Class information for: |
Basic class information |
| Class id | #P | Avg. number of references |
Database coverage of references |
|---|---|---|---|
| 26532 | 252 | 31.8 | 55% |
Hierarchy of classes |
The table includes all classes above and classes immediately below the current class. |
| Cluster id | Level | Cluster label | #P |
|---|---|---|---|
| 0 | 4 | BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY | 4064930 |
| 405 | 3 | BACTERIORHODOPSIN//G PROTEIN COUPLED RECEPTOR//G PROTEIN | 29641 |
| 705 | 2 | G PROTEIN COUPLED RECEPTOR//GPCR//RHODOPSIN | 12950 |
| 26532 | 1 | AGONIST AFFINITY//ANTAGONIST DISSOCIATION CONSTANTS//IRREVERSIBLE RECEPTOR INACTIVATION METHOD | 252 |
Terms with highest relevance score |
| rank | Term | termType | Chi square | Shr. of publ. in class containing term |
Class's shr. of term's tot. occurrences |
#P with term in class |
|---|---|---|---|---|---|---|
| 1 | AGONIST AFFINITY | authKW | 392585 | 4% | 36% | 9 |
| 2 | ANTAGONIST DISSOCIATION CONSTANTS | authKW | 242344 | 1% | 100% | 2 |
| 3 | IRREVERSIBLE RECEPTOR INACTIVATION METHOD | authKW | 242344 | 1% | 100% | 2 |
| 4 | OPERATIONAL MODEL OF AGONISM | authKW | 233017 | 2% | 38% | 5 |
| 5 | FUNCTIONAL ANTAGONISM | authKW | 152230 | 3% | 18% | 7 |
| 6 | SPARE RECEPTOR | authKW | 126213 | 2% | 21% | 5 |
| 7 | 68 HALF MOON LANE | address | 121172 | 0% | 100% | 1 |
| 8 | A9L CELLS | authKW | 121172 | 0% | 100% | 1 |
| 9 | AGONIST ANTAGONIST COMBINATION | authKW | 121172 | 0% | 100% | 1 |
| 10 | AGONIST ANTAGONIST COMBINATION FIXED | authKW | 121172 | 0% | 100% | 1 |
Web of Science journal categories |
| Rank | Term | Chi square | Shr. of publ. in class containing term |
Class's shr. of term's tot. occurrences |
#P with term in class |
|---|---|---|---|---|---|
| 1 | Pharmacology & Pharmacy | 3615 | 69% | 0% | 173 |
| 2 | Mathematical & Computational Biology | 888 | 11% | 0% | 28 |
| 3 | Biology | 379 | 12% | 0% | 29 |
| 4 | Toxicology | 89 | 6% | 0% | 16 |
| 5 | Medicine, Research & Experimental | 29 | 5% | 0% | 13 |
| 6 | CYTOLOGY & HISTOLOGY | 14 | 0% | 0% | 1 |
| 7 | Cell Biology | 14 | 6% | 0% | 15 |
| 8 | Biochemical Research Methods | 11 | 3% | 0% | 8 |
| 9 | Biochemistry & Molecular Biology | 7 | 10% | 0% | 24 |
| 10 | Medicine, Legal | 2 | 0% | 0% | 1 |
Address terms |
| Rank | Term | Chi square | Shr. of publ. in class containing term |
Class's shr. of term's tot. occurrences |
#P with term in class |
|---|---|---|---|---|---|
| 1 | 68 HALF MOON LANE | 121172 | 0% | 100% | 1 |
| 2 | GRP BIOMAT REC | 121172 | 0% | 100% | 1 |
| 3 | GRP MODELITZACIO ESTRUCT FUNCT SISTEMAS BIOL | 121172 | 0% | 100% | 1 |
| 4 | NIHDH HS | 121172 | 0% | 100% | 1 |
| 5 | REFERENCIA VECTO CE RE VE | 121172 | 0% | 100% | 1 |
| 6 | SIMCYP QSP | 121172 | 0% | 100% | 1 |
| 7 | RECEPTOR BIOCHEM | 94657 | 2% | 16% | 5 |
| 8 | BIO DISCOVERY | 60585 | 0% | 50% | 1 |
| 9 | EST BIO | 60585 | 0% | 50% | 1 |
| 10 | MATH MED | 38336 | 2% | 6% | 5 |
Journals |
| Rank | Term | Chi square | Shr. of publ. in class containing term |
Class's shr. of term's tot. occurrences |
#P with term in class |
|---|---|---|---|---|---|
| 1 | TRENDS IN PHARMACOLOGICAL SCIENCES | 30021 | 12% | 1% | 29 |
| 2 | JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS | 12851 | 4% | 1% | 11 |
| 3 | BRITISH JOURNAL OF PHARMACOLOGY | 6151 | 12% | 0% | 30 |
| 4 | JOURNAL OF PHARMACOLOGICAL METHODS | 5624 | 2% | 1% | 6 |
| 5 | JOURNAL OF THEORETICAL BIOLOGY | 3622 | 7% | 0% | 18 |
| 6 | PHARMACOLOGICAL REVIEWS | 2762 | 2% | 1% | 4 |
| 7 | EUROPEAN JOURNAL OF PHARMACOLOGY | 1540 | 8% | 0% | 19 |
| 8 | ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY | 1245 | 1% | 0% | 3 |
| 9 | JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS | 1112 | 6% | 0% | 14 |
| 10 | NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY | 971 | 3% | 0% | 7 |
Author Key Words |
Core articles |
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c: (1) Number of references referring to publications in the class. (2) Share of total number of active references referring to publications in the class. (3) Age of the article. New articles get higher score than old articles. (4) Citation rate, normalized to year. |
| Rank | Reference | # ref. in cl. |
Shr. of ref. in cl. |
Citations |
|---|---|---|---|---|
| 1 | TRZECIAKOWSKI, JP , (1999) STIMULUS AMPLIFICATION, EFFICACY, AND THE OPERATIONAL MODEL. PART II - TERNARY COMPLEX OCCUPANCY MECHANISMS.JOURNAL OF THEORETICAL BIOLOGY. VOL. 198. ISSUE 3. P. 347-374 | 17 | 57% | 9 |
| 2 | GIRALDO, J , VIVAS, NM , VILA, E , BADIA, A , (2002) ASSESSING THE (A)SYMMETRY OF CONCENTRATION-EFFECT CURVES: EMPIRICAL VERSUS MECHANISTIC MODELS.PHARMACOLOGY & THERAPEUTICS. VOL. 95. ISSUE 1. P. 21 -45 | 15 | 52% | 64 |
| 3 | TRZECIAKOWSKI, JP , (1999) STIMULUS AMPLIFICATION, EFFICACY, AND THE OPERATIONAL MODEL. PART I - BINARY COMPLEX OCCUPANCY MECHANISMS.JOURNAL OF THEORETICAL BIOLOGY. VOL. 198. ISSUE 3. P. 329 -346 | 11 | 79% | 11 |
| 4 | WOODROFFE, PJ , BRIDGE, LJ , KING, JR , CHEN, CY , HILL, SJ , (2010) MODELLING OF THE ACTIVATION OF G-PROTEIN COUPLED RECEPTORS: DRUG FREE CONSTITUTIVE RECEPTOR ACTIVITY.JOURNAL OF MATHEMATICAL BIOLOGY. VOL. 60. ISSUE 3. P. 313 -346 | 9 | 56% | 1 |
| 5 | GIRALDO, J , SERRA, J , ROCHE, D , ROVIRA, X , (2007) ASSESSING RECEPTOR AFFINITY FOR INVERSE AGONISTS: SCHILD AND CHENG-PRUSOFF METHODS REVISITED.CURRENT DRUG TARGETS. VOL. 8. ISSUE 1. P. 197 -202 | 11 | 42% | 11 |
| 6 | VAN DER GRAAF, PH , STAM, WB , (1999) ANALYSIS OF RECEPTOR INACTIVATION EXPERIMENTS WITH THE OPERATIONAL MODEL OF AGONISM YIELDS CORRELATED ESTIMATES OF AGONIST AFFINITY AND EFFICACY.JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS. VOL. 41. ISSUE 2-3. P. 117-125 | 12 | 46% | 7 |
| 7 | MEIER, E , SCHOUSBOE, A , BELHAGE, B , (2012) PROCEDURE FOR CALCULATION OF POTENCY AND EFFICACY FOR LIGANDS ACTING ON G(S)- AND G(I)-COUPLED RECEPTORS.NEUROCHEMICAL RESEARCH. VOL. 37. ISSUE 12. P. 2767-2775 | 6 | 60% | 1 |
| 8 | ROCHES, D , VAN DER GRAAF, PH , GIRALDO, J , (2016) HAVE MANY ESTIMATES OF EFFICACY AND AFFINITY BEEN MISLED? REVISITING THE OPERATIONAL MODEL OF AGONISM.DRUG DISCOVERY TODAY. VOL. 21. ISSUE 11. P. 1735 -1739 | 4 | 80% | 0 |
| 9 | DIAZTOLEDO, A , JURKIEWICZ, A , (1990) DISSOCIATION-CONSTANTS AND RELATIVE EFFICACIES ESTIMATED FROM THE FUNCTIONAL ANTAGONISM OF BETA-ADRENOCEPTOR AGONISTS ON TRANSMURAL-STIMULATION IN RAT VAS-DEFERENS.EUROPEAN JOURNAL OF PHARMACOLOGY. VOL. 191. ISSUE 2. P. 157-165 | 8 | 89% | 2 |
| 10 | BARLOW, RB , BOND, SM , GRANT, C , MCQUEEN, DS , YAQOOB, Z , (2001) A COMPARISON OF EFFECTS MEASURED WITH ISOTONIC AND ISOMETRIC RECORDING: II. CONCENTRATION-EFFECT CURVES FOR PHYSIOLOGICAL ANTAGONISTS.BRITISH JOURNAL OF PHARMACOLOGY. VOL. 133. ISSUE 7. P. 1087-1095 | 6 | 75% | 3 |
Classes with closest relation at Level 1 |