Class information for:
Level 1: ICOS//B7RP 1//INDUCIBLE COSTIMULATOR

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
24008 326 39.8 96%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
10 3       IMMUNOLOGY//JOURNAL OF IMMUNOLOGY//IMMUNOL 134299
919 2             PD L1//PD 1//FOXP3 11160
24008 1                   ICOS//B7RP 1//INDUCIBLE COSTIMULATOR 326

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ICOS authKW 2053124 17% 40% 55
2 B7RP 1 authKW 936662 3% 100% 10
3 INDUCIBLE COSTIMULATOR authKW 556304 4% 42% 14
4 ICOSL authKW 509957 2% 78% 7
5 PHARMACEUT FRONTIER S address 288872 5% 19% 16
6 B7H authKW 210747 1% 75% 3
7 INDUCIBLE COSTIMULATOR ICOS authKW 210747 1% 75% 3
8 AILIM ICOS authKW 187332 1% 100% 2
9 COSTIMULATION authKW 171107 16% 4% 51
10 ICOS LIGAND authKW 124887 1% 67% 2

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Immunology 6165 65% 0% 212
2 Transplantation 555 9% 0% 29
3 Rheumatology 114 4% 0% 12
4 Medicine, Research & Experimental 111 8% 0% 26
5 Allergy 98 3% 0% 9
6 Cell Biology 49 8% 0% 27
7 Surgery 26 7% 0% 23
8 Hematology 23 3% 0% 11
9 Respiratory System 11 2% 0% 7
10 Biochemical Research Methods 6 2% 0% 8

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PHARMACEUT FRONTIER S 288872 5% 19% 16
2 ABT INFETIONSMED 93666 0% 100% 1
3 ANAT PHARMACOL EXPT MED 93666 0% 100% 1
4 BIOANALYT SCI PKDM 93666 0% 100% 1
5 BLOOD MARROW TRANSPLATAT PROGRAM 93666 0% 100% 1
6 EQUIPE EL LIGUE CANC 93666 0% 100% 1
7 FUNDED OTSUKA CHEM CO LTD 93666 0% 100% 1
8 GLOBAL DRUG DISCOVERY TARGET DISCOVERY TRANSGEN 93666 0% 100% 1
9 INSERM 599 93666 0% 100% 1
10 LIFE SCI ADDIT 441 93666 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 HYBRIDOMA AND HYBRIDOMICS 6109 1% 2% 4
2 JOURNAL OF IMMUNOLOGY 5297 17% 0% 55
3 EUROPEAN JOURNAL OF IMMUNOLOGY 3758 7% 0% 23
4 INTERNATIONAL IMMUNOLOGY 2321 3% 0% 10
5 CLINICAL IMMUNOLOGY 1253 2% 0% 6
6 NATURE IMMUNOLOGY 1053 2% 0% 5
7 EXPERT OPINION ON THERAPEUTIC PATENTS 1044 2% 0% 5
8 AMERICAN JOURNAL OF TRANSPLANTATION 701 2% 0% 6
9 IMMUNITY 675 2% 0% 5
10 CURRENT OPINION IN IMMUNOLOGY 538 1% 0% 4

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 ICOS 2053124 17% 40% 55 Search ICOS Search ICOS
2 B7RP 1 936662 3% 100% 10 Search B7RP+1 Search B7RP+1
3 INDUCIBLE COSTIMULATOR 556304 4% 42% 14 Search INDUCIBLE+COSTIMULATOR Search INDUCIBLE+COSTIMULATOR
4 ICOSL 509957 2% 78% 7 Search ICOSL Search ICOSL
5 B7H 210747 1% 75% 3 Search B7H Search B7H
6 INDUCIBLE COSTIMULATOR ICOS 210747 1% 75% 3 Search INDUCIBLE+COSTIMULATOR+ICOS Search INDUCIBLE+COSTIMULATOR+ICOS
7 AILIM ICOS 187332 1% 100% 2 Search AILIM+ICOS Search AILIM+ICOS
8 COSTIMULATION 171107 16% 4% 51 Search COSTIMULATION Search COSTIMULATION
9 ICOS LIGAND 124887 1% 67% 2 Search ICOS+LIGAND Search ICOS+LIGAND
10 ICOSLG 124887 1% 67% 2 Search ICOSLG Search ICOSLG

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 YONG, PFK , SALZER, U , GRIMBACHER, B , (2009) THE ROLE OF COSTIMULATION IN ANTIBODY DEFICIENCIES: ICOS AND COMMON VARIABLE IMMUNODEFICIENCY.IMMUNOLOGICAL REVIEWS. VOL. 229. ISSUE . P. 101 -113 61 50% 28
2 WIKENHEISER, DJ , STUMHOFER, JS , (2016) ICOS CO-STIMULATION: FRIEND OR FOE?.FRONTIERS IN IMMUNOLOGY. VOL. 7. ISSUE . P. - 56 44% 0
3 TAJIMA, N , TEZUKA, K , TANAKA, M , TANIMOTO, M , MIYAI, A , TAKESHIMA, H , WATANABE, Y , (2008) CRITICAL ROLE OF ACTIVATION-INDUCIBLE LYMPHOCYTE IMMUNOMEDIATORY MOLECULE/INDUCIBLE COSTIMULATOR IN THE EFFECTOR FUNCTION OF HUMAN T CELLS: A COMPARATIVE IN VITRO STUDY OF EFFECTS OF ITS BLOCKADE AND CD28 BLOCKADE IN HUMAN BEINGS AND MONKEYS.HUMAN IMMUNOLOGY. VOL. 69. ISSUE 7. P. 399-408 32 78% 1
4 TAJIMA, N , TEZUKA, K , TANIMOTO, A , MIYAI, A , TANIMOTO, M , MARUHASHI, J , WATANABE, Y , (2008) JTA-009, A FULLY HUMAN ANTIBODY AGAINST HUMAN AILIM/ICOS, AMELIORATES GRAFT-VS-HOST REACTION IN SCID MICE GRAFTED WITH HUMAN PBMCS.EXPERIMENTAL HEMATOLOGY. VOL. 36. ISSUE 11. P. 1514-1523 32 76% 3
5 MESTURINI, R , NICOLA, S , CHIOCCHETTI, A , BERNARDONE, IS , CASTELLI, L , BENSI, T , FERRETTI, M , COMI, C , DONG, C , ROJO, JM , ET AL (2006) ICOS COOPERATES WITH CD28, IL-2, AND IFN-GAMMA AND MODULATES ACTIVATION OF HUMAN NALVE CD4(+) T CELLS.EUROPEAN JOURNAL OF IMMUNOLOGY. VOL. 36. ISSUE 10. P. 2601-2612 32 73% 17
6 ROJO, JM , PINI, E , OJEDA, G , BELLO, R , DONG, C , FLAVELL, RA , DIANZANI, U , PORTOLES, P , (2008) CD4(+)ICOS(+) T LYMPHOCYTES INHIBIT T CELL ACTIVATION 'IN VITRO' AND ATTENUATE AUTOIMMUNE ENCEPHALITIS 'IN VIVO'.INTERNATIONAL IMMUNOLOGY. VOL. 20. ISSUE 4. P. 577 -589 36 61% 12
7 SIMPSON, TR , QUEZADA, SA , ALLISON, JP , (2010) REGULATION OF CD4 T CELL ACTIVATION AND EFFECTOR FUNCTION BY INDUCIBLE COSTIMULATOR (ICOS).CURRENT OPINION IN IMMUNOLOGY. VOL. 22. ISSUE 3. P. 326-332 31 56% 74
8 BUSSE, M , KRECH, M , MEYER-BAHLBURG, A , HENNIG, C , HANSEN, G , (2012) ICOS MEDIATES THE GENERATION AND FUNCTION OF CD4(+)CD25(+) FOXP3(+) REGULATORY T CELLS CONVEYING RESPIRATORY TOLERANCE.JOURNAL OF IMMUNOLOGY. VOL. 189. ISSUE 4. P. 1975-1982 28 60% 30
9 LARIMORE, K , LIANG, LD , BAKKOUR, S , SHA, WC , (2012) B7H-EXPRESSING DENDRITIC CELLS AND PLASMA B CELLS MEDIATE DISTINCT OUTCOMES OF ICOS COSTIMULATION IN T CELL-DEPENDENT ANTIBODY RESPONSES.BMC IMMUNOLOGY. VOL. 13. ISSUE . P. - 30 63% 2
10 SAKTHIVEL, P , GEREKE, M , BREITHAUPT, A , FUCHS, D , GIGLIOTTI, L , GRUBER, AD , DIANZANI, U , BRUDER, D , (2014) ATTENUATION OF IMMUNE-MEDIATED INFLUENZA PNEUMONIA BY TARGETING THE INDUCIBLE CO-STIMULATOR (ICOS) MOLECULE ON T CELLS.PLOS ONE. VOL. 9. ISSUE 7. P. - 30 58% 3

Classes with closest relation at Level 1


Rank Class id link
1 2395 CD28//COSTIMULATION//B7
2 23216 B7 H4//B7 H3//SOLUBLE B7 H4
3 7678 IL 21//INTERLEUKIN 21//T FOLLICULAR HELPER CELLS
4 8384 4 1BB//OX40//CD137
5 721 PD L1//PD 1//IPILIMUMAB
6 8234 CTLA 4//CTLA 4 GENE//GRAVES DISEASE
7 5296 TRANSPLANTAT BIOL//MIXED CHIMERISM//EMORY TRANSPLANT
8 10271 T BET//GATA 3//TBX21
9 10449 LYMPHOTOXIN//BTLA//TERTIARY LYMPHOID ORGANS
10 19364 SECT HUMAN TRANSLAT IMMUNOL//HEART ENDOTHELIAL CELLS//NON MHC

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