Class information for:
Level 1: ARYLPIPERAZINES//5 HT1A LIGANDS//LONG CHAIN ARYLPIPERAZINES

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
18005 571 26.9 63%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
11 4 NEUROSCIENCES//CLINICAL NEUROLOGY//NEUROL 1112395
76 3       NEUROSCIENCES//DOPAMINE//SEROTONIN 81359
218 2             SEROTONIN//5 HT1A RECEPTOR//5 HT2A RECEPTOR 20633
18005 1                   ARYLPIPERAZINES//5 HT1A LIGANDS//LONG CHAIN ARYLPIPERAZINES 571

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ARYLPIPERAZINES authKW 940460 8% 37% 48
2 5 HT1A LIGANDS authKW 462179 2% 79% 11
3 LONG CHAIN ARYLPIPERAZINES authKW 430343 2% 62% 13
4 5 HT1A RECEPTOR LIGANDS authKW 361408 2% 48% 14
5 NEW DRUGS address 309068 3% 34% 17
6 1 ARYLPIPERAZINE authKW 285199 1% 67% 8
7 5 HT1A 5 HT2A RECEPTOR LIGANDS authKW 222814 1% 83% 5
8 5 HT1A AND 5 HT2A RECEPTOR AFFINITY authKW 213903 1% 100% 4
9 DRUG TECHNOL address 194647 3% 20% 18
10 PURINE 2 6 DIONES authKW 190982 1% 71% 5

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Medicinal 15712 49% 0% 279
2 Pharmacology & Pharmacy 1546 32% 0% 180
3 Chemistry, Organic 833 18% 0% 105
4 Chemistry, Multidisciplinary 657 24% 0% 136
5 Crystallography 551 9% 0% 51
6 Computer Science, Interdisciplinary Applications 9 2% 0% 10
7 Mathematical & Computational Biology 5 1% 0% 5
8 Chemistry, Physical 4 5% 0% 31
9 Biochemical Research Methods 4 2% 0% 11
10 Chemistry, Analytical 4 3% 0% 16

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 NEW DRUGS 309068 3% 34% 17
2 DRUG TECHNOL 194647 3% 20% 18
3 DIPARTIMENTO FARMACOL G SEGRE 122227 1% 57% 4
4 CAJAL NEUROPHARMACOL 106952 0% 100% 2
5 NEW DRUG 91375 4% 9% 20
6 PHARMACOL SCREENING 58519 2% 12% 9
7 CHEM DRUGS 55620 3% 7% 16
8 ICTM CHEM 54994 1% 17% 6
9 AMINO ACIDES PROT 53476 0% 100% 1
10 CATTAR MANZIL PALACE MED CHEM 53476 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 FARMACO 23930 5% 2% 28
2 POLISH JOURNAL OF PHARMACOLOGY 23418 3% 3% 17
3 ARCHIV DER PHARMAZIE 18887 7% 1% 39
4 JOURNAL OF MEDICINAL CHEMISTRY 11511 12% 0% 68
5 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 9164 7% 0% 40
6 FARMACO-EDIZIONE SCIENTIFICA 5207 2% 1% 9
7 ACTA POLONIAE PHARMACEUTICA 3720 2% 1% 10
8 MEDICINAL CHEMISTRY RESEARCH 2827 2% 0% 13
9 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2713 6% 0% 36
10 PHARMAZIE 2625 4% 0% 21

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 ARYLPIPERAZINES 940460 8% 37% 48 Search ARYLPIPERAZINES Search ARYLPIPERAZINES
2 5 HT1A LIGANDS 462179 2% 79% 11 Search 5+HT1A+LIGANDS Search 5+HT1A+LIGANDS
3 LONG CHAIN ARYLPIPERAZINES 430343 2% 62% 13 Search LONG+CHAIN+ARYLPIPERAZINES Search LONG+CHAIN+ARYLPIPERAZINES
4 5 HT1A RECEPTOR LIGANDS 361408 2% 48% 14 Search 5+HT1A+RECEPTOR+LIGANDS Search 5+HT1A+RECEPTOR+LIGANDS
5 1 ARYLPIPERAZINE 285199 1% 67% 8 Search 1+ARYLPIPERAZINE Search 1+ARYLPIPERAZINE
6 5 HT1A 5 HT2A RECEPTOR LIGANDS 222814 1% 83% 5 Search 5+HT1A+5+HT2A+RECEPTOR+LIGANDS Search 5+HT1A+5+HT2A+RECEPTOR+LIGANDS
7 5 HT1A AND 5 HT2A RECEPTOR AFFINITY 213903 1% 100% 4 Search 5+HT1A+AND+5+HT2A+RECEPTOR+AFFINITY Search 5+HT1A+AND+5+HT2A+RECEPTOR+AFFINITY
8 PURINE 2 6 DIONES 190982 1% 71% 5 Search PURINE+2+6+DIONES Search PURINE+2+6+DIONES
9 1 ARYLPIPERAZINE DERIVATIVES 160427 1% 100% 3 Search 1+ARYLPIPERAZINE+DERIVATIVES Search 1+ARYLPIPERAZINE+DERIVATIVES
10 ANALGESIC AND SEDATIVE ACTIVITIES 160427 1% 100% 3 Search ANALGESIC+AND+SEDATIVE+ACTIVITIES Search ANALGESIC+AND+SEDATIVE+ACTIVITIES

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 KOWALSKI, P , MITKA, K , JASKOWSKA, J , DUSZYNSKA, B , BOJARSKI, AJ , (2013) NEW ARYLPIPERAZINES WITH FLEXIBLE VERSUS PARTLY CONSTRAINED LINKER AS SEROTONIN 5-HT1A/5-HT7 RECEPTOR LIGANDS.ARCHIV DER PHARMAZIE. VOL. 346. ISSUE 5. P. 339 -348 24 75% 5
2 BIELENICA, A , KOZIOL, AE , STRUGA, M , (2013) COMPUTATIONAL METHODS IN DETERMINATION OF PHARMACOPHORE MODELS OF 5-HT1A, 5-HT2A AND 5-HT7 RECEPTORS.MINI-REVIEWS IN MEDICINAL CHEMISTRY. VOL. 13. ISSUE 7. P. 933-951 36 46% 0
3 BIELENICA, A , KOZIOL, AE , STRUGA, M , (2013) BINDING MODES OF CHAIN ARYLPIPERAZINES TO 5-HT1A, 5-HT2A AND 5-HT7 RECEPTORS.MINI-REVIEWS IN MEDICINAL CHEMISTRY. VOL. 13. ISSUE 10. P. 1516-1539 38 41% 4
4 PALUCHOWSKA, MH , BOJARSKI, AJ , CHARAKCHIEVA-MINOL, S , WESOLOWSKA, A , (2002) ACTIVE CONFORMATION OF SOME ARYLPIPERAZINE POSTSYNAPTIC 5-HT1A RECEPTOR ANTAGONISTS.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. VOL. 37. ISSUE 4. P. 273-283 24 73% 15
5 LOPEZ-RODRIGUEZ, ML , AYALA, D , BENHAMU, B , MORCILLO, MJ , VISO, A , (2002) ARYLPIPERAZINE DERIVATIVES ACTING AT 5-HT1A RECEPTORS.CURRENT MEDICINAL CHEMISTRY. VOL. 9. ISSUE 4. P. 443 -469 54 27% 117
6 NOWAK, M , KOLACZKOWSKI, M , PAWLOWSKI, M , BOJARSKI, AJ , (2006) HOMOLOGY MODELING OF THE SEROTONIN 5-HT1A RECEPTOR USING AUTOMATED DOCKING OF BIOACTIVE COMPOUNDS WITH DEFINED GEOMETRY.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 49. ISSUE 1. P. 205-214 23 52% 65
7 HEROLD, F , KROL, M , KLEPS, J , NOWAK, G , (2006) SYNTHESIS OF NEW HEXAHYDRO AND OCTAHYDROPYRIDO[1,2-C]PYRIMIDINE DERIVATIVES WITH AN ARYLPIPERAZINE MOIETY AS LIGANDS FOR 5-HT1A AND 5-HT2A RECEPTORS. PART 4.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. VOL. 41. ISSUE 1. P. 125 -134 21 62% 11
8 CHLON-RZEPA, G , ZMUDZKI, P , PAWLOWSKI, M , WESOLOWSKA, A , SATALA, G , BOJARSKI, AJ , JABLONSKI, M , KALINOWSKA-TLUSCIK, J , (2014) NEW 7-ARYLPIPERAZINYLALKYL-8-MORPHOLIN-4-YL-PURINE-2,6-DIONE DERIVATIVES WITH ANXIOLYTIC ACTIVITY - SYNTHESIS, CRYSTAL STRUCTURE AND STRUCTURE-ACTIVITY STUDY.JOURNAL OF MOLECULAR STRUCTURE. VOL. 1067. ISSUE . P. 243-251 15 65% 1
9 FIORINO, F , SEVERINO, B , DE ANGELIS, F , PERISSUTTI, E , MAGLI, E , FRECENTESE, F , ESPOSITO, A , MASSARELLI, P , NENCINI, C , SANTAGADA, V , ET AL (2010) NEW 5-HT1A RECEPTOR LIGANDS CONTAINING A N '-CYANOISONICOTINAMIDINE NUCLEUS: SYNTHESIS AND IN VITRO PHARMACOLOGICAL EVALUATION.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. VOL. 20. ISSUE 9. P. 2978-2982 18 58% 4
10 BOJARSKI, AJ , MOKROSZ, MJ , MINOL, SC , KOZIOL, A , WESOLOWSKA, A , TATARCZYNSKA, E , KLODZINSKA, A , CHOJNACKA-WOJCIK, E , (2002) THE INFLUENCE OF SUBSTITUTION AT AROMATIC PART OF 1,2,3,4-TETRAHYDROISOQUINOLINE ON IN VITRO AND IN VIVO 5-HT1A/5-HT2A RECEPTOR ACTIVITIES OF ITS 1-ADAMANTOYLOAMINOALKYL DERIVATIVES.BIOORGANIC & MEDICINAL CHEMISTRY. VOL. 10. ISSUE 1. P. 87-95 18 69% 11

Classes with closest relation at Level 1


Rank Class id link
1 3624 5 HT1A RECEPTOR//BUSPIRONE//8 OH DPAT
2 11145 5 HT7 RECEPTOR//5 HT6 RECEPTOR//5 HT6
3 29693 BLEOMYCIN AMPLIFICATION//DNA DOCKING//2 5 DIARYLPYRIMIDINE
4 30338 IMIDAZO4 5 GQUINOLINES//PYRIDO2 3 GQUINOXALINES//TRIAZOLO4 5 GQUINOLINES
5 12327 ARIPIPRAZOLE//BLONANSERIN//CONDITIONED AVOIDANCE RESPONSE
6 25248 THIETHANE//ALPHA1 AND ALPHA2 RECEPTOR LIGANDS//CNS ACTIVITY OF FUSED2 1 FTHEOPHYLLINES
7 4196 G PROTEIN COUPLED RECEPTOR//GPCR//MEMBRANE PROT STRUCT FUNCT UNIT
8 33946 QUIM MED COMPUTAC//BIOTECNOL MOL ESTRUTURAL//GRP QUIM MED PROD NAT
9 12452 OSU6162//ROXINDOLE//TERGURIDE
10 23579 23H BENZOXAZOLONE//23H BENZOTHIAZOLONE//UNITE CHIM PHARMACEUT

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