Class information for:
Level 1: PROTEASE ACTIVATED RECEPTOR//PROTEASE ACTIVATED RECEPTOR 2//THROMBIN RECEPTOR

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
2064 2368 44.8 91%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
111 3       THROMBOSIS RESEARCH//THROMBOSIS AND HAEMOSTASIS//HEMATOLOGY 71244
2517 2             PROTEASE ACTIVATED RECEPTOR//THROMBIN//THROMBIN RECEPTOR 3827
2064 1                   PROTEASE ACTIVATED RECEPTOR//PROTEASE ACTIVATED RECEPTOR 2//THROMBIN RECEPTOR 2368

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PROTEASE ACTIVATED RECEPTOR authKW 1765041 10% 56% 246
2 PROTEASE ACTIVATED RECEPTOR 2 authKW 762369 4% 56% 106
3 THROMBIN RECEPTOR authKW 698554 4% 53% 102
4 THROMBIN authKW 672219 19% 11% 455
5 PROTEINASE ACTIVATED RECEPTOR authKW 582214 3% 62% 73
6 PAR2 authKW 515838 2% 68% 59
7 PROTEINASE ACTIVATED RECEPTOR 2 authKW 481974 2% 69% 54
8 PAR 2 authKW 342540 2% 45% 59
9 PROTEASE ACTIVATED RECEPTOR 2 PAR 2 authKW 183523 1% 65% 22
10 PAR1 authKW 175448 1% 39% 35

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Hematology 4391 14% 0% 325
2 Peripheral Vascular Diseases 3504 12% 0% 281
3 Pharmacology & Pharmacy 1975 19% 0% 446
4 Cell Biology 1455 14% 0% 340
5 Biochemistry & Molecular Biology 1303 23% 0% 543
6 Physiology 846 7% 0% 176
7 Medicine, Research & Experimental 358 6% 0% 136
8 Chemistry, Medicinal 308 4% 0% 98
9 Immunology 224 7% 0% 155
10 Gastroenterology & Hepatology 193 4% 0% 84

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DIABET ENDOCRINE GRP 97708 1% 63% 12
2 MUCOSAL INFLAMMAT GRP 80293 1% 23% 27
3 ENDOCRINE GRP 68457 1% 30% 18
4 DAIICHI 58933 0% 57% 8
5 CANADIAN HLTH PROTEINASES INFLAMMAT NE 51573 0% 100% 4
6 KEY IMMUNOPHARMACOL GUANGDONG PROVINCE 51573 0% 100% 4
7 KEY IMMUNOPHARMACOL GUANGDONG PROV 46411 0% 60% 6
8 GRP PHARMACOL HEMOSTASEOL 46044 0% 71% 5
9 CENT NERVOUS SYST CARDIOVASC CHEM 38680 0% 100% 3
10 PROTEINASES INFLAMMAT NETWORK 38680 0% 100% 3

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BRITISH JOURNAL OF PHARMACOLOGY 6718 4% 1% 97
2 THROMBOSIS AND HAEMOSTASIS 4117 2% 1% 57
3 JOURNAL OF THROMBOSIS AND HAEMOSTASIS 2537 1% 1% 28
4 ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2178 2% 0% 36
5 THROMBOSIS RESEARCH 1756 2% 0% 38
6 DRUG DEVELOPMENT RESEARCH 1715 1% 1% 20
7 JOURNAL OF BIOLOGICAL CHEMISTRY 1607 6% 0% 146
8 SEMINARS IN THROMBOSIS AND HEMOSTASIS 1549 1% 1% 18
9 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 1449 2% 0% 50
10 JOURNAL OF PHARMACOLOGICAL SCIENCES 1060 1% 1% 14

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 PROTEASE ACTIVATED RECEPTOR 1765041 10% 56% 246 Search PROTEASE+ACTIVATED+RECEPTOR Search PROTEASE+ACTIVATED+RECEPTOR
2 PROTEASE ACTIVATED RECEPTOR 2 762369 4% 56% 106 Search PROTEASE+ACTIVATED+RECEPTOR+2 Search PROTEASE+ACTIVATED+RECEPTOR+2
3 THROMBIN RECEPTOR 698554 4% 53% 102 Search THROMBIN+RECEPTOR Search THROMBIN+RECEPTOR
4 THROMBIN 672219 19% 11% 455 Search THROMBIN Search THROMBIN
5 PROTEINASE ACTIVATED RECEPTOR 582214 3% 62% 73 Search PROTEINASE+ACTIVATED+RECEPTOR Search PROTEINASE+ACTIVATED+RECEPTOR
6 PAR2 515838 2% 68% 59 Search PAR2 Search PAR2
7 PROTEINASE ACTIVATED RECEPTOR 2 481974 2% 69% 54 Search PROTEINASE+ACTIVATED+RECEPTOR+2 Search PROTEINASE+ACTIVATED+RECEPTOR+2
8 PAR 2 342540 2% 45% 59 Search PAR+2 Search PAR+2
9 PROTEASE ACTIVATED RECEPTOR 2 PAR 2 183523 1% 65% 22 Search PROTEASE+ACTIVATED+RECEPTOR+2+PAR+2 Search PROTEASE+ACTIVATED+RECEPTOR+2+PAR+2
10 PAR1 175448 1% 39% 35 Search PAR1 Search PAR1

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 ADAMS, MN , RAMACHANDRAN, R , YAU, MK , SUEN, JY , FAIRLIE, DP , HOLLENBERG, MD , HOOPER, JD , (2011) STRUCTURE, FUNCTION AND PATHOPHYSIOLOGY OF PROTEASE ACTIVATED RECEPTORS.PHARMACOLOGY & THERAPEUTICS. VOL. 130. ISSUE 3. P. 248 -282 325 66% 106
2 STEINHOFF, M , BUDDENKOTTE, J , SHPACOVITCH, V , RATTENHOLL, A , MOORMANN, C , VERGNOLLE, N , LUGER, TA , HOLLENBERG, MD , (2005) PROTEINASE-ACTIVATED RECEPTORS: TRANSDUCERS OF PROTEINASE-MEDIATED SIGNALING IN INFLAMMATION AND IMMUNE RESPONSE.ENDOCRINE REVIEWS. VOL. 26. ISSUE 1. P. 1-43 319 72% 331
3 MACFARLANE, SR , SEATTER, MJ , KANKE, T , HUNTER, GD , PLEVIN, R , (2001) PROTEINASE-ACTIVATED RECEPTORS.PHARMACOLOGICAL REVIEWS. VOL. 53. ISSUE 2. P. 245 -282 253 63% 836
4 OSSOVSKAYA, VS , BUNNETT, NW , (2004) PROTEASE-ACTIVATED RECEPTORS: CONTRIBUTION TO PHYSIOLOGY AND DISEASE.PHYSIOLOGICAL REVIEWS. VOL. 84. ISSUE 2. P. 579-621 215 69% 643
5 RAMACHANDRAN, R , HOLLENBERG, MD , (2008) PROTEINASES AND SIGNALLING: PATHOPHYSIOLOGICAL AND THERAPEUTIC IMPLICATIONS VIA PARS AND MORE.BRITISH JOURNAL OF PHARMACOLOGY. VOL. 153. ISSUE . P. S263 -S282 198 73% 182
6 GUTIERREZ-RODRIGUEZ, M , HERRANZ, R , (2015) FROM MULTIPLE PAR1 RECEPTOR/PROTEIN INTERACTIONS TO THEIR MULTIPLE THERAPEUTIC IMPLICATIONS.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 15. ISSUE 20. P. 2080 -2114 240 59% 3
7 RAMACHANDRAN, R , NOORBAKHSH, F , DEFEA, K , HOLLENBERG, MD , (2012) TARGETING PROTEINASE-ACTIVATED RECEPTORS: THERAPEUTIC POTENTIAL AND CHALLENGES.NATURE REVIEWS DRUG DISCOVERY. VOL. 11. ISSUE 1. P. 69 -86 147 69% 111
8 BARRY, GD , LE, GT , FAIRLIE, DP , (2006) AGONISTS AND ANTAGONISTS OF PROTEASE ACTIVATED RECEPTORS (PARS).CURRENT MEDICINAL CHEMISTRY. VOL. 13. ISSUE 3. P. 243-265 159 86% 49
9 LEE, H , HAMILTON, JR , (2012) PHYSIOLOGY, PHARMACOLOGY, AND THERAPEUTIC POTENTIAL OF PROTEASE-ACTIVATED RECEPTORS IN VASCULAR DISEASE.PHARMACOLOGY & THERAPEUTICS. VOL. 134. ISSUE 2. P. 246 -259 149 76% 19
10 YAU, MK , LIU, LG , FAIRLIE, DP , (2013) TOWARD DRUGS FOR PROTEASE-ACTIVATED RECEPTOR 2 (PAR2).JOURNAL OF MEDICINAL CHEMISTRY. VOL. 56. ISSUE 19. P. 7477-7497 141 75% 16

Classes with closest relation at Level 1


Rank Class id link
1 16609 PROTEASE NEXIN 1//THROMBIN//PROTEASE NEXIN I
2 22690 TUMOR ASSOCIATED TRYPSIN INHIBITOR//TATI//PEC 60
3 16281 BERNARD SOULIER SYNDROME//GPIB IX V COMPLEX//BERNARD SOULIER
4 23907 CROSS LINKED FIBRIN//NEPHROL A//AKT PHOSHPHORYLATION
5 4860 THROMBOMODULIN//ACTIVATED PROTEIN C//ENDOTHELIAL PROTEIN C RECEPTOR
6 21510 ADMINISTRATION BY INHALATION//SPECIALTY CARE SERV//TEXAS LUNG INJURY
7 942 TISSUE FACTOR//TISSUE FACTOR PATHWAY INHIBITOR//TFPI
8 10262 NETHERTON SYNDROME//KALLIKREIN//KALLIKREIN RELATED PEPTIDASES
9 11188 DENDRITIC CELLS//PER A 10//DER P 1
10 26062 LOE 908//G ALPHA12//VOLTAGE INDEPENDENT CALCIUM CHANNEL

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