Class information for:
Level 1: TRANSTHYRETIN//FAMILIAL AMYLOIDOTIC POLYNEUROPATHY//FAMILIAL AMYLOID POLYNEUROPATHY

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
2986 2093 34.5 75%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
482 3       MULTIPLE MYELOMA//AMYLOIDOSIS//TRANSTHYRETIN 23544
967 2             AMYLOIDOSIS//TRANSTHYRETIN//AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS 10681
2986 1                   TRANSTHYRETIN//FAMILIAL AMYLOIDOTIC POLYNEUROPATHY//FAMILIAL AMYLOID POLYNEUROPATHY 2093

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 TRANSTHYRETIN authKW 6277086 33% 63% 683
2 FAMILIAL AMYLOIDOTIC POLYNEUROPATHY authKW 2178363 8% 89% 168
3 FAMILIAL AMYLOID POLYNEUROPATHY authKW 1973831 7% 88% 153
4 AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS journal 992536 11% 29% 231
5 AMYLOID UNIT address 368899 1% 82% 31
6 AMYLOIDOSIS authKW 363858 12% 10% 244
7 SENILE SYSTEMIC AMYLOIDOSIS authKW 328204 1% 75% 30
8 ESTUDOS PARAMILOIDOSE address 300079 1% 86% 24
9 TRANSTHYRETIN TTR authKW 287399 1% 73% 27
10 TAFAMIDIS authKW 263302 1% 95% 19

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biochemistry & Molecular Biology 3545 36% 0% 755
2 Medicine, Research & Experimental 2886 15% 0% 308
3 Medicine, General & Internal 2383 17% 0% 351
4 Clinical Neurology 1809 14% 0% 294
5 Transplantation 1252 5% 0% 114
6 Biophysics 691 8% 0% 159
7 Neurosciences 607 12% 0% 257
8 Pathology 442 5% 0% 100
9 Medical Laboratory Technology 414 3% 0% 54
10 Ophthalmology 378 4% 0% 89

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 AMYLOID UNIT 368899 1% 82% 31
2 ESTUDOS PARAMILOIDOSE 300079 1% 86% 24
3 UNIDADE CLIN PARAMILOIDOSE 150474 1% 74% 14
4 DIAGNOST MED 137619 3% 13% 72
5 GRP ESTUDIO 87525 0% 100% 6
6 AMYLOID TREATMENT PROGRAM 71447 1% 23% 21
7 UNIDADE CORINO ANDRADE 58350 0% 100% 4
8 UNIDADE TRANSPLANTACAO 52095 0% 71% 5
9 MED NEUROL RHEUMATOL 51021 1% 17% 21
10 ICBAS 48468 3% 5% 68

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS 992536 11% 29% 231
2 AMYLOID-INTERNATIONAL JOURNAL OF EXPERIMENTAL AND CLINICAL INVESTIGATION 15187 0% 21% 5
3 LIVER TRANSPLANTATION 2794 1% 1% 25
4 MUSCLE & NERVE 1805 1% 0% 30
5 MOLECULAR BIOLOGY & MEDICINE 1752 0% 2% 5
6 JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM 1512 0% 1% 8
7 NEUROLOGY 1446 2% 0% 47
8 JOURNAL OF THE NEUROLOGICAL SCIENCES 1251 1% 0% 30
9 JOURNAL OF INTERNAL MEDICINE 850 1% 0% 15
10 CLINICAL GENETICS 798 1% 0% 17

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 TRANSTHYRETIN 6277086 33% 63% 683 Search TRANSTHYRETIN Search TRANSTHYRETIN
2 FAMILIAL AMYLOIDOTIC POLYNEUROPATHY 2178363 8% 89% 168 Search FAMILIAL+AMYLOIDOTIC+POLYNEUROPATHY Search FAMILIAL+AMYLOIDOTIC+POLYNEUROPATHY
3 FAMILIAL AMYLOID POLYNEUROPATHY 1973831 7% 88% 153 Search FAMILIAL+AMYLOID+POLYNEUROPATHY Search FAMILIAL+AMYLOID+POLYNEUROPATHY
4 AMYLOIDOSIS 363858 12% 10% 244 Search AMYLOIDOSIS Search AMYLOIDOSIS
5 SENILE SYSTEMIC AMYLOIDOSIS 328204 1% 75% 30 Search SENILE+SYSTEMIC+AMYLOIDOSIS Search SENILE+SYSTEMIC+AMYLOIDOSIS
6 TRANSTHYRETIN TTR 287399 1% 73% 27 Search TRANSTHYRETIN+TTR Search TRANSTHYRETIN+TTR
7 TAFAMIDIS 263302 1% 95% 19 Search TAFAMIDIS Search TAFAMIDIS
8 HEREDITARY AMYLOIDOSIS 259577 1% 57% 31 Search HEREDITARY+AMYLOIDOSIS Search HEREDITARY+AMYLOIDOSIS
9 FAMILIAL AMYLOIDOTIC POLYNEUROPATHY FAP 221880 1% 89% 17 Search FAMILIAL+AMYLOIDOTIC+POLYNEUROPATHY+FAP Search FAMILIAL+AMYLOIDOTIC+POLYNEUROPATHY+FAP
10 DOMINO LIVER TRANSPLANTATION 168180 1% 82% 14 Search DOMINO+LIVER+TRANSPLANTATION Search DOMINO+LIVER+TRANSPLANTATION

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 PALANINATHAN, SK , (2012) NEARLY 200 X-RAY CRYSTAL STRUCTURES OF TRANSTHYRETIN: WHAT DO THEY TELL US ABOUT THIS PROTEIN AND THE DESIGN OF DRUGS FOR TTR AMYLOIDOSES?.CURRENT MEDICINAL CHEMISTRY. VOL. 19. ISSUE 15. P. 2324 -2342 123 88% 14
2 JOHNSON, SM , CONNELLY, S , FEARNS, C , POWERS, ET , KELLY, JW , (2012) THE TRANSTHYRETIN AMYLOIDOSES: FROM DELINEATING THE MOLECULAR MECHANISM OF AGGREGATION LINKED TO PATHOLOGY TO A REGULATORY-AGENCY-APPROVED DRUG.JOURNAL OF MOLECULAR BIOLOGY. VOL. 421. ISSUE 2-3. P. 185-203 110 71% 94
3 CONNORS, LH , RICHARDSON, AM , THEBERGE, R , COSTELLO, CE , (2000) TABULATION OF TRANSTHYRETIN (TTR) VARIANTS AS OF 1/1/2000.AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS. VOL. 7. ISSUE 1. P. 54 -69 131 97% 91
4 ANKARCRONA, M , WINBLAD, B , MONTEIRO, C , FEARNS, C , POWERS, ET , JOHANSSON, J , WESTERMARK, GT , PRESTO, J , ERICZON, BG , KELLY, JW , (2016) Y CURRENT AND FUTURE TREATMENT OF AMYLOID DISEASES.JOURNAL OF INTERNAL MEDICINE. VOL. 280. ISSUE 2. P. 177 -202 116 57% 6
5 SEKIJIMA, Y , (2014) RECENT PROGRESS IN THE UNDERSTANDING AND TREATMENT OF TRANSTHYRETIN AMYLOIDOSIS.JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS. VOL. 39. ISSUE 3. P. 225-233 85 91% 20
6 SEKIJIMA, Y , KELLY, JW , IKEDA, S , (2008) PATHOGENESIS OF AND THERAPEUTIC STRATEGIES TO AMELIORATE THE TRANSTHYRETIN AMYLOIDOSES.CURRENT PHARMACEUTICAL DESIGN. VOL. 14. ISSUE 30. P. 3219 -3230 102 79% 67
7 HOU, X , AGUILAR, MI , SMALL, DH , (2007) TRANSTHYRETIN AND FAMILIAL AMYLOIDOTIC POLYNEUROPATHY - RECENT PROGRESS IN UNDERSTANDING THE MOLECULAR MECHANISM OF NEURODEGENERATION.FEBS JOURNAL. VOL. 274. ISSUE 7. P. 1637 -1650 97 79% 83
8 GALANT, NJ , WESTERMARK, P , HIGAKI, JN , CHAKRABARTTY, A , (2017) TRANSTHYRETIN AMYLOIDOSIS: AN UNDER-RECOGNIZED NEUROPATHY AND CARDIOMYOPATHY.CLINICAL SCIENCE. VOL. 131. ISSUE 5. P. 395 -409 98 71% 0
9 SARAIVA, MJM , (2001) TRANSTHYRETIN MUTATIONS IN HYPERTHYROXINEMIA AND AMYLOID DISEASES.HUMAN MUTATION. VOL. 17. ISSUE 6. P. 493-503 87 99% 131
10 SEKIJIMA, Y , (2015) TRANSTHYRETIN (ATTR) AMYLOIDOSIS: CLINICAL SPECTRUM, MOLECULAR PATHOGENESIS AND DISEASE-MODIFYING TREATMENTS.JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. VOL. 86. ISSUE 9. P. 1036 -1043 58 98% 13

Classes with closest relation at Level 1


Rank Class id link
1 403 AMYLOIDOSIS//AL AMYLOIDOSIS//CARDIAC AMYLOIDOSIS
2 35772 ASPARTIC SALTS//RAT THYROXINE BINDING GLOBULIN//CARDILAN
3 13143 RETINOL BINDING PROTEIN 4//RBP4//RETINOL BINDING PROTEIN
4 28605 PARTIAL ILEAL BYPASS//COMBINED HEART LIVER TRANSPLANT//HEART LIVER TRANSPLANTATION
5 25915 LIGHT CHAIN AMYLOIDOSIS//GLYCOSYLATED IMMUNOGLOBULIN LIGHT CHAIN//IMMUNOLOGICAL SIGNAL
6 2153 AMYLOID FIBRILS//AMYLOID//DIALYSIS RELATED AMYLOIDOSIS
7 16257 CHOROID PLEXUS//CEREBROSPINAL FLUID FORMATION//BLOOD CSF BARRIER
8 23511 URICASE//UNIT ANALYT PROBES PROT BIOTECHNOLEDUC MINIST//URATE OXIDASE
9 31869 FAMILIAL BRITISH DEMENTIA//FAMILIAL DANISH DEMENTIA//BRI2
10 36900 CHICK FETUSES//COLONEL S//LEHRSTUHL ZOOL OKOL

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