Class information for:
Level 1: FURIN//CARBOXYPEPTIDASE E//PROHORMONE CONVERTASE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
2440 2242 43.7 85%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
11 4 NEUROSCIENCES//CLINICAL NEUROLOGY//NEUROL 1112395
209 3       GHRELIN//ADRENOMEDULLIN//NEUROPEPTIDE Y 51926
2223 2             CHROMOGRANIN A//CHROMOGRANIN//SECRETOGRANIN II 4799
2440 1                   FURIN//CARBOXYPEPTIDASE E//PROHORMONE CONVERTASE 2242

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 FURIN authKW 882388 7% 41% 160
2 CARBOXYPEPTIDASE E authKW 680203 3% 78% 64
3 PROHORMONE CONVERTASE authKW 655855 4% 57% 85
4 PROPROTEIN CONVERTASE authKW 572660 4% 52% 81
5 BIOCHEM NEUROENDOCRINOL address 486324 4% 37% 96
6 PC2 authKW 407086 2% 59% 51
7 7B2 authKW 387939 2% 81% 35
8 PROPROTEIN CONVERTASES authKW 381502 2% 68% 41
9 PC1 authKW 339527 2% 64% 39
10 PACE4 authKW 322517 1% 79% 30

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Biochemistry & Molecular Biology 9938 55% 0% 1232
2 Endocrinology & Metabolism 3953 17% 0% 382
3 Cell Biology 3854 22% 0% 503
4 Biophysics 1387 10% 0% 223
5 Neurosciences 418 10% 0% 234
6 Genetics & Heredity 81 4% 0% 90
7 Developmental Biology 66 1% 0% 33
8 Biochemical Research Methods 39 2% 0% 54
9 Medicine, Research & Experimental 34 3% 0% 61
10 Biotechnology & Applied Microbiology 31 3% 0% 71

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOCHEM NEUROENDOCRINOL 486324 4% 37% 96
2 CELLULAR NEUROBIOL SECT 284243 2% 46% 45
3 REG PROT CHEM 180077 1% 58% 23
4 DIS AGING PROGRAM 127091 1% 67% 14
5 JA DESEVE BIOCHEM NEUROENDOCRINOL 79227 0% 73% 8
6 NEUROPEPTIDES STRUCT METAB 72623 0% 67% 8
7 MOL MED DIS AGING 68090 0% 100% 5
8 JA DESEVE MOLEC NEUROENDOCRINOL 67036 0% 62% 8
9 PHARMACOL SHERBROOKE 64419 1% 18% 27
10 BIOCHEM MOLEC NEUROENDOCRINOL S 55601 0% 58% 7

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF BIOLOGICAL CHEMISTRY 8266 14% 0% 308
2 ENDOCRINOLOGY 3948 4% 0% 86
3 FEBS LETTERS 3084 4% 0% 98
4 BIOCHEMICAL JOURNAL 3021 4% 0% 82
5 JOURNAL OF NEUROCHEMISTRY 2749 3% 0% 66
6 JOURNAL OF CELL BIOLOGY 2691 3% 0% 57
7 DNA AND CELL BIOLOGY 2619 1% 1% 23
8 MOLECULAR ENDOCRINOLOGY 2129 1% 1% 30
9 MOLECULAR AND CELLULAR ENDOCRINOLOGY 1559 1% 0% 32
10 NEUROPEPTIDES 1345 1% 1% 16

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 FURIN 882388 7% 41% 160 Search FURIN Search FURIN
2 CARBOXYPEPTIDASE E 680203 3% 78% 64 Search CARBOXYPEPTIDASE+E Search CARBOXYPEPTIDASE+E
3 PROHORMONE CONVERTASE 655855 4% 57% 85 Search PROHORMONE+CONVERTASE Search PROHORMONE+CONVERTASE
4 PROPROTEIN CONVERTASE 572660 4% 52% 81 Search PROPROTEIN+CONVERTASE Search PROPROTEIN+CONVERTASE
5 PC2 407086 2% 59% 51 Search PC2 Search PC2
6 7B2 387939 2% 81% 35 Search 7B2 Search 7B2
7 PROPROTEIN CONVERTASES 381502 2% 68% 41 Search PROPROTEIN+CONVERTASES Search PROPROTEIN+CONVERTASES
8 PC1 339527 2% 64% 39 Search PC1 Search PC1
9 PACE4 322517 1% 79% 30 Search PACE4 Search PACE4
10 PROHORMONE PROCESSING 185893 1% 43% 32 Search PROHORMONE+PROCESSING Search PROHORMONE+PROCESSING

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 STIJNEN, P , RAMOS-MOLINA, B , O'RAHILLY, S , CREEMERS, JWM , (2016) PCSK1 MUTATIONS AND HUMAN ENDOCRINOPATHIES: FROM OBESITY TO GASTROINTESTINAL DISORDERS.ENDOCRINE REVIEWS. VOL. 37. ISSUE 4. P. 347 -371 143 68% 2
2 BERGERON, F , LEDUC, R , DAY, R , (2000) SUBTILASE-LIKE PRO-PROTEIN CONVERTASES: FROM MOLECULAR SPECIFICITY TO THERAPEUTIC APPLICATIONS.JOURNAL OF MOLECULAR ENDOCRINOLOGY. VOL. 24. ISSUE 1. P. 1-22 145 86% 127
3 SEIDAH, NG , PRAT, A , (2012) THE BIOLOGY AND THERAPEUTIC TARGETING OF THE PROPROTEIN CONVERTASES.NATURE REVIEWS DRUG DISCOVERY. VOL. 11. ISSUE 5. P. 367 -383 120 52% 184
4 NAKAYAMA, K , (1997) FURIN: A MAMMALIAN SUBTILISIN/KEX2P-LIKE ENDOPROTEASE INVOLVED IN PROCESSING OF A WIDE VARIETY OF PRECURSOR PROTEINS.BIOCHEMICAL JOURNAL. VOL. 327. ISSUE . P. 625-635 117 76% 600
5 MBIKAY, M , SEIDAH, NG , CHRETIEN, M , (2001) NEUROENDOCRINE SECRETORY PROTEIN 7B2: STRUCTURE, EXPRESSION AND FUNCTIONS.BIOCHEMICAL JOURNAL. VOL. 357. ISSUE . P. 329-342 140 84% 110
6 CAWLEY, NX , LI, ZJ , LOH, YP , (2016) 60 YEARS OF POMC BIOSYNTHESIS, TRAFFICKING, AND SECRETION OF PRO-OPIOMELANOCORTIN-DERIVED PEPTIDES.JOURNAL OF MOLECULAR ENDOCRINOLOGY. VOL. 56. ISSUE 4. P. T77 -T97 94 59% 5
7 ROUILLE, Y , DUGUAY, SJ , LUND, K , FURUTA, M , GONG, QM , LIPKIND, G , OLIVA, AA , CHAN, SJ , STEINER, DF , (1995) PROTEOLYTIC PROCESSING MECHANISMS IN THE BIOSYNTHESIS OF NEUROENDOCRINE PEPTIDES - THE SUBTILISIN-LIKE PROPROTEIN CONVERTASES.FRONTIERS IN NEUROENDOCRINOLOGY. VOL. 16. ISSUE 4. P. 322-361 131 76% 229
8 HALBAN, PA , IRMINGER, JC , (1994) SORTING AND PROCESSING OF SECRETORY PROTEINS.BIOCHEMICAL JOURNAL. VOL. 299. ISSUE . P. 1-18 160 62% 256
9 MULLER, L , LINDBERG, I , (2000) THE CELL BIOLOGY OF THE PROHORMONE CONVERTASES PC1 AND PC2.PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY, VOL 63. VOL. 63. ISSUE . P. 69 -108 132 76% 8
10 TAYLOR, NA , VAN DE VEN, WJM , CREEMERS, JWM , (2003) CURBING ACTIVATION: PROPROTEIN CONVERTASES IN HOMEOSTASIS AND PATHOLOGY.FASEB JOURNAL. VOL. 17. ISSUE 10. P. 1215 -1227 99 76% 140

Classes with closest relation at Level 1


Rank Class id link
1 12043 CYTOCHROME B561//PEPTIDYLGLYCINE ALPHA AMIDATING MONOOXYGENASE//PEPTIDYLGLYCINE ALPHA HYDROXYLATING MONOOXYGENASE
2 5450 CHROMOGRANIN A//CHROMOGRANIN//SECRETOGRANIN II
3 25097 INSULIN GENE THERAPY//ENDOCRINOL METAB SECT 111//INSULIN STORAGE
4 20705 PROINSULIN//INTACT PROINSULIN//TRUE INSULIN
5 19330 ZYMOGEN GRANULES//UNIT GRANULE//GP2
6 12128 PROENKEPHALIN//MET ENKEPHALIN ARG6 PHE7//ENKEPHALIN PRECURSORS
7 19466 E2A GENE//RAT INSULIN II GENE//UNITE DIABETOL CLIN
8 5522 PROOPIOMELANOCORTIN//BETA ENDORPHIN//PROOPIOCORTIN
9 31095 VGF//NEF//TLQP 21
10 11601 NEUROPHYSIN//AVP GENE//NEUROHYPOPHYSEAL DIABETES INSIPIDUS

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