0]HEPTANE: FURTHER INSIGHTS INTO A CLASS OF TRIPLE RE-UPTAKE INHIBITORS.BIOORGANIC & MEDICINAL CHEMISTRY. VOL. 19. ISSUE 11. P. 3451-3461 11 61% 1
7 YUN, J , HAN, M , SONG, C , CHEON, SH , CHOI, K , HAHN, HG , (2014) SYNTHESIS AND BIOLOGICAL EVALUATION OF 3-PHENETHYLAZETIDINE DERIVATIVES AS TRIPLE REUPTAKE INHIBITORS.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. VOL. 24. ISSUE 15. P. 3234 -3237 10 59% 2
8 MICHELI, F , CAVANNI, P , ANDREOTTI, D , ARBAN, R , BENEDETTI, R , BERTANI, B , BETTATI, M , BETTELINI, L , BONANOMI, G , BRAGGIO, S , ET AL (2010) 6-(3,4-DICHLOROPHENYL)-1-[(METHYLOXY)METHYL]-3-AZABICYCLO[4.1.0]HEPTANE: A NEW POTENT AND SELECTIVE TRIPLE REUPTAKE INHIBITOR.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 53. ISSUE 13. P. 4989 -5001 10 59% 30
9 MARKS, DM , (2012) AMITIFADINE HYDROCHLORIDE TRIPLE REUPTAKE INHIBITOR TREATMENT OF DEPRESSION.DRUGS OF THE FUTURE. VOL. 37. ISSUE 4. P. 241-246 12 50% 0
10 HONDA, E , ISHICHI, Y , KIMURA, E , YOSHIKAWA, M , KANZAKI, N , NAKAGAWA, H , TERAO, Y , SUZUKI, A , KAWAI, T , ARAKAWA, Y , ET AL (2014) DESIGN, SYNTHESIS, AND BIOLOGICAL ACTIVITIES OF 1-ARYL-1,4-DIAZEPAN-2-ONE DERIVATIVES AS NOVEL TRIPLE REUPTAKE INHIBITORS.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. VOL. 24. ISSUE 16. P. 3898 -3902 10 53% 1

Classes with closest relation at Level 1


Rank Class id link
1 20903 REBOXETINE//S S F 18FMENER D 2//NOREPINEPHRINE TRANSPORTER
2 7952 PINDOLOL//VILAZODONE//5 HT1A RECEPTOR
3 29476 AMINEPTINE HCL//DECREASED POSITIVE MOOD SYMPTOMS//DOG MAN
4 23627 MOUSE FORCED SWIMMING//GALNAC ALPHA 1 3GALNAC LIPID//TAIL SUSPENSION TEST
5 26382 DULOXETINE//DULOXETINE HYDROCHLORIDE//GLOBAL PHARMACOKINET PHARMACODYNAM TRIAL SIMULAT
6 6431 DOPAMINE TRANSPORTER//PSYCHOBIOL SECT//TROPANE
7 7414 TREATMENT RESISTANT DEPRESSION//RESISTANT DEPRESSION//LITHIUM AUGMENTATION
8 32254 VORTIOXETINE//LU AA21004//BIS ARYL SULFANYLA MINE
9 3683 ESCITALOPRAM//VENLAFAXINE//MILNACIPRAN
10 19999 ALUMINUM CARBENOID//CYCLOPROPYLBORONIC ACID//FR 900848

Go to start page