Class information for:
Level 1: PHARMACODYNAM THER EUT//PHARMACODYNAMIE THER EUT//SERV CHIM PHARMACEUT

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
27571 226 26.5 63%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
8 4 CARDIAC & CARDIOVASCULAR SYSTEM//PERIPHERAL VASCULAR DISEASES//CARDIOL 1276458
11 3       ATRIAL FIBRILLATION//CARDIAC & CARDIOVASCULAR SYSTEM//CATHETER ABLATION 130936
1189 2             NICORANDIL//ISCHEMIC PRECONDITIONING//K ATP CHANNEL 9282
27571 1                   PHARMACODYNAM THER EUT//PHARMACODYNAMIE THER EUT//SERV CHIM PHARMACEUT 226

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PHARMACODYNAM THER EUT address 1261039 6% 67% 14
2 PHARMACODYNAMIE THER EUT address 810662 5% 50% 12
3 SERV CHIM PHARMACEUT address 786103 4% 73% 8
4 UNITE CRISTALLOG address 653931 5% 44% 11
5 CHIM PHARMACEUT address 502997 10% 17% 22
6 AMINO DECHLORINATION authKW 405337 1% 100% 3
7 BENZOTHIADIAZINE DIOXIDES authKW 304001 1% 75% 3
8 MED CP 617 address 304001 1% 75% 3
9 1 2 4 BENZOTHIADIAZINES authKW 270225 1% 100% 2
10 ADV TECHNOL CORP ATC SA address 270225 1% 100% 2

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Medicinal 2669 32% 0% 73
2 Chemistry, Organic 634 25% 0% 56
3 Crystallography 546 14% 0% 31
4 Endocrinology & Metabolism 506 19% 0% 43
5 Pharmacology & Pharmacy 193 19% 0% 43
6 Chemistry, Multidisciplinary 71 14% 0% 32
7 Biochemistry & Molecular Biology 2 8% 0% 18
8 Physiology 2 2% 0% 5
9 Chemistry, Inorganic & Nuclear 1 2% 0% 4
10 Medicine, Research & Experimental 0 2% 0% 4

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PHARMACODYNAM THER EUT 1261039 6% 67% 14
2 PHARMACODYNAMIE THER EUT 810662 5% 50% 12
3 SERV CHIM PHARMACEUT 786103 4% 73% 8
4 UNITE CRISTALLOG 653931 5% 44% 11
5 CHIM PHARMACEUT 502997 10% 17% 22
6 MED CP 617 304001 1% 75% 3
7 ADV TECHNOL CORP ATC SA 270225 1% 100% 2
8 INTER RECH MED CHIM PHARMACEUT 270225 1% 100% 2
9 STATE PHARMACOKINET PHARMACODYNAM 180148 1% 67% 2
10 CHIM BIOANAL TOXICOL CHIM PHYS PL 135112 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF HETEROCYCLIC CHEMISTRY 3173 7% 0% 16
2 JOURNAL OF MEDICINAL CHEMISTRY 2026 8% 0% 18
3 DIABETOLOGIE UND STOFFWECHSEL 2005 1% 1% 2
4 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 1744 5% 0% 11
5 ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS 1303 4% 0% 10
6 ARCHIV DER PHARMAZIE 1122 3% 0% 6
7 BIOORGANIC & MEDICINAL CHEMISTRY 1028 4% 0% 10
8 DIABETES OBESITY & METABOLISM 976 2% 0% 4
9 DIABETOLOGIA 789 3% 0% 7
10 PHARMAZIE 735 3% 0% 7

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 AMINO DECHLORINATION 405337 1% 100% 3 Search AMINO+DECHLORINATION Search AMINO+DECHLORINATION
2 BENZOTHIADIAZINE DIOXIDES 304001 1% 75% 3 Search BENZOTHIADIAZINE+DIOXIDES Search BENZOTHIADIAZINE+DIOXIDES
3 1 2 4 BENZOTHIADIAZINES 270225 1% 100% 2 Search 1+2+4+BENZOTHIADIAZINES Search 1+2+4+BENZOTHIADIAZINES
4 ANTIPLATELET AGGREGATION ACTIVITIES 270225 1% 100% 2 Search ANTIPLATELET+AGGREGATION+ACTIVITIES Search ANTIPLATELET+AGGREGATION+ACTIVITIES
5 BPDZ 44 270225 1% 100% 2 Search BPDZ+44 Search BPDZ+44
6 KIR62 SUR1 270225 1% 100% 2 Search KIR62+SUR1 Search KIR62+SUR1
7 PYRAZOLOTHIADIAZINES 270225 1% 100% 2 Search PYRAZOLOTHIADIAZINES Search PYRAZOLOTHIADIAZINES
8 PYRIDOTHIADIAZINE DIOXIDES 270225 1% 100% 2 Search PYRIDOTHIADIAZINE+DIOXIDES Search PYRIDOTHIADIAZINE+DIOXIDES
9 RB 86 CA 45 FLUXES 270225 1% 100% 2 Search RB+86+CA+45+FLUXES Search RB+86+CA+45+FLUXES
10 NN414 243200 1% 60% 3 Search NN414 Search NN414

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 DE TULLIO, P , LEBRUN, P , FLORENCE, X , ANTOINE, MH , FRANCOTTE, P , PIROTTE, B , (2006) SELECTIVE PANCREATIC ATP-SENSITIVE POTASSIUM CHANNEL OPENERS FOR THE TREATMENT OF GLUCOSE HOMEOSTASIS DISORDERS.DRUGS OF THE FUTURE. VOL. 31. ISSUE 11. P. 991-1001 40 41% 1
2 LYNCH, CJ , ZHOU, Q , SHYNG, SL , HEAL, DJ , CHEETHAM, SC , DICKINSON, K , GREGORY, P , FIRNGES, M , NORDHEIM, U , GOSHORN, S , ET AL (2012) SOME CANNABINOID RECEPTOR LIGANDS AND THEIR DISTOMERS ARE DIRECT-ACTING OPENERS OF SUR1 K-ATP CHANNELS.AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. VOL. 302. ISSUE 5. P. E540-E551 30 39% 5
3 CHROBAK, E , BORYCZKA, S , WLEKLINSKI, M , KUSZ, J , ZUBKO, M , MASLANKIEWICZ, A , (2015) SYNTHESIS AND TRANSFORMATIONS OF 2-OXO-2,3-DIHYDRO-(1H, 3H)-QUINO[4,3-E]-1,2,4-THIADIAZINE 4,4-DIOXIDE TO N-METHYL-, 2-CHLORO- AND 2-AMINOQUINO[4,3-E]-1,2,4-THIADIAZINE 4,4-DIOXIDES.HETEROCYCLES. VOL. 91. ISSUE 11. P. 2097 -2112 16 67% 0
4 PIROTTE, B , DE TULLIO, P , FLORENCE, X , GOFFIN, E , SOMERS, F , BOVERIE, S , LEBRUN, P , (2013) 1,4,2-BENZO/PYRIDODITHIAZINE 1,1-DIOXIDES STRUCTURALLY RELATED TO THE ATP-SENSITIVE POTASSIUM CHANNEL OPENERS 1,2,4-BENZO/PYRIDOTHIADIAZINE 1,1-DIOXIDES EXERT A MYORELAXANT ACTIVITY LINKED TO A DISTINCT MECHANISM OF ACTION.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 56. ISSUE 8. P. 3247 -3256 14 61% 3
5 HANSEN, JB , (2006) TOWARDS SELECTIVE KIR6.2/SUR1 POTASSIUM CHANNEL OPENERS, MEDICINAL CHEMISTRY AND THERAPEUTIC PERSPECTIVES.CURRENT MEDICINAL CHEMISTRY. VOL. 13. ISSUE 4. P. 361-376 33 29% 30
6 NIELSEN, FE , EBDRUP, S , JENSEN, AF , YNDDAL, L , BODVARSDOTTIR, TB , STIDSEN, C , WORSAAE, A , BOONEN, HCM , ARKHAMMAR, POG , FREMMING, T , ET AL (2006) NEW 3-ALKYLAMINO-4H-THIENO-1,2,4-THIADIAZINE 1,1-DIOXIDE DERIVATIVES ACTIVATE ATP-SENSITIVE POTASSIUM CHANNELS OF PANCREATIC BETA CELLS.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 49. ISSUE 14. P. 4127 -4139 17 47% 21
7 PIROTTE, B , DE TULLIO, P , BOVERIE, S , MICHAUX, C , LEBRUN, P , (2011) IMPACT OF THE NATURE OF THE SUBSTITUENT AT THE 3-POSITION OF 4H-1,2,4-BENZOTHIADIAZINE 1,1-DIOXIDES ON THEIR OPENING ACTIVITY TOWARD ATP-SENSITIVE POTASSIUM CHANNELS.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 54. ISSUE 9. P. 3188 -3199 14 50% 3
8 NIELSEN, FE , JACOBSEN, P , WORSAAE, A , ARKHAMMAR, POG , WAHL, P , HANSEN, JB , (2004) 2-(4-METHOXYPHENOXY)-5NITRO-N-(4-SULFAMOYLPHENYL)BENZAMIDE ACTIVATES KIR6.2/SUR1 K-ATP CHANNELS.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. VOL. 14. ISSUE 23. P. 5727-5730 12 67% 7
9 DE TULLIO, P , BECKER, B , BOVERIE, S , DABROWSKI, M , WAHL, P , ANTOINE, MH , SOMERS, F , SEBILLE, S , OUEDRAOGO, R , HANSEN, JB , ET AL (2003) TOWARD TISSUE-SELECTIVE PANCREATIC B-CELLS K-ATP CHANNEL OPENERS BELONGING TO 3-ALKYLAMINO-7-HALO-4H-1,2,4-BENZOTHIADIAZINE 1,1-DIOXIDES.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 46. ISSUE 15. P. 3342 -3353 14 56% 32
10 DE TULLIO, P , DUPONT, L , FRANCOTTE, P , COUNEROTTE, S , LEBRUN, P , PIROTTE, B , (2006) THREE-DIMENSIONAL QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS OF ATP-SENSITIVE POTASSIUM (K-ATP) CHANNEL OPENERS BELONGING TO THE 3-ALKYLAMINO-4H-1,2,4-BENZO- AND 3-ALKYLAMINO-4H-1,2,4-PYRIDOTHIADIAZINE 1,1-DIOXIDE FAMILIES.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 49. ISSUE 23. P. 6779-6788 17 44% 10

Classes with closest relation at Level 1


Rank Class id link
1 761 ATP SENSITIVE K CHANNEL//K ATP CHANNEL//ATP SENSITIVE POTASSIUM CHANNEL
2 22680 GK RAT//INSULIN GLUCOSE CLAMP//PHOSPHORYLATIVE SYSTEM
3 18225 N ALKYLSULFAMATES//1 2 5 THIADIAZOLE 1 1 DIOXIDE DERIVATIVES//1 2 5 THIADIAZOLE DERIVATIVES
4 25516 SULOFENUR//INDISULAM//E7070
5 31316 ADENOSINE 5 O 2 THIODIPHOSPHATE ADP BETA S//UNIT UP EA 1677//2 METHYLTHIOADENOSINE
6 32124 MERCURYII EDTA DEHYDROGENATION//C AMINOMETHYLATION//HGII INDUCED DEHYDROGENATION
7 11430 CONGENITAL HYPERINSULINISM//NESIDIOBLASTOSIS//HYPERINSULINISM
8 35953 ISOPINOCAMPHONE//HYSSOPUS OFFICINALIS//HYSSOPUS OFFICINALIS L
9 20898 ISOTHIAZOLIUM SALTS//1 2 BENZISOTHIAZOL 32H ONE//INTERUNIV RIC REAZ PERICICLICHE SINTESI SIS
10 11790 INTRACELLULAR ION CHANNELS//DIAZOXIDE//5 HYDROXYDECANOATE

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