Class information for:
Level 1: THROMBIN INHIBITOR//HIRUDIN//XIMELAGATRAN

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
2400 2258 35.3 74%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
111 3       THROMBOSIS RESEARCH//THROMBOSIS AND HAEMOSTASIS//HEMATOLOGY 71244
2272 2             HEPARIN INDUCED THROMBOCYTOPENIA//ARGATROBAN//HIRUDIN 4638
2400 1                   THROMBIN INHIBITOR//HIRUDIN//XIMELAGATRAN 2258

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 THROMBIN INHIBITOR authKW 893396 7% 40% 167
2 HIRUDIN authKW 841113 8% 36% 173
3 XIMELAGATRAN authKW 538597 3% 57% 70
4 MELAGATRAN authKW 470100 2% 63% 55
5 FACTOR XA INHIBITOR authKW 463730 5% 29% 117
6 FACTOR XA authKW 356988 5% 23% 114
7 RECOMBINANT HIRUDIN authKW 239097 2% 45% 39
8 ANTICOAGULANTS authKW 205975 11% 6% 247
9 DX 9065A authKW 203376 1% 79% 19
10 THROMBIN authKW 147107 9% 5% 208

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Medicinal 20382 28% 0% 640
2 Hematology 16419 26% 0% 594
3 Peripheral Vascular Diseases 12820 22% 0% 507
4 Chemistry, Organic 2529 16% 0% 369
5 Pharmacology & Pharmacy 1617 18% 0% 399
6 Biochemistry & Molecular Biology 646 18% 0% 408
7 Cardiac & Cardiovascular System 631 8% 0% 176
8 Biophysics 61 3% 0% 69
9 Chemistry, Multidisciplinary 55 7% 0% 147
10 Biochemical Research Methods 31 2% 0% 51

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MED COMBINATORIAL CHEM 81795 0% 55% 11
2 ZENTRUM VASKULARE BIOL MED 71156 0% 53% 10
3 CARDIOVASC THER EUT SECT 40564 0% 100% 3
4 NEW LEADS GENERAT 40564 0% 100% 3
5 UNIT PHARMACOL HAEMOSTASEOL 32444 0% 40% 6
6 MOL DESIGN ERS 28808 0% 24% 9
7 BIOPHYS PHYSIOL CELL 27043 0% 100% 2
8 DRUG DEV SCI GRP 27043 0% 100% 2
9 PROT CHEM 3 27043 0% 100% 2
10 STRUCT CHEM ENZYMOL 27043 0% 100% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 35928 11% 1% 259
2 THROMBOSIS RESEARCH 35873 7% 2% 165
3 THROMBOSIS AND HAEMOSTASIS 28419 6% 1% 145
4 HAEMOSTASIS 22084 2% 4% 45
5 SEMINARS IN THROMBOSIS AND HEMOSTASIS 17142 3% 2% 58
6 BLOOD COAGULATION & FIBRINOLYSIS 10227 2% 2% 50
7 JOURNAL OF ENZYME INHIBITION 9693 1% 4% 16
8 JOURNAL OF MEDICINAL CHEMISTRY 8634 5% 1% 118
9 PHARMAZIE 6136 3% 1% 64
10 PATHOPHYSIOLOGY OF HAEMOSTASIS AND THROMBOSIS 4511 0% 3% 11

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 THROMBIN INHIBITOR 893396 7% 40% 167 Search THROMBIN+INHIBITOR Search THROMBIN+INHIBITOR
2 HIRUDIN 841113 8% 36% 173 Search HIRUDIN Search HIRUDIN
3 XIMELAGATRAN 538597 3% 57% 70 Search XIMELAGATRAN Search XIMELAGATRAN
4 MELAGATRAN 470100 2% 63% 55 Search MELAGATRAN Search MELAGATRAN
5 FACTOR XA INHIBITOR 463730 5% 29% 117 Search FACTOR+XA+INHIBITOR Search FACTOR+XA+INHIBITOR
6 FACTOR XA 356988 5% 23% 114 Search FACTOR+XA Search FACTOR+XA
7 RECOMBINANT HIRUDIN 239097 2% 45% 39 Search RECOMBINANT+HIRUDIN Search RECOMBINANT+HIRUDIN
8 ANTICOAGULANTS 205975 11% 6% 247 Search ANTICOAGULANTS Search ANTICOAGULANTS
9 DX 9065A 203376 1% 79% 19 Search DX+9065A Search DX+9065A
10 THROMBIN 147107 9% 5% 208 Search THROMBIN Search THROMBIN

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 HAUPTMANN, J , STURZEBECHER, J , (1999) SYNTHETIC INHIBITORS OF THROMBIN AND FACTOR XA: FROM BENCH TO BEDSIDE.THROMBOSIS RESEARCH. VOL. 93. ISSUE 5. P. 203 -241 189 77% 108
2 LEE, YK , PLAYER, MR , (2011) DEVELOPMENTS IN FACTOR XA INHIBITORS FOR THE TREATMENT OF THROMBOEMBOLIC DISORDERS.MEDICINAL RESEARCH REVIEWS. VOL. 31. ISSUE 2. P. 202-283 129 63% 15
3 STEINMETZER, T , STURZEBECHER, J , (2004) PROGRESS IN THE DEVELOPMENT OF SYNTHETIC THROMBIN INHIBITORS AS NEW ORALLY ACTIVE ANTICOAGULANTS.CURRENT MEDICINAL CHEMISTRY. VOL. 11. ISSUE 17. P. 2297-2321 123 77% 54
4 SCHWIENHORST, A , (2006) DIRECT THROMBIN INHIBITORS - A SURVEY OF RECENT DEVELOPMENTS.CELLULAR AND MOLECULAR LIFE SCIENCES. VOL. 63. ISSUE 23. P. 2773-2791 107 62% 59
5 GUO, LW , MA, ST , (2015) ADVANCES IN INHIBITORS OF FXA.CURRENT DRUG TARGETS. VOL. 16. ISSUE 11. P. 1207 -1232 77 76% 0
6 PINTO, DJP , SMALLHEER, JM , CHENEY, DL , KNABB, RM , WEXLER, RR , (2010) FACTOR XA INHIBITORS: NEXT-GENERATION ANTITHROMBOTIC AGENTS.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 53. ISSUE 17. P. 6243 -6274 103 53% 51
7 CORRAL-RODRIGUEZ, MA , MACEDO-RIBEIRO, S , PEREIRA, PJB , FUENTES-PRIOR, P , (2010) LEECH-DERIVED THROMBIN INHIBITORS: FROM STRUCTURES TO MECHANISMS TO CLINICAL APPLICATIONS.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 53. ISSUE 10. P. 3847-3861 89 66% 20
8 MARKWARDT, F , (1994) THE DEVELOPMENT OF HIRUDIN AS AN ANTITHROMBOTIC DRUG.THROMBOSIS RESEARCH. VOL. 74. ISSUE 1. P. 1-23 83 94% 192
9 CASIMIRO-GARCIA, A , DUDLEY, DA , HEEMSTRA, RJ , FILIPSKI, KJ , BIGGE, CF , EDMUNDS, JJ , (2006) PROGRESS IN THE DISCOVERY OF FACTOR XA INHIBITORS.EXPERT OPINION ON THERAPEUTIC PATENTS. VOL. 16. ISSUE 2. P. 119-145 63 94% 27
10 STEINMETZER, T , HAUPTMANN, J , STURZEBECHER, J , (2001) ADVANCES IN THE DEVELOPMENT OF THROMBIN INHIBITORS.EXPERT OPINION ON INVESTIGATIONAL DRUGS. VOL. 10. ISSUE 5. P. 845 -864 78 83% 57

Classes with closest relation at Level 1


Rank Class id link
1 17506 5 6 TRANS PROSTAGLANDIN E2//IN VITRO THROMBOLYSIS//REOCCLUSION AFTER THROMBOLYSIS
2 3016 FACTOR VA//FACTOR V DEFICIENCY//PROTHROMBINASE
3 2034 HEPARIN INDUCED THROMBOCYTOPENIA//ARGATROBAN//LEPIRUDIN
4 12739 LEECH//HIRUDINEA//HIRUDINIDA
5 10627 BIVALIRUDIN//PERCUTANEOUS CORONARY INTERVENTION//ENOXAPARIN
6 7924 UNSTABLE ANGINA//NON Q WAVE MYOCARDIAL INFARCTION//UNSTABLE ANGINA PECTORIS
7 17915 THROMBIN GENERATION//THROMBIN GENERATION ASSAY//ENDOGENOUS THROMBIN POTENTIAL
8 18710 L IDURONIC ACID//CARDIOVASC THROMBOSE//DARA
9 1905 LOW MOLECULAR WEIGHT HEPARIN//UNFRACTIONATED HEPARIN//ENOXAPARIN
10 28279 AROMATIC POLYAMIDINES//TRYPSIN ISOFORMS//DMC AZALYS ONP

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