Class information for:
Level 1: NIPRADILOL//BOPINDOLOL//BOPINDOLOL METABOLITES

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
24830 300 19.8 51%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
8 4 CARDIAC & CARDIOVASCULAR SYSTEM//PERIPHERAL VASCULAR DISEASES//CARDIOL 1276458
522 3       MAGNESIUM-BULLETIN//MAGNESIUM RESEARCH//MAGNESIUM 20526
878 2             NEBIVOLOL//CARVEDILOL//BETA BLOCKERS 11463
24830 1                   NIPRADILOL//BOPINDOLOL//BOPINDOLOL METABOLITES 300

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 NIPRADILOL authKW 1556344 10% 53% 29
2 BOPINDOLOL authKW 1454047 7% 71% 20
3 BOPINDOLOL METABOLITES authKW 508920 2% 100% 5
4 SLOW DISSOCIATING ANTAGONIST authKW 305352 1% 100% 3
5 H 3 CGP12177 authKW 232646 1% 57% 4
6 BETA BLOCKING ACTION authKW 229013 1% 75% 3
7 CAS 81486 22 8 authKW 229013 1% 75% 3
8 1 5 BENZOTHIAZEPIN 45H ONE authKW 101784 0% 100% 1
9 ALPHA 1 BLOCKING AND BETA BLOCKING ACTIVITY authKW 101784 0% 100% 1
10 BDTI authKW 101784 0% 100% 1

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Pharmacology & Pharmacy 4939 73% 0% 220
2 Cardiac & Cardiovascular System 401 15% 0% 46
3 Chemistry, Medicinal 184 8% 0% 24
4 Medicine, Research & Experimental 174 10% 0% 30
5 Chemistry, Multidisciplinary 60 12% 0% 36
6 Ophthalmology 38 4% 0% 11
7 Peripheral Vascular Diseases 17 3% 0% 9
8 Toxicology 2 2% 0% 5
9 Physiology 1 2% 0% 5
10 Medical Informatics 1 0% 0% 1

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DEV SDRUG DELIVERY 101784 0% 100% 1
2 MED STROMATOL 101784 0% 100% 1
3 PHARMACOL PHARM 5829 KAMISHINEI CHO 101784 0% 100% 1
4 DEV MINATO KU 101782 1% 50% 2
5 JJ VAN ROOD CLIN TRANSFUS 50891 0% 50% 1
6 PREVENT MED PROGRAM ATHEROSCLEROSIS PROJECT 50891 0% 50% 1
7 NEUROL PSYCHIAT ABT 14539 0% 14% 1
8 FLOW ANAL 12721 0% 13% 1
9 MED INTERNAL MED 2 BUNKYO KU 6360 0% 6% 1
10 GENE THER Y CORE 5985 0% 6% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JAPANESE JOURNAL OF PHARMACOLOGY 18226 9% 1% 28
2 ARCHIVES INTERNATIONALES DE PHARMACODYNAMIE ET DE THERAPIE 10131 5% 1% 15
3 CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL 6875 6% 0% 18
4 PHARMACOLOGY 4454 4% 0% 12
5 JOURNAL OF CARDIOVASCULAR PHARMACOLOGY 3326 6% 0% 19
6 JAPANESE HEART JOURNAL 3066 3% 0% 8
7 COR ET VASA 2720 1% 1% 3
8 SHARP TECHNICAL JOURNAL 2543 0% 3% 1
9 FOLIA PHARMACOLOGICA JAPONICA 2308 2% 0% 5
10 JOURNAL OF PHARMACOBIO-DYNAMICS 1554 2% 0% 5

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 NIPRADILOL 1556344 10% 53% 29 Search NIPRADILOL Search NIPRADILOL
2 BOPINDOLOL 1454047 7% 71% 20 Search BOPINDOLOL Search BOPINDOLOL
3 BOPINDOLOL METABOLITES 508920 2% 100% 5 Search BOPINDOLOL+METABOLITES Search BOPINDOLOL+METABOLITES
4 SLOW DISSOCIATING ANTAGONIST 305352 1% 100% 3 Search SLOW+DISSOCIATING+ANTAGONIST Search SLOW+DISSOCIATING+ANTAGONIST
5 H 3 CGP12177 232646 1% 57% 4 Search H+3+CGP12177 Search H+3+CGP12177
6 BETA BLOCKING ACTION 229013 1% 75% 3 Search BETA+BLOCKING+ACTION Search BETA+BLOCKING+ACTION
7 CAS 81486 22 8 229013 1% 75% 3 Search CAS+81486+22+8 Search CAS+81486+22+8
8 1 5 BENZOTHIAZEPIN 45H ONE 101784 0% 100% 1 Search 1+5+BENZOTHIAZEPIN+45H+ONE Search 1+5+BENZOTHIAZEPIN+45H+ONE
9 ALPHA 1 BLOCKING AND BETA BLOCKING ACTIVITY 101784 0% 100% 1 Search ALPHA+1+BLOCKING+AND+BETA+BLOCKING+ACTIVITY Search ALPHA+1+BLOCKING+AND+BETA+BLOCKING+ACTIVITY
10 BDTI 101784 0% 100% 1 Search BDTI Search BDTI

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 HAYASHI, T , IGUCHI, A , (1998) NIPRADILOL: A BETA-ADRENOCEPTOR ANTAGONIST WITH NITRIC OXIDE-RELEASING ACTION.CARDIOVASCULAR DRUG REVIEWS. VOL. 16. ISSUE 3. P. 212 -235 24 65% 3
2 NAGATOMO, T , HOSOHATA, Y , OHNUKI, T , NAKAMURA, T , HATTORI, K , SUZUKI, J , ISHIGURO, M , (2001) BOPINDOLOL: PHARMACOLOGICAL BASIS AND CLINICAL IMPLICATIONS.CARDIOVASCULAR DRUG REVIEWS. VOL. 19. ISSUE 1. P. 9 -24 25 51% 1
3 HARRON, DWG , GOA, KL , LANGTRY, HD , (1991) BOPINDOLOL - A REVIEW OF ITS PHARMACODYNAMIC AND PHARMACOKINETIC PROPERTIES AND THERAPEUTIC EFFICACY.DRUGS. VOL. 41. ISSUE 1. P. 130-149 25 74% 7
4 SAKUMA, N , TSUCHIHASHI, H , HOSOHATA, Y , AKASHI, H , KINAMI, J , NAGATOMO, T , (1991) BETA-BLOCKING POTENCY AND SELECTIVITY OF BOPINDOLOL AND ITS 2 METABOLITES FOR BETA-1-ADRENERGIC AND BETA-2-ADRENERGIC RECEPTORS AS ASSESSED BY RADIOLIGAND BINDING ASSAY.JOURNAL OF PHARMACOBIO-DYNAMICS. VOL. 14. ISSUE 5. P. 250-255 17 85% 1
5 HATTORI, K , SUZUKI, J , HOSOHATA, Y , OHNUKI, T , NAKAMURA, T , WATANABE, K , MURAMATSU, I , NAGATOMO, T , (1999) SUSTAINING EFFECTS OF BOPINDOLOL ON INHIBITORY CHRONOTROPIC ACTIONS IN GUINEA PIG ATRIA.PHARMACOLOGY. VOL. 59. ISSUE 4. P. 183-191 11 92% 0
6 ABIKO, Y , GOTOH, H , YOKOYAMA, T , ABIKO, T , HASHIZUME, H , AKIYAMA, K , (1994) BOPINDOLOL AND ITS METABOLITE 18-502 ATTENUATE REGIONAL MYOCARDIAL ACIDOSIS DURING PARTIAL OCCLUSION OF THE CORONARY-ARTERY IN DOGS.ARCHIVES INTERNATIONALES DE PHARMACODYNAMIE ET DE THERAPIE. VOL. 327. ISSUE 1. P. 40-55 11 92% 2
7 HIRO, T , HAYASE, N , CHIBA, K , ICHIHARA, K , ABIKO, Y , (1989) NIPRADILOL, A BETA-ADRENOCEPTOR ANTAGONIST HAVING A VASODILATORY ACTION, ATTENUATES MYOCARDIAL ACIDOSIS INDUCED BY CORONARY-ARTERY OCCLUSION IN DOGS.METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY. VOL. 11. ISSUE 6. P. 373 -378 13 93% 1
8 BRASCH, H , DOMINIAK, P , (1992) BETA-ADRENOCEPTOR BLOCKING EFFECTS OF 2 BOPINDOLOL METABOLITES IN ISOLATED GUINEA-PIG ATRIA.ARZNEIMITTELFORSCHUNG-DRUG RESEARCH. VOL. 42-1. ISSUE 2. P. 97-100 12 80% 1
9 ISHIBASHI, T , MITOMI, A , TATEBE, S , IMAI, S , (1989) CARDIOHEMODYNAMIC EFFECTS OF BOPINDOLOL IN NORMOTENSIVE CONSCIOUS DOGS - A COMPARATIVE-STUDY WITH PINDOLOL.ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH. VOL. 39-1. ISSUE 4. P. 454-457 13 81% 5
10 NAKANISHI, T , TAKAHASHI, H , NISHIMURA, M , YOSIMURA, M , (1993) EFFECTS OF BENIDIPINE HYDROCHLORIDE ON 24-HOUR BLOOD-PRESSURE.CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL. VOL. 53. ISSUE 3. P. 270 -276 10 83% 4

Classes with closest relation at Level 1


Rank Class id link
1 20681 CELIPROLOL//PERINDOPRIL THERAPEUTIC USE//1 BETA ADRENERGIC RECEPTOR
2 18811 BISOPROLOL//BISOPROLOL EFFICACY//INTRAVESICAL BCG INSTILLATION
3 23518 POLYVINYLACETATE POVIDONE EXCIPIENT//RECEPTOR OCCUPANCY THEORY//CAS 318 98 9
4 31463 SHICHIMOTSUKOKATO//AGE DEPENDENT HEMODYNAMIC CHANGE//BENAZEPRIL HYDROCHLORIDE CENTRAL NERVOUS SYSTEM EFFECTS GENERAL PHARMACOLOGY
5 12676 AMOSULALOL//DILEVALOL//AARHUS CTY HOSP MED 1
6 15756 NICORANDIL//KRN2391//CAS 65141 46 0
7 32353 FOSTEDIL//BENZOB PYRAN DERIVATIVES//CAS 132031 81 3
8 35925 BIOPHYS CYTOCHEM//C13 OVARIAN CELL//HOSP ALMIRANTE NEF MED NEFROL
9 37399 ANTHRAQUINONE AZO PIGMENTS//CONDENSATION PIGMENTS//ECOLOGICAL TOXICOLOGY
10 12867 GLYCEROL OUTPUT//PALMITOYLCARNITINE//OXFENICINE

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