Class information for:
Level 1: BUTYRYLCHOLINESTERASE//ACETYLCHOLINESTERASE//ACETYLCHOLINESTERASE INHIBITORS

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
2765 2154 42.1 74%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
11 4 NEUROSCIENCES//CLINICAL NEUROLOGY//NEUROL 1112395
471 3       ACETYLCHOLINESTERASE//PARAOXONASE//SULFUR MUSTARD 23986
1440 2             ACETYLCHOLINESTERASE//BUTYRYLCHOLINESTERASE//TACRINE 7842
2765 1                   BUTYRYLCHOLINESTERASE//ACETYLCHOLINESTERASE//ACETYLCHOLINESTERASE INHIBITORS 2154

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BUTYRYLCHOLINESTERASE authKW 568607 10% 20% 205
2 ACETYLCHOLINESTERASE authKW 549883 20% 9% 438
3 ACETYLCHOLINESTERASE INHIBITORS authKW 470396 8% 20% 164
4 BIS7 TACRINE authKW 383194 1% 97% 28
5 MULTI TARGET DIRECTED LIGANDS authKW 316763 1% 72% 31
6 TACRINE authKW 264637 4% 20% 94
7 BUTYRYLCHOLINESTERASE INHIBITORS authKW 260544 1% 74% 25
8 ACHE INHIBITORS authKW 186661 2% 38% 35
9 BETA AMYLOID AGGREGATION authKW 170392 1% 52% 23
10 BUCHE authKW 145134 1% 64% 16

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Medicinal 34739 38% 0% 810
2 Biochemistry & Molecular Biology 3862 37% 0% 796
3 Chemistry, Organic 2951 18% 0% 385
4 Pharmacology & Pharmacy 1885 19% 0% 414
5 Biophysics 822 8% 0% 174
6 Chemistry, Multidisciplinary 409 12% 0% 254
7 Toxicology 311 4% 0% 94
8 Neurosciences 295 9% 0% 202
9 Computer Science, Interdisciplinary Applications 106 3% 0% 55
10 Mathematical & Computational Biology 31 1% 0% 22

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MAYO CANC 113770 1% 47% 17
2 UNITE ENZYMOL 113542 1% 32% 25
3 IQOG 90746 2% 19% 33
4 TEOFILO HERNANDO 89022 2% 16% 39
5 PHYSICOCHEM DRUG ANAL 83279 1% 26% 23
6 TRADIT CHINESE MED PHARMACOL TOXICOL 72895 0% 86% 6
7 FARMACOL TER EUT TOXICOL 66883 1% 20% 24
8 MED NEUROL GERIATR MED 64418 0% 45% 10
9 FARMACOL TER EUT 60386 2% 9% 46
10 WUHAN NEUROSCI DRUG 59058 0% 83% 5

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 21451 6% 1% 119
2 BIOORGANIC & MEDICINAL CHEMISTRY 20068 6% 1% 136
3 JOURNAL OF MEDICINAL CHEMISTRY 11722 6% 1% 134
4 JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 10471 2% 2% 38
5 CHEMICO-BIOLOGICAL INTERACTIONS 10188 3% 1% 64
6 BIOORGANIC CHEMISTRY 8614 1% 2% 30
7 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 5058 4% 0% 96
8 MEDICINAL CHEMISTRY RESEARCH 3208 1% 1% 27
9 BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY 2338 1% 1% 19
10 MINI-REVIEWS IN MEDICINAL CHEMISTRY 2252 1% 1% 16

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 BUTYRYLCHOLINESTERASE 568607 10% 20% 205 Search BUTYRYLCHOLINESTERASE Search BUTYRYLCHOLINESTERASE
2 ACETYLCHOLINESTERASE 549883 20% 9% 438 Search ACETYLCHOLINESTERASE Search ACETYLCHOLINESTERASE
3 ACETYLCHOLINESTERASE INHIBITORS 470396 8% 20% 164 Search ACETYLCHOLINESTERASE+INHIBITORS Search ACETYLCHOLINESTERASE+INHIBITORS
4 BIS7 TACRINE 383194 1% 97% 28 Search BIS7+TACRINE Search BIS7+TACRINE
5 MULTI TARGET DIRECTED LIGANDS 316763 1% 72% 31 Search MULTI+TARGET+DIRECTED+LIGANDS Search MULTI+TARGET+DIRECTED+LIGANDS
6 TACRINE 264637 4% 20% 94 Search TACRINE Search TACRINE
7 BUTYRYLCHOLINESTERASE INHIBITORS 260544 1% 74% 25 Search BUTYRYLCHOLINESTERASE+INHIBITORS Search BUTYRYLCHOLINESTERASE+INHIBITORS
8 ACHE INHIBITORS 186661 2% 38% 35 Search ACHE+INHIBITORS Search ACHE+INHIBITORS
9 BETA AMYLOID AGGREGATION 170392 1% 52% 23 Search BETA+AMYLOID+AGGREGATION Search BETA+AMYLOID+AGGREGATION
10 BUCHE 145134 1% 64% 16 Search BUCHE Search BUCHE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 GUZIOR, N , WIECKOWSKA, A , PANEK, D , MALAWSKA, B , (2015) RECENT DEVELOPMENT OF MULTIFUNCTIONAL AGENTS AS POTENTIAL DRUG CANDIDATES FOR THE TREATMENT OF ALZHEIMER'S DISEASE.CURRENT MEDICINAL CHEMISTRY. VOL. 22. ISSUE 3. P. 373 -404 117 53% 38
2 CARREIRAS, MC , MENDES, E , PERRY, MJ , FRANCISCO, AP , MARCO-CONTELLES, J , (2013) THE MULTIFACTORIAL NATURE OF ALZHEIMER'S DISEASE FOR DEVELOPING POTENTIAL THERAPEUTICS.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 13. ISSUE 15. P. 1745 -1770 133 52% 48
3 ANAND, P , SINGH, B , (2013) A REVIEW ON CHOLINESTERASE INHIBITORS FOR ALZHEIMER'S DISEASE.ARCHIVES OF PHARMACAL RESEARCH. VOL. 36. ISSUE 4. P. 375-399 73 69% 91
4 CAMPS, P , FORMOSA, X , GALDEANO, C , MUNOZ-TORRERO, D , RAMIREZ, L , GOMEZ, E , ISAMBERT, N , LAVILLA, R , BADIA, A , CLOS, MV , ET AL (2009) PYRANO[3,2-C]QUINOLINE-6-CHLOROTACRINE HYBRIDS AS A NOVEL FAMILY OF ACETYLCHOLINESTERASE- AND BETA-AMYLOID-DIRECTED ANTI-ALZHEIMER COMPOUNDS.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 52. ISSUE 17. P. 5365 -5379 79 81% 89
5 MUNOZ-TORRERO, D , (2008) ACETYLCHOLINESTERASE INHIBITORS AS DISEASE-MODIFYING THERAPIES FOR ALZHEIMER'S DISEASE.CURRENT MEDICINAL CHEMISTRY. VOL. 15. ISSUE 24. P. 2433 -2455 94 62% 122
6 BERMUDEZ-LUGO, JA , ROSALES-HERNANDEZ, MC , DEEB, O , TRUJILLO-FERRARA, J , CORREA-BASURTO, J , (2011) IN SILICO METHODS TO ASSIST DRUG DEVELOPERS IN ACETYLCHOLINESTERASE INHIBITOR DESIGN.CURRENT MEDICINAL CHEMISTRY. VOL. 18. ISSUE 8. P. 1122-1136 93 70% 4
7 CHAVES, S , CHAND, K , SANTOS, MA , (2016) RECENT PROGRESS IN REPOSITIONING ALZHEIMER'S DISEASE DRUGS BASED ON A MULTITARGET STRATEGY.FUTURE MEDICINAL CHEMISTRY. VOL. 8. ISSUE 17. P. 2113 -2142 89 55% 1
8 VIAYNA, E , SABATE, R , MUNOZ-TORRERO, D , (2013) DUAL INHIBITORS OF BETA-AMYLOID AGGREGATION AND ACETYLCHOLINESTERASE AS MULTI-TARGET ANTI-ALZHEIMER DRUG CANDIDATES.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 13. ISSUE 15. P. 1820-1842 77 58% 28
9 SINGH, M , KAUR, M , CHADHA, N , SILAKARI, O , (2016) HYBRIDS: A NEW PARADIGM TO TREAT ALZHEIMER'S DISEASE.MOLECULAR DIVERSITY. VOL. 20. ISSUE 1. P. 271 -297 60 65% 3
10 MUNOZ-TORRERO, D , CAMPS, P , (2006) DIMERIC AND HYBRID ANTI-ALZHEIMER DRUG CANDIDATES.CURRENT MEDICINAL CHEMISTRY. VOL. 13. ISSUE 4. P. 399 -422 97 55% 77

Classes with closest relation at Level 1


Rank Class id link
1 35366 CIS DIAMMINEDIAQUAPLATINUM II//ACETYTCHOLINESTERASE//CIS DIAMMINEDIAQUAPLATINUM
2 3449 ACETYLCHOLINESTERASE//BUTYRYLCHOLINESTERASE//MOLECULAR FORMS
3 10092 TACRINE//METRIFONATE//TETRAHYDROAMINOACRIDINE
4 13987 HUPERZINE A//LYCOPODIUM ALKALOIDS//LYCOPODIACEAE
5 16578 ACETYLCHOLINESTERASE//ORGANOPHOSPHATE RESISTANCE//INSECTICIDE RESISTANCE
6 15351 BUTYRYLCHOLINESTERASE//SERUM CHOLINESTERASE//DIBUCAINE NUMBER
7 2910 DONEPEZIL//RIVASTIGMINE//GALANTAMINE
8 30106 COMPARATIVE ENZYMOLOGY//REVERSIBLE INHIBITORS//INSECTOACARICIDES
9 29205 BUXACEAE//SARCOCOCCA SALIGNA//CYCLOVIROBUXINE D
10 871 SOMAN//NERVE AGENTS//HI 6

Go to start page